SUMMARY The voltage biased SQUID Bootstrap Circuit (SBC) was recently demonstrated for direct readout of SQUID signals. The SBC combines current- and voltage-feedbacks in one circuit to suppress the preamplifier noise. It offers not only a good noise performance, but also wide tolerance of SQUID parameters. Using SBC gradiometer, the bio-magnetic signals were successfully measured. In this paper, we overview the concept of SBC and its applications.