Blood Flow In Microvessels Research Articles

Interplay between endothelial glycocalyx layer and red blood cell in microvascular blood flow: A numerical study.

The endothelial glycocalyx layer (EGL) plays a crucial role in regulating blood flow in microvessels. Experimental evidence suggests that there is greater blood flow resistance in vivo compared to in vitro, partially due to the presence of the EGL. However, the complex relationship between EGL deformation and blood cell behavior in shear flow and its quantification remains incompletely understood. To address this gap, we employ a particle-based numerical simulation technique to examine the interaction of the EGL with flowing red blood cells (RBCs) in microtubes. We examine changes in EGL deformation in response to variations in shear rate, EGL graft density, and contour height. Our results indicate that the alterations in EGL height are influenced by the mechanical properties of the EGL, flow conditions, and the RBC-EGL interaction. The flowing RBC compresses the EGL, causing a notable reduction in EGL height near the RBC flow. Additionally, we find that the presence of the EGL in the microtube results in increased RBC deformation and a wider gap between the RBC and tube wall due to spatial occupancy. The significant impact of the EGL on RBC flow is particularly evident in microtubes with diameters ranging from 7 to 10µm, a range consistent with notable differences in vascular flow resistance observed between in vivo and in vitro experiments. The simulation results shed insight on the dynamic interplay between RBC and the EGL in microvascular blood flow.

Non-similar analysis of suction/injection and Cattaneo-Christov model in 3D viscoelastic non-Newtonian fluids flow due to Riga plate: A biological applications

Bioconvective non-Newtonian fluids with motile microorganisms have diverse applications in biology and medicine, offering numerous research opportunities. This article presents a comprehensive investigation into the non-similar analysis of bio-convective micropolar flow induced by a Darcy-Forchheimer exponentially stretchable sheet, considering the effects of suction/injection and thermal radiation in a three-dimensional framework. The fluid under scrutiny is a viscoelastic tangent hyperbolic nanofluid, the impact of Cattaneo-Christov heat subjected to Riga plate is considered for novelty. The role of activation energy and heat source are also computed. The governing equations of viscoelastic tangent hyperbolic nanofluids are transformed into couple of ordinary differential equations via similarity approximations. The resulting ODEs are tackled numerically via bvp4c tool of MATLAB. The impression of appropriate parameters like magnetic parameter, bio-convection parameter, viscoelasticity parameter suction/injection parameter etc. on involved profiles are computed via graphical and tabulated trends. It is observed that velocity layer f′ is dwindled for growing value of Forchheimer number Fr, while reverse relation in velocity curve is noted for developing value of mixed convection parameter δ. Micropolar fluids find biomedical engineering applications in modeling blood flow in microvessels, understanding cerebrospinal fluid dynamics, and optimization of biomedical devices and therapies and simulating drug delivery in tissues.

Numerical analysis of blood flow through stenosed microvessels using a multi-phase model

Blood flow in arterioles have attracted considerable research attention due to their clinical implications. However, the fluid structure interaction between red blood cells and plasma in the blood poses formidable difficulty to the computational efforts. In this contribution, we seek to represent the red blood cells in the blood as a continuous non-Newtonian phase and construct a multi-phase model for the blood flow in microvessels. The methods are presented and validated using a channel with sudden expansion. And the resulting blood flow inside a stenosed microvessel is investigated at different inlet velocity amplitudes and hematocrits. It is show that the increase of both inlet velocity amplitude and inlet hematocrit leads to longer and thicker cell-rich layer downstream the stenosis. Besides, it is found that the maximum values of wall shear stress scales up with inlet velocity amplitudes and hematocrits. These results show the validity of the proposed computational model and provide helpful insights into blood flow behaviors inside stenosed vessels.

The effectiveness of photodynamic effects on the clinical and functional state of periodontal tissues in periodontitis

A clinical and functional study and treatment of chronic generalized periodontitis of moderate degree were conducted in 56 people (22 men and 34 women) aged 37 to 55 years. The patients were divided into 2 groups depending on the type of treatment: group 1 (main) - 28 people (11 men and 17 women, the average age of the group was 43.5±2.8 years, photodynamic therapy (PDT) with 1% dimegin gel using an AFS Spectrum LED emitter with a wavelength of 660 nm and an energy density of 95 J/cm2), in group 2 (control) - 28 people. (9 men and 19 women, the average age of the group was 45.0±3.1 years) standard treatment was performed without PDT. The level of tissue blood flow, its activity and vasomotor activity of microvessels, as well as the blood flow bypass index were determined by laser Doppler flowmetry. The study of oxygenation was carried out by optical tissue oximetry with determination of the index of oxygenation, specific oxygen consumption and perfusion oxygen saturation. After PDT, the periodontal tissues showed an increase in blood flow by 65.5% after 3 months, the level of oxygen metabolism increased by 51%, which increased after 6 months. The use of PDT in the complex treatment of chronic generalized periodontitis of moderate severity has an activating effect on the microcirculation system and the level of oxygen metabolism in periodontal tissues both in the near and long-term follow-up periods. The use of PDT with 1% dimegin gel has an effective effect on the state of microhemodynamics and oxygenation in periodontal tissues.

Investigating flow features and heat/mass transfer in two-layer vertical channel with [formula omitted] hybrid nanofluid under MHD and radiation effects

This study aims to investigate the physical mechanisms of mass and heat transfer of nanofluid and hybrid nanofluid in a two-layer vertical channel. The Casson fluid model is used to depict the non-Newtonian behavior of blood flow (base fluid). The two-layer vertical channel represents a realistic model of blood flow in microvessels, where region-I contains titanium dioxide nanofluid. In contrast, region-II contains hybrid nanofluid of graphene and titanium dioxide. The formulation of the flow model incorporates laminar, incompressible flow with added MHD, viscous dissipation, and radiation effects. Homotopy analysis technique (HAM) is used to solve non-linear ordinary differential equations (ODEs) after the governing equations are converted into nondimensional. The graphical representation of the effect of physical parameters on velocity and temperature is presented, while the variation of skin friction and Nusselt number with emerging parameters is tabulated. The findings of current study are that an increase in the magnetic parameter has a similar effect on both velocity and temperature profiles. The Nusselt number rises with the rising of the Eckert number, Prandtl number, and magnetic parameter at the right wall but drops with the rising of these values at the left wall. Temperature is directly proportional to Eckert and Prandtl numbers, whereas a rise in radiation leads to a drop in temperature. The findings have potential implications for biomedical applications, especially in drug delivery through blood vessels to treat cardiovascular diseases.

The role of boundary conditions for modeling the blood flow in microvessels

The article considers a mathematical model of blood motion in microvessels of diameter from 4 to 8 µm. The blood is considered as a fluid consisting of plasma and red blood cells (RBCs) fractions, wherein the RBCs fraction has much higher viscosity in contrast with the plasma fraction. As a numerical approach, the finite element method based on the Stokes equations with variable viscosity is applied. The adequacy of the model is assessed by comparing the numerical results and experimental (in vitro and in vivo) data. Different approaches to the construction of suitable boundary conditions are discussed and implemented.

The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging.

The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.

Peristaltic flow of a hyperbolic tangent fluid with variable parameters

This article investigates the peristaltic flow of a hyperbolic tangent fluid with variable viscosity and thermal conductivity through a vertical asymmetric channel. Consideration is given to the effects of viscous dissipation, chemical reactions, and convection heat at the channel walls. The relevant mathematical modeling incorporates lubrication approximation. The resulting system of highly non-linear differential equations is converted non-dimensional via suitable quantities. The non-dimensional parameters formed in viscosity or thermal conductivity are treated as variables. This treatment is the fundamental recommendation of the current study to avoid obtaining unrealistic results. Using the built-in package (ParametricNDSolve) in the computing program Mathematica, the analysis is performed numerically, and the results for temperature and concentration profiles in addition to the trapping phenomenon are shown through graphs. The major findings show that an increase in temperature is associated with a decrease in viscosity, whereas the opposite (unrealistic) behavior is maintained when the variable parameters are treated as constants. Results also indicate that the thermal conductivity at relatively low temperatures is enhanced, whereas the opposite trend is noted at higher temperature values. Potential applications for the current work include cooling techniques used in medical and industrial applications, food processing, and blood flow in microvessels.

Red blood cells tracking and cell-free layer formation in a microchannel with hyperbolic contraction: A CFD model validation

Background and ObjectiveIn recent years, progress in microfabrication technologies has attracted the attention of researchers across disciplines. Microfluidic devices have the potential to be developed into powerful tools that can elucidate the biophysical behavior of blood flow in microvessels. Such devices can also be used to separate the suspended physiological fluid from whole in vitro blood, which includes cells. Therefore, it is essential to acquire a detailed description of the complex interaction between erythrocytes (red blood cells; RBCs) and plasma. RBCs tend to undergo axial migration caused by occurrence of the Fåhræus-Lindqvist effect. These dynamics result in a cell-free layer (CFL), or a low volume fraction of cells, near the vessel wall. The aim of the paper is to develop a numerical model capable of reproducing the behavior of multiphase flow in a microchannel obtained under laboratory conditions and to compare two multiphase modelling techniques Euler-Euler and Euler-Lagrange. MethodsIn this work, we employed a numerical Computational Fluid Dynamics (CFD) model of the blood flow within microchannels with two hyperbolic contraction shapes. The simulation was used to reproduce the blood flow behavior in a microchannel under laboratory conditions, where the CFL formation is visible downstream of the hyperbolic contraction. The multiphase numerical model was developed using Euler-Euler and hybrid Euler-Lagrange approaches. The hybrid CFD simulation of the RBC transport model was performed using a Discrete Phase Model. Blood was assumed to be a nonhomogeneous mixture of two components: dextran, whose properties are consistent with plasma, and RBCs, at a hematocrit of 5% (percent by volume of RBCs). ResultsThe results show a 5 μm thick CFL in a microchannel with a broader contraction and a 35 μm thick CFL in a microchannel with a narrower contraction. The RBC volume fraction in the CFL is less than 2%, compared to 7–8% in the core flow. The results are consistent for both multiphase simulation techniques used. The simulation results were then validated against the experimentally-measured CFL in each of the studied microchannel geometries. ConclusionsReasonable agreement between experiments and simulations was achieved. A validated model such as the one tested in this study can expedite the microchannel design process by minimizing the need to prefabricate prototypes and test them under laboratory conditions.

Shear stress and intravascular pressure effects on vascular dynamics: two-phase blood flow in elastic microvessels accounting for the passive stresses.

We study the steady hemodynamics in physiological elastic microvessels proposing an advanced fluid-structure interaction model. The arteriolar tissue is modeled as a two-layer fiber-reinforced hyperelastic material representing its Media and Adventitia layers. The constitutive model employed (Holzapfel et al. in J Elast 61:1-48, 2000) is parametrized via available data on stress-strain experiments for arterioles. The model is completed by simulating the blood/plasma flow in the lumen, using the thixotropic elasto-viscoplastic model in its core, and the linear Phan-Thien and Tanner viscoelastic model in its annular part. The Cell-Free Layer (CFL) and the Fåhraeus and Fåhraeus-Lindqvist effects are considered via analytical expressions based on experimental data (Giannokostas et al. in Materials (Basel) 14:367, 2021b). The coupling between tissue deformation and blood flow is achieved through the experimentally verified pressure-shear hypothesis (Pries et al. Circ Res 77:1017-1023, 1995). Our calculations confirm that the increase in the reference inner radius produces larger expansion. Also, by increasing the intraluminal pressure, the thinning of the walls is more pronounced and it may reach 40% of the initial thickness. Comparing our predictions with those in rigid-wall microtubes, we conclude that apart from the vital importance of vasodilation, there is an up to 25% reduction in wall shear stress. The passive vasodilation contributes to the decrease in the tissue stress fields and affects the hemodynamic features such as the CFL thickness, reducing the plasma layer when blood flows in vessels with elastic walls, in quantitative agreement with previous experiments. Our calculations verify the correctness of the pressure-shear hypothesis but not that of the Laplace law.

Microvascular flow imaging to differentiate focal hepatic lesions: the spoke-wheel pattern as a specific sign of focal nodular hyperplasia.

Microvascular flow imaging (MVFI) is an advanced Doppler ultrasound technique designed to detect slow-velocity blood flow in small-caliber microvessels. This technique is capable of realtime, highly detailed visualization of tumor vessels without using a contrast agent. MVFI has been recently applied for the characterization of focal liver lesions and has revealed typical vascularity distributions in multiple types thereof. Focal nodular hyperplasia (FNH) constitutes an important differential diagnosis of malignant liver tumors. In this essay, we provide iconographic documentation of the MVFI appearance of FNH and other common solid liver lesions. Identifying the typical patterns of vascularity, including the spoke-wheel pattern with MVFI, can expedite the diagnosis, spare patients from unnecessary procedures, and save costs.

Solute dispersion in non-Newtonian fluids flow through small blood vessels: A varying viscosity approach

Present work concerns the combined effect of Jeffrey fluid parameter and varying nature of viscosity on the solute dispersion in non-Newtonian fluids flow through small blood vessels. The generalized dispersion model of Sankarasubramanian and Gill (1973) has been considered. The objective of the present work is to understand the solute dispersion in non-Newtonian fluids flow through microvessels with absorbing walls under varying viscosity assumption. For more realistic modeling of blood flow in microvessels, Jeffrey and Herschel–Bulkley fluids model have been considered for a comparative study due to its low shear rate flow in small blood vessels such as arterioles, venules and capillaries. The whole solute dispersion analysis has been done for two alternative non-Newtonian fluids (Herschel–Bulkley and Jeffrey fluids) owing to their physiological importance. The present model has been validated by reducing it to previously studied specific cases of Newtonian, Bingham-plastic and Power-law fluids with constant/varying viscosities. It is perceived that the mean concentration, convection and axial dispersion coefficients are significantly affected by varying viscosity and Jeffrey fluid parameters. A noteworthy observation is that an increase in ratio of relaxation to retardation times (Jeffrey fluid parameter) enhanced the values of the transport coefficients. The outcome of the present study shows the diffusion of drugs to the physiological system through small blood vessels is significantly affected by the varying nature of viscosity and Jeffrey fluid parameters.

Confocal laser speckle autocorrelation imaging of dynamic flow in microvasculature

Laser speckle imaging has been widely used for in-vivo visualization of blood perfusion in biological tissues. However, existing laser speckle imaging techniques suffer from limited quantification accuracy and spatial resolution. Here we report a novel design and implementation of a powerful laser speckle imaging platform to solve the two critical limitations. The core technique of our platform is a combination of line scan confocal microscopy with laser speckle autocorrelation imaging, which is termed Line Scan Laser Speckle Autocorrelation Imaging (LS-LSAI). The technical advantages of LS-LSAI include high spatial resolution (~4.4 μm) for visualizing and quantifying blood flow in microvessels, as well as video-rate imaging speed for tracing dynamic flow.

Clinical utility of directional eFLOW compared with contrast-enhanced harmonic endoscopic ultrasound for assessing the vascularity of pancreatic and peripancreatic masses

BackgroundContrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) can be used for the differential diagnosis of pancreatic lesions by evaluating microvascular circulation and patterns of contrast enhancement. However, routine use of CEH-EUS is limited by its high cost, the lack of contrast agent availability and the absence of expertise with this technique. Directional eFLOW (D-eFLOW) (Aloka Co., Ltd., Tokyo, Japan) was introduced as a new high-definition modality that detects blood flow in microvessels. Because it uses built-in functions, it entails no additional cost and reduces time for examination. The present study compared the usefulness of D-eFLOW and CEH-EUS for differential diagnosis of pancreatic and peripancreatic lesions. MethodsThis retrospective study analyzed 130 patients who underwent EUS and D-eFLOW examinations from January 2016 to March 2020 to evaluate pancreatic and peripancreatic masses. ResultsAll 130 patients underwent D-eFLOW and CEH-EUS examinations. Histological diagnoses were confirmed in 130 patients by EUS-FNA and/or surgery. D-eFLOW and CEH-EUS showed good correlation in evaluating the vascularity of pancreatic and peripancreatic tumors (Fisher's exact test, p < 0.05). ConclusionsIn evaluating the characteristics of tumorous lesions, vascularity detected by D-eFLOW showed good correlation with enhancement patterns of CEH-EUS. D-eFLOW can be considered a good alternative to CEH-EUS in diagnosing pancreatic and peripancreatic masses.

Multiscale parareal algorithm for long-time mesoscopic simulations of microvascular blood flow in zebrafish

Various biological processes such as transport of oxygen and nutrients, thrombus formation, vascular angiogenesis and remodeling are related to cellular/subcellular level biological processes, where mesoscopic simulations resolving detailed cell dynamics provide a key to understanding and identifying the cellular basis of disease. However, the intrinsic stochastic effects can play an important role in mesoscopic processes, while the time step allowed in a mesoscopic simulation is restricted by rapid cellular/subcellular dynamic processes. These challenges significantly limit the timescale that can be reached by mesoscopic simulations even with high-performance computing. To break this bottleneck and achieve a biologically meaningful timescale, we propose a multiscale parareal algorithm in which a continuum-based solver supervises a mesoscopic simulation in the time-domain. Using an iterative prediction-correction strategy, the parallel-in-time mesoscopic simulation supervised by its continuum-based counterpart can converge fast. The effectiveness of the proposed method is first verified in a time-dependent flow with a sinusoidal flowrate through a Y-shaped bifurcation channel. The results show that the supervised mesoscopic simulations of both Newtonian fluids and non-Newtonian bloods converge to reference solutions after a few iterations. Physical quantities of interest including velocity, wall shear stress and flowrate are computed to compare against those of reference solutions, showing a less than 1% relative error on flowrate in the Newtonian flow and a less than 3% relative error in the non-Newtonian blood flow. The proposed method is then applied to a large-scale mesoscopic simulation of microvessel blood flow in a zebrafish hindbrain for temporal acceleration. The three-dimensional geometry of the vasculature is constructed directly from the images of live zebrafish under a confocal microscope, resulting in a complex vascular network with 95 branches and 57 bifurcations. The time-dependent blood flow from heartbeats in this realistic vascular network of zebrafish hindbrain is simulated using dissipative particle dynamics as the mesoscopic model, which is supervised by a one-dimensional blood flow model (continuum-based model) in multiple temporal sub-domains. The computational analysis shows that the resulting microvessel blood flow converges to the reference solution after only two iterations. The proposed method is suitable for long-time mesoscopic simulations with complex fluids and geometries. It can be readily combined with classical spatial decomposition for further acceleration.

Effects of Acute Low-Frequency Pulsed Electromagnetic Field Therapy on Aerobic Performance during a Preseason Training Camp: A Pilot Study.

Bio-electromagnetic-energy-regulation (BEMER) therapy is a technology using a low-frequency pulsed electromagnetic field (PEMF) in a biorhythmic format. BEMER has been shown to optimize recovery and decrease fatigue by increasing blood flow in microvessels. Our aim was to determine its effects during preseason training in endurance athletes. A total of 14 male cross-country runners (19.07 ± 0.92 y.o.) were placed in either the intervention (PEMF; n = 8) or control (CON; n = 6) group using a covariate-based, constrained randomization. Participants completed six running sessions at altitudes ranging from 881.83 (±135.98 m) to 1027.0 (±223.44 m) above sea level. PEMF group used BEMER therapy before and after each training session, totaling 12 times. There were no significant changes in absolute or relative VO2Peak, ventilation or maximum respiration rate for either the PEMF or CON group (p > 0.05). There was a significant effect of time for absolute and relative ventilatory threshold (VT), and maximum heart rate, heart rate at VT and respiration rate at VT. This study was the first of its kind to study PEMF technology in combination with elevated preseason training. Results indicate some evidence for the use of PEMF therapy during short-term training camps to improve VT.

A systematic study for determining the optimal relaxation time in the lattice Boltzmann method at low Reynolds numbers

In the lattice Boltzmann method (LBM), the relaxation time plays a significant role in the accuracy of simulation. However, there has been little attention directed toward evaluating the optimal relaxation time in literature. This paper proposes a systematic approach for the determination of the optimal relaxation time, particularly for very-low Reynolds (Re) number flows as analogues for blood flow in micro-vessels. The LBM with D2Q9 lattice model is used to simulate Poiseuille flow in a micro-channel and its accuracy is verified against the analytical solution. It was found that for a given number of grid points in the y-direction, the value of optimal relaxation time predicted analytically differs from that obtained from the numerical solutions. This indicates that the analytical relaxation time should be corrected when used in the LBM code.

Vascular Disaggregated Platelet Control in Newborn Piglets

The balance of platelet and vascular functions clearly determines the functioning of primary hemostasis in the piglet’s body. This is of particular physiological importance at the beginning of piglet ontogenesis. The degree of functional readiness of platelets and blood vessels in piglets during the neonatal period determines the state of blood microcirculation in tissues and the activity of many functional mechanisms at this stage of development. The activity of the disaggregation properties of blood vessels, which significantly determines the intensity of anabolism and, ultimately, the productivity of animals, is particularly important at this age. This study examined 31 healthy newborn piglets. A decrease in the amount of peroxidation products was found in the blood of all animals due to an increase in the antioxidant potential of their plasma, which created conditions in newborn piglets for weak alteration of the vascular endothelium and its optimal synthetic activity. This led to an increase in the vascular control over the platelet aggregation activity, maintaining the optimal blood flow in microvessels from the beginning of individual development.&#x0D; Keywords: piglets, neonatal phase, blood vessels, platelets, aggregation, lipid peroxidation

Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study

BackgroundThe availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfused microvessels and increased penetration of erythrocytes into the endothelial glycocalyx are essential components of microvascular dysfunction. The aim of this study was to identify novel microvascular variables to determine the level of microvascular dysfunction in sepsis and its relationship with clinical variables.MethodsThis observational, prospective, cross-sectional study included 51 participants, of which 34 critically ill sepsis patients were recruited from intensive care units of a university hospital. Seventeen healthy volunteers served as controls. All participants underwent sublingual videomicroscopy by sidestream darkfield imaging. A new developed version of the Glycocheck™ software was used to quantify vascular density, perfused boundary region (PBR-an inverse variable of endothelial glycocalyx dimensions), red blood cell (RBC) velocity, RBC content, and blood flow in sublingual microvessels with diameters between 4 and 25 µm.ResultsA detailed analysis of adjacent diameter classes (1 µm each) of vessels between 4 and 25 µm revealed a severe reduction of vascular density in very small capillaries (5–7 µm), which correlated with markers of sepsis severity. Analysis of RBC velocity (VRBC) revealed a strong dependency between capillary and feed vessel VRBC in sepsis patients (R2 = 0.63, p < 0.0001) but not in healthy controls (R2 = 0.04, p = 0.43), indicating impaired capillary (de-)recruitment in sepsis. This finding enabled the calculation of capillary recruitment and dynamic capillary blood volume (CBVdynamic). Moreover, adjustment of PBR to feed vessel VRBC further improved discrimination between sepsis patients and controls by about 50%. By combining these dynamic microvascular and glycocalyx variables, we developed the microvascular health score (MVHSdynamic™), which decreased from 7.4 [4.6–8.7] in controls to 1.8 [1.4–2.7] in sepsis patients (p < 0.0001) and correlated with sepsis severity.ConclusionWe introduce new important diameter-specific quantification and differentiated analysis of RBC kinetics, a key to understand microvascular dysfunction in sepsis. MVHSdynamic, which has a broad bandwidth to detect microvascular (dys-) function, might serve as a valuable tool to detect microvascular impairment in critically ill patients.

Solute dispersion in micropolar-Newtonian fluid flowing through porous layered tubes with absorbing walls

The physical mechanism of heat and mass transfer in solute dispersion in a two-fluid model of the blood flow through porous layered tubes with absorbing walls has been studied in the present work. For a more realistic representation of the blood flow in microvessels, the two-fluid approach is employed by considering the fluid in which the blood particles like RBCs, WBCs, and platelets are suspended as a micropolar fluid in the core region and the cell-free layer of plasma as Newtonian fluid in the peripheral region. A thin Brinkman layer mathematically governed by the Brinkman equation replicates the mechanical aspects of the porous layer near the tube wall. Either no-spin or no-couple stress condition at the micropolar-Newtonian fluid interface has been taken in to account to compare our findings with previous studies and the stress-jump condition of Ochoa-Tapia and Whitaker (J.A. Ochoa-Tapia and S. Whitaker, Int. J. Heat Mass Transfer 38 (1995) 2635–2646) is employed at the fluid-porous interface. A uniform magnetic field has also been applied in the transverse direction of the flow pattern to understand some of the clinically relevant aspects of blood flow in the cardiovascular system. Analytical expressions for the velocity and temperature field are used to obtain the expressions for diffusion coefficients and mean concentration by following the method of Sankarasubramanian and Gill (R. Sankarasubramanian and W.N. Gill, Proc. R. Soc. London. Ser. A 333 (1973) 115–132), to analyze the solute dispersion process in fluid flowing through tubes with wall reactions. The effect of plasma layer thickness, radiation parameter, coupling number, micro-rotation, thermal conductivity, Hartmann number, and permeability on the diffusion coefficients and mean concentration of the miscible species are discussed and depicted graphically. The multi-motivational work with the combination of a porous layer near the wall and heat transfers may leave a significant impact on drug delivery through the blood vessels for the treatment of cardiovascular diseases.