This article addresses the optimization of a Vehicle Active Suspension System (VASS) through the application of a Linear Quadratic Regulator (LQR) controller. The primary objective is to enhance ride comfort and ensure vehicle stability by addressing the divergent needs of vibration control. The research identifies key issues in existing optimization algorithms, namely, the exploration stage inefficiency in Big Bang Big Crunch Optimization (B3C) and the slow convergence rate in Coyote Optimization (CO). To overcome these challenges, a novel hybrid algorithm, Hybrid Coyote optimization based Big Bang Big Crunch (HB3C), is proposed. The research objective is to optimize the LQR weighting matrices using the HB3C algorithm, aiming for improved ride comfort and vehicle safety. The problem statement involves the inadequacies of existing algorithms in addressing the exploration and convergence issues. The motivation lies in enhancing the efficiency of VASS through optimal control, leading to better ride comfort and safety. The methodology involves integrating CO within a loop with B3C to compute the optimum reduction rate for the algorithm. Since, B3C algorithm’s success is highly dependent on selecting the ideal reduction rate. This hybrid approach is then applied to optimize the existing LQR weighting matrices. The results are evaluated in terms of time domain and frequency domain response analysis, with a focus on ride comfort based on ISO 2631-1 standards. The study demonstrates a maximum reduction of approximately 74% achieved by the optimized HB3C-LQR controllers.