ObjectivesThe current research aimed to assess the impact of an intra-articular injection of injectable PRF (I-PRF) following arthrocentesis and the use of an anterior repositioning splint (ARS) as a proposed treatment approach for addressing symptomatic internal TMJ derangement. Materials and methodsThis study encompassed thirty patients who presented with bilateral disc displacement without reduction. The patients were evenly distributed into two groups: Group I underwent treatment involving ARS and arthrocentesis alone, while Group II underwent treatment with ARS, arthrocentesis, and the injection of I-PRF. Clinical assessment of all patients was done post-operatively in the following intervals first week, first month, third months, and sixth months for maximum mouth opening (MMO), right and left lateral excursion, and pain score. Magnetic resonance imaging (MRI) assessment for all joints was done at the 6th month post-operatively. ResultsBoth groups in this research demonstrated improvement in MMO, lateral excursion, and pain. Significant statistical differences were observed in the mean values of MMO and Visual Analog Scale (VAS), favoring the I-PRF group. MRI postoperatively showed non-significant changes in disk position or morphology at the end of the 6th month. ConclusionAdministering an intra-articular I-PRF injection subsequent to arthrocentesis demonstrates effectiveness as a treatment approach for alleviating the signs and symptoms associated with TMJ internal derangement.