One of the significant challenges in cancer therapy is the development of biocompatible drug delivery systems (DDS) with enhanced penetration retention effect (EPR) and precision targeting. The current study aimed to establish a one-pot synthesis of 7-ethyl-10-hydroxy camptothecin (SN-38) loaded europium-metal-organic framework (SN-38@Eu-MOF) and evaluate its anticancer potential against breast cancer. High drug loading efficiency (85.3 ± 0.02 % in 48 h at pH 5.0) and pH-sensitive regulated release of drug SN-38 were two characteristics of the fabricated Eu-MOFs. According to material characterization, the material's surface formed a monodispersed homogeneous rod-shaped structure adorned with SN-38, with an average particle size of 72 ± 0.23 nm. Results of anticancer assays demonstrated that when compared to SN-38 alone, SN-38@Eu-MOFs showed improved anticancer potential in breast cancer cells (MCF-7 and MDA-MB-231). According to the mechanism of anticancer potential, SN-38@Eu-MOFs increased reactive oxygen species (ROS) levels and caused mitochondrial malfunction and DNA damage, which resulted in apoptosis. The study's findings indicate that SN-38@Eu-MOFs is a potentially biocompatible nanomaterial for drug delivery systems for treating breast cancer and other pharmaceutical applications.