Biochemical Parameters Of Metabolic Syndrome Research Articles

Comparison of the effectiveness of lifestyle interventions and multi-interventional therapy on biochemical parameters of metabolic syndrome among women.

Metabolic syndrome is one of the emerging health issues in developing countries. It includes diabetes, high blood pressure, obesity, and elevated blood cholesterol. This study aimed to compare the effects of two different types of interventions: multi-interventional therapy (MIT) and lifestyle interventions (LIs) on high-density lipoprotein (HDL), triglycerides, and fasting blood sugar (FBS) among women with metabolic syndrome. The study used a quasi-experimental nonequivalent control group design with two experimental groups and one control group. This study was conducted among self-help group women from nine area development societies (ADS) in a selected area in South India from March 1, 2019, to February 28, 2020. Women (aged between 35 and 55 years) with metabolic syndrome were recruited by multistage sampling (N = 220) and randomly assigned into three groups: (a) control, (b) MIT (intervention 1), and (c) LIs (intervention 2). Reflexology foot massage, dietary modification, moderate-intensity exercise, and structured education were given to the MIT group and dietary modification, moderate-intensity exercise, and structured education were given to the LI group for 12 weeks. The control group received routine care. A demographic and clinical data sheet is used to collect the basic information. Biochemical variables (HDL, triglycerides, and FBS) were assessed before and after the intervention. The data obtained from the study were computed using a frequency distribution to describe the demographic characteristics, and a Chi-square (x2) test was conducted to find the homogeneity. Both parametric and nonparametric tests were conducted for the comparison of the effectiveness of different methods of interventions on biochemical parameters of metabolic syndrome. Women who received MIT and LI had significantly lower values of HDL, triglycerides, and FBS after the treatment from baseline and compared with the control group. The study found a significant improvement in the biochemical parameters in the MIT group as compared to the control group and the LI group (<0.001). Paired t-test shows significant improvement in HDL, triglycerides, and FBS (P < 0.001) in both the LI and MIT groups. In case of triglycerides, MIT was found to be more effective (P < 0.001). Both MIT and LIs can be considered interventions for reducing triglycerides and FBS and increasing HDL.

The Influence of Probiotic Supplementation on the Severity of Anxiety and Depressive Symptoms; Function and Composition of Gut Microbiota; and Metabolic, Inflammation, and Oxidative Stress Markers in Patients with Depression—A Study Protocol

This article aims to present the theoretical basis, methodology, and design of a clinical trial we will conduct. The study will be prospective, randomized, placebo-controlled, and double-blind. Each intervention period will last 8 weeks and the trial will be conducted on 100 patients in total, who will be randomly divided into two groups consisting of 50 patients each. We plan to investigate the impact of Lactobacillus helveticus Rosell and Bifidobacterium longum Rosell on the depressive, anxiety, and stress levels in patients with depressive disorders with possible comorbid anxiety. In addition to assessing the influence of probiotics on the clinical condition, we also plan to study the clinical and biochemical parameters of metabolic syndrome, which often coexists with depression. Both depressive and metabolic issues may have part of their etiopathology in common, e.g., inflammation, oxidative stress, and dysbiosis. This is why we will additionally investigate the parameters related to gut microbiota, inflammatory, and oxidative statuses. Thus, the primary endpoint of the study will be the change in depression score measured with the Montgomery-Åsberg Depression Rating Scale. The secondary endpoints will include changes in anxiety and stress levels, as well as metabolic, inflammation, and oxidative stress parameters.

METABOLIC SYNDROME AND THYROID DYSFUNCTION IN PATIENTS WITH ACROMEGALY IN SULAIMANI

Background &#x0D; Acromegaly is a chronic endocrinology disorder caused by the over-production of growth hormone (GH) predominantly by a pituitary adenoma. Acromegaly is associated with metabolic changes and thyroid dysfunction (ThD) in the body. However, the frequency of metabolic syndrome (MtS) in acromegaly patients is unknown, and studies assessing the frequency of different ThD types in acromegaly cases were few.&#x0D; Objectives &#x0D; To analyze the frequencies of MtS and ThD in patients with acromegaly in comparison to controls in Sulaimani city, to find the frequencies of MtS and ThDs in active cases compared to inactive cases in acromegaly patients, and to assess the relationship between the cumulative exposure to Insulin-like Growth Factor 1 (IGF-1) with ThD and MtS in acromegaly.&#x0D; Patients and Methods&#x0D; In this case-control study, 82 subjects were enrolled, which included 22 patients with acromegaly who visited the Sulaimani endocrinology center from August 2021 to February 2022 and 60 control subjects. The mean age of cases was 47.55 [11.50] years, with 7 (31.8%) male and 15 (68.2%) female. Thyroid function test, clinical, and biochemical parameters of MtS were measured in both groups in addition to IGF1. Chi-square test, Student T-test, and ANOVA were used in data analysis. Correlation between quantitative variables determined by Pearson correlation, with a P-value ≤ 0.05, is significant&#x0D; Results&#x0D; Out of 22 patients with acromegaly, 68.2% were euthyroid, 9.1% had primary hypothyroidism, 18.2% had central hypothyroidism, and 4.5% had hyperthyroidism, which is significantly higher than the control group (p-value =0.002). MtS frequency is 68.18% in cases, significantly higher than control, p-value=0.011. Most MtS and ThD parameters were significantly higher in acromegaly patients than in controls, P-value &lt; 0.001. No significant correlation between the last IGF1 and other parameters existed except free T3, which has a significant negative correlation with IGF1, P &lt; 0.05. &#x0D; Conclusion&#x0D; In acromegaly, the frequency of MtS is high (68.18%), and the frequency of ThD is 31.8%. Both MtS and ThDs are more common in patients compared to controls. No significant relationship exists between disease activity and the presence of MtS or ThD. Because both MtS and ThDs increase the metabolic markers, consequently increasing cardiovascular disease (CVD) morbidity and mortality in cases.

Study of lipoprotein (a) and biochemical parameters of metabolic syndrome among younger population

Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. Aim &amp; Objective: Due to the scarcity of studies about the epidemiological behaviour of Lp(a) in our country, the main aim of our research is to study the relationship between Lp(a) and the metabolic syndrome and its components in younger population Materials &amp; Methods: A total of 136 subjects were enrolled into the study. A pre-structured and pretested proforma was used to collect the data. Baseline data including age, gender, religion, detailed medical history, clinical examinations and relevant investigations such as HDL-cholesterol, triglyceride, lipoprotein (a) and fasting glucose were done in the study. Analysis was done by SPSS version 18. In our study, 46.2% males and 43.1% females were affected by metabolic syndrome with no significant correlation with sex. Lipoprotein (a) level is increased in the metabolic syndrome category by Modified NCEP ATP III Criteria and IDF Criteria. Lipoprotein (a) level has significant correlation with the metabolic syndrome according to their p values (&lt;0.01). It has significantly correlated with the individual components of metabolic syndrome and age category too (p value &lt;0.01).

Does a Gluten-free Diet Improve Metabolic Syndrome Parameters? A Systematic Review

To review scientific evidence on the effects of a gluten-free diet on body composition and improvement of clinical and biochemical parameters of metabolic syndrome. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes – PRISMA guidelines were followed. A literature search was performed in the PubMed, ScienceDirect, Trip Database, Bireme and Scielo databases, without language restriction, until March 2021. The terms “gluten-free diet”, “obesity”, “metabolic syndrome”, and “weight loss”, and Boolean operators (AND/OR) were used. The clinical hypothesis was [...]

Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p&lt;0.01),stimulated serum C peptide (p&lt;0.01), serum fasting insulin (p&lt;0.01) and HOMA IR (p&lt;0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR &gt;2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.

Study of metabolic syndrome in south Indian PCOS women

PCOS is one of the common endocrine disorders in women leading to various complications like infertility, menstrual, psychological disturbances and metabolic syndrome. The objectives of this study were to study the clinical and biochemical parameters of metabolic syndrome in women of reproductive age group with PCOS.This cross-sectional study was conducted in a tertiary care centre from September 2018 to June 2020. Fifty six women diagnosed with PCOS, underwent clinical and laboratory assessments for the diagnosis of metabolic syndrome, as per international diabetes federation (IDF) criteria.14.3% subjects had metabolic syndrome. The prevalence of individual components of the metabolic syndrome among PCOS patients were: waist circumference &amp;#62;80cms in 100%, HDL &amp;#60; 50mg/dl in 100%, triglycerides &amp;#62; 150mg/dl in 75%, blood pressure &amp;#62;130/85mmhg in 12.5%, fasting plasma glucose &amp;#62; 100 mg /dl in 87.5%. Subjects with metabolic syndrome had significantly higher BMI compared to those without metabolic syndrome (p=0.043).The metabolic syndrome and its individual components, like waist circumference and decreased HDL were found to be more common among PCOS patients in this study. As the risk of MetS increases with age and BMI, early screening and timely interventions like lifestyle changes will prevent metabolic complications like cardiovascular diseases and type II diabetes mellitus.

To evaluate the thickness of epicardial fat by 2-D echocardiography and its correlation with various parameters of metabolic syndrome

Introduction: There is increase in prevalence of metabolic syndrome in younger population in India. Epicardial fat is one of the components of visceral adipose tissue. There is little evidence to suggest that the extent of epicardial fat is strongly related to overall adiposity. The relationship between epicardial fat and metabolic syndrome is still unexplored. Hence the hypothesis of the study is to evaluate whether epicardial adipose tissue is related to anthropometric, clinical and biochemical parameters of metabolic syndrome. Materials and Methods: The present study is a case control study which included 66 subjects- 33 cases (patients who fulfilled the NCEP ATP III criteria for metabolic syndrome) and 33 Controls. Detailed clinical history and physical examination (including blood pressure, height, weight, waist/hip circumference) along with biochemical examination (blood glucose, HbA1C, HOMA IR, serum insulin levels, fasting lipid profile) was done. Each subject underwent transthoracic two dimensional M-mode echocardiogram in left lateral decubitus position on Philips Sonos 5500 echocardiography machine to evaluate epicardial fat thickness. Results: In our study we found a strong positive correlation between the epicardial fat thickness and the following parameters in patients of metabolic syndrome: BMI: r = 0.52, p =0.02; HOMA IR; r = 0.58, p =< 0.001; FPG; r = 0.79, p =< 0.00; HbA1c, r = 0.59, p =

Effectiveness of reflexology related interventions on physiological and biochemical parameters of metabolic syndrome among women

The purpose of the study was First to evaluate the effectiveness of reflexology related interventions on biochemical and physiological parameters of metabolic syndrome among women; Second to find out the association between physiological and biochemical parameters of metabolic syndrome among women with socio-demographic variables. The study used a true experimental design with one experimental group and one control group. Data were collected from 40 self-help group women who were the members of Kudumbashree from a selected area in South India. Samples were collected by using multistage sampling. Reflexology related intervention was given to the experimental group for 12 weeks. The control group did not receive an intervention. Repeated measures ANOVA and t-test were used for data analysis. The study found there is a significant change in the physiological and biochemical parameters of metabolic syndrome among the experimental group as compared to the control group (p&lt;0.001). Even if there is no statistically significant difference between the different groups, the observed difference is clinically significant. The study concludes that reflexology related intervention was effective in improving the parameters of metabolic syndrome. It can be implemented in the clinical setting for patients with metabolic syndrome and related lifestyle disorders

A case control study of clinical and biochemical parameters of metabolic syndrome with special attention among young and middle aged population

BackgroundMetabolic syndrome (MS) increases the risk of heart disease, stroke, and other complications. AimThe aim of this study was to assess the clinical and biochemical parameters of MS and its complications (cerebrovascular accidents, cardiovascular accidents, DN or chronic kidney disease (CKD) compared with healthy controls especially among the younger population in Northern India. Material and methodsA total of 245 (healthy, MS and it's complicated) aged 18–70 years participated in the Open-Label, Single Centered; hospital-based random selection case-control comparative study. All anthropometric and biochemical assessment was done after proper consent. The metabolic syndrome was determined by IDF criteria. ResultsThe key risk parameters in three groups i.e. Control, Metabolic syndrome, and Complicated was TG (96.5 ± 46.9, 194.1 ± 87.8, 148.0 ± 102.2). LDL (91.2 ± 27.2, 114.0 ± 31.8, 69.1 ± 42.5, BP (120.1 ± 9.9, 139.3 ± 13.3, 132.1 ± 15.0) and high fasting glucose (81.1 ± 13.7, 164.5 ± 84.3, 138.0 ± 74.5). The hs-CRP is also significantly increased in the complicated group. The subanalysis of data also indicates that younger middle age (36–55 years) group both male and female is obese, hypertensive, diabetic with lipid abnormality according to IDF criteria. Conclusion: The risk factors like high TG, low HDL, high BP, and high fasting glucose were found higher particularly in younger population which may lead to diagnosis & complications of diabetes, hypertension and lipid abnormality. Due to changing physiology in young and middle age population these individuals are moving towards metabolic syndrome easily and needs frequent monitoring, preventive checkups, and lifestyle changes to prevent complications.

Effect of Nigella Sativa oil on various clinical and biochemical parameters of metabolic syndrome

Background: The seeds of Nigella sativa plant have been used to promote health and fight disease for centuries especially in the Middle East and Southeast Asia. This plant has been a great focus of research. This clinical study was undertaken to determine the adjuvant effect of Nigella sativa oil on various clinical and biochemical parameters of the metabolic syndrome. Methodology: This prospective study was conducted at a tertiary health care centre in North India. After final diagnosis and considering inclusion and exclusion criteria, sixty patients were enrolled in this study. Informed and written consent was taken from all the patients enrolled. Approval from institutional ethical committee was obtained. Patients were divided into two groups of thirty. In group I (standard group) patients were given tablet Atorvastatin 10 mg once a day and tablet Metformin 500 mg twice a day for a period of six weeks. In group II (Nigella sativa) group, patients were given tablet Atorvastatin 10 mg once a day, tablet Metformin 500 mg twice a day and Nigella sativa oil 2.5 ml twice daily for a period of six weeks. Blood sugar, both fasting and postprandial, fasting lipid profile, body mass index, body weight and waist circumference were recorded before and after completion of therapy. Result: The above mentioned methodology was followed and it was found that the difference in percentage improvement in group II was significant with reference to total cholesterol, low density lipoprotein (LDL) and fasting blood glucose (p<0.05). Conclusion: Nigella sativa oil is effective as an add-on therapy in patients with metabolic syndrome. Nigella sativa oil has a significant therapeutic activity in diabetic and dyslipidemic patients.

Comparison of the Clinical and Biochemical Profile of Metabolic Syndrome Between Obese Children Below and Above 10-Years Old Attending Paediatric Clinic Hospital Universiti Sains Malaysia from 2006 to 2015.

ObjectivesWe aim to compare the clinical and biochemical profile of metabolic syndrome between obese children below and above 10 years attending Paediatric clinic Hospital Universiti Sains Malaysia (HUSM) from 2006 to 2015. This is to determine if age, particularly the transition to puberty, modifies the prevalence of components of metabolic syndrome in obese children.MethodologyThe medical records of 84 obese children under 18 years of age seen at Paediatric clinic HUSM from 2006 to 2015 were reviewed. Demographic (age, gender, ethnicity), anthropometric (weight and height), clinical [body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP)] and biochemical [serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG)] parameters were recorded, analyzed and compared.ResultsMajority of subjects in both age groups were boys, with 68.2% <10 years old. Mean age was 9.69 years (±3.36). The clinical and biochemical parameters of metabolic syndrome were similar between those <10 years old and >10 years, with the exception of BMI, waist circumference, SBP and TG level. Multivariate regression analysis showed that the parameters of metabolic syndrome significantly associated with age ≥10 years were systolic hypertension (adjusted OR 7.17, 95% CI, 1.48 to 34.8) and BMI >30 kg/m2 (adjusted OR 3.02, 95% CI, 1.16 to 7.86).ConclusionThere were similar clinical and biochemical parameters of metabolic syndrome in both age groups. The proportions of children with metabolic syndrome were similar regardless of age group. The overall prevalence rate of metabolic syndrome was 27.3%. In view of the alarming presence of components of metabolic syndrome even in children less than 10 years of age, efforts aimed at the prevention of childhood obesity in the community should be intensified.

Is it important to analyse serum liver enzymes in patients with established metabolic syndrome? A Pilot study to tie the knot

Background: Metabolic Syndrome (MetS) is one of theemerging health problems which is the major area of concern as it is not only a potential risk factor for some many diseases but it also affecting globally. It is a common multi-factorial disorder of metabolic derangements and prominent etiological factors for the development and progression of atherosclerotic vascular disease and type 2 diabetes. The relation between elevated serum gamma-glutamyltranferase and metabolic syndrome, however, have been not well explored in a developing country like India. Aims and Objectives: The current study was designed to estimate the levels of alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyltransferase (GGT) in metabolic syndrome patients with age-sex matched healthy controls. Furthermore the relation of liver function status with the various biochemical parameters of metabolic syndrome was explored.Materials and Methods: In this present only patients of metabolic syndrome were selected based on inclusion and exclusion criteria of selecting cases. All the biochemical parameters were analysed using standard methods. Data collected were analysed using Statistical Package for the Social Sciences (version 20.0). P value (p&lt;0.05) was considered to be significant.Results: Of the 200 cases and controlsselected, the differences in serum GGT (p&lt;0.001) and ALT (p=0.048) were statistically significant. In case of male subjects,study and controls groups were compared only for serum GGT level (p=0.032) and in case of female subjects, studyand controls were compared for serum ALT (p=0.027) and serum GGT level (p&lt;0.001)and the differences were found to be highly significant. When male and female subjects of study group were compared, significant differences were observed in their serum ALT and GGT levels.Conclusion: Patients suspected of metabolic syndrome must also get their liver profile enzymes analysed as liver functionis also affected with metabolic syndrome and it could be an additional risk factor additive of metabolic syndrome. Early detection and management can be preventive and can have a better treatment modalities is managing patients with metabolic syndrome. It not only prevent disease progression but also prevents additional cost burden beard by the patients.Asian Journal of Medical Sciences Vol.8(3) 2017 35-40

Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation.

BackgroundIn GSDIa, glucose 6-phosphate (G6P) accumulates in the endoplasmic reticulum (ER); in GSDIb, G6P levels are reduced in ER. G6P availability directly modulates the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), an ER-bound enzyme playing a key role in the development of the metabolic syndrome (MS).ObjectiveTo evaluate the prevalence of MS and Insulin Resistance (IR) in GSDIa and GSDIb patients.Patients and MethodsThis was a prospective study. All the enrolled patients were followed at the Department of Pediatrics “Federico II” University of Naples for 10 years. Clinical and biochemical parameters of MS and the presence of IR were recorded. The results were correlated with the biochemical parameters of GSDI-related metabolic control. 10 GSDIa patient (median age 12.10 ± 1.50), 7 GSDIb patients (median age 14.90 ± 2.20 were enrolled in the study. They were compared to 20 and 14 age and sex matched controls, respectively. 10 GSDIa patients (median age 24.60 ± 1.50) and 6 GSDIb patients (median age 25.10 ± 2.00) completed the 10-year-follow-up. At the end of the study the patients’ data were compared to 10 and 6 age and sex matched controls, respectively.ResultsAt study entry, 20 % GSDIa patients had MS and 80 % showed 2 criteria for MS. GSDIa patients showed higher HOMA-IR than controls and GSDIb patients (p < 0.001, p < 0.05), respectively. Baseline ISI was lower in GSDIa than controls (p < 0.001). QUICKI was significantly lower in GSDIa than in controls (p < 0.001). At the end of the study 70 % of GSDIa patients had MS and 30 % showed 2 criteria for MS. HOMA-IR was higher in GSDIa than controls (p < 0.01). Baseline ISI was higher in GSDIb than controls (p < 0.005) and GSD1a (p < 0.05). QUICKI was lower in GSD1a patients than in controls (p < 0.03). VAI was higher in GSDIa patients than controls (p < 0.001) and GSDIb patients (p = 0.002).ConclusionsOur data showed high prevalence of IR and MS in GSDIa patients. We speculate a possible role of 11βHSD1 modulation by G6P availability. We suggest a routine metabolic assessment in GSDIa patients.

The stabilizing effect of dehydroepiandrosterone on clinical parameters of metabolic syndrome in patients with schizophrenia treated with olanzapine - a randomized, double-blind trial

Epidemiological studies have shown that low levels of dehydroepiandrosterone might increase the risk of developing metabolic syndrome. The aim of this study was to evaluate whether dehydroepiandrosterone supplementation in schizophrenic patients treated with olanzapine would influence the anthropometric and biochemical parameters of metabolic syndrome. Male schizophrenic patients (no=55) participated in a twelve-week, randomized, double blind, placebo controlled study. They received 100 mg dehydroepiandrosterone (DHEA) or placebo as an augmentation of olanzapine treatment (an average dosage 15 mg/day). Main outcomes of the study were changes in lipid profile, fasting glucose levels, body mass index and waist circumference values. Forty five patients completed the study. There were no major changes in the overall cholesterol value, HDL cholesterol, LDL cholesterol or triglycerides in either group. The results of the repeated measures analysis of the system: fasting glucose level 2x, (at the beginning and end of the study), 2x (the study group and the control group), showed a significant interaction (F =5.7, df= 1.000 p= 0.021). The blood glucose level was decreased in the DHEA group. Furthermore, increases in waist circumference (delta= -1.11, t=-2.87; df=20; p=0.01) and BMI value (delta= -0.48, t=-2.38; df=19; p=0.028) were observed in the placebo group. Dehydroepiandrosterone supplementation results in stabilization of BMI, waist circumference and fasting glycaemia values in schizophrenic patients treated with olanzapine. To confirm the insulin-like effect of dehydroepiandrosterone, long-term research concentrating on the evaluation of glucose metabolism has to be performed.

Relationship of High Sensitivity C-Reactive Protein and Other Biochemical Parameters of Metabolic Syndrome in Women with Polycystic Ovarian Syndrome and BMI Matched Controls

Background : Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic anovulation and infertility. In addition to reproductive abnormalities, a significant proportion of women suffer from obesity, insulin resistance and other features of metabolic syndrome. Metabolic complications associated with insulin resistance are increased in PCOS independent of obesity including an adverse cardiovascular risk profile. Methods: High sensitivity CRP (hs CRP) was measured in 60 PCOS women and 60 age and BMI matched controls with regular menstruation. Other biochemical parameters like fasting blood glucose (FBS), lipid profile (Low density lipoprotein-(LDL), high density lipoprotein (HDL) and triglycerides (TG)) were measured in a subset of 18 PCOs women and age and BMI matched controls. Results : A significant positive relationship was observed between BMI & hs CRP (P < .001); the degree of relationship was stronger among PCOS cases than controls. Relationship of hs-CRP and FBS was stronger among cases (P < .001) than controls (P =0.03) A significant relationship was observed between LDL and hs-CRP among cases (P .001) and inverse but insignificant (p=0.110) relationship was found among controls. Conclusion: Though hs-CRP significantly correlated with obesity, other biochemical parameters like fasting blood glucose and LDL correlated with hs CRP significantly in PCOS women.

Performance of Abdominal Bioelectrical Impedance Analysis and Comparison with Other Known Parameters in Predicting the Metabolic Syndrome

Although obesity is a powerful risk factor for metabolic syndrome (MetS) it is not present in all obese individuals. Increased visceral adipose tissue is the hallmark of this syndrome. In this cross sectional survey we aimed to use abdominal bioelectrical impedance analysis to measure the visceral adipose tissue (VAT) and trunk fat percentages (TF%) in the study population, correlate these findings with traditional anthropometric measures and biochemical parameters of metabolic syndrome and estimate a cut-off value of visceral fat for development of MetS. A total of 285 subjects were enrolled. VAT and TF% were measured by the AB-140 device via abdominal bioelectrical impedance analysis. Fat% was measured by a body composition analyzer (TBF-300). VAT was significantly positively correlated with body mass index, waist circumference, TF%, HOMA IR, fat percentage, fasting plasma glucose and triglycerides. Strongest correlations were between VAT and TF%, VAT and device measured waist circumference and between VAT and manual waist circumference (r=0.95, r=0.93, r=0.92 respectively). Correlations of VAT and TF% with metabolic parameters were significant but weak. The mean VAT and TF% in MetS (+) groups were significantly higher than patients in MetS (-) groups in both sexes. The areas under the ROC curves were 0.730 (95% CI: 0.661-0.791) for female VAT and 0.702 (95% CI: 0.654-0.749) for male VAT in predicting MetS which were similar to the areas under ROC curves calculated for device and manually measured waist circumference, HOMA IR and TF% in predicting MetS (p>0.05 for all comparisons). The accuracy of VAT and TF% for predicting MetS was not sufficient. From our results we can deduce that the performance of abdominal BIA in predicting MetS is weak but could be used in the follow-up of patients with obesity and/or MetS. This has to be confirmed in future studies.

Nigella sativa provides protection against metabolic syndrome

The seeds of Nigella sativa have been used in folk medicine all over the world. The plant has been of interest due to its low degree of toxicity and beneficial pharmacological properties like antihypertensive, hypoglycemic, antifungal, anti-inflammatory, antihistaminic, antioxidant, along with significant anti-neuplastic activities. The present clinical study was undertaken to ascertain the adjuvant effect of Nigella seeds on various clinical and biochemical parameters of metabolic syndrome. After final diagnosis and considering inclusion and exclusion criteria, one hundred and fifty nine patients were enrolled in this study. Patients were divided into two groups. In Group I (standard group), patients were advised to take simvastatin 10 mg once a day, metformin 500 mg twice a day, Enalapril 10 mg once a day, Atenolol 50 mg once a day and clopidagrel 75 mg once a day for a period of six weeks. In Group II ( Nigella seeds group), patients were advised the above standard medication plus Nigella seeds 250 mg twice daily for a period of six weeks. Blood sugar both fasting and postprandial, fasting lipid profile and different parameters of obesity were recorded before therapy and after completion of therapy. It was found that the addition of Nigella seeds provide beneficial effects in all the clinical and biochemical parameters for the adult’s treatment panel-III of metabolic disorders especially in fasting blood sugar, low density lipoproteins and high density lipoproteins. No sign of toxicity of the plant appeared in the Group II. Improvement in all other parameters like blood pressure, circumference of waist and serum triglyceride was also observed. Thus, Nigella seeds were found to be effective as an adjuvant therapy in patients of dyslipidemia and hyperglycemia. Keywords: Nigella sativa , toxicity, hyperglycemia, adjuvant, antihistaminic, antioxidant, patients

Effect of Tulsi ( Ocimum sanctum Linn.) on Clinical and Biochemical Parameters of Metabolic Syndrome

Metabolic syndrome can be defined as a set of symptoms, associated with a risk of coronary artery disease, hypertension, hyperlipidemia, hyperglycemia and obesity. Eugenol is a phenolic compound and major constituent of essential oils extracted from different parts of Tulsi plant. Its therapeutic use has been established on the basis of several pharmacological studies related with hyperglycemia, hypertension and dyslipidemia. To investigate the effect of Tulsi on clinical and biochemical parameters of metabolic syndrome. Hundred patients randomly selected for this study, further categorized in 2 groups, control group and study group. Patients were asked to take 5ml of Tulsi extract two times a day for three months. Baseline parameters were taken for every patient i.e. BMI, W/H Ratio fasting blood sugar, blood pressure, HbA1c, lipid profile. Biochemical and anthropometric data were also recorded at the end of the study. On comparing control and study population for effect of Tulsi therapy, an improving trend was observed in study group.BMI (27.00±3.23 to 27.10±8.64 kg/m 2 , p<0.9), SBP (151.30±8.48 to 138.68±9.84 mmHg, p<0.001), DBP (95.76±3.63 to 87.12±8.81 mmHg, p<0.001), glycemic control - FBS (209.26±40.15 to 155.28±20.70 mg/dl, p<0.001), HbA1c (8.82±1.25 to 7.34±0.89%, p<0.001). Lipid profile-total cholesterol (244.04±26.30 to 209.28±29.03mg/dl, p<0.001), triglyceride (176.48±16.75 to 138.32±15.17mg/dl, p<0.001), HDL (33.58±3.47 to 39.36±4.25mg/dl, p<0.001), LDL (174.9±26.82 to 142.11±27.50mg/dl, p<0.001), VLDL (35.37±3.84 to 27.66±3.03mg/dl, p<0.001). In metabolic syndrome, Tulsi therapy significantly reduces blood glucose, blood pressure and lipid profile. It shows the therapeutic effect of Tulsi and it may be used as an adjunct with diet and drugs in management of metabolic syndrome.

Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease

Objective We evaluated the effect of diet therapy as exclusive treatment on insulin resistance, biochemical parameters of metabolic syndrome, and degree of hepatic steatosis in patients with non-alcoholic fatty liver disease. Methods Thirty-one patients with non-alcoholic fatty liver disease received a diet with a reduction of 500 to 1000 cal/d, containing 15% protein, 55% carbohydrates, and 30% fat, for 6 mo. At entry and 6 mo after dietary instructions, degrees of hepatic steatosis and visceral obesity were assessed by computed tomography; serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, glucose, triacylglycerols, and high-density lipoprotein cholesterol were measured by automated methods. Body mass index, waist circumference, waist-to-hip ratio, and food intake (7-d diary) were also evaluated. At the end of follow-up, the patients were classified as adherent or non-adherent to treatment according to a weight loss of more or less than 5% of initial body weight, respectively. Results Seventeen patients were classified as adherent (group 1) and 14 as non-adherent (group 2). Group 2 only presented a significant reduction in body mass index and waist circumference. In contrast, in group 1, in addition to significant improvement of all anthropometric parameters, a significant reduction was observed in alanine aminotransferase and γ-glutamyl transferase levels, homeostasis model assessment for insulin resistance, visceral fat and tomographic liver density, together with an increase in serum high-density lipoprotein cholesterol levels. These patients presented a significant decrease in total energy intake and in total and saturated fats. Conclusion Nutritional intervention as exclusive treatment, with a loss of at least 5% of initial weight, is effective in the treatment of non-alcoholic fatty liver disease.