Benign Osteoblastoma Research Articles

The CT and MRI features of benign calvarium and skull base osteoblastoma.

We retrospectively reviewed the CT and MRI features of patients with benign osteoblastoma in the calvarium and skull base (CSBOB). Nine cases of pathologically confirmed benign CSBOB were analysed retrospectively. The patients had undergone CT and/or MRI. Tumour location, size, and imaging features were reviewed and recorded. The patients included four males and five females with a mean age of 27.0 years (age 14-40 years). The tumours were located in the frontal bone in 3 patients, the occipital bone in 3 patients, and in the parietal bone, sphenoid bone, and skull base in 1 patient each. On CT, the tumours measured 5.1 ± 3.3 (1.8-8.4) cm. Seven tumours were shown to have caused expansile bony destruction with an eggshell appearance and varying degrees of calcification or matrix mineralization. Multiple septa were observed in 5 tumours. Intracranial growth was observed in 5 tumours. On MRI, 7 tumours showed heterogeneous hypo- to isointensity on T1WI. Heterogeneous high signal patterns with low signal rims and septa were observed in 6 tumours on T2WI, and 4 showed a fluid-fluid level. On contrast-enhanced imaging, 6 tumours showed peripheral and septal enhancement, and 2 showed the dural tail sign. Benign CSBOB is a rare tumour characterized by expansile bony destruction, septa, a sclerotic rim and calcification or matrix mineralization on CT and MRI. The findings from this study contribute to a better understanding of benign CSBOB and provide valuable imaging features that can aid in its diagnosis and differentiation from other tumours in the calvarium and skull base.

Computer navigation-guided transpedicular excision of L4 vertebral body osteoblastoma

Abstract Osteoblastoma is a benign bone tumor that accounts for 10% of all spinal tumors and mostly arises from the posterior spinal elements. Isolated vertebral body osteoblastoma is relatively rare and generally requires extensive surgery. We report a rare case of L4 vertebral body osteoblastoma, which was managed successfully by computer navigation-guided transpedicular excision. A 22-year-old female presented with progressive lower back pain for the past six months. Radiological investigation revealed a sclerotic lesion involving the anterior cortex with a prominent central nidus in the anterior part of the L4 vertebral body. Based on the lesion size, a diagnosis of benign osteoblastoma (Enneking stage 2) was made, and she underwent computer navigation-assisted intralesional excision of the lesion by the bilateral transpedicular route. Histopathological examination confirmed the diagnosis of osteoblastoma. In the immediate postoperative period, the patient was completely relieved of symptoms, and the final follow-up magnetic resonance imaging showed no evidence of recurrence at the end of seven years. The intraoperative 3D navigation technology allowed a transpedicular minimal access approach to excise an osteoblastoma of the L4 vertebral body while preserving intervertebral stability and decreasing morbidity.

Case report on Osteoblastoma of maxilla.

Osteoblastoma is an unusual neoplasm, usually found in the vertebral column and long bones of extremities. Maxillary involvement is extremely rare. We present a case report of benign osteoblastoma of maxilla affecting a 17 year old young male patient. The clinical presentation, radiological and the histopathological features as well as the treatment modalities of this unusual neoplasm are briefly discussed. Lastly an attempt is made to clarify the diagnostic dilemmas associated with this tumour with a hope to provide the best possible treatment for this rare neoplasm.

A Case Report of Osteoblastoma of Distal Femur: A Diagnostic Challenge

Osteoblastoma is uncommon benign bone tumor, representing approximately 1% of all primary bone tumor. The nidus of osteoblastoma is simulating to that of osteoid osteoma on histopathology and imaging, but it is larger in size. Osteoblastomas have a variable imaging appearance ranging from indolent to very aggressive, and many times difficult to differentiate from osteoid osteoma only based on imaging. A combination of thorough medical history, radiographic examination and clinical suspicion is at most important for differentiating osteoblastoma from osteoid osteoma. We present a case report of benign osteoblastoma of meta-diaphysis of distal femur in 15-year-old male child and histopathological confirmation.

Clinical, imaging characteristics of benign and aggressive spinal osteoblastoma

Objective To investigate the clinical and imaging manifestations of benign and aggressive spinal osteoblastoma. Methods Seventeen patients with benign osteoblastoma (BO) and 18 patients with aggressive osteoblastoma(AO) from May 2004 to November 2015 diagnosed by orthopedic doctor and pathologist were analyzed retrospectively. Thirty four patients (17 BO, 17 AO) underwent CT plain scanning, 26 patients underwent MRI. The follow-up time was 6 to 96 months, the postoperative recurrence rate was calculated. The continuous variables including the age, the duration of symptoms and the size of tumor were compared between AO and BO with the 2-tailed Student t test or Mann-Whitney U test. The categorical variables were compared between AO and BO with χ2 test.A P value<0.05 was considered statistically significant. Results The age was significantly different between AO and BO [(29.82±14.69) Y vs (19.76±10.33)Y, P 0.05).The recurrence rate of AO (37.50%) was significantly different from that of BO (6.67%, P=0.04). Conclusion The clinical features including the age, duration of symptoms, neurological deficit contributed to differentiating BO from AO. The size of AO was bigger than BO, and AO didn't have intact bony cortex. In the AO group, there was less calcification in the lesion, less edema of bone marrow and adjacent soft tissue around the lesion. The post-operation recurrence of AO was higher than BO. Key words: Spine; Bone neoplasms; Tomography, X-ray computed; Magnetic resonance imaging; Neoplasm recurrence, local

Benign osteoblastoma of the mandible

Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tumors. It is characterized by osteoid and bone formation with the presence of numerous osteoblasts. A 24-year-old female presented with a chief complaint of a painless swelling beneath the mandible, which was growing during the past 3 years. Radiological picture disclosed a well-circumscribed lesion with patchy radiopaque internal structure. After complete excision, the histopathological diagnosis was a benign osteoblastoma of the mandible. Differential diagnosis and immunohistochemical features are potentially useful for refining diagnosis of osteoblastoma.

Osteoblastoma of the temporal articular tubercle misdiagnosed as a temporomandibular joint disorder

The case of a 17-year-old female with a benign osteoblastoma in the temporomandibular joint (TMJ) is reported. The patient had a 2.5-year history of reduced mouth opening accompanied by tenderness and swelling in the left TMJ. Initial treatment included stabilization of the occlusion with a splint, jaw exercises, and analgesics. At first the patient's symptoms decreased, but they then increased 18 months later, prompting a cone beam computed tomography (CBCT) evaluation of the joint. The radiographic findings showed a somewhat ill-defined, radiolucent, expansile lesion containing small scattered calcifications located in the temporal articular tubercle. The lesion was removed under general anaesthesia and sent for histopathological examination. At the 12-month follow-up, the patient had normal TMJ function without clinical symptoms. CBCT examination showed a small recurrence of 3mm. Another 12 months later, CBCT showed a 1-mm increase in the recurrence. Her function was normal, with slight tenderness lateral to the left TMJ. The decision from a multidisciplinary meeting was further annual follow-up. The present case illustrates the importance of initial radiographic examination together with clinical examination in patients with TMJ dysfunction.

Non Aggressive Mandibular Osteoblastoma– A Rare Maxillofacial Entity

Benign osteoblastoma is a very rare, bone tumour occurring in the facial region. These lesions are most frequently seen in long bones. They are characterised by proliferation of compact or cancellous bone. The lesion is usually asymptomatic until it causes significant facial asymmetry or displacement of the teeth if present in the alveolar region. The clinical appearance of osteoblastoma is very similar to peripheral ossifying fibroma or any fibro-osseous lesion. The tumour is characterised by bone formation along with the presence of numerous osteoblasts. This case report describes the presence of a bony hard mass in the right side of mandible of a 27-year-old female patient with the chief complaint of a painless growth since past 10 years. The growth slowly increased in size displacing the teeth associated with it. The patient also complained of difficulty in speech and mastication.

Osteoblastoma of Patella: A Rare Case

Benign osteoblastoma of the patella is a rare tumor. Majority of the tumors occur in the spine, femur, and tibia. Osteoblastoma presents as a diagnostic dilemma due to clinical similarity with other benign bone forming tumors. Histopathological examination is the main stay of diagnosis and has good prognosis.

A Systematic Review of Skull Base Osteoblastoma: Clinical Features, Treatment, and Outcomes

Objective: Osteoblastoma is a solitary, vascular osteoid-forming bone tumor that is rich in osteoblasts, comprising approximately 3.5% of all benign primary bone tumors. It involves the head in 13 to 21% of total cases, with only 2 to 4% arising in the cranium. Osteoblastoma can be subcategorized into two groups: benign osteoblastoma and aggressive osteoblastoma. Aggressive osteoblastoma is much more rare, locally aggressive, and destructive, and histologically intermediate between benign osteoblastoma and osteosarcoma. Because of its rarity, studies examining the clinical features and the relationship between treatment and clinical outcomes of osteoblastoma are limited. Here, we systematically analyze clinical features, radiologic characteristics, and treatment strategies and outcomes for skull base osteoblastoma. In addition, we analyze and compare the treatment and outcomes differences between the two subtypes of osteoblastoma to determine whether each subtype needs to be treated differently.

Benign osteoblastoma of the mandible in a 12-year-old female: A case report.

Benign osteoblastoma refers to a benign tumor of the bone. Osteoblastoma most commonly affects the vertebrae and long tubular bones, however, in rare cases is observed in the facial bones. The current study presents the case of a 12-year-old female patient with a tumor in the mandibular body. Radiological imaging revealed a lesion with regular contours. The lesion was radically resected and histological analysis of the specimen demonstrated features that are typical of a benign osteoblastoma. The consequential defects of the jaw were reconstructed using titanium implants and autologous bone transplantation. The patient remains disease free subsequent to a five-month follow-up period. The aim of the present report is to present a rare case of benign osteoblastoma of the mandible. This study demonstrated that correct diagnosis and complete surgical excision are important to reduce the risk of recurrence of a benign osteoblastoma.

A rare case of an aggressive osteoblastoma of the squamous temporal bone: A unique presentation with literature review

Aggressive osteoblastoma is a rare osteoid tissue forming tumour commonly affecting the spine with predilection for the posterior elements. Calvarial involvement is extremely rare with only two reported cases in the literature. Due to its overlapping clinical, radiographic and histological features with ossifying fibroma, benign osteoblastoma and osteosarcoma, it is very difficult accurately to diagnose this lesion at an early stage. A rare case of an aggressive osteoblastoma of the squamous temporal bone in a young male is presented here which was misdiagnosed twice before reaching the final diagnosis by correlating clinical, radiographic and histopathological features.

Rib osteoblastoma as an incidental finding in a patient with adolescent idiopathic scoliosis

The purpose of this article is to present an unreported case of rib osteoblastoma associated with progressive adolescent idiopathic scoliosis and to discuss thoracogenic scoliosis as a potential cause of curve progression after tumor resection. An 11-year and 8-month-old girl with adolescent idiopathic scoliosis was referred with an incidental finding of an expansile lesion in the posterior left seventh rib. A computed tomography-guided needle biopsy established the diagnosis of benign osteoblastoma. Transarterial embolization was performed followed by wide resection. Sixteen months after surgery the patient underwent posterior spinal fusion to address her scoliosis progression during the growth spurt. Forty-one and 25 months after rib resection and spinal fusion, respectively, the patient remains asymptomatic, without local tumor recurrence, and with excellent correction of her spinal deformity. Although scoliosis secondary to rib osteoblastoma has been described in the literature, rib osteoblastoma may coexist with idiopathic scoliosis. In such a case, surgical management of osteoblastoma should not interfere with treatment of idiopathic scoliosis.

Recurrent osteoblastoma of the maxilla

Osteoblastoma is a benign neoplasm which commonly occurs in the vertebral column and long bones. The tumour grows slowly and rarely recurs after surgery. This report presents the clinicopathological and radiological findings of a case of recurrent osteoblastoma in the maxilla. A 7-year-old male patient visited our department with chief complaints of left facial swelling and pain. A panoramic radiograph showed a homogeneous radio-opaque expansile lesion in the left maxilla. The lesion was thought to be fibrous dysplasia and the patient underwent a surgical excision using the Caldwell-Luc procedure. Histopathological examination of the lesion confirmed it as benign osteoblastoma. The lesion recurred 6 months after the initial surgery. CT images revealed a large mass with multiple internal calcifications. Subsequently, the patient underwent mass excision with subtotal left maxillectomy. Follow-up CT scans at 1 year intervals showed no recurrence for 5 years.

Long-term follow-up of a hip joint osteoblastoma after intralesional curettage and cement packing: a case report

This article reports a case of intraarticularly expanding benign osteoblastoma of the acetabulum caused femoral head destruction by impingement in a 17-year-old male that was diagnosed for two years from the onset of symptoms. As a treatment, by surgical dislocation of the hip joint, polymethyl-methacrylate was packed inside the gap of the acetabular site after intralesional wide curettage. Femoral head remodeling was observed without recurrence after ten years follow-up.

Osteoblastoma of the rib: A rare benign tumor with an unusual location

INTRODUCTIONOsteoblastoma is a rare benign bone tumor commonly located at spine and long bones. However, rib involvement has been reported less frequently. PRESENTATION OF CASEIn this report, we describe a young adult male presenting with left posterolateral chest wall pain. Chest computed tomography showed a calcified tumor in the left third posterior segment of the rib. Radical mass resection was performed and histopathology confirmed a benign osteoblastoma. At last follow-up, 10 months postoperatively, the patient has eventually relieved of the unbearable chest pain. Imaging evaluation revealed no evidence of recurrent tumor. DISCUSSIONOsteoblastoma is an uncommon primary bone tumor accounting for only 1% of all bone tumors. Ribs are involved in less than 5% of patients. The disease has usually good prognosis with a tendency for local destruction and recurrence. CONCLUSIONRadical surgery remains the treatment of choice to prevent recurrences and to provide a definite diagnosis differentiating it from osteoblastoma-like osteosarcoma.

Osteoblastoma of the rib with CT and MR imaging: a case report and literature review

Osteoblastoma is a rare bone tumor which is mostly found in the vertebral column and long bone. We describe a 59-year-old woman with osteoblastoma in the right fifth posterior segment of the rib, whose presenting symptoms were right back pain for two years and awakened at night. Chest computer tomography (CT) and thoracic spine magnetic resonance (MR) imaging findings included an expansile lesion of the right fifth rib and an ossified matrix. Surgical resection of the lesion confirmed a benign osteoblastoma. 12 months follow-up revealed disappearance of right back pain. Rib osteoblastoma in plain film has been described previously; however, to our knowledge this is the only case report emphasized in CT and MR imaging.

Benign Osteoblastoma Involving Maxilla: A Case Report and Review of the Literature

Background. Osteoblastoma is a rare benign tumor. This tumor is characterized by osteoid and bone formation with the presence of numerous osteoblasts. The lesion is more frequently seen in long bones and rarely involves maxilla and mandible. Due to its clinical and histological similarity with other bone tumors such as osteoid osteoma and fibro-osseous lesions, osteoblastoma presents a diagnostic dilemma. Case Report. Very few cases of osteoblastomas involving maxillofacial region have been reported in the literature. This case report involves osteoblastoma involving right maxilla in an 18-year-old male patient. Following detailed clinical examination, radiological interpretation, and histopathological diagnosis, surgical excision was performed. The patient was followed up for a period of 3 years and was disease free. Summary and Conclusion. Benign osteoblastoma involving jaw bones is a rare tumor. There is a close resemblance of this tumor with other lesions such as fibro-osseous lesions and odontogenic tumors and thus faces a diagnostic challenge. Surgical excision with a long-term follow-up gives good prognosis to this lesion—Benign Osteoblastoma.

Benign Osteoblastoma - An Unusual Rare Clinical Presentation

Benign Osteoblastoma is an uncommon osteoblastic tumor that rarely involves facial bones. It is an uncommon lesion that accounts for 1% of all bone tumors and about 3% of all benign bone tumors. The data search has revealed that only 59 cases affecting the facial bones are reported in the literature. An unusual new case of benign osteoblastoma is presented with emphasis on clinical, radiographic and microscopic aspects, as well as differential diagnosis, treatment and follow-up are discussed. The importance of the correct diagnosis of this lesion is stressed due to presence of similarity to other bone lesions. The purpose of this article is to add one more case of this rare lesion to the academic literature and to provide a descriptive review.

Osteoblastoma of the nasal septum

To present a case of, and to review the literature concerning, osteoblastoma of the nasal cavity, and to demonstrate the importance of considering this rare entity when assessing patients presenting with a nasal septum lesion. Benign osteoblastoma is a rare tumour, constituting 1 per cent of all bone tumours. Most cases occur in the long bones. Osteoblastoma involving the nasal cavity is rare, with only 10 reported cases in the English-language literature. Most nasal cavity cases originate from the ethmoid sinus and spread to involve the nasal cavity. There are only four reported cases of osteoblastoma originating from the bones of the nasal cavity. We report a case of osteoblastoma originating from the bony nasal septum in a 45-year-old man with a history of recurrent, right-sided epistaxis and nasal obstruction. This is the second report in the English-language literature of osteoblastoma originating from the bony nasal septum.