Blood Pressure In Second Trimester Research Articles

Is There an Association Between Second Trimester Blood Pressure and Pregnancy-Induced Hypertensive Disorders? [19L

INTRODUCTION: In 2017, the American College of Cardiology (ACC) and the American Heart Association (AHA) revised the guidelines for abnormal blood pressure (BP): elevated (120-129/<80), stage 1 (130-139/80-89) and stage 2 hypertension (≥140/90) on ≥2 occasions in adults. This study aims to determine a relationship between elevated and stage 1 ACC/AHA hypertension in the second trimester and pregnancy-induced hypertensive disorders (PIH). METHODS: In this IRB approved retrospective cohort study, we collected the highest two blood pressure measurements in second trimester for singleton pregnancies prior to the ACOG diagnosis of PIH (gestational hypertension, preeclampsia, HELLP, eclampsia). Patients were grouped by ACC/AHA criteria and compared using Pearson chi-square tests, Fisher’s exact tests, T-tests or Mann-Whitney U tests. RESULTS: 200 patients were included; 54.9% had normal BP, 10.5% had elevated BP, and 34% had stage 1 ACC/AHA hypertension. There was no association between the severity of PIH and normal versus elevated/stage 1 BP in second trimester. Among those with elevated/stage 1 hypertension, gestational age was significantly lower at diagnosis of PIH (P<.001) and delivery (P<.001) compared to normotensive patients. CONCLUSION: Gestational age at PIH diagnosis and delivery were significantly lower among women with ACC/AHA elevated or stage 1 hypertension in second trimester compared to normotensive women. Therefore, further research is warranted to determine a relationship between the ACC/AHA guidelines for hypertension and PIH with the possibility of earlier recognition of the disease and intervention.

Clinical significance of elevated mean arterial blood pressure in second trimester and threshold increase in systolic or diastolic blood pressure during third trimester

The purpose of this investigation was to determine the diagnostic value of an average mean arterial blood pressure in the second trimester of greater than or equal to 90 mm Hg and a threshold increase in diastolic blood pressure of greater than or equal to 15 mm Hg or in systolic blood pressure of greater than or equal to 30 mm Hg, on two occasions, 6 hours apart, in predicting preeclampsia. The study population consisted of 700 young normotensive primigravid women who were evaluated prospectively during pregnancy. Systolic and diastolic blood pressures were carefully measured at each prenatal visit, and the mean arterial blood pressure in the second trimester was calculated for each measurement. An average greater than 90 mm Hg was considered abnormal. One hundred thirty-seven patients had preeclampsia, for an overall incidence of 19.6%. An average greater than 90 mm Hg had a sensitivity of 8% and a positive predictive value of 23%. The respective values for a threshold increase of greater than 15 mm Hg in diastolic pressure were 39% and 32%. For a threshold increase of greater than 30 mm Hg in systolic pressure, values were 22% and 33%. The negative predictive values for all tests studied ranged between 81% and 85%. Neither a mean arterial blood pressure in the second trimester of greater than 90 mm Hg nor a threshold increase in systolic or diastolic blood pressure during the third trimester was significantly predictive of the development of preeclampsia.