CoCrMo alloys are extensively used in the field of artificial knee joints. However, wear performance is one of the most important problems of artificial knee joints, limiting service life. In this paper, symmetrically biomimetic textures with the spacing of 200 μm, the width of 45 μm, and the depth of 45 μm are fabricated on the surfaces of CoCrMo artificial knee joints to improve its tribological properties. Friction tests are conducted under the following conditions: frequency 1.5 Hz, sliding time 30 min, load (5 ∼ 15 N), lubricant concentration (15 ∼ 55 mg/ml). Results show that textures, lubricating condition, load and surface wettability have significant influence of friction properties, and textured CoCrMo artificial knee joints show the better friction performances compared STT-0, and samples with scaly textured structure (STT-3) own best friction performances with the lowest coefficients of friction. The responsible mechanisms on the enhancement of friction properties of textured joint are explained as follows: micro-texture plays the role of storing the wear debris and lubricating fluid, preventing the wear debris from entering between the friction pairs and forming hydrodynamic pressure to generate hydrodynamic lubrication effect. Derivative-cutting behavior of the lower edge of biomimetic textures can act as “another cutting tool” to remove the wear debris which adhered on the bottom of the PEEK balls.