Bitot's Spots Research Articles

Prevalence of Xerophthalmia in Rural Children of Latur, Maharashtra

Purpose To ascertain the prevalence of Vitamin A deficiency (VAD) among rural children in Latur, Maharashtra.  Methods The study was conducted in a community setting and used a cross-sectional design, meaning data was collected at a single point in time. A total of 1,604 children aged 0- 15 years from rural areas in Latur, Maharashtra, participated in the study. Participants were chosen using a simple random sampling method, ensuring each child in the population had an equal chance of being selected. Data collection involved a pretested structured questionnaire, which helps ensure consistency and reliability in the responses, and ophthalmic examinations to check for Vitamin A deficiency.  Results The study found an overall Xerophthalmia prevalence of 5.6%. In children under six years old, the prevalence of Bitot's spots was 2.1%, compared to 4.2% in children over six. Older children were more frequently affected by Xerophthalmia. Factors contributing to Xerophthalmia included low income, poor consumption of fruits and vegetables, febrile illnesses, and lack of immunization. Additionally, the study noted that dietary patterns and economic status significantly influenced the prevalence of VAD. Children from lower-income families and those with limited access to nutritious foods were at a higher risk.  Conclusion The findings suggest a declining trend in Vitamin A deficiency, with a milder form of Xerophthalmia and a 2.1% prevalence of Bitot's spots among children under six years old. The higher prevalence of Xerophthalmia in older children highlights the need to strengthen Vitamin A prophylaxis programs and promote health education to improve dietary diversity. It is essential to ensure the inclusion of vegetables and fruits in children's diets to maintain better Vitamin A status across all age groups.

A comprehensive analysis of food insecurity in the drought-prone rural areas of Tigray.

The number of globally food-insecure people is increasing since 2017. Sub-Saharan Africa has the highest proportion of severely food-insecure people in the world. Tigray region of Ethiopia is one of the food-insecure regions, which, over the past many decades has been affected by recurrent food insecurities. In the drought-prone rural areas of Tigray, many people are living under the condition of chronic hunger. Proper food security studies are vital for proper intervention mechanisms. Yet, previous food security studies have rarely addressed the four pillars of food security: availability, access, utilization, and stability. In this study, all components are duly considered to assess the food insecurity status in the drought-prone rural areas of Tigray, Ethiopia. Of the 34 rural districts in Tigray, 363 households from three drought-prone rural districts were studied. Household Food Insecurity Access Scale and Food Insecurity Experience Scale were adapted to measure the food availability, access to food, and stability components of food security; and, Household Dietary Diversity Score (HDDS), Food Consumption Score (FCS), mid-upper arm circumference, and Bitot's spot were used to analyze the food utilization aspect. Findings show that 68% of the studied community frequently ate less food than they felt they needed and 82.1% of the households have experienced hunger because of lack of food. The study rural districts were unconnected to road networks; hence, 87.9% of the elderly and 20.4% of the women and girls had no access to food markets. Regarding the food utilization, 81.5% of the studied households had poor FCS; and the average HDDS and FCS for the study areas were 2.47 and 18.9, respectively. The prevalence of Global acute malnutrition, severe acute malnutrition (SAM), and moderate acute malnutrition (MAM) for 6-59months of age children in the study areas were 50.3, 4.2, and 46.1%, respectively. More notably, the prevalence of SAM for children from the food-insecure households was 21.2%. The prevalence of MAM for pregnant and lactating women (PLW) in the study areas was 59.5. Further, the prevalence of Bitot's spot among 6-59months of age children was 1.9%. On the other hand, all the rural households had anxiety about their future food demands. The rural households living in the studied areas were critically food-insecure. All the measurements implied that the food insecurity situation in the study areas was unacceptably worrisome and life-threatening. This calls for an instant action to avert the occurrence of famine and starvation in the drought-prone rural areas of Tigray region. Thus, interventions should primarily target the vulnerable rural people and need to be planned based on attaining food availability first rather than concurrently addressing all components of food security. Further, due emphasis should be given to diversifying livelihood strategies of the vulnerable villagers.

Ocular morbidity profiles of out-of-school children in a North Indian urban slum.

This study evaluates the recent trends in ocular morbidities and vision-related practices in "out-of-school" children in urban slums of Gurugram in North India. In this observational study, a validated questionnaire was administered to 161 students from two nonformal slum schools. Sociocultural, demographic data, vision-related practices, and visual acuity with subjective refraction of the children were recorded. A total of 80 boys and 81 girls (9.17 ± 2.58 years) participated in this study. About 40% of the children were from lower socioeconomic status. The visual acuity recorded for all the children, except three children, was 6/6 in both eyes. One child had a pre-phthisical eye with no light perception, following a childhood trauma, with the other eye having 6/6 vision. Two children had refractive errors (myopia and compound myopic astigmatism), with a best corrected visual acuity (BCVA) of 6/6. Thirteen children (8%) had Bitot's spots and 67 (35.4%) had allergic conjunctivitis. Eight (5%) children complained of dry eye-related symptoms like redness and watering of eyes, while 19 (11.8%) had diffuse headache. Average number of years spent in school for these children was less than 1.7 years (range: 1 month-6 years). Only 10.5% of the children gave the history of watching television more than 30 h/week. Significant association was found between the income of father and use of digital devices in children below 10 years ( P = 0.003) and children playing outdoors ( P = 0.001). There was a significant association noted for age and use of digital devices ( P = 0.037). The prevalence of refractive errors in "out-of-school" children of urban slum was much less than the national average. Almost one in three children suffered from eye allergies, while 8% children had Bitot's spots. The data about the prevalence of ocular comorbidities in underserved areas like urban slums can be used to update and strategize eye health-care delivery models for out-of-school children.

Clinical vitamin A deficiency among preschool aged children in southwest Ethiopia.

The clinical manifestations of vitamin A deficiency (VAD) involve night blindness, bitot's spots, corneal xerosis, and corneal scars. It is the most important cause of preventable childhood blindness among children and causes morbidity and mortality. Even though Ethiopia implemented high-potency vitamin A supplements, the occurrence of VAD remains significant. This study was to identify determinants of clinical VAD among preschool-aged children (PSC) in southwest Ethiopia. A community-based survey was conducted among 411 randomly selected PSCs. A pretested and structured questionnaire coupled with clinical observation for signs of vitamin A deficiency by a trained ophthalmologist was used to collect the data. An anthropometric measurement of height was taken and analyzed using WHO Anthro to calculate Z-scores for each index. The public health significance of VAD was declared after comparison with international references. A bi-variable and multi-variable logistic analysis was done. We reported the adjusted odds ratio (AOR), 95% confidence interval, and p-value. A total of 411 children were screened for clinical VAD, and the overall prevalence was 2.2% (95% CI: 1.5-2.5). Of which, night blindness affects 1.2%, bitot's spots affects 0.7%, and corneal xerosis affects 0.2%, indicating a major public health problem compared to the international reference. The odds of clinical VAD were 81% lower among children who received vitamin A supplementation (VAS; AOR = 0.19, 95% CI: 0.04-0.92). On the other hand, PSC of mothers who had attended ANC visits were 89% less likely to develop clinical VAD (AOR = 0.11, 95% CI: 0.02-0.53). In addition, the study revealed that the odds of developing clinical VAD are 82% lower among PSC aged 36 to 47 months (AOR = 0.18; 95% CI: 0.03-0.97). The prevalence of clinical VAD among PSC is a public health problem and is associated with ANC visits, VAS status, and the age of the child, which could be used to target interventions to further reduce existing VAD. Further studies using reliable dietary intake and biomarker data could further depict the burden of subclinical VAD.

Immunohistochemistry in an Adult Case of Bitot's Spots Caused by Vitamin A Deficiency.

Bitot's spots (BS) are the buildup of superficially located keratin in the conjunctiva and are early indicators of vitamin A deficiency (VAD), primarily due to malnutrition and malabsorption, thus leading to xerophthalmia. BS are particularly prevalent in developing countries, and their presence necessitates prompt vitamin A supplementation to avert blindness, with the immunohistochemical characteristics of BS aiding in understanding the extent of epithelial abnormalities and the efficacy of vitamin A supplementation. We describe the case of a 34-year-old male with persistent BS despite extensive vitamin A supplementation and topical treatments who underwent surgical excision of the BS followed by amniotic membrane transplantation, thus resulting in symptom relief and epithelialization, with no recurrence observed during follow-up. Histopathologic and immunohistochemical evaluations revealed expression of keratinization-related proteins, along with an absence of mucin-5AC-positive cells, suggesting impaired differentiation into goblet cells due to VAD. This case highlights the potential age-related disparity in the efficacy of vitamin A supplementation, emphasizing the need for early detection and a multidisciplinary approach in the management of VAD, especially in young adults. The favorable outcome of surgical intervention highlights its viability in the management of persistent BS and encourages further investigation to optimize therapeutic strategies for VAD-related ocular manifestations.

Risk Factors Associated with Xerophthalmia in Northern Sudan

The prevalence of eye signs and symptoms of vitamin A deficiency was determined among 29,615 Sudanese children between 6 and 72 mo of age, in five rural areas of Khartoum and Gezira provinces. Of all children, 2.9% were vitamin A deficient, and of these > 90% had Bitot's spots. Bivariate associations were found between xerophthalmia and the rural councils where the children lived, household wealth, consumption of vitamin A-containing foods, child sex, child age and weight-for-height Z-scores. Multivariate analysis showed that the following factors made significant independent contributions to the risk of xerophthalmia: living in remote and arid regions, male gender, age, poverty of the household, and prevalence of diarrhea. On the other hand, less xerophthalmia was observed among children who during the 24 h preceding the survey had consumed dairy products or non-leafy vegetables containing vitamin A. Intervention programs aimed at increasing household income and promoting consumption of foods containing vitamin A should contribute to the reduction of vitamin A deficiency among Sudanese children.

Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mucormycosis (Black Fungus): An Analytical Perspective.

Mucormycosis is a rare but serious opportunistic fungal disease characterized by rhino-orbito-cerebral and pulmonary involvement. It is mainly seen in people with secondary immunosuppression, isolated vitamin A deficiency, measles, and AIDS patients. It showed a rise during the second wave of the COVID-19 epidemic in the spring of 2021 in India, especially in diabetic COVID-19 patients. Vitamin A deficiency is known to cause nutritional immunodeficiency and hence leading the way to increased opportunistic fungal, bacterial, and viral infections. In the eye, it causes keratitis, night blindness, xerophthalmia, conjunctivitis, Bitot spots, keratomalacia, and retinopathy. It also causes decreased tear secretion and deterioration of the anatomical/physiological defense barrier of the eye. The negative impact of vitamin A deficiency has been previously demonstrated in measles, AIDS, and COVID-19. We think that mucormycosis in COVID-19 might be rendered by vitamin A deficiency and that vitamin A supplementation may have preventive and therapeutic values against mucormycosis and other ocular symptoms associated with COVID-19. However, any vitamin A treatment regimen needs to be based on laboratory and clinical data and supervised by medical professionals.

Nyctalopia and Bitot Spots

Vitamin A deficiency is endemic in resource-poor areas of low- and middle-income countries in Latin America, sub-Saharan Africa, and South Asia. Although rare in the United States, individuals at risk such as the homeless, those with malabsorptive disorders, or any person with a chronically poor diet may present pathognomonic clinical signs and symptoms.

Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.

Vitamin A deficiency (VAD) is a major public health problem in low- and middle-income countries, affecting 190 million children under five years of age and leading to many adverse health consequences, including death. Based on prior evidence and a previous version of this review, the World Health Organization has continued to recommend vitamin A supplementation (VAS) for children aged 6 to 59 months. The last version of this review was published in 2017, and this is an updated version of that review. To assess the effects of vitamin A supplementation (VAS) for preventing morbidity and mortality in children aged six months to five years. We searched CENTRAL, MEDLINE, Embase, six other databases, and two trials registers up to March 2021. We also checked reference lists and contacted relevant organisations and researchers to identify additional studies. Randomised controlled trials (RCTs) and cluster-RCTs evaluating the effect of synthetic VAS in children aged six months to five years living in the community. We excluded studies involving children in hospital and children with disease or infection. We also excluded studies evaluating the effects of food fortification, consumption of vitamin A rich foods, or beta-carotene supplementation. For this update, two review authors independently assessed studies for inclusion resolving discrepancies by discussion. We performed meta-analyses for outcomes, including all-cause and cause-specific mortality, disease, vision, and side effects. We used the GRADE approach to assess the quality of the evidence. The updated search identified no new RCTs. We identified 47 studies, involving approximately 1,223,856 children. Studies were set in 19 countries: 30 (63%) in Asia, 16 of these in India; 8 (17%) in Africa; 7 (15%) in Latin America, and 2 (4%) in Australia. About one-third of the studies were in urban/periurban settings, and half were in rural settings; the remaining studies did not clearly report settings. Most studies included equal numbers of girls and boys and lasted about one year. The mean age of the children was about 33 months. The included studies were at variable overall risk of bias; however, evidence for the primary outcome was at low risk of bias. A meta-analysis for all-cause mortality included 19 trials (1,202,382 children). At longest follow-up, there was a 12% observed reduction in the risk of all-cause mortality for VAS compared with control using a fixed-effect model (risk ratio (RR) 0.88, 95% confidence interval (CI) 0.83 to 0.93; high-certainty evidence). Nine trials reported mortality due to diarrhoea and showed a 12% overall reduction for VAS (RR 0.88, 95% CI 0.79 to 0.98; 1,098,538 children; high-certainty evidence). There was no evidence of a difference for VAS on mortality due to measles (RR 0.88, 95% CI 0.69 to 1.11; 6 studies, 1,088,261 children; low-certainty evidence), respiratory disease (RR 0.98, 95% CI 0.86 to 1.12; 9 studies, 1,098,538 children; low-certainty evidence), and meningitis. VAS reduced the incidence of diarrhoea (RR 0.85, 95% CI 0.82 to 0.87; 15 studies, 77,946 children; low-certainty evidence), measles (RR 0.50, 95% CI 0.37 to 0.67; 6 studies, 19,566 children; moderate-certainty evidence), Bitot's spots (RR 0.42, 95% CI 0.33 to 0.53; 5 studies, 1,063,278 children; moderate-certainty evidence), night blindness (RR 0.32, 95% CI 0.21 to 0.50; 2 studies, 22,972 children; moderate-certainty evidence), and VAD (RR 0.71, 95% CI 0.65 to 0.78; 4 studies, 2262 children, moderate-certainty evidence). However, there was no evidence of a difference on incidence of respiratory disease (RR 0.99, 95% CI 0.92 to 1.06; 11 studies, 27,540 children; low-certainty evidence) or hospitalisations due to diarrhoea or pneumonia. There was an increased risk of vomiting within the first 48 hours of VAS (RR 1.97, 95% CI 1.44 to 2.69; 4 studies, 10,541 children; moderate-certainty evidence). This update identified no new eligible studies and the conclusions remain the same. VAS is associated with a clinically meaningful reduction in morbidity and mortality in children. Further placebo-controlled trials of VAS in children between six months and five years of age would not change the conclusions of this review, although studies that compare different doses and delivery mechanisms are needed. In populations with documented VAD, it would be unethical to conduct placebo-controlled trials.

HIV positive children living in orphanages and home care: Assessment of nutritional deficiencies and opportunistic infections.

With the introduction of antiretroviral treatment (ART), opportunistic infections (OIs) reduced a lot and most HIV-associated OIs are preventable and treatable with safe cost-effective interventions. But however, in order to prevent and early diagnosis, we need to have baseline estimation of OIs among HIV positive children and other factors associated, especially nutritional deficiencies. A cross-sectional study was carried out in pediatric outpatient department (OPD) of a large multicentric hospital among 106 children. Data were collected by means of pretested predesigned semi-structed questionnaire prepared on consultation with experts in the subjects and clinical assessment was done in day light to detect signs of nutritional disorders. Institutional ethical clearance was taken, and strict confidentiality was maintained. Majority (39.6%) of the children belong to 5-9 years. Children were equitably distributed between orphanage and family care giver. Bitot's spots, cheilosis, and gum bleeding were found to be more than twice as common in subjects living with family, as compared to those living in orphanage while aphthous ulcer, knock knee, bow leg were found to be more than twice as common in female subjects as compared males. The prevalence of Pneumonia, Mumps, Herpes zoster, Pulmonary Tuberculosis, Oral candidiasis, and recurrent upper respiratory tract infections (URTI) was found to be about twice as common in subjects living with family, as compared to those living in orphanage while males had more Chicken pox, Herpes zoster, Pulmonary Tuberculosis, Oral candidiasis, and Recurrent URTI as compared to those in females. Vitamin deficiencies and opportunistic infections were higher than the prevalence reported by the various studies done on normal children. All efforts to be made to improve adequate nutrition to HIV positive children and ensure protection against opportunistic infections especially for children in home-based care.

Morbidity, its Patterns and Associated Factors among School Children Residing in a North Indian City

INTRODUCTION: Children are the pillars of the future of a country shall rest, are no less than a treasure and need to be as healthy as possible. AIM: To assess the health status of school children in various areas of Una city, Himachal Pradesh, India. MATERIALS AND METHOD: The present study was conducted among school children aged 7-18 present on the day of the study. Data collected was cross-sectionally using a pre-validated and pre-tested questionnaire duly standardized prior to commencement of the study. The first section of the questionnaire contained details about the demographic profile, and in the second, the examiners recorded the presence or absence of common childhood diseases, namely pallor, lymphadenopathy (L.N.), Bitot spots, Worm infections, Scabies, Ear discharge, Dental caries and Fluorosis. Statistical analysis included the Shapiro-wilk test to check for data normalcy, followed by descriptive statistics and Pearson’s correlation. Significance value (p) was kept significant at ≤0.5. RESULTS: Most children belonged to the age group of 12-15 years (42.8%), followed by 7-11 years(34.3%) and 16-18 years(22.9%). Majority of the students were girls (61.5%) and most them belonged to the age group of 12-15 years(41.0%). Disease in any from was observed in 813 (76.2%) of the children, with the most prevalent disease observed being dental caries (32.3%), followed by fluorosis (20.5%) and pallor (14.3%). Pearson’s correlation revealed a strong, positive association between the disease status and age (0.7) and gender (0.8). CONCLUSION: The results of the present study indicate the need to have various specific programmes to reduce the burden of various diseases, namely dental caries and pallor among school children through efforts of various programmes.

Bitot-like spots in children with normal vitamin A levels.

A Bitot spot is a conjunctival lesion, classically associated with severe vitamin A deficiency. In this paediatric series, we describe conjunctival lesions indistinguishable from Bitot spots, seen in the presence of normal vitamin A levels. This descriptive case series was performed by retrospective review of case notes, including all patients with Bitot-like spots found to have normal serum vitamin A levels, seen at the Hospital for Sick Children, Toronto, between 2006 and 2016. Data collected included age at presentation, ophthalmic and systemic diagnoses, and the presence of recognised genetic mutations. Histopathology was reviewed in one case. Ten patients with Bitot-like spots with laboratory-confirmed normal serum vitamin A levels were identified. The conjunctival lesions were indistinguishable clinically and histopathologically from classic Bitot spots and were noted to occur in a range of anterior segment pathologies, including aniridia, WAGR syndrome, Axenfeld-Rieger syndrome, and blepharokeratoconjunctivitis. Bitot-like spots are found in children with a number of anterior segment pathologies in the absence of vitamin A deficiency.

Malnutrition status and other common comorbidities among inmates of childcare homes in puducherry, India - An Analytical Cross-Sectional study

BackgroundInmates of child care institutions constitutes a vulnerable group. It is important to monitor their health status. This study aimed at estimating the prevalence of malnutrition and other common comorbidities among them. MethodsThis is an Analytical Cross-Sectional study done in randomly selected twelve childcare institutions in Puducherry. All eligible 563 inmates, aged 5–18 years, from the selected institutions were included in the study. Pretested structured questionnaire was used to collect data. Nutrition status of participants were assessed using WHO BMI-for-age and Height-for-age growth charts. Inmates were clinically examined for nutrition status, vitamin deficiencies, skin conditions and goiter. Assessment of common comorbidities was done using modified Rashtriya Bal Swasthya Karyakram (RBSK) questionnaire. Inmates were also assessed for Presumptive Tuberculosis. ResultsThe prevalence of undernutrition was 39.4% (95% CI 35.48–43.53). Prevalence of thinness was 27% (95% CI 23.5–30.8) and prevalence of stunting was 20% (95% CI 16.9–23.5). Dental problems were found in 61% of the study population. Other nutritional deficiencies found on examination were palmar pallor (26.8%), Goiter (2%) and Bitot spots (0.7%). Around 4.6% of inmates reported that they had cough for 2 weeks or more and 3.7% had history of contact with a known case of Tuberculosis. ConclusionThe common comorbidities among the inmates were dental problems, undernourishment and anemia. There is need for regular health education and screening for these conditions for timely identification and initiation of appropriate interventions. There is also a need for symptomatic screening for early identification and reporting of presumptive Tuberculosis cases.

Changes in Vitamin A Levels and the Effect of Early Vitamin A Supplementation on Vitamin A Levels in Infants Throughout the First 6 Months of Life: A Prospective Cohort Study in Chongqing, China.

Objectives: This study aimed to explore the changes in infant vitamin A (VA) status and the effect of early VA supplementation on VA level throughout the first 6 months of life.Methods: A prospective cohort study was conducted in Chongqing, China. A total of 1,016 healthy infants were enrolled at birth. Then, 930, 882, 854 and 822 healthy infants were followed up at postnatal day 7 and postnatal months 1, 3, and 6, respectively. Blood samples and dietary survey and physical development data were collected. Serum VA was measured by chromatography tandem-mass spectrometry and was classified according to the VA deficiency (VAD) criteria for older children aged 6–70 months (<0.70, 0.70–1.05, ≥1.05 μmol/L). Normally distributed continuous variables are presented as the mean ± standard deviation. The categorical variables are described by the frequency and percentage (%). The reference interval for the VA level was the 2.5th−97.5th percentile. Changes in VA status with age and the relationship of VA supplementation with VA level were investigated by generalized estimating equations followed by Bonferroni post hoc test, controlling for the effects of feeding pattern and sex.Results: Infant VA levels increased significantly from 0.499 ± 0.146 to 1.061 ± 0.414 μmol/L with age at 6 months, even without VA supplementation (P < 0.05). From birth to 6 months, the percentage of infants with a VA level <0.70 μmol/L decreased from 88.6 to 19.5%. During follow-up, no infant demonstrated clinical VAD conditions, such as night blindness, conjunctival xerosis or Bitot's spots. Less than 7.0% of infants were underdeveloped in terms of weight, length and head circumference. The VA status of infants with VA≥0.588 μmol/L at birth gradually increased to adequate VA (VA ≥ 1.05 μmol/L) at 6 months. For these infants, there was no significant difference in VA level between the VA supplementation and non-supplementation groups (P > 0.05). Infants with VA <0.430 μmol/L at birth still had VA <0.70 μmol/L at 6 months; in this group, VA levels increased by 0.08 μmol/L more among supplemented infants than among non-supplemented infants (P < 0.05).Conclusions: A low VA level among neonates at birth may be a normal physiological state and may increase with age; thus, not all neonates may need early VA supplementation. More multicenter studies are needed to determine a new cutoff point for the diagnosis of neonatal VAD and the administration of nutritional intervention.

Bitot's spots, dry eyes, and night blindness indicate vitamin A deficiency

Bitot's spots, dry eyes, and night blindness indicate vitamin A deficiency

Child Night Blindness and Bitot's Spots Are Public Health Problems in Lay Armachiho District, Central Gondar Zone, Northwest Ethiopia, 2019: A Community-Based Cross-Sectional Study.

Background Night blindness (XN) is a condition in which a person cannot see in dim light and is the earliest clinical manifestation of vitamin A deficiency. Globally, vitamin A deficiency is a public health problem in 122 countries, of which 45 countries have moderate to severe child night blindness. Therefore, this study is aimed at assessing the prevalence and associated factors of night blindness and Bitot's spot among children aged 24-59 months. Methods A community-based cross-sectional study was employed from February to March 2019 among children aged 24-59 months in the Lay Armachiho District, Amhara region. A structured and pretested questionnaire was used for data collection. Descriptive summary statistics were used to describe the study population. Bivariate and multivariable logistic regression models were used to identify associated factors. Results Out of 1007 children, 1.9% and 2.2% had night blindness and Bitot's spot, respectively. Illiterate mothers (AOR = 2.94; 95%CI = (1.12, 6.72)), age of 48 to 59 months (AOR = 9.81; 95%CI = (1.24, 77.36)), ≥4 family sizes (AOR = 4.52; 95%CI = (1.02, 19.90)), had diarrhea (AOR = 5.00; 95%CI = (1.73, 14.54)), and had a respiratory tract infection (AOR = 3.14; 95%CI = (1.02, 9.70)) were significantly associated with night blindness. Age of 48-59 months (AOR = 4.23; 95%CI = (1.13, 14.86)) and mothers who did not wash their hands after using the toilet (AOR = 3.02; 95%CI = (1.01, 9.13)) were predictor variables for Bitot's spots. Conclusion The prevalence of night blindness and Bitot's spots was high. Child's age, mother's educational status, family size, diarrhea in the last 2 weeks, and respiratory tract infection in the last 2 weeks were predictive variables for night blindness. Besides, handwashing practice after using the toilet and child's age were significantly associated with Bitot's spot among children. Therefore, both night blindness and Bitot's spots are a public health problem and call for the attention of health professionals in primary health care facilities.

Prevalence and Associated Factors of Clinical Vitamin A Deficiency Among Pre-School Children 1-5 Years of Age in Rural Kebeles in Farta District, South Gondar Zone, Ethiopia: A Mixed Methods Study.

BackgroundGlobally, pre-school children are the most at-risk population groups for vitamin A deficiency (VAD). The 2009 World Health Organization (WHO) report stated that one-third (190 million) of pre-school children worldwide are deficient in vitamin A. Both clinical and subclinical VAD have been a long-standing problem in developing countries. In Ethiopia, VAD was recognized as a public health problem 4–5 decades before. Since then, researches conducted in other parts of the country still showed varied and high prevalence, which is 2–8 times higher than WHO cut-off points. This community-based study was therefore conducted on pre-school children of rural kebeles in Farta district to determine the prevalence of clinical VAD (Bitot’s spot and night blindness) and associated factors.MethodsA community-based cross-sectional mixed quantitative and qualitative study was conducted. Randomly selected 588 pre-school children participated in the study. The clinical aspect of the study investigated the presence of Bitot’s spots on the children’s eye with the aid of a magnifying loop and torch. Data on the history of night blindness were obtained from mothers/caregivers by using WHO standard questions. The qualitative study data were obtained via a key informant interview with the mothers/caregivers whose child has clinical VAD. Quantitative data were entered using Epi Data statistical software and analysed by using SPSS version 20 statistical software package. A bivariable logistic regression was employed, and variables that showed significant association with clinical VAD (P < 0.2) were entered a multivariable logistic regression model to identify independent predictors of clinical VAD.ResultsThe prevalence of Bitot’s spot and night blindness was 0.8% and 1.2%, respectively. Pre-school children who were from highland (AOR: 3.71; 95% CI: 1.01–13.68), a mother having antenatal care (ANC) visit during pregnancy of a child (AOR: 8.63; 95% CI: 2.58–28.79), family monthly income (AOR: 8.63; 95% CI: 2.58–28.79) and handwashing frequency were found to be determinants of VAD (p < 0.05).ConclusionClinical vitamin A deficiency in the study area is of public health concern because the prevalence of Bitot’s and night blindness was above the WHO threshold level. Accordingly, effective preventive measures should be designed to reduce VAD prevalence.

Tribal Odisha Eye Disease Study Report # 6. Opportunistic screening of vitamin A deficiency through School Sight Program in tribal Odisha (India).

Purpose:To explore the possibility of vitamin A deficiency (VAD) detection through School Sight Program (SSP) in a tribal district of Odisha, India.Methods:In a cross-sectional observational study, we tracked school children with ocular signs/symptoms of VAD to their villages. The ophthalmologist examined their under-5 siblings and other under-5 children in the village. Information pertaining to family belief and practices of food, water, sanitation, and the socioeconomic status of the family were collected.Results:The ocular features of VAD were detected in 207 of 4801 (4.3%) examined children. This included 70 children (mean age 11 ± 2.6 years) detected in the school, 22 siblings (mean age 3.2 ± 1.2 years) of these children detected at their home, and 115 children (mean age 3 ± 1.5 years) detected in their habitat. The average family size was 5.8 ± 2.02 and the birth order of the child with VAD was 2.3 ± 1.25. Most parents were farmer, living in asbestos-roofed house, depended on public underground water, and practiced open-air defecation. The distribution of VAD in 207 children was conjunctival xerosis (X1A = 207; 100% of VAD and 4.3% of all children), Bitot's spot (X1B = 169; 81.6% of VAD and 3.5% of all children), corneal scar (XS = 3; 1.4% of VAD and 0.06% of all children), and night blindness (XN = 35; 16.9% of VAD and 0.72% of all children).Conclusion:An opportunistic screening for detection of VAD through a SSP could be cost-effective and complement the existing strategy.

Association between the socioeconomic determinants and soil-transmitted helminthiasis among school-going children in a rural area of Haryana.

Background:WHO indicates that India has the highest burden of soil-transmitted helminthiasis (STH) in the world, contributing to 25% of the total global cases, with 220 million children aged 1–14 estimated to be at risk.Aim and Objective:To study the association between the socioeconomic factors and STHs among primary school children in a rural area of Haryana.Methodology:The study was conducted among children aged 6–10 years studying in the rural government primary schools in the rural areas of Haryana. A total of 300 children were enrolled from government school.Results:The study found that the prevalence of helminthiasis was 28.7% (86/300) and of these 14.0% children were infected with Ascaris lumbricoides and sex wise association with Helminthic infection was observed as statistically nonsignificant. One third of the (31.39%; 27/86) children were pallor and 5.81% subjects were having Bitot's spot while 13.95% children were having constitutional symptoms such as weakness, 6.97% subjects have fatigue, and 5.81% children have body ache.Discussion:The morbidity can be reduced with appropriate inputs to improve the environmental factors. This may need investment for sanitary latrines, food hygiene, and safe drinking water, anti-helminthic drugs, and health education.Conclusion and Recommendations:The results of the study concluded and recommended that proper implementation of national deworming day and other long-term strategies like sanitation, clean drinking water, adequate sanitation, and also improvement in nutritional status through various nutritional health programmes.

Study on ocular diseases in school children in west Hyderabad

Introduction: A study on ocular diseases in children is important because early detection and treatment will reduce the burden of blindness in the society as children in the school-going age group (5-16 years) represent 25% of the population in developing countries. Most of the eye diseases start from childhood. If they are not detected early they can hamper children’s activities in school and may also cause severe ocular disability in their future. Objectives: Our school eye survey will help in early detection and treatment of ocular morbidities in rural schools of Film nagar, Hyderabad. Materials and Methods: In this study 1218 school children aged between 5 to 16 years were screened for ocular morbidities and specific treatment was given to the children with ocular diseases. SPSS software was used for statistical analysis. Results: The total prevalence of ocular morbidity was 32.5%.Refractive errors accounted for 11.0% of the cases followed by Blepharitis accounting for 10.1% of cases. The other ocular morbidities were Allergic conjunctivitis 7.6%, Amblyopia 1%, Duane's Retraction syndrome 0.3%, Meibomian gland dysfunction 0.5%, Congenital cataract 0.3%, Exotropia 0.5%, intrastromal corneal foreign body 0.2%, Bitot's spots (Vitamin A deficiency) 0.2% Corneal opacity 0.5%, Double elevator palsy 0.2%, Axenfield rieger's syndrome 0.2%, Chalazion 0.2%. Conclusion: Refractive errors was the most common ocular morbidity followed by Blepharitis. Periodic school eye health programs and ocular hygiene play an important role in reducing the ocular morbidities. Keywords: Ocular morbidity, School children, Refractive errors, School eye camps, Ocular hygiene.