You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Urodynamic Testing1 Apr 20122315 ATP RELEASE DURING BLADDER FILLING IN WOMEN WITH BLADDER OVERSENSITIVITY Ying Cheng, Kylie Mansfield, Elizabeth Burcher, and Kate Moore Ying ChengYing Cheng Kogarah, Australia More articles by this author , Kylie MansfieldKylie Mansfield Wollongong, Australia More articles by this author , Elizabeth BurcherElizabeth Burcher Randwick, Australia More articles by this author , and Kate MooreKate Moore Kogarah, Australia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2496AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Patients with bladder oversensitivity (BO) (previously called painful bladder syndrome, PBS) suffer from urgency and frequency, often accompanied by suprapubic pain. Because ATP is an important signalling molecule in bladder function and dysfunction, ATP might play a unique role in women with BO. Our aim was to investigate the correlation between ATP release and urodynamic parameters, i.e., first desire to void (FDV) and maximum cystometry capacity (MCC) in BO patients, as well as urine pH. METHODS Routine cystometry was performed in a consecutive series of 237 women, 28 women were diagnosed with BO. 4 patients with urinary tract infection were excluded. The voided urodynamic fluid was stored at -20oC and ATP measured using a bioluminescence assay. Midstream urine was collected for pH measurement. Statistical analysis was performed using GraphPad Prism 5.0 software. Correlations between two factors were tested by linear regression analysis. RESULTS There was a significant reverse correlation between the concentration of ATP in bladder washings and FDV (r2= 0.25; P=0.013) (Fig 1). The correlation between ATP concentration and MCC (P=0.32) or voided volume (VV) (P=0.31) was not significant. There was a significant reverse correlation between ATP concentration in voided urodynamic fluid and the urine pH (Fig 2). CONCLUSIONS ATP is an important factor for initial perception of need to urinate (as indicated by FDV). This is similar to our previous findings in patients with detrusor overactivity, suggesting that ATP may mediate initial afferent sensation in patients with bladder dysfunctions characterised by urgency. ATP release of BO patients was also strongly affected by their urine pH. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e934-e935 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ying Cheng Kogarah, Australia More articles by this author Kylie Mansfield Wollongong, Australia More articles by this author Elizabeth Burcher Randwick, Australia More articles by this author Kate Moore Kogarah, Australia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...