Blood Pressure In Chinese Adolescents Research Articles

RELATIONSHIP BETWEEN SERUM OSTEOCALCIN AND BLOOD PRESSURE IN CHINESE ADOLESCENTS AGED 12–18 YEARS

Objective: The relationship between serum osteocalcin level and blood pressure remains unclear. The aim of this study was to determine whether osteocalcin would be associated with blood pressure in Chinese adolescents. Design and method: A total of 1686 subjects (1022 boys,60.6%) aged 12–18 years from Ningxia were randomly selected through a stratified cluster sampling. Serum osteocalcin levels were measured by ELISA. Blood pressure (BP) by using a calibrated electronic sphygmomanometer according to the standard method by the American Hypertension Education Project Working Group. Results: The proportions of Hypertension was highest in the< = 33th percentile subgroup (39.8%) and lowest in the > 66th percentile subgroup (26.3%) in boys, with statistically significant differences between groups (2 = 10.988, P = 0.027). Compared with the subgroup of the< = 33th percentile, the odds ratios (ORs) for abnormal blood pressure were 0.73(95% confidence interval (CI), 0.55—0.96) in the 34th–66th percentile subgroup, 0.64(95% CI, 0.48—0.84) in the > 66th percentile subgroup, respectively. Additionally, the corresponding ORs for high BP were 0.63(95%CI,0.45–0.89) in the 34th–66th percentile subgroup,0.59(95%CI,0.42–0.84) in the > 66th percentile subgroup, respectively. Similar results were found in boys (P all < 0.05). After Adjusting age, fasting blood glucose and BMI, the ORs for high BP were 0.60(95%CI,0.36–0.99) in the > 66th percentile subgroup compared with the reference subgroup. Conclusions: Serum osteocalcin is a protective factor for hypertension in Chinese adolescents, especially in boys.

Overweight Influence on Circadian Variations of Ambulatory Blood Pressure in Chinese Adolescents

Overweight Influence on Circadian Variations of Ambulatory Blood Pressure in Chinese Adolescents

Overweight Influence on Circadian Variations of Ambulatory Blood Pressure in Chinese Adolescents

Childhood obesity and its consequences have been the subject of intense interest in recent years. In this study we examined the influence of overweight on circadian variations of ambulatory blood pressure (ABP) in Chinese adolescents. First, 24-hr ABP monitoring was performed in 252 adolescents divided into two groups with equivalent sex, age, and body height (49 girls and 77 boys in each group): controls (normal weight) were aged 13.68 ± 1.21 years, height 165.37 ± 9.45 cm, body mass index (BMI) 18.82 ± 2.3; overweights (BMI = 24) were aged 13.71 ± 1.23 years, height 165.75 ± 9.47 cm, BMI 27.70 ± 3.1. ABP recordings were treated by ABP database system and analyzed by cosinor method and conventional statistics methods. The circadian variations of ABP in adolescent patterned as “dipper” and circadian rhythmicity of ABP variations were confirmed by cosinor analysis in most adolescents of both groups. Significant statistical differences were found for rhythm parameters: the MESOR (midline estimate statistic of rhythm), peak, trough (the maximum and minimum values derived from the composed curves, respectively), and amplitude values between control and overweight groups. Significant higher values also were seen in the overweight group for most of ABP parameters (p < .01), such as, BP means (SBP, DBP, MAP: mean arterial pressure, or PP: pulse pressure), BP variability, BP loads and rate-pressure product (HR × SBP). Our results have shown that overweight influenced significantly on ABP and parameters derived from ABP recordings in Chinese adolescents, which suggests an increasing risk of cardiovascular diseases in overweight adolescents.