Blood Lipoids Research Articles

Effects of moxibustion at 45 ℃ on blood lipoids and serum level of ox-LDL and NO in rats with hyperlipidemia

To observe the effects of moxibustion at different temperatures (38 ℃ and 45 ℃) on blood lipoids and serum level of oxidized low density lipoprotein (ox-LDL) and nitric oxide (NO) in rats with hyperlipidemia, and to explore the correlation between regulating blood fat and anti-oxidative stress and protection of vascular endothelium of moxibustion at 45 ℃. According to random number table, 60 SD rats were randomly divided into a normal group, a model group, a moxibustion at 38 ℃ group and a moxibustion at 45 ℃ group, 15 rats in each group. The rats in the normal group received no treatment; the rats in the remaining three groups were fed with high-fat diet for 8 weeks to prepare rat models of hyperlipidemia. After successful modeling, the rats in the model group received no treatment; the rats in the moxibustion at 38 ℃ group and moxibustion at 45 ℃ group were treated with moxibustion at "Shenque" (CV 8) and "Zusanli" (ST 36), and the temperature was controlled at (38±1) ℃ and (45±1) ℃, respectively. The moxibustion was given for 10 min at each acupoint, once every two days, and totally 4-week treatment was given. After treatment, the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured by using biochemical colorimetric method; the levels of ox-LDL and NO were measured by using ELISA method. ① Compared with the normal group, the levels of TC, TG and LDL-C were significantly increased in the model group (all P<0.01); compared with the model group and moxibustion at 38 ℃ group, the levels of TC, TG and LDL-C were significantly decreased in the moxibustion at 45 ℃ group (P<0.01，P<0.05); compared with the model group, the levels of TC, TG and LDL-C were insignificantly decreased in the moxibustion at 38 ℃ group (all P>0.05). ② Compared with the normal group, the level of ox-LDL was increased but that of NO was decreased in the model group (both P<0.01); compared with the model group and moxibustion at 38 ℃ group, the level of ox-LDL was decreased but that of NO was increased in the moxibustion at 45 ℃ group (P<0.01, P<0.05); compared with the model group, the level of ox-LDL was decreased but that of NO was increased in the moxibustion at 38 ℃ group (both P<0.05). Moxibustion at 45 ℃ has regulating effects on blood lipid in rats with hyperlipidemia, which can regulate blood lipid through various ways, such as anti-oxidative stress and protection of vascular endothelium.

The effects of behavioral intervention on the life quantity, mental state and metabolic indices control in patients with type 2 diabetes

目的 探讨行为干预对2型糖尿病患者生命质量、心理状况和病情控制的影响.方法对2型糖尿病患者按登记顺序随机分为观察组(A组)、对照组(B组),进行糖尿病知识问卷、糖尿病生命质量问卷调查和症状自评量表评分,并对其血糖、血脂、体重等代谢指标的控制情况进行比较,两组均给以降糖药物治疗,A组并给予行为干预,6个月后两组重复上述量表测评及代谢指标检测,最后进行统计学分析.问卷采用自拟糖尿病知识问卷、丁元林修订的糖尿病生命质量量表(A-DQOL)和症状自评量表(SCL-90).结果两组治疗后比较,生命质量问卷总分:A组100.3±28.6、B组138.9±10.7;生命质量满意度:A组33.3±8.4、B组42.8±9.2;影响程度:A组46.4±3.4、B组57.2±4.2;忧郁程度Ⅰ:A组12.6±2.1、 B组18.8±2.4;忧郁程度Ⅱ:A组8.8±2.6、B组13.9±1.1,均有显著性差异(P 0.05);两组治疗前后强迫症状均有显著差异(P <0.05);空腹血糖、餐后2h血糖、糖化血红蛋白、血清总胆固醇、甘油三酯、低密度脂蛋白、体重指数等,A组较B组均有显著性改善(P <0.01).结论行为干预治疗对改善糖尿病患者的生命质量、心理状况及糖代谢情况起着确切的积极作用。

The Effect of Pantothenic Acid Deficiency on the Blood Lipoids of the Dog

The Effect of Pantothenic Acid Deficiency on the Blood Lipoids of the Dog

CIRCULATION TIME AS A DIAGNOSTIC AID IN HYPERTHYROIDISM

Article1 April 1938CIRCULATION TIME AS A DIAGNOSTIC AID IN HYPERTHYROIDISMSAMUEL J. GOLDBERG, M.D., F.A.C.P.SAMUEL J. GOLDBERG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-10-1818 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe satisfactory results of present day treatment of hyperthyroidism make it essential that an accurate diagnosis be made before the late effects of the disease damage the heart and other viscera. The widespread use of basal metabolism equipment indicates the acceptance of this principle by the medical profession.It is well known, however, that increased basal metabolism is not always synonymous with hyperthyroidism. There are a number of conditions which may at one time or another in their course exhibit such elevations in metabolism. This may be noted in heart failure; in some cases of hypertension; during the course of...Bibliography1. TROELL A: Basedow mit niedrigem Grundumsatzwert, Arch. f. klin. Chir., 1932, clxix, 774. MORRIS, R. S.: The thyroid heart with low basal metabolic rate, Am. Jr. Med. Sci., 1931, clxxxi, 297. SCARF, M.: Hyperthyroidism with normal basal metabolic rate (4 cases), Mt. Sinai Hosp. Clin. Soc., 1936. (Unpublished.) Google Scholar2. HURXTHAL LM: Value of blood cholesterol determination in thyroid diseases, Surg. Clin. N. Am., 1933, xiii, 779. EPSTEIN, A. A., and LANDE, H.: Studies on blood lipoids: 1. The relation of cholesterol and protein deficiency to basal metabolism, Arch. Int. Med., 1922, xxx, 563. Google Scholar3. BLUMGART H: Velocity of blood flow in health and disease: velocity of blood flow in man and its relation to other measurements of the circulation, Medicine, 1931, x, 1. BLUMGART, H. L., GARGILL, S. L., and GILLIGAN, D. R.: Studies on the velocity of blood flow. XIII. The circulatory response to thyrotoxicosis, Jr. Clin. Invest., 1930, ix, 69. XIV. The circulation in myxedema with a comparison of blood flow in myxedema and thyrotoxicosis, ibid., p. 91. CrossrefGoogle Scholar4. MACYCLAIBORNEHURXTHAL JWTSLM: Circulation rate in relation to metabolism in thyroid and pituitary states (decholin method), Jr. Clin. Invest., 1936, xv, 37. BOOTHBY, W. M., and RYNEARSON, E. H.: Increase in circulation rate produced by exophthalmic goiter compared with that produced in normal subjects by work, Arch. Int. Med., 1935, lv, 547. ROSENBLUM, H.: Blood flow in patients receiving dinitrophenol, Jr. Am. Med. Assoc., 1935, civ, 1592. CrossrefGoogle Scholar5. FISHBERGHITZIGKING AMWMFH: Measurement of the circulation time with saccharin, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 651. HITZIG, W. M., KING, F. H., and FISHBERG, A. M.: Circulation time in failure in left side of heart, Arch. Int. Med., 1935, lv, 112. CrossrefGoogle Scholar6. GARGILL SL: Use of sodium dehydrocholate as a clinical test of velocity of blood flow, New England Jr. Med., 1933, ccix, 1089. TARR, L., OPPENHEIMER, B. S., and SAGER, R. V.: Circulation time in various clinical conditions determined by use of sodium dehydrocholate, Am. Heart Jr., 1933, viii, 766. CrossrefGoogle Scholar7. GOLDBERG SJ: The use of calcium gluconate as a circulation time test, Am. Jr. Med. Sci., 1936, cxcii, 36. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 24, 1937.From Medical Service No. 2, The Mount Sinai Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDer jugendliche HochdruckVelocity of Blood Flow in Health and DiseaseKrankheiten der SchilddrüsePreoperative and postoperative treatment of the toxic thyroidOn the Magnesium Sulfate and Ether Circulation Times During Pregnancy**Read at a meeting of the Jefferson Society for Clinical Investigation, Jefferson Medical College, Philadelphia, December 19, 1940.BIBLIOGRAPHIEThe rate of the circulation in the arteries and veins of manMeasurement of circulation time with calcium gluconate in patients receiving digitalis, with electrocardiographic studiesThe use of magnesium sulfate in the measurement of circulation time 1 April 1938Volume 11, Issue 10Page: 1818-1823KeywordsAIDSCardiovascular therapyHeart diseasesHeart failureHypertensionHyperthyroidismMedical services ePublished: 1 December 2008 Issue Published: 1 April 1938 PDF downloadLoading ...

Hyperlipemia in Experimental Trypanosomiasis of Rabbits.

Although changes in the lipoid content of the blood have been described in a variety of physiological and pathological conditions, they have not been sufficiently studied in animals with protozoal infections. Nakanishi observed some increase in the serum cholesterol, fatty acids and phosphatides in the early stage of syphilis in rabbits but all these elements decreased when generalized infection was established. Santos and Borel, et al., found that in patients suffering from malaria the serum cholesterol was subnormal. On the other hand, a slight increase in the blood cholesterol in filariasis was described by Boyd. Linton demonstrated some increase of plasma lipoid phosphorus in rats acutely infected with Trypanosoma equiperdum. In a study of anemia produced by the same organism Dubin found in one dog a slight increase in total lipoid of whole blood and plasma accompanied by a decrease of cholesterol. Lannoy and Lagodsk noted some elevation in the serum cholesterol of rabbits infected with Trypanosoma annamense without mentioning any variation in the total lipoid content. The changes so far recorded have not been constant and the variation from normal limits has been rather slight. In view of the meagre information available regarding the abnormalities of blood lipoids further investigation of the changes of these substances in the course of an experimental protozoal infection seems desirable. The present study was, therefore, undertaken to determine whether or not there is any change in the plasma lipoids of rabbits infected with Trypanosoma brucei, a strain which hitherto has not been used for the study of blood chemistry.

A study of the blood lipoids and blood protein in Canadian Eastern Arctic Eskimos

THE data reported here were part of a clinical and metabolic study of Eskimos in 1935, during the Canadian Government Eastern Arctic Patrol on the R.M.S. Nascopie. They included Eskimos in Hudson Bay and Strait, the more northerly parts of Baffin Island and in Devon and Ellesmere Islands, as far north as 760 12' latitude-828 nautical miles from the Pole. The clinical and other metabolic data were reported elsewhere [Rabinowitch, 1936; Rabinowitch & Smith, 1936]. This communication is concerned with blood lipoids only.

The effect of pregnancy and pseudopregnancy upon the blood lipoids of rabbits

The effect of pregnancy and pseudopregnancy upon the blood lipoids of rabbits

STUDIES ON LIPOIDS AND LIPOID DISEASES

The beneficial effects of the ketogenic diet high in fats in a goodly percentage of the cases of marked epilepsy in children treated by this means prompted McQuarrie, Husted and Bloor 1 to investigate the lipoids of the blood plasma in epilepsy. Prior to this work, observations had been made on the cholesterol content of the blood in epilepsy, but no uniformity of results was established. Some investigators found hypocholesteremia, and some, hypercholesteremia, while others were unable to demonstrate any change in the cholesterol content of the blood. Until the report of McQuarrie and his associates, little or no knowledge was obtainable concerning the other blood lipoids in epilepsy. These workers demonstrated clearly that the phospholipoid-cholesterol ratio in the blood of an epileptic patient during, or just preceding or following, an attack is higher than at any other time, thus establishing definitely a relationship of the blood lipoids to status

"CHOLESTEROLEMIA AND THYROID DISORDER"

ABSTRACT To the Editor:— I have read with interest your editorial of July 14 on cholesterolemia and thyroid disorder.The reader who has not followed the evolution of the subject would doubtless conclude, from what you have written, that the discovery of the relationship between thyroid activity and the cholesterol content of the blood is a very recent one. For this reason it might be of interest to mention that Lande and I pointed out in 1922 (Studies on Blood Lipoids, Arch. Int. Med.30:563 [Nov.] 1922) and supported by extensive protocols the existence of an inverse relationship between thyroid activity and cholesterolemia. In subsequent publications (Thyroid Therapy and Thyroid Tolerance in Chronic Nephrosis, The Journal, Sept. 18, 1926, p. 913; Ueber Diabetes albuminuricus, die sogenannte chronische Nephrose, Arch. f. Verdauungskr.44:31 [Aug.] 1928) I have repeatedly discussed this subject and have utilized the principles involved as an index

EFFECTS OF INTERRENAL FUNCTION ON FAT METABOLISM AND TISSUE RESPIRATION*

The striking effect of adrenal cortical extracts upon the survival of the adrenalectomized animal has caught the general attention to such an extent that other phases of glandular activity pertaining to the cortex have received but little consideration. Yet I emphasized in 1927 (1) that purified extracts of the adrenal cortex which are capable of maintaining life in the adrenaleetomized animal also show remarkable effects upon the blood lipoids. Intravenous injection of the active substance is followed by a fallf both cholesterol and phosphatides of the blood. I have continued these investigations during the past six years and was able to show that this drop of lipoids can be produced not only in the rabbit, rat and dog, but also in man. Chart 1 illustrates the effect obtained with three different samples of interrenin on the blood cholesterol of the rabbit. There was an average drop of cholesterol of 14 per cent in the first group, 48.5 per cent in the second, 29 per cent in the third, and a total averag...

Effects of Pituitary Antidiuresis on Non-Cardiac Edema

From a previous study, describing the induction of pituitary antidiuresis in non-edematous subjects, we were impressed by the magnitude of the net loss in body weight at the end of the recovery period. The obvious fact, that the reduction in weight which follows withdrawal of the antidiuretic agent is due under these conditions to loss of body water with its accompanying mineral elements, suggested the desirability of determining the effects of the procedure on the water and mineral exchanges in the presence of edema. This has been done in 2 cases of typical lipoid nephrosis, one of chronic glomerulonephritis with superimposed nephrosis and one of edema of undetermined etiology. The total serum proteins were low in these subjects at the time of the tests. The case of edema of undetermined cause differed from the other 3 in showing no proteinuria and no increase in the blood lipoids. Throughout the entire period of observation all 4 patients were maintained in the metabolism ward under practically uniform conditions as regards room temperature and humidity, diet and routine for obtaining the body weight and for collecting samples of the excreta. The total water exchange was determined according to the method outlined by Newburg and Johnston. After a preliminary control period of several days on a standard diet relatively low in NaCl, the patient was given a medium-sized dose of the antidiuretic pituitary extract (pitressin P. D.) subcutaneously at 3-hourly intervals for one or 2 days, the exact body weight being measured every 6 hours. After this had been increased by from 3 to 5% due to water storage, the pitressin was discontinued. Balances for the following mineral elements were determined: Na, K, Ca, Mg, CI, N, S and P. The entire procedure was carried out on 2 occasions for each patient.

Psychosis and Blood Lipoids. Quantitative Variations of Total Cholesterin and Total Fatty Acids in the Blood.

Acta Medica ScandinavicaVolume 71, Issue 1 p. 558-597 Psychosis and Blood Lipoids. Quantitative Variations of Total Cholesterin and Total Fatty Acids in the Blood. I. In Manic-Depressive Psychosis1 SVEN STENBERG, SVEN STENBERG Psychiatric Clinic, Hospital Konrndsberg, Stockholm. (Chief: Prof. Bror Gadelius.)Search for more papers by this author SVEN STENBERG, SVEN STENBERG Psychiatric Clinic, Hospital Konrndsberg, Stockholm. (Chief: Prof. Bror Gadelius.)Search for more papers by this author First published: January/December 1929 https://doi.org/10.1111/j.0954-6820.1929.tb14118.xCitations: 3 1 In the following second part of this work the dementia aeeox material is treated. Further, the relation between the emotional disturbances and the blood lipoids, besides some questions and problems arising out o‘ the parallelism, established by these investigations, between quantitative charges of the lipoid content of the blood and emotional disturbances. Summary und literature will be found after part II. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume71, Issue1January/December 1929Pages 558-597 RelatedInformation

Psychosis and Blood Lipoids. Quantitative Variations of Total Cholesterin and Total Fatty Acids in the Blood. In Dementia Præcox.1

Psychosis and Blood Lipoids. Quantitative Variations of Total Cholesterin and Total Fatty Acids in the Blood. In Dementia Præcox.¹

LIPOID HISTIOCYTOSIS (NIEMANN-PICK'S DISEASE)

At no period during life is an enlarged spleen so common an observation as in infancy. The majority of these splenic enlargements are secondary to or associated with an easily determined primary condition. There remains, however, a considerable group of obscure cases of splenomegaly in infancy, which are difficult of differentiation and which are frequently diagnosed only postmortem. There is, nevertheless, a splenomegaly occurring in lipoid histiocytosis (Niemann-Pick's disease) in which the diagnosis can definitely be made by means of splenic puncture and the determination of the blood lipoids. This is clearly shown in the following case. REPORT OF CASE History .—L. S., a white Jewish girl, aged 15 months, entered the hospital on April 4, 1927, with a complaint of vomiting and distended abdomen since the second month of life, and evidence of mental impairment, such as inability to sit up or to recognize parents. The condition was of

THE EFFECT OF THYROID MEDICATION IN NEPHROSIS

With the recent advances in the study of blood chemistry and metabolism, there has been gathered more and more evidence in support of the view that the nephritis often called chronic parenchymatous nephritis results from some general metabolic disorder. Epstein¹is one of the foremost exponents of this theory. He calls this type of nephritis nephrosis, regarding it as fundamenally different from all the other types. It is characterized by insidious onset, apparently unassociated with any known infection, by anasarca and effusion into the serous membranes, by marked albuminuria, with or without casts, by changes in the blood chemistry, namely, reduction of plasma protein, inversion of albuminglobulin ratio and increase of blood lipoids (cholesterol), and, finally, by a decrease of basal metabolism. In contrast to other kinds of nephritis, there is, at least in the early stages, no hypertension, cardiac enlargement, hematuria or marked retention of nonprotein nitrogen in the blood.

A critical study of Bang's micromethod for the determination of blood lipoids1

A critical study of Bang's micromethod for the determination of blood lipoids¹

THE LIPOID PARTITION IN BLOOD IN HEALTH AND IN DISEASE

The development in recent years of methods for the chemical analysis of the fatty constituents of blood has made possible the study of the partition of cholesterol and lecithin between the blood plasma and cells, a matter of great interest in view of the reported antagonism existing between these substances. This article is part of a group of studies on the concentration and distribution of these lipoids in normal and pathologic blood, and the relation of these factors to certain physicochemical properties of the red blood cells possibly dependent on them. It is also planned to study from this standpoint the balance between free and combined cholesterol. The investigation herein reported is concerned only with the lipoid partition in the blood of normal subjects and of patients suffering from a variety of conditions in which abnormalities in blood lipoids were expected. It has been reported by Bloor, 1 Chauffard, Laroche and

FAT METABOLISM IN NEPHRITIS

Determinations of the plasma lipoids and of the respiratory quotient and total metabolism (Tissot method) have been performed with nephritics and normal subjects before and after they ingested fat in the proportion of 1 gm. per kilo body weight. After fat ingestion a greater increase of fatty acids and lecithin was noted in the plasma of nephritics with initially high blood lipoids than in the plasma of normal subjects or of nephritics without constant lipemia. In cholesterol no differences were found. The nephritic patients with constant lipemia were able to burn fat as efficiently as normal individuals. The accumulation of fat in their blood may be due to a disturbance in the mechanism for transferring lipoids from the blood to the tissue depots.

EFFECT OF INSULIN IN TREATMENT OF DIABETIC LIPEMIA WITH LIPEMIA RETINALIS

Lipemia is characterized by an accumulation of fat in the blood. A moderate alimentary lipemia occurs ofter the ingestion of food, and only when it persists in spite of fasting is the condition to be considered pathologic. Patients with diabetes are predisposed to lipemia; and, even though the blood plasma may not appear milky, the lipoids are generally abnormally high, especially in the severe cases. The distribution of lipoids in the blood under pathologic conditions, especially diabetes, has been extensively studied by Bloor¹and others. In the latter condition, high values for total blood lipoids have been reported by Bloor (13 gm. per hundred cubic centimeters of plasm), by Frugoni²(27 gm. per hundred cubic centimeters of plasm), and by Neisser and Derlin³(19.7 gm. per hundred cubic centimeters of plasm). The treatment of lipemia has always been slow in yielding results. Allen,4 feeling that blood fat

METABOLIC STUDIES IN PERNICIOUS ANEMIA

It should require considerable courage to add to the voluminous literature on the pathogenesis and chemistry of the so-called idiopathic pernicious anemia of Addison and Biermer. Our excuse is a threefold one:—first, to investigate with the aid of modern microchemical methods the metabolism of the blood lipoids as of probable diagnostic if not of etiological significance; second, to determine the nitrogen metabolism both in regard to its diagnostic as well as its prognostic value; and, third, to test the efficiency of Whipple's high iron diet when given to patients suffering from idiopathic anemia. We have had the opportunity to study eleven cases of pernicious anemia, several of which have been available for considerable periods of time or during subsequent admissions. As controls, and in order to obtain comparative data on the anemias, four additional cases have been employed, a case of aplastic anemia with von Recklinghausen's disease, a pregnancy anemia,