In this study, calcium alginate-immobilized microalgae beads were utilized for treating Cd2+-containing wastewater by optimizing the algal species, the preparation conditions of immobilized beads, and the Cd2+ treatment conditions to enhance treatment efficiency. The results revealed that under optimal preparation conditions with a CaCl2 concentration of 3 % and a sodium alginate concentration of 2 %, the removal rate of Cd2+ reached 94.99 % after 3 h of adsorption when 4 g of immobilized Tetradesmus obliquus algal beads were added to a 20 mg/L Cd2+ solution. Additionally, under optimal removal conditions at pH=6, with immobilized Tetradesmus obliquus algal beads as the adsorbent and a dosage of 6 g of immobilized algal beads added to a solution with an initial Cd2+ concentration of 15 mg/L, the Cd2+ removal rate reached 99.85 % after 4 h of adsorption, surpassing that of suspended microalgae and blank algal beads. The adsorption process followed the pseudo-second-order kinetic model and the Langmuir adsorption isotherm model. FTIR analysis indicated that functional groups such as O-H, CO, C-O, C-N, among others, might play a role in the adsorption process. After five adsorption-desorption cycles, the adsorption capacity decreased by only 10 %. This study demonstrated that immobilized Tetradesmus obliquus algal beads is an efficient and renewable and recyclable adsorbent.