Lauren Beukes’s Moxyland is a dystopian science fiction novel set in a near-future Cape Town, South Africa, which delves into the complex interplay between posthuman biopolitics, technology, authority, and the human body. This article examined the posthuman dimension through the lens of biopolitics. The article depicts the oppressive nature of pervasive surveillance and corporate control informed by the apartheid past, wherein four characters become entrapped in a society governed by these forces. Moreover, it demonstrates how the bodily integration of the regulatory technology derives from the racial idea of Western personhood, which intensifies the subjugation by altering subjects into posthuman entities. By adopting the Foucauldian theory of biopolitics as an analytical framework, this study traces the pivotal role played by biopolitics in the transformation of individuals into posthumans. The amalgamation of surveillance technologies and bioengineered enhancements leads to the commodification and perpetual manipulation of the subject, serving to uphold social order and preserve capitalist systems. The findings of this study shed light on the intensification of the control exerted by posthuman biopolitics, thereby contributing to the reconfiguration of the place of humans in academic discourse surrounding the intersection of power, technology, and the human body. By critically analysing the novel through the lens of Foucauldian theory, this article offers insights into the consequences of biopolitical control, underscoring the need for critical examination and discourse on the ethical implications of emergent posthuman societies in the Global South.