Along with the increasing awareness about the destructive force of humankind on nature, existential questions about how to create a more sustainable relationship with the natural world have emerged. To acquire a more ecoâfriendly attitude, we need to go beyond the wellâestablished knowledge cultures that highlight a nature versus culture dichotomy. This study focuses on bio art as an epistemic vehicle to reâimagine our understanding of and connection to the natural world. Drawing on the theoretical stance of philosophical posthumanism, we discuss how artistic coâcreation processes involving humans and otherâthanâhumans hold the potential to introduce a shift in our worldview from anthropocentric to ecocentric. We further question what this shift might imply for how we approach the complex relationship between humans and otherâthanâhumans in our own research. We conducted a withinâcase and crossâcase analysis of five bio art projects that previously won the Bio Art & Design Award (2018â2020). To analyze the data, we used a combined approach of visual and context analysis and material semiotics. Qualitative interviews were used as a data collection technique to investigate the lived experiences of both artists and scientists involved in the projects. Our findings suggest that bio artâs epistemic significance can primarily be found in its multispecies perspective: By following the wills and ways of bioâorganisms, bio art makes the invisible connection between nature and culture visible. Bio art can provoke our thinking about how to include and approach otherâthanâhuman agency in the context of socially engaged research practices.