Abstract In this study, Proper Orthogonal Decomposition (POD) was applied to Large Eddy Simulations (LES) of two high-loaded low-pressure turbine cascades under unsteady inflow conditions to investigate entropy production within different parts of the blade passage. The terms for Turbulent Kinetic Energy (TKE) production, diffusion, and dissipation from the stagnation pressure transport equation were integrated across the computational domain. The POD-based method enables the decomposition of contributions from various coherent flow dynamics to TKE production and dissipation, such as the migration, bowing, tilting, and reorientation of incoming wake filaments, as well as the breakdown of streaky structures in the blade boundary layer and the formation of Von Karman vortices in the blade wake. This approach helps designers identify the dominant POD modes (i.e., turbulent flow structures) responsible for loss generation, understand their dynamics and locate where they primarily act. Using this optimization strategy, a new low-pressure turbine profile was designed. LES calculations on the optimized geometry showed that it is possible to design a higher-loaded profile with a lower global loss coefficient. The new loading distribution, characterized by stronger acceleration in the early part of the blade passage, results in reduced upstream wake migration losses and lower TKE production in the trailing edge wake zone due to early suction side boundary layer transition.