ABSTRACT The electronic structure and magnetic properties of Fe2Te2 are studied by first-principles calculations. The ground state for Fe2Te2 is bi-collinear antiferromagnetic order with Fe magnetic moment (∼2.5 μB). When hydrostatic and uniaxial pressure (Phy or PC ) increased, the density of states at the Fermi-level N(E F ) and the hybrid bandwidth (HBW) of Fe-3d and Te-5p near the Fermi-level both increased slightly accompanied by the decreasing of Fe magnetic moment M Fe(μB). However, compared with 122 type iron-based materials, no significant changes in the band structure, density of states and M Fe were observed when the physical pressure increased. Fe2Te2 is not sensitive to the changes of pressure and it is difficult to induce its superconductivity only by applying its physical pressure.