Blood Pressure In Obese Adolescents Research Articles

Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant

It is known that telomere length (TL) (evaluated with T/S ratio) is shortened in the presence of obesity. In this study, we aimed to investigate how obesity in adolescents and non-alcoholic liver disease (NAFLD) within the obese group affect TL and the clinical significance of the human telomerase reverse transcriptase (hTERT) gene MNS16A VNTR variant in terms of NAFLD. Adolescents with exogenous obesity and healthy controls (aged 10–19 years) who applied to our adolescent outpatient clinic between May-October 2023 were included in this study. We performed upper abdominal ultrasonography to investigate the presence of NAFLD in adolescents with obesity and divided into two groups: those without hepatosteatosis (obese NAFLD (-)) and those with hepatosteatosis (obese NAFLD (+)). We recorded body weight, height, waist circumference, and blood pressure measurements and measured the T/S ratio (telomere sequence copy number/gene single copy number) by the Quantitative Polymerase Chain Reaction method. The groups were compared using frequentist and Bayesian methods. Eighty-three obese adolescents [63 NAFLD(+) 20 NAFLD(-)] and 69 lean controls were included in the study. Pairwise comparisons revealed that T/S ratio was significantly lower in the obese NAFLD (-) group than the obese NAFLD (+) and the control group (p = 0.025, p = 0.007, respectively). T/S ratio was lower in the LL allele group than in the other alleles (p = 0.022) and slightly higher in the obese group with metabolic syndrome compared to the obese group without metabolic syndrome (p = 0.072). hTERT-MNS16A-VNTR gene variant LL allele had a negative correlation with T/S ratio among the obese adolescent group. Patients with LL alleles had higher ALT, GGT, HOMA-IR, and ALT/AST. Diastolic blood pressure had a significant correlation with the T/S ratio. The T/S ratio was shorter in the obese adolescent group compared to healthy ones but was higher in the NAFLD (+) obese compared to the NAFLD (-) obese. ALT level and ALT/AST ratio were higher, T/S ratio was lower in the hTERT MNS16A VNTR variant LL allele group among obese adolescents. In addition, there was a significant correlation between the T/S ratio and diastolic blood pressure in obese adolescents.

Evaluation of the Relationship Between Adropin Levels and Blood Pressure in Obese Adolescents

Background: Adropin is a bioactive protein that maintains energy balance through the metabolism of glucose and lipids. Adropin is associated with blood pressure, endothelial function, and glucose metabolism, according to reported studies. High blood pressure is one of the complications of obesity. Objectives: Our study investigated the relationship between adropin levels and systolic and diastolic blood pressure in obese adolescents. Methods: The study was conducted with a total of 88 adolescents, 45 females and 43 males, aged 10 - 18 years. The mean age of the participants was 13.79 ± 1.98 years. Participants were divided into two groups: "obese" (n = 61) and "control" (n = 27). Adolescents with a body mass index (BMI) above the 95% percentile for age, gender, and race were defined as "obese." The control group comprised adolescents with a body mass index between the 5th and 85th percentiles. A sample was taken from the forearm pit of the subjects after fasting for at least 12 hours for the determination of glucose, insulin, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C- reactive protein (CRP), total cholesterol, low-density lipoprotein- cholesterol (LDL-cholesterol), high-density lipoprotein- cholesterol (HDL- cholesterol), triglyceride, thyroid-stimulating hormone (TSH), free T4 (fT4), and 25-hydroxyvitamin D3. In both groups, systolic and diastolic blood pressures were assessed using an aneroid manometer and a suitable cuff after subjects had rested for at least 10 minutes in the outpatient clinic. The following formula determined the homeostatic model of assessment for insulin resistance (HOMA-IR): fasting insulin (uIU/mL) × fasting glucose (mg/dL) /405. An enzyme-linked immunosorbent assay (ELISA) kit was used to measure adropin levels. Results: The insulin, HOMA-IR, AST, ALT, GGT, CRP, triglyceride, and LDL-cholesterol levels of adolescents in the obese group were statistically significantly higher than those in the control group (P < 0.05). HDL-cholesterol and 25-hydroxyvitamin D3 levels of adolescents in the obese group were statistically significantly lower than those of the control group (P < 0.05). There was no statistically significant difference between groups in glucose, urea, creatinine, total cholesterol, TSH, fT4, and adropin levels (P > 0.05). In the obese group, there was an inverse and statistically significant correlation between adropin level and diastolic blood pressure (P: 0.029; P < 0.05). Conclusions: We found an inverse relationship between adropin levels and DBP but no relationship between adropin levels and SBP in obese adolescents.

Sodium intake and high blood pressure among adults on caloric deficit: a multi-year cross-sectional analysis of the U.S. population, 2007-2018.

Small studies have shown reduced sodium-sensitivity of blood pressure in obese adolescents on a caloric deficit. We aimed to explore the association between mean daily sodium intake and prevalent hypertension among a nationally representative sample of U.S. adults on a calorie deficit. We used a design-based regression model to explore the association between sodium intake and prevalent hypertension. We also conducted sensitivity analyses using multiple imputation chained equations and propensity score matching. We also measured the effect of a binary exposure derived from the widely recommended threshold of 2.3 grams of sodium intake per day. Among 5756 individuals, we did not detect any significant association between increased sodium and the odds of hypertension (OR: 0.97; 95% CI: 0.90; 1.05). All our sensitivity analyses are consistent with our main findings. People on a calorie deficit-a component of healthy weight loss-without malnutrition saw no benefit in reduced sodium intake to lower blood pressure. These results highlight the need to explore new population-specific strategies for sodium intake reduction, including new dietary prescription approaches to improve dietary adherence and reduce the risk associated with sodium-deficient diets.

The Effect of Nutrition Education on Body Mass Index, Waist Circumference, Mid-upper Arm Circumference and Blood Pressure in Obese Adolescents

Purpose: The aim of the study was to determine the effect of nutrition education in the form of DASH diet booklets on body mass index, waist circumference, mid-upper arm circumference, and blood pressure in obese adolescents. Methods: This study was quasi-experimental, which is pre-test and post-test with control group design. The number of subjects was 60 respondents. The groups in this study were divided into two; one treatment group and one control group. The first group was given a nutrition education intervention with a booklet and the second group was not treated. Data analysis used paired t-test and independent t-test (p=0.05; CI=95%), Wilcoxon test, Mann-Whitney test, and Spearman rank test. Results: There were differences in BMI, waist circumference, mid-upper arm circumference, and significant systolic blood pressure in the treatment group after the intervention. The mean average of the treatment group decreased significantly; BMI: 0.36±0.05 kg/m2; waist circumference: 0.84±0.14 cm; mid-upper arm circumference: 0.37±0.63 cm, and systolic blood pressure: 1.13±1.36 mmHg. In the control group the average BMI, waist circumference, mid-upper arm circumference, and systolic blood pressure were increased significantly. The treatment group experienced a decrease in energy intake by 524.65±85.77 kcal while physical activity increased by 0.635±0.09. Conversely, the control group experienced an increase in energy intake by 147.29±25.18 kcal, while physical activity decreased by 0.470±0.08. Changes in energy intake and physical activity between the treatment group and the control group were identified as significant correlations (p<0.001). Similar to it, the changes in the BMI, waist circumference, mid-upper arm circumference, and significant systolic blood pressure were identified as significant correlations (p<0.001). Application: The use of booklets can be a solution for the continuation of effective nutrition education as the nutritional information becomes easier to be comprehended and adapted by the booklet recipients and used in everyday life.

HUBUNGAN FAKTOR ASUPAN DENGAN LINGKAR PINGGANG, KADAR GULA DARAH PUASA DAN TEKANAN DARAH PADA REMAJA OBESITAS DI SMA NEGERI 9 SEMARANG

Background : Obesity in adolescence associated with the incidence of metabolic syndrome. The metabolic syndrome is a group of metabolic disorders characterized by high blood pressure, high fasting blood glucose, high triglycerides, low HDL and central obesity. An increasing number of metabolic syndrome in line with the increase in the number of obesity. Based on RISKESDAS 2013 increased the proportion of central obesity from 2007 to 2013 by 18.8% to 26.6%. The prevalence of central obesity in Semarang 21.5%.Aim : Knowing the relationship among intake with waist circumference, fasting blood glucose level and blood pressure in obese adolescents in SMAN 9 Semarang.Method : This study was an observational study with cross-sectional design. Sampling was conducted randomized to receive 47 samples. The data collected is macro nutrients intake factors with 24 hours recall method, weight, height, waist circumference, fasting blood glucose level and blood pressure. Data was collected by the method of anthropometry; interviews, blood pressure measurement and fasting blood glucose level measurement. The correlations test using linear regression.Results: There is a correlation between intake with waist circumference (p 0.046 0.05) with a moderate relationship (R = 0.454) and contributed 20.6%, there is a correlation between intake with fasting blood glucose level (0.039 p 0.05) with the level of relationship is (R = 0.448) and contributed 20.1%, there is a correlation between intake with systolic blood pressure (p 0.004 0.05) with a strong correlation (R = 0.556) and contributed 30.6%, and there is no correlation between intake factor with diastolic blood pressure (p 0.113 0.05) and contributed 16.3%.Conclusion: There is a correlation among intake with waist circumference, fasting blood glucose level and systolic blood pressure. There is no correlation between intake with diastolic blood pressure.

HUBUNGAN KADAR ASAM URAT DENGAN TEKANAN DARAH PADA REMAJA OBESITAS DI KOTA SEMARANG

Background : Obesity in adolescents may cause elevated uric acid levels, leading to increased blood pressure. This occurs as a result of high uric acid levels inducing arteriolopathy in preglomerular vessels. Consequently, the autoregulator response of the afferent arterioles is impaired and eventually causing hypertension. This study aimed to determine the association of uric acid levels with blood pressure in obese adolescents. Adolescent with hypertension could continue in adulthood and had an higher increased risk of mortality. Objective : To analyze correlation of serum uric acid with blood pressure in obese adolescent in SemarangMethods : This was an observational, cross-sectional study with fifty-three subjects selected through consecutive sampling. Food intakes were assessed using Semi Quantitative Food Frequency Questionare. Serum uric acid levels were measured by Uricase PAP, while physical activity levels were determined by Short International Physical Activity Questionare. Data were analyzed using Rank-Spearman test. Result : Mean serum uric acid levels in male adolescents was 4.897±1.223 mg/dL with an average systolic blood pressure of 1.219±9.544 and a mean diastolic blood pressure of 85.85±8.359. In female subjects, the mean serum uric acid levels was 4.841±0.883 mg/dL with an average systolic blood pressure of 1.175±9.653 and an average diastolic blood pressure of 81.67±8.348. Serum uric acid levels were significantly correlated with systolic blood pressure (p = 0.000; r=0,495) and diastolic blood pressure (p = 0.010, r=0,325).Conclusion : Serum uric acid levels were significantly correlated with blood pressure among obese adolescents in Semarang.

Relationship between fat distribution ratio and blood pressure in obese adolescents

Background The incidence of obesity in big cities increasessignificantly. The association between obesity and increased riskof cardiovascular disease and hypertension in adults has beenknown but less information is available in adolescents. Similarly,the relationship between body-fat distribution and cardiovasculardiseases in adolescents is less clear tha that in adults.Objective This study aimed to determine the association betweenbody fat distribution and increased blood pressure in obeseadolescents in Bandung.Methods This cross-sectional study was conducted from June toAugust 2006. Subjects were students aged 15-18 years at highschools in Bandung with body mass index (BMI) measured usingCDC chart 2000 (&gt; P95) and increased blood pressure (&gt; P90)depended on age and gender according to National High BloodPressure Education Program Working Group on High BloodPressure in Children and Adolescents 2004. Waist-to-hip ratio(central fat), and subscapula skinfold-to-triceps skinfold ratio(peripheral fat) were used to measure fat distribution. Correlationbetween body fat distribution and blood pressure was analyzedusing Pearson correlation statistical test.Results Out of 3170 adolescents examined, 34 obese adolescentgirls and 43 obese adolescent boys had increased blood pressure.Correlation between waist-to-hip ratio and systole blood pressurein boys showed by r=0.495; P=0.003 and girls showed r=0.494;P=O.OOl. Correlation between subscapula skinfold-to-tricepsskinfold ratio in boys showed r=0.289; P=0.097 and girls showedby r=0.248; P=0.109.Conclusion Central fat is moderately correlated with increasedblood pressure in obese adolescents.

In Obese Teens, Are Blood Pressure &amp; Periodontal Disease Linked?

Research Article| September 01 2015 In Obese Teens, Are Blood Pressure & Periodontal Disease Linked? AAP Grand Rounds (2015) 34 (3): 33. https://doi.org/10.1542/gr.34-3-33 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation In Obese Teens, Are Blood Pressure & Periodontal Disease Linked?. AAP Grand Rounds September 2015; 34 (3): 33. https://doi.org/10.1542/gr.34-3-33 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: obesity, periodontal diseases, blood pressure Source: Zeigler CC, Wondimu B, Marcus C, et al. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15(1): 41; doi: https://doi.org/10.1186/s12903-015-0026-6Google Scholar Investigators from the Karolinska Institutet in Stockholm, Sweden conducted a cross-sectional study of obese adolescents to assess the association between periodontal disease and blood pressure. Participants were recruited from the National Childhood Obesity Center at Karolinska University Hospital, and were eligible if they were 12–18 years of age, not a smoker, had not taken systemic antibiotics in the past 3 months, and were not undergoing orthodontic treatment. The primary independent variable of interest was periodontal disease. This was determined by the presence of pathological periodontal pockets (PD) ≥4mm on dental examination indicating the presence of an abnormal depth of the gingival sulcus where the gingival tissue contacts the tooth. The primary outcome was diastolic blood pressure (DBP), measured manually in the sitting position and expressed as the mean of 2 separate readings. Additional variables collected included body mass index (BMI), gender, age, medications, dietary habits, parents’ education, and mother’s country of birth. Gingival inflammation was also measured by dental examination based on bleeding on probing (BOP). Lastly, fasting blood samples were obtained to measure factors known to be associated with periodontal disease, obesity, or blood pressure, including total cholesterol, high density lipoprotein, thyroid stimulating hormone (TSH), c-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-1b, 6 and 8, and leptin. Among the 75 participants enrolled, 14 had PDs ≥4 mm. The DBP among participants with PDs ≥4 mm was 7 points higher than the DBP among participants without pathologic PDs (74 mmHg vs 67 mmHg, respectively; P = .008). After adjusting for BMI, age, gender, mother’s country of birth, BOP, IL-6, IL-8, leptin, MCP-1, TSH, and total cholesterol, PDs ≥4 mm remained significantly associated with DBP (P = .006). The investigators conclude that there is an association between periodontal disease and DBP among obese adolescents. Dr Slayton has disclosed no financial relationship relevant to this commentary. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device. Periodontal disease is a chronic inflammatory disease that involves interaction between pathogenic bacteria and the host’s immune system resulting in gingivitis and alveolar bone loss.1 Loss of alveolar bone leads to partial or complete loss of teeth. Obesity is a common, chronic condition that has been linked to periodontal disease in recent studies.2,3 In a 20-year Department of Veterans Affairs Dental Longitudinal Study, it was found that rapid weight gain, waist circumference and increases in arm fat were associated with more periodontitis and periodontitis progression in men.2 The results of a second longitudinal study of men indicated that there was a greater risk for periodontal disease associated with waist circumference and waist to hip measurements and that participants with a BMI ≥30 kg/m2 were at significantly greater risk for... You do not currently have access to this content.

Morning Blood Pressure Is Associated with Sleep Quality in Obese Adolescents

To examine relationships among blood pressure (BP), adiposity, and sleep quality with the use of overnight polysomnography in obese adolescents. Overnight polysomnogram and morning BP measurements were performed in obese (body mass index [BMI] >95th percentile) nondiabetic adolescents (eligible age range 12-18 years, n = 49). Subjects were stratified into 2 groups, one with normal BP, and one with elevated BP, and demographic and clinical characteristics were compared between the groups. Multiple linear regression analysis was used to assess the effects of sleep quality on BP. Participants (n = 27) had a normal morning BP, and 22 (44.9%) had elevated morning BP. There were no differences in age (P = .53), sex (P = .44), race (P = .58), or BMI (P = .56) between the 2 BP groups. The group with elevated BP spent shorter percentages of time in rapid eye movement (REM; P = .006) and slow-wave sleep (SWS; P = .024). Multiple linear regression analysis showed that a lower percentage of both REM and SWS was associated with increased morning BP after we adjusted for pubertal stage, sex, race, and BMI. Lack of deeper stages of sleep, REM sleep, and SWS is associated with greater morning BP in obese adolescents, independent of BMI. Poor sleep quality should be considered in the work-up of obese youth with hypertension. Intervention studies are needed to evaluate whether improving the quality of sleep will decrease BP elevation.

Association between lipid profile and blood pressure in obese adolescents in Padang

Results Increased blood pressure occurred in 32% of all samples with 27% of prehypertension and 5% hypertension. Dyslipidemia, cholesterol levels, high LDL and triglycerides and low HDL levels found respectively 40%, 41.3%, 25% and 43.8% of the total sample. Obese adolescents with increased blood pressure have high triglyceride levels compared with obese adolescents with normal blood pressure, (40.6% vs 14.6% with P 0.009).

A Review of Randomized Controlled Trials of Aerobic Exercise Training on Fitness and Cardiometabolic Risk Factors in Obese Adolescents

Aerobic training is the most prescribed exercise modality for the management of pediatric obesity. There is strong evidence that it decreases waist circumference, percent body fat and visceral fat, increases cardiorespiratory fitness, and decreases blood pressure in obese adolescents. However, the independent effects of aerobic exercise training on other cardiometabolic risk factors (ie, insulin resistance markers, plasma lipid levels, and inflammatory markers) are limited and yield inconsistent findings. Our article reviews randomized controlled trials evaluating the effects of aerobic exercise training on body composition, fitness, lipid levels, and insulin resistance in obese adolescents (aged 13-18 years) and outlines future research directions for this population.

THE ROLE OF HUMORAL FACTORS IN FORMATION OF ARTERIAL HYPERTENSION IN OBESE

It was studied performance monitoring of blood pressure in obese adolescents according to that of the "office"blood pressure. It was shown that adolescents with obesity indicators increase ambulatory blood pressure monitoring and associated with increased vaspin, resistin and osteopontin in the blood serum.

The effect of aerobic exercise on blood pressure and lipid metabolism in obese adolescents

ObjectivesObesity is a major risk factor for type 2 diabetes, insulin resistance, dyslipidemia, hypertension and many other chronic diseases. Aerobic exercise has been shown to be beneficial to lipid metabolism...

Obesity Hypertension in Adolescents: Epidemiology, Evaluation, and Management

The prevalence of hypertension among all adolescents is approximately 3.5%, with somewhat higher rates of prehypertension. Obesity affects approximately 20% of adolescents in the United States, and the prevalence of hypertension is much higher among obese adolescents compared with nonobese adolescents. As in other populations, the evaluation of elevated blood pressure in obese adolescents should begin with a confirmation of the blood pressure elevation, followed by a focused diagnostic work-up to detect possible secondary causes of hypertension. Primary therapy for obesity-related hypertension in adolescents begins with weight loss, and may include antihypertensive medications if target-organ damage or other indications for drug therapy are present. The emphasis of management should be reduction of future cardiovascular risk.

Relationship Between Adiponectin and Ambulatory Blood Pressure in Obese Adolescents

Obesity is associated with elevated blood pressure (BP), insulin resistance, and altered plasma adiponectin levels; the relationship between the biochemical features of obesity and 24-h ambulatory blood pressure (24-h ABP) parameters in adolescents remains unknown. Anthropometric measurements and 24-h ABP monitoring were obtained on 41 obese adolescents with and without type 2 diabetes mellitus (T2DM). Serum adiponectin, high sensitivity C-reactive protein (hs-CRP), lipid profile, insulin, fasting glucose, liver enzymes, Hb A1c (HbA1c), and two random urine samples were obtained for creatinine and microalbumin measurements. The determinants of 24-h systolic (SBP) and diastolic (DBP) BP were examined using multivariate linear regression models with BP parameters as outcome variables. Forty-one obese adolescents were studied. Adiponectin levels were reduced and hs-CRP levels were elevated, and were inversely and significantly correlated (rho = -0.3, p = 0.05). ABP showed blunted nocturnal SBP dipping. Twenty-four hour SBP and DBP indexes were significantly (p < 0.05) and inversely correlated with adiponectin (rho = -0.4 and -0.42), respectively. In multivariate models, lower adiponectin level was independently associated with 24-h SBP and DBP. Adiponectin inversely correlate with ABP parameters in obese adolescents. Larger studies are needed to examine the relationship between adiponectin and mechanisms of BP regulation.