David Ring MD, PhD (left) and Ana-Maria Vranceanu PhD (right)The International Musculoskeletal Mental and Social Health Consortium (I-MESH) brings together clinicians and researchers with a passion for reducing the global toll of musculoskeletal disorders. United by a desire to break down the silos between those who care for people with musculoskeletal conditions, we developed I-MESH in 2020 to share knowledge and resources and develop actionable strategies to transition musculoskeletal care toward a biopsychosocial model. I-MESH includes more than 60 international clinicians and researchers who are trained as orthopaedic surgeons, social workers, psychologists, nonoperative specialists, athletic trainers, as well as physical, occupational, and hand therapists. We welcome new members who share our mission! I-MESH started with developing working definitions of mental and social health. We believe mental health includes thoughts, emotions, and behaviors that help us thrive, and that social health encompasses role, relationship, job, financial, home, and food security. Social health also is affected by educational access and quality, economic stability, healthcare access and quality, neighborhood and built environment, and social and community context including racism, discrimination, and violence. In the initial I-MESH meetings, we used a consensus-based decision-making approach to identify three key priorities for I-MESH. First, we sought common ground on the terminology and language to help foster quality patient care and research. Second, we set out to conduct qualitative and mixed-methods research to gain a nuanced understanding of the barriers and facilitators to implementation of psychosocial care at the level of patients, providers, and organizations. Third, we aimed to develop clinical and research resources to foster interdisciplinary collaborations. For example, we developed special interest groups within I-MESH focusing on research, communication, and clinical practice. Our first white paper delineates details on I-MESH’s mission, vision, and values [1]. We are proud to share the selected proceedings of the inaugural I-MESH meeting in this month’s Clinical Orthopaedics and Related Research®. These papers were presented at our virtual meeting in March 2021, which included qualitative, quantitative, and mixed-methods research. These papers not only draw attention to the notable influence of unhelpful thoughts, feelings of distress, and circumstances of insecurity on symptom intensity and the magnitude of capability (how one feels and what one can do), but they also hit on areas that have the potential to enhance overall health through collaboration and coordination of biopsychosocial strategies. Collectively, the papers in these selected proceedings add to the evidence that unhelpful thinking (such as worst-case thoughts and fear of painful worry or despair have notable associations with symptom intensity and magnitude of limitations. The I-MESH papers in these selected proceedings show that orthopaedic surgeons can identify unhelpful thinking using a number of easy-to-employ measurements and communication strategies, and that specific barriers can be lowered as we craft care strategies that take advantage of this knowledge. We hope that these selected proceedings in CORR® and I-MESH can help increase the momentum toward adoption of the biopsychosocial paradigm in musculoskeletal health and in medicine more generally. We plan to hold the second I-MESH meeting in Spring 2022 and welcome abstract submissions, which individuals can send to [email protected]. Selected proceedings from that meeting will again be published in CORR.