South Asian U.S. college students experience socialization from South Asian cultures they grew up with and White culture outside the South Asian community. The present study considers that the ways of navigating two conflicting cultures and experiences of shame are associated with anxiety and life satisfaction among South Asian U.S. college students. An anonymous survey, distributed to 271 South Asian students (mean age = 22, 38.2% male, 59.2% female, 2.3% nonbinary), quantitively assessed how bicultural stress and shame are related to anxiety and life satisfaction. Open-ended questions asked students to describe experiences of bicultural identity stressors and shame. Survey results indicated bicultural stress and shame as predictors of anxiety and lower life satisfaction. Thematic analysis of open-ended question responses revealed experienced stressors related to academics, finances, family expectations, and fitting in. Shame experiences were tied to bicultural stress and family and self-imposed expectations of participants. There is a need to further investigate the relationships found in the present study and explore ways to support South Asian students experiencing bicultural stress and shame. (PsycInfo Database Record (c) 2024 APA, all rights reserved).