Bigger Waist Circumference Research Articles

The Association Between Psoriasis and Trace Element Serum Levels and Dietary Intake: Results from USA National Health and Nutrition Examination Survey 2011-2014.

Psoriasis is a common chronic inflammatory disease. However, trace elements are essential to biochemical processes of the skin, it is suspected that the trace elements are vital in the pathogenesis of psoriasis. Our research is aimed to investigate the association between serum levels and dietary intake levels of selenium, zinc, and copper with psoriasis. In this cross-sectional study, we utilized the National Health and Nutrition Examination Survey data from 2011 to 2014 to examine the association between psoriasis and serum concentration and dietary intake of trace elements including copper, zinc, and selenium in the US individuals. Our research combined two cycles and weighted the data. Student's t-tests and χ2 test were used. Subgroup analyses and interaction tests were conducted by IBM SPSS Statistics 22 and EmpowerStats. This study indicates that the population with psoriasis has a lower dose of dietary intake selenium than the controls, and risk analysis showed that the men with selenium daily intake >150 mcg/day have a decreasing risk for psoriasis compared to those with daily intaking selenium <75 mcg/day. However, there are no differences on daily intake of selenium, zinc, and copper and serum levels of Zinc and Copper between psoriasis and healthy controls. The current study showed that the psoriasis group was significantly older with a bigger waist circumference, a higher education level, a higher ratio of people with smoke every day, and a higher ratio of people in USA and being non-Hispanic White. This cross-section study showed that a high selenium intake may benefit USA adults from psoriasis, especially for males. The social and cultural background and ethnic differences between the two groups influence the eating and living models, including the trace element intake. The national recommended dietary allowances (RDAs) might be considered to be modified with more reliable investigative clinical data and certain considering the social and cultural models.

Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome

IntroductionCholecystokinin (CCK) is involved in several metabolic pathways and CCK agonist are considered as potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor genes (CCKAR and CCKBR, respectively) may modify its biological actions, we investigated the impact of CCKAR and CCKBR genetic variability on anthropometric and metabolic parameters in patients with PCOS.Material and methodsOur cross-sectional study included 168 patients with PCOS and 82 healthy female controls genotyped for polymorphisms in CCKAR (rs6448456 and rs1800857) and CCKBR (rs2929180, rs1800843, rs1042047 and rs1042048) genes.ResultsThe investigated polymorphisms were not associated with anthropometric characteristics of patients with PCOS, however, among healthy controls carriers of at least one polymorphic CCKBR rs1800843 allele had bigger waist circumference (p=0.027) and more visceral fat (p=0.046). Among PCOS patients carriers of at least one polymorphic CCKAR rs6448456 C allele had significantly higher total blood cholesterol and LDL, and significantly lower blood glucose levels after 30, 60 and 90 minutes of the oral glucose tolerance test (all p&lt;0.05). Healthy controls with at least one polymorphic CCKAR rs1800857 C allele were less likely to have high metabolic syndrome burden (p=0.029).ConclusionsGenetic variability in CCKAR affects lipid profile and post-load glucose levels in patients with PCOS and is associated with metabolic sydrome burden in healthy young women. Further investigation of the role of genetic variability in CCKAR and CCKBR could contribute to development of individually tailored treatment strategies with CCK receptor agonists.

A nationwide school fruit and vegetable policy and childhood and adolescent overweight: A quasi-natural experimental study.

School free fruit and vegetable (FFV) policies are used to promote healthy dietary habits and tackle obesity; however, our understanding of their effects on weight outcomes is limited. We assess the effect of a nationwide FFV policy on childhood and adolescent weight status and explore heterogeneity by sex and socioeconomic position. This study used a quasi-natural experimental design. Between 2007 and 2014, Norwegian combined schools (grades 1-10, age 6 to 16 years) were obligated to provide FFVs while elementary schools (grades 1-7) were not. We used 4 nationwide studies (n = 11,215 children) from the Norwegian Growth Cohort with longitudinal or cross-sectional anthropometric data up to age 8.5 and 13 years to capture variation in FFV exposure. Outcomes were body mass index standard deviation score (BMISDS), overweight and obesity (OW/OB), waist circumference (WC), and weight to height ratio (WtHR) at age 8.5 years, and BMISDS and OW/OB at age 13 years. Analyses included longitudinal models of the pre- and post-exposure trajectories to estimate the policy effect. The participation rate in each cohort was >80%, and in most analyses <4% were excluded due to missing data. Estimates were adjusted for region, population density, and parental education. In pooled models additionally adjusted for pre-exposure BMISDS, there was little evidence of any benefit or unintended consequence from 1-2.5 years of exposure to the FFV policy on BMISDS, OW/OB, WC, or WtHR in either sex. For example, boys exposed to the FFV policy had a 0.05 higher BMISDS (95% CI: -0.04, 0.14), a 1.20-fold higher odds of OW/OB (95% CI: 0.86, 1.66) and a 0.3 cm bigger WC (95% CI: -0.3, 0.8); while exposed girls had a 0.04 higher BMISDS (95% CI: -0.04, 0.13), a 1.03 fold higher odds of OW/OB (95% CI: 0.75, 1.39), and a 0-cm difference in WC (95% CI: -0.6, 0.6). There was evidence of heterogeneity in the policy effect estimates at 8.5 years across cohorts and socioeconomic position; however, these results were inconsistent with other comparisons. Analysis at age 13 years, after 4 years of policy exposure, also showed little evidence of an effect on BMISDS or OW/OB. The main limitations of this study are the potential for residual confounding and exposure misclassification, despite efforts to minimize their impact on conclusions. In this study we observed little evidence that the Norwegian nationwide FFV policy had any notable beneficial effect or unintended consequence on weight status among Norwegian children and adolescents.

Prevalence and factors associated with prediabetes and diabetes in fishing communities in penang, Malaysia: A cross-sectional study.

BackgroundDiabetes is a metabolic disorder, characterized by hyperglycemic state of the body. A silent killer, which can take the lives of victims if undiagnosed at the earliest stage. Prediabetes has become an important health concern across countries due to its huge potential for the development of diabetes and other complications. The objectives of this study were to determine the prevalence of prediabetes and diabetes and its associated factors among rural fishing communities in Penang, Malaysia.MethodsA cross-sectional study was conducted among fishing communities in Southwest District of Penang, Malaysia from August to November 2017. Blood sample (finger prick test) and physical examination were performed on sample of 168 participants consented in this study. Pre-validated Malay versions of International Physical Activity 7 (IPAQ-7) and Perceived Stress Scale (PSS) questionnaires were used to assess the level of physical activity and stress levels of the participants. Multinomial logistic regression models were fitted to identify factors associated with prediabetes and diabetes.ResultsThe prevalence of diabetes and prediabetes were 19.6% (95% CI: 14.3, 26.4) and 10.12% (95% CI: 6.4, 15.7) respectively. The median physical activity (interquartile range) in MET-minutes per week for those with diabetes (1071.0 (2120.0)) and prediabetes (1314.0 (1710.0)) was generally lower as compared to non-diabetes. Majority reported moderate stress (57.3%) from PSS system. Abdominal obesity, family history of diabetes and being hypertensive were significant factors associated with diabetes; while older age, bigger waist circumference and self-perceived poor routine diet were factors associated with prediabetes.ConclusionsThe screening for prediabetes in this population gives the opportunity to implement lifestyle interventions at the earliest possible, which could prevent the development of diabetes. The identification of diabetic individuals provides an opportunity to conduct health promotion and education to ensure good metabolic control and hence reduce the risks of complications.

Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.

PurposeNon-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to investigate the association between AF and advanced liver fibrosis in NAFLD patients.Materials and MethodsOut of 53704 adults who participated in the health check-up program, 6293 subjects aged 35 years and older were diagnosed as NAFLD using ultrasound. The stage of liver fibrosis was assessed based on the newly adjusted NAFLD fibrosis score (NFS) and Fibrosis-4 (Fib-4) Index, which were used to determine the low and high cut-off values (COVs).ResultsOf 6293 patients with NAFLD, 59 (0.9%) were diagnosed with AF. Patients with AF were older (52.0 vs. 64.6 years, p<0.001), had higher body mass index (25.2 vs. 26.6 kg/m2, p<0.001), and had bigger waist circumference (84.0 vs. 89.9 cm, p<0.001) than those without AF. In NAFLD patients, AF was independently associated with advanced liver fibrosis, assessed using both COVs of NFS [low-COV group: final adjusted odds ratios (aORs)=2.85, p=0.004; high-COV group: ORs=12.29, p<0.001). AF was independently associated with advanced liver fibrosis, assessed using both COVs of Fib-4 (low-COV group: aORs=2.49, p<0.001; high-COV group: aORs=3.84, p=0.016).ConclusionAF is independently associated with advanced liver fibrosis in patients with NAFLD.

Clustering of lifestyle characteristics and their association with cardio-metabolic health: the Lifestyles and Endothelial Dysfunction (EVIDENT) study.

Little is known about the clustering patterns of lifestyle behaviours in adult populations. We explored clusters in multiple lifestyle behaviours including physical activity (PA), smoking, alcohol use and eating habits in a sample of adult population. A cross-sectional and multi-centre study was performed with six participating groups distributed throughout Spain. Participants (n 1327) were part of the Lifestyles and Endothelial Dysfunction (EVIDENT) study and were aged between 20 and 80 years. The lifestyle and cardiovascular risk (CVR) factors were analysed using a clustering method based on the HJ-biplot coordinates to understand the variables underlying these groupings. The following three clusters were identified. Cluster 1: unhealthy, 677 subjects (51%), with a slight majority of men (58.7%), who were more sedentary and smokers with higher consumption of whole-fat dairy products, bigger waist circumference as well as higher TAG levels, systolic blood pressure (SBP) and CVR. Cluster 2: healthy/PA, 265 subjects (20%), including 24.0% of males with high PA. Cluster 3: healthy/diet, including 29% of the participants, with a higher consumption of olive oil, fish, fruits, nuts, vegetables and lower alcohol consumption. Using the unhealthy cluster as a reference, and after adjusting for age and sex, the multiple regression analysis showed that belonging to the healthy/PA cluster was associated with a lower waist circumference, body fat percentage, SBP and CVR. In summary, the three clusters were identified according to lifestyles. The 'unhealthy' cluster had the least favourable clinical parameters, the 'healthy/PA' cluster had good HDL-cholesterol levels and low SBP and the 'healthy/diet' cluster had lower LDL-cholesterol levels and clinical blood pressure.

P834: Nocebo effect dissociates the laser-pain rating from the N2/P2 laser evoked potential amplitude

P834: Nocebo effect dissociates the laser-pain rating from the N2/P2 laser evoked potential amplitude

Hypertension among HIV-Infected Adults Receiving Highly Active Antiretroviral Therapy (HAART) in Malaysia

There are increasing researches about non-communicable disease such as elevated blood pressure among people living with HIV before and after initiation of highly active antiretroviral therapy (HAART). This cross-sectional study was designed to determine the prevalence of hypertension and associated risk factors among 340 HIV-infected patients on antiretroviral therapy at a Malaysian public hospital providing HIV-related treatment. Data on socioeconomic background, anthropometry, medical history and dietary intake of the patients were collected. Hypertension is defined as blood pressure ≥130/85 (mm Hg). Prevalence of hypertension was 45.60% (n=155) of which 86.5% of the hypertensive group were male (n=134). The results showed that increase in age (OR 1.051, 95% confidence interval (CI) 1.024-1.078), higher body mass index (OR 1.18, 95% CI 1.106-2.71), bigger waist circumference (OR 1.18, 95%CI 1.106-2.71), higher waist-hip ratio (OR 1.070, 95%CI 1.034-1.106), higher fasting plasma glucose (OR 1.332, 95% CI 0.845-2.100) and percentage energy intake from protein >15 (OR 2.519, 95%CI 1.391-4.561) were significant risk factors for hypertension (p<0.001). After adjusting for other variables, increasing age (adjusted odds ratio (aOR) 1.069 95%CI 1.016-1.124, p=0.010), being male (aOR 3.026, 95%CI 1.175-7.794, p=0.022) and higher body mass index (aOR 1.26, 95%CI 1.032-1.551, p=0.024) were independently associated with hypertension. None of the antiretroviral therapy and immunologic factors was linked to hypertension. In conclusion hypertension among PLHIV was linked to the well-known risk factors such as age, gender and body mass index. With HAART, people can live longer by making monitoring and control of some reversible factors, especially excessive weight gain for maintaining quality of life.

Regional anthropometric measures associated with the severity of liver injury in patients with non‐alcoholic fatty liver disease

Not all NAFLD patients are obese and many obese patients do not have NAFLD. Impaired peripheral fat storage may increase the delivery of lipids to the liver and facilitate NAFLD progression. To assess the association of anthropometric measures of regional adiposity including arm fat index (AFI) (upper body fat), waist circumference (visceral fat) and body mass index (total body fat) on liver injury and fibrosis in NAFLD. One hundred and forty-one patients with histological evidence of NAFLD were included in this study. Multivariate logistic regression models examined the contribution of age, sex, body mass index, AFI, triceps fold thickness (TST), waist and hip circumference to the odds of liver injury (NAS scores ≥3) and fibrosis (fibrosis scores ≥2) by liver biopsy. Arm fat index (OR: 0.82, 95% CI: 0.59-0.91) and TST (OR: 0.13, 95% CI: 0.04-0.42) were negatively correlated with NAFLD histological severity. In women, waist circumference was positively correlated with NAFLD severity (OR: 1.21(1.02-1.44). Age (OR: 1.05, 95% CI: 1.01-1.0) and waist circumference (OR: 1.07, 95% CI: 1.00-1.15) were significantly associated with fibrosis risk. In women, AFI (OR: 0.87, 95% CI: 0.76-0.99) and TST (OR: 0.22, 95% CI: 0.05-0.95) were negatively associated with fibrosis risk. Regional anthropometric measures are associated with severity of NAFLD in a sex-specific manner. Men and women with lower arm fat depots and women with bigger waist circumference have a greater likelihood of liver injury. Age and waist circumference seem to be associated with liver fibrosis. Simple anthropometric measurements of peripheral fat deposits may help stratify significant liver injury risk.

Factors Associated with Abdominal Obesity among HIV-infected Adults on Antiretroviral Therapy in Malaysia

Abdominal or central obesity is a common morphological alteration among HIV-infected subjects on antiretroviral treatment. There is concern that this condition places the subjects at risk of cardiovascular disease. This is a cross-sectional study of 334, HIV-infected adult subjects on antiretroviral therapy at a public hospital in Malaysia. It was aimed at determining the association between nutritional factors and abdominal obesity among PLHIV receiving antiretroviral treatment. Abdominal obesity was prevalent in 36.5% of the respondents. Respondents with abdominal obesity were significantly (p<0.05) older in age, had significantly higher blood triglycerides, fasting plasma glucose, lower HDL-cholesterol, higher BMI at the start of medication and also at the time of the study, bigger waist circumference, higher waist hip ratio, body fat mass, systolic and diastolic blood pressure. They also had lower mean CD4 cell count at start of medication and body lean mass than those without abdominal obesity. After adjusting for the covariates, a significantly higher risk of abdominal obesity was observed in those who were older (adjusted OR=1.053, CI=1.012-1.095), had higher fasting plasma glucose (adjusted OR=1.189, CI=1.014-1.394), higher BMI at the time of study (adjusted OR=1.426, CI=1.215-1.674). Being Malay was a protective factor (adjusted OR=0.264, CI=00.102-0.685) for abdominal obesity. These results suggest that care of the HIV-infected population must include intervention to address abdominal obesity in order to provide better quality of life.

비만에 따른 여성 연령대별 인체비례의 탐색적 연구

The objectives of this study were to investigate the progress of obesity in women from childhood to adulthood and to analyze the characteristics of obese figures through comparing their body proportions to normal-weight people, to provide a basic reference for development of new size categories and improved pattern grading. Body measurement was made on 6,704 women age between 7-39 in Sizekorea 2004 database. The age range was divided into three groups: children(7-12), teenagers(13-18) and adults(19-39). The result of research into the characteristics of body proportions of obese figures and the classification of different figure groups of obese people are as follows: The ratio between width and circumference for each part of the body was investigated according to body weight which was grouped into three different weights of low, normal and obese body weights. And the result demonstrated that in all the ranges of age, the obese groups had the lowest ratio between width and circumference, having a thick body shape. And according to the result of comparing the ratio of the circumference of each body part divided by the waist circumference, the obese group also showed a low ratio, indicating that they have bigger waist circumference than any other body parts. By analyzing the ratio of circumference of body parts divided by waist circumference, three factors were identified as contributing to obesity. Using the factor loadings of the upper, distal and lower body obesity, a cluster analysis was carried out and three different categories of obesity were defined; abdominal obesity, distal obesity and proximal obesity.

Waist circumference as an indicator of adiposity and the relevance of body height

Waist circumference (WC) is an obvious indicator of adiposity, but there is a confusing diversity of approaches to its quantitative use. Because taller people of any given relative fat content tend to have bigger WCs, indices of adiposity commonly take the form WC/height(q), where q is 1 or less. Sometimes the influence of height is regarded as insignificant, so that q is taken as zero. More attention has been given to such indices than to establishing how to use them for predicting adiposity. The usual approach has been empirical and statistical, but many published findings can be integrated using a more analytical approach. This leads to several hypotheses that are supported by published evidence, but which remain to be fully tested. Testing mainly requires data sets of the kind that have already been used for related purposes. The main hypotheses are as follow. For adults, the preferred index is WC/height(0.5), while for adolescents and children it is WC/height. However, to obtain equations for the prediction of percentage body fat, the latter should be regressed on the reciprocals of the squares of these indices, namely 1/(WC(2)/height) and 1/(WC/height)(2) respectively. These expressions decrease with increasing percentage body fat, but should do so in a linear manner. Two other hypotheses are that the non-fat content of the abdomen tends to increase with percentage body fat and that the ratio WC(2)/height is approximately proportional to the body mass index. The analysis is based mainly on the following ideas: firstly, that the area of fat or adipose tissue in a transverse computed tomogram of the abdomen equals the total area less the fat-free area, the former being the main determinant of WC and the latter being partly determined by fat-free body size as represented by height; secondly, that guidance can be usefully be sought in simple, dimensionally-correct models of body form, but that parameters in the resulting equations may become attenuated by the necessary use of regression analysis or the maximizing of correlations. There may be a better measure of fat-free body size with which to replace height in these indices, but the waist-to-hip ratio is unhelpful. It is hoped that this analysis can be usefully extended to the problem of estimating intra-abdominal (visceral) fat from waist circumference.

연령대 변화에 따른 비만 남성 체형 특성 연구

This study investigates the progress of obesity in men from childhood to adulthood, by analyzing the measurement references from the 5th Size Korea. It also seeks to analyze the characteristics of obese figures through the comparison of body proportions to normal-weight people, to provide a basic reference for the development of new size categories and improved pattern grading. The age range is divided into three groups: children (2-7), teenagers (13-18), and adults (19-39). The results of research into the characteristics of body proportions of obese figures and the classification of different figure groups of obese people are as follows. The ratio between width and circumference for each part of the body was investigated according to body weight that was grouped into three different categories of low, normal, and obese body weights. The result demonstrated that in all the ranges of age, the obese groups had the lowest ratio between width and circumference in having a thick body shape. According to the results that compared the ratio of the circumference of each body part divided by the waist circumference, the obese group showed a low ratio that indicates that they have a bigger waist circumference than other parts of the body. Two factors are identified as contributing to obesity in analyzing the ratio of the circumference of body parts divided by waist circumference. Using the factor loadings of the upper and lower body obesity, a cluster analysis was carried out and three different categories of obesity were defined; lower body obesity, abdominal obesity, and upper body obesity. The obese groups of children and teenagers were mostly in body shape with lower obesity and abdominal obesity, whereas the adults group showed the obesity present in the upper body obesity that have fewer cases in lower body obesity.