Forty (40) weaned pigs (Large white x Landrace, 10 week old, 14.9±0.18 kg body weight) were used to assess the effect of processed cassava root meal on the zootechnical response, profitability, blood parameters, organ weight, carcass characteristics and organoleptic properties of the pigs. The pigs were randomly allotted into four treatments with ten pigs serving as replicates in a completely randomized design. The experiment lasted for forty-nine (49) days. The feed had 0.00%, 32.50%, 48.80% and 65.00% processed cassava root meal in the diets tagged D1, D2, D3 and D4 respectively. The final weight, total weight gain, average daily weight gain, total feed intake, average daily feed intake and feed conversion ratio were significantly different (P<0.05). There were significant differences (P <0.05) in the profitability indices except the feed cost per kg weight gain. All the hematological parameters were significantly affected (P<0.05) except for the mean corpuscular hemoglobin concentration and platelet. All the serum biochemical parameters were significantly (P<0.05) affected except aspartate aminotransferase, urea, total protein, glucose and triglyceride. The weight of the empty stomach, pancreas and heart were not significantly influenced (P>0.05) across the treatments while others were significantly influenced (P<0.05). All the carcass parameters were significantly influenced by processed cassava root meal (P<0.05) except the bled weight, trotter, picnic shoulder and spare rib. The color and juiciness of the meat were also significantly influenced by processed cassava root meal (P<0.05). In conclusion, up to 48.8% is considered favorable in the diet of weaned pigs.