In the present study, numerical and experimental investigation of stress distribution pattern has been performed for thick walled nuclear rotor pipe joint of Alloy 617 and 10Cr steel. Hot wire Tungsten Inert Gas (HW-TIG) welding process has been adopted for multipass narrow groove welding since it yields better mechanical properties at low heat input than manual TIG welding and decreases the accumulation of residual stress significantly. The residual stress generated at the surface of the welded joint was evaluated experimentally using the Blind hole drilling technique (BHD), and consequently, the distribution of stresses along the thickness of the welded joint was masured using the Deep hole drilling (DHD) method. According to the findings, shrinkage at the HAZ area of the weld influences the stresses generated at the cylinder outer surface. The distribution of residual stresses in the weld region is driven mostly by the bending effect produced during the welding process. The influence of post weld heat treatment (PWHT) on residual stress distribution has also been investigated using both experimental and numerical approaches. Numerical investigations have been performed using ABAQUS finite element method. A 2D finite element model has been developed to simulate the welding process and the subsequent heat treatment, using coupled thermo-mechanical analysis. The residual stress results obtained from the numerical approach were validated with the experimentally obtained results and a good correlation has been found. The lumped pass model along with an equal density heat source has been implemented to minimize the computation complexity without affecting the accuracy of the simulated results. The obtained findings revealed that apart from weld centerline, hoop tensile residual stresses were higher around the buttered layer of Alloy 617 and 10Cr steel in an as-welded state. It has been found that nearly 80% of the stresses generated along the weld section have been released after PWHT.