Objective: This study aims to comprehensively review digital entrepreneurship (DE) research, identifying key themes, trends, and future research directions. Theoretical Framework: The review draws upon frameworks including entrepreneurial ecosystem theory, digital platform theory, and theories of entrepreneurial intention formation to understand DE dynamics. Method: A systematic and bibliometric analysis of 276 English-language articles published between 2000 and 2023 from the Scopus database was conducted. VOSviewer software analyzed publication trends, keywords, and citations. Results and Discussion: DE research has significantly grown, particularly in the last five years. Five thematic clusters emerged: DE ecosystems, cultivating digital entrepreneurs, entrepreneurship in the digital economy, exploring new frontiers, and sustainable, competitive digital enterprises. The study highlights influential works and emerging areas such as digital platforms, entrepreneurial intention, and DE education. The discussion contextualizes these findings within the theoretical frameworks and their implications. Research Implications: This research provides valuable insights for researchers, educators, and policymakers. It emphasizes the need for further research on the impact of digital technologies on entrepreneurial ecosystems, individual entrepreneurial intentions, and the role of education in fostering DE. Originality/Value: This study contributes by offering a comprehensive and up-to-date overview of DE research, identifying knowledge gaps, and proposing a future research agenda. The systematic approach utilizing bibliometric techniques provides a robust analysis of the DE literature, enhancing understanding of this evolving field.