Bilateral Choroidal Osteoma Research Articles

Clinical case of bilateral rapidly progressive osteoma of the choroid

Choroidal osteoma is a benign neoplasm characterized by the appearance of mature bone tissues at the level of the choroid and unilateral development. This study highlights a clinical case of bilateral rapidly progressing osteoma of the choroid in a child, which was complicated by tumor decalcification and choroidal neovascularization. A 14-year-old male teen has been under observation in the S. Fyodorov Eye Microsurgery Federal State Institution, Saint-Petersburg branch since 2019, for bilateral choroidal osteoma. At the initial visit, a yellow-orange lesion with clear boundaries was noted in the left eye, localized at the level of the choroid and parapapillary, and had a trabecular bone structure. Based on the clinical picture and data from instrumental studies (ultrasound and optical coherence tomography), he was diagnosed with choroidal osteoma. During observation, a similar lesion appeared in the right eye, and its relatively rapid growth was observed in both eyes. Owing to the absence of zones of decalcification and neovascularization, further follow-up was initiated. However, in the presence of zones of decalcification of the bone tissue and newly formed vessels of the choroid, a threefold intravitreal injection of an angiogenesis inhibitor was performed. Consequently, regression of choroidal neovascularization was observed. Speculatively, the main reason for the atypical disease course in this teenager is the specificity of bone tissue development in childhood and adolescence.

Bilateral multifocal choroidal osteoma presented with optic disc edema

Bilateral multifocal choroidal osteoma presented with optic disc edema

Bilateral choroidal osteoma associated with unilateral limbal dermoid in an infant

Ocular choristomas are uncommon. In the choroid, two types of ectopic tissues have been described, smooth muscle and osseous tissue, being the latter the most frequent. Choroidal osteomas are benign ossifying tumors, mostly unilateral, with unknown etiology. They are usually found in young women and are rarely diagnosed in infants. Herein we present an 8-year-old girl with congenital unilateral limbal dermoid who, over the years, developed bilateral choroidal osteomas outside the framework of systemic diseases.

Spontaneous Regression of Asymptomatic Bilateral Choroidal Osteoma with Preserved Vision.

[Ophthalmic Surg Lasers Imaging Retina. 2021;52:519.].

Peculiar presentation of bilateral choroidal osteoma in a child

To report a peculiar presentation of bilateral choroidal osteoma in a very young child. Case report. During a school screening, a 4-year-old girl was detected with anisometropia as the first sign of a bilateral choroidal osteoma. The diagnosis was based on funduscopy, optical coherence tomography and B-scan ultrasonography. Choroidal osteomas are rare benign tumors that can lead to severe visual loss due to progression or complications. They are found mostly in young adults, but in our case, the refractive screening allowed an early diagnosis despite the lack of visual symptoms.

Imagerie multimodale d’un ostéome choroïdien bilatéral avec complication néovasculaire

Imagerie multimodale d’un ostéome choroïdien bilatéral avec complication néovasculaire

Choroidal Osteoma in a Young Female – a Case Report

We present a case of23 year old female, who presented with history of decreased central vision in the right eye for 3 months. Best corrected visual acuity was 6/36 OD and 6/9 OS. Anterior segment was normal OU. Fundus examination revealed a yellowish white peripapillary lesion extending up to the macula in the right eye. A similar lesion was seen in the left eye. OCT macula showed central macular thickness of 193 – 323 µm with cystoid spaces and 290 – 436 µm with serous retinal detachment in the right and left eye respectively. CT scan showed a hyper dense opacity similar to the bony tissue OU. All lab investigations were normal. The patient was diagnosed as a case of bilateral choroidal osteoma. After 6 months no progression or complication was noted.
 Key Words: Choroid, Osteoma, Choroidal Neoplasm.

A case series of choroidal lesions and their unique presentation

Background: To investigate the clinic-pathological manifestations of different choroidal lesions in aiding better diagnosis. Method: Patients aged 29, 21, 56years presented with visual acuity deficit due to focal choroidal lesions. Anterior segment: Normal in first two cases. 56year old patient had festooned pupil right eye with 1+ cell’s in anterior chamber Fundus: Case 1: A well-defined lesion which appears elevated with scalloped margins in juxta papillary region with similar lesion in the left eye Case 2: Bilateral single well defined choroidal lesion in the posterior pole beneath superotemporal arcade with sub retinal fluid present. Case 3: A raised grey white lesion the temporal posterior pole near macula. Result: Diagnosis of bilateral choroidal osteoma, choroid granuloma secondary to TB with crohns and choroidal granuloma secondary to toxoplasmosis was considered respectively and treated. Conclusion: Every choroidal lesion has special characteristics, and supported ancillary testing aids in diagnosis and treatment.

Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept.

Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept.

Bilateral Choroidal Osteoma - A rare entity

A 24 years old female presented to us with the chief complaint of dimness of vision in her right eye since few days and loss of vision in right eye since childhood. On examination she was having well defined yellow to orange slight elevated lesion at macula and peripapillary area and in the left eye marked depigmentation of macula with subretinal fibrosis. She had undergone Optical coherence tomography (OCT) and Ultrasonography (USG-Bscan) of both the eyes. On the basis of clinical findings and investigation, diagnosis of choroidal osteoma was made. The purpose of reporting this case here is that bilateral choroidal osteoma is a very rare entity and whenever a young female is presenting with this kind of lesion in retina, we should keep the possibility of choroidal osteoma in differential diagnosis. Keywords: Choroidal osteoma, Choroidal tumors, Choroidal neovasular membrane, Antivascular endothelial growth factor.

Bilateral Choroidal Osteomas in Rosai-Dorfman Disease

Purpose: The purpose of this case report is to describe a case of bilateral choroidal osteomas in Rosai-Dorfman disease, a rare pseudolymphomatous disorder. Methods: A case report was conducted. Results: A middle-aged man with biopsy-proven Rosai-Dorfman disease presented with chronic poor vision of the left eye. Clinical examination showed bilateral white lesions with scalloped edges, and optical coherence tomography revealed hyporeflective choroidal lesions. Ultrasonography confirmed the lesions as choroidal osteomas. The patient was observed and remains stable after 9 months of follow-up. Conclusions: Bilateral choroidal osteomas in the setting of Rosai-Dorfman disease are an uncommon finding. While the best treatment for the disease remains unclear, observation is a reasonable option for stable patients.

Enhanced depth imaging optical coherence tomography and fundus autofluorescence findings in bilateral choroidal osteoma: a case report

The authors present enhanced depth imaging optical coherence tomography (EDI OCT) and fundus autofluorescence (FAF) characteristics of a patient with bilateral choroidal osteoma and try to make a correlation between two imaging techniques. Two eyes of a patient with choroidal osteoma underwent complete ophthalmic examination. Enhanced depth imaging optical coherence tomography revealed a cage-like pattern, which corresponded to the calcified region of the tumor. Fundus autofluorescence imaging of the same area showed slight hyperautofluorescence. Three different reflectivity patterns in the decalcified area were defined. In the areas of subretinal fluid, outer segment elongations similar to central serous chorioretinopathy were observed. Hyperautofluorescent spots were evident in fundus autofluorescence in the same area. Calcified and decalcified portions of choroidal osteoma as well as the atrophy of choriocapillaris demonstrated different patterns with enhanced depth imaging and fundus autofluorescence imaging. Both techniques were found to be beneficial in the diagnosis and follow-up of choroidal osteoma.

Two Sets of Sisters in Two Families with Bilateral Choroidal Osteoma

Background: To describe the clinical characteristics of two sets of sisters in two families with bilateral choroidal. Methods: The ocular clinical examinations of all the families were performed. Results: (1) Thirteen immediate family members from three generations were included and screened in two families. Bilateral choroidal osteoma was found in two sets of two sisters in the second generation of both families. (2) All of the four patients were young women aged 22 years, 26 years, 26 years and 30 years respectively. (3) Choroidal osteoma lesions located at the posterior to the optic disc and showed a relatively large area. Fundus findings, fluorescein angiography and computed tomography scan results showed typical characteristics of choroidal osteoma. Conclusions: This is the first report of such cases in China. The clinical characteristics of bilateral choroidal osteoma are a larger lesion around the optic disc and early onset. Eyesight of the patient is damaged with the time lapse.

Progressive Growth of Bilateral Choroidal Osteomas in a Child

A 7-year-old girl was referred for retinal dystrophy. On examination, visual acuity was 20/20 in the right eye and 20/30 in the left eye. Fundus examination revealed bilateral orange-colored subfoveal choroidal tumors. Ultrasonography showed calcification, confirming the diagnosis of choroidal osteoma. Because vision was preserved without subretinal fluid or choroidal neovascularization, observation with calcium supplementation was recommended. Three years later, there was minimal tumor growth and visual acuity was maintained. Choroidal osteomas are rare, benign tumors that may decrease vision through decalcification, particularly when subfoveal. In these cases, cautious observation and possibly calcium supplementation may help protect vision.

Bilateral choroidal osteoma with optic atrophy

Choroidal osteoma is a rare, yellowish-white lesion of the choroid that predominantly affects young women in the second decade of life. Subretinal neovascularization or collection of subretinal fluid may occur in 50 % or more patients in the long run. A 15-year-old girl presented to our practice with bilateral choroidal osteoma associated with advanced bilateral optic atrophy. The underlying cause for optic atrophy is unclear; possible explanations include mechanical pressure effect and ischemic damage.

Bilateral Choroidal Osteoma Associated with Optic Neuritis in Behçet's Disease.

Three-dimensional optical coherence tomography (OCT) were founded to be useful to evaluate posterior pole involvement in an unusual concurrence of bilateral choroidal osteoma after optic disk inflammation in a 36-year-old woman in whom optic neuritis was the first symptom of Behçet's disease. Bilateral asymmetric choroidal osteoma was observed after optic disk inflammation following disease recurrence. B-scan ultrasonography and orbital axial CT were essential for the diagnosis. Bilateral full-thickness calcified plaques in juxtapapillary choroids were the main intraocular feature after optic neuritis. The pathogenesis of bone formation in choroidal osteoma remains uncertain and although several etiological factors have been associated with its onset, intraocular inflammation is a very unusual cause.

Intravitreal bevacizumab (avastin) and ranibizumab (lucentis) for choroidal neovascularization overlying choroidal osteoma.

To report the effect of anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularization overlying choroidal osteoma. In an interventional case report, intravitreal anti-VEGF therapy was used for tumor-related choroidal neovascularization. A 34-year-old woman with bilateral choroidal osteoma had a decrease in visual acuity in the right eye from 20/30 to 20/100. Ophthalmoscopy revealed partially decalcified circumpapillary, macular choroidal osteoma with overlying subretinal hemorrhage and choroidal neovascular membrane. Intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) resulted in membrane regression and visual acuity improvement to 20/50 at 6 weeks. Further therapy with intravitreal ranibizumab (Lucentis; Genentech, Inc.) resolved persistent subretinal fluid, and visual acuity improved to 20/30 at the 6-month follow-up. Therapy with intravitreal anti-VEGF medications might be an alternative for patients with choroidal neovascularization overlying choroidal osteoma.

BILATERAL CHOROIDAL OSTEOMAS WITH POLYPOIDAL CHOROIDAL VASCULOPATHY

A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area. The major cause of visual loss is secondary to the development of a subretinal neovascular membrane. The pattern of neovascularization that develops with osteomas has been typically described as classic choroidal neovascularization (CNV). Interventional case report. A case of bilateral polypoidal choroidal neovascularization (PCV) occurring with bilateral choroidal osteomas is described in a 55-year-old Japanese woman. To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor. Clinical, angiographic, and optical coherence tomographic features are discussed. Subretinal hemorrhage in the left eye from polypoidal neovascularization in the macula was successfully treated with photodynamic therapy. The association between choroidal osteoma and PCV may have a better prognosis than that with classic CNV. Indocyanine green angiography is a useful tool in characterizing the nature of the neovascularization.

MIDPERIPHERAL MOTTLING PIGMENTATION WITH FAMILIAL CHOROIDAL OSTEOMA

To describe a rare presentation of familial choroidal osteoma in two siblings. The clinical findings in two siblings over 4 years' follow-up. Two brothers (15 and 12 years old) had bilateral choroidal osteomas. Both had bilateral peripapillary yellowish-white lesions and midperipheral mottling pigment appearance, which are not seen in sporadic cases. Extensive midperipheral area with mottling pigment appearance was noted by fluorescein angiography (FA) as scattered multiple hyperfluorescent dots. The yellowish-white lesions showed diffuse hyperfluorescence with FA and hypofluorescence with indocyanine green angiography (ICG). ICG also revealed irregular hyperfluorescent areas within the tumor, indicating abnormal choroidal vessels on the tumor. In the left eye of the younger brother, the subretinal fibrosis due to choroidal neovascularization superior to the macula extended down toward the foveal region over 2 years, resulting in visual deterioration. The midperipheral mottling pigment appearance of familial choroidal osteoma cases is unique and different from most sporadic cases, suggesting that familial choroidal osteoma might have separate etiologic or modified factors.

Presence of bilateral limbal dermoids and choroidal osteomas in a family with inherited limbal dermoids

We report a case of bilateral limbal dermoids and bilateral choroidal osteomas in a 14-year-old girl with no extraocular anomalies. Histopathological examination of a limbal lesion confirmed the clinical diagnosis of dermoid. Computerized tomography and ultrasonography were compatible with a diagnosis of choroidal osteoma. Limbal dermoids were present in the patient's mother, in a brother with Down syndrome, and in an aunt with no choroidal osteoma. The present pedigree is compatible with autosomal dominant inheritance of bilateral limbal dermoids. The same gene may be involved in the pathogenesis of ocular choristomas in same patients.