Benign Neonatal Hemangiomatosis Research Articles

Diagnóstico clínico de hemangiomatose neonatal disseminada: um relato de caso

Hemangioma is the most common vascular tumor of childhood. It may present as multiple cutaneous hemangiomas on rare occasions, with or without visceral involvement. The condition of lesions restricted to the skin is called benign neonatal hemangiomatosis, and in the case of visceral lesions associated with cutaneous lesions, the denomination is disseminated or diffuse neonatal hemangiomatosis (DNH). For the diagnosis of DNH, three criteria must be met: onset in the neonatal period, involvement of three or more organs, and absence of malignancy in hemangiomas. ASAS, a full-term, vaginally delivered newborn, weight: 3560g, length: 52cm, head circumference: 35cm, APGAR: 9/9. Maternal history of syphilis during pregnancy - mother adequately treated in pregnancy. At birth, she presented with purpuric lesions of variable size on the chest, limbs, feet, and hands, which discolored under digital pressure; larger lesions with relief, not scaly. He developed severe heart failure and was admitted to the Neonatal Intensive Care Unit (NICU) in a secondary hospital in the Federal District. Imaging tests were performed: Computed tomography of the skull, thorax, and total abdomen, which revealed the presence of a possible hemangioma in the left frontal lobe, telangiectasias in the lungs, and multiple hepatic hemangiomas. He had a clinical diagnosis of DNH. The case described corroborates the fact that knowledge about the disease is relevant, as early diagnosis can lead to more accurate approaches that may reduce morbidity and mortality from the disease.

Benign Neonatal Hemangiomatosis.

Benign neonatal hemangiomatosis (BNH) is a rare, self-limiting subtype of infantile hemangiomas (IHs), in which infants with multiple cutaneous hemangiomas lack visceral involvement. Other subtypes of IHs exist that may mimic BNH and can be life-threatening depending on hemangioma location and size. At birth, a 29 5 / 7 -week preterm female presented with several pinhead-sized pink papules distributed throughout her body. At 10 days of age, the patient had 12 enlarged domed-shaped red papules in a generalized distribution throughout her body. Over several weeks, the number and size of the domed-shaped red papules continued to increase to a total of 26 located on the head, chest, abdomen, back, legs and arms. They were of firm consistency with both smooth and lobulated surfaces. A diagnosis of BNH was made after extensive workup did not reveal any extracutaneous hemangiomas. Due to the lack of extracutaneous involvement and low-risk location/size of hemangiomas in our patient, no interventions were pursued and an observation-only approach was implemented. The patient remained stable while followed up over 8 months, with the size of the hemangiomas only increasing slightly in proportion to the patient's natural body growth. Given the life-threatening nature of certain hemangioma subtypes, it is important to implement a proper workup and subtype diagnosis as early as possible in any infant with multiple hemangiomas.

Consumptive hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis: a case report

IntroductionBenign neonatal hemangiomatosis is a condition in which multiple cutaneous hemangiomas appear at birth or shortly thereafter; visceral complications are absent. Here, we report a case of a consumption hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis.Case presentationAn 8-month-old Egyptian boy with benign neonatal hemangiomatosis was referred to our institution for evaluation of developmental delay. Initial examination revealed a quiet baby who was able to sit only with support. He had hypotonia, a large anterior fontanelle, puffy eyes, cold extremities, hypothermia, bradycardia, and abdominal distension. An examination of his skin revealed more than 100 dome-shaped red-purple cutaneous hemangiomas that varied in size from 5 to 10mm on the back, the abdomen and the extremities without mucus membrane involvement. He had low serum free thyroxine concentration and triiodothyronine levels and high thyroid-stimulating hormone and reverse-triiodothyronine levels. A work-up that involved appropriate imaging ruled out visceral involvement. Based on the above mentioned data, a diagnosis of consumptive hypothyroidism due to benign neonatal hemangiomatosis was made. He was started on oral thyroid medication which was gradually increased to 90μg L-thyroxine daily (15μg/kg/day). After three months of treatment, he was able to sit alone without support and he had normal levels of thyroid-stimulating hormone and serum free thyroxine.ConclusionThyroid function should be assessed periodically in babies with benign neonatal hemangiomatosis, especially if symptoms of hypothyroidism appear or the size and number of hemangiomatosis increase rapidly. Moreover, high doses of L-thyroxine may be needed to achieve euthyroidism during the infancy.

Chorioangioma of the placenta associated with benign multiple neonatal hemangiomatosis

Chorioangioma of the placenta associated with benign multiple neonatal hemangiomatosis

Congenital atresia of the portal vein and extrahepatic portocaval shunt associated with benign neonatal hemangiomatosis, congenital adrenal hyperplasia, and atrial septal defect

A rare case of congenital atresia of the portal vein and ductus venosus, extrahepatic portocaval shunt, benign neonatal hemangiomatosis, congenital adrenal hyperplasia, and an atrial septal defect is reported. Twenty-two cases of congenital extrahepatic end-to-side shunts have been described before. Although additional anomalies are common in this type of shunt, hemangiomatosis has been described only once. Adrenal hyperplasia has never been reported in this anomaly.

An infant with multiple hemangiomas showing favorable prognosis

A 36‐day‐old baby with a 1‐month history of cough, dyspnea, fever, and failure to thrive was seen by the pediatric clinic of SÛişli Etfal Hospital. The patient was sent to the dermatology clinic because of widespread red spots on her body. Dermatologic examination revealed discrete, dark red, nonblanching, angiomatous lesions (2 mm to 2 cm) on the head, trunk, and extremities ( Fig. 1). In addition, there were a few such lesions in the oral mucosa, on the gingivae and hard palate, and on the labia minora in the genital area. Ophthalmologic examination revealed a few angiomatous spots on the inferior lid of the right eye, but the conjunctival mucosae and fundus were normal. All these lesions had existed since birth and had progressively increased.Patient before treatment. There are multiple hemangiomas on the trunk and a large one on the left wristimageAt the initial physical examination, the baby girl weighed 4.150 kg (25–50th percentile), had a height of 52 cm (10th percentile),and a head circumference of 34.5 cm (25th percentile). The rectal temperature was 37.6 °C. The respiratory rate per minute was 44 and the beat per minute was 48. She had a long expiration, bilateral sibilant and fine wet rales, and coarse rhonchi on auscultation of the lung. The liver was palpable 1 cm below the costal margin. The rest of the general examination was unremarkable.Initial routine laboratory tests showed a red blood cell count of 3688 × 103/mm3, a hemoglobin level of 10.90 g/dL, a hematocrit of 32.31, a thrombocyte count of 654.000, a white blood cell count of 12,060/mm3, aspartate transferase (AST) 40, alanine aminotransferase (ALT) 57, alkaline phosphatase (ALP) 192, total bilirubin 1.50 mg/dL, direct bilirubin 0.69 mg/dL, indirect bilirubin 0.81 mg/dL, total protein 5.7 g/dL, and albumin/globulin rate of 2.2. Serologic tests of hepatitis A and B were negative.Histopathologic examination of a cutaneous skin biopsy specimen revealed numerous capillary lumina including erythrocytes in the papillary and deep dermis. No nuclear atypia and mitotic figures were observed.On thorax computerized tomography (CT), on the left inferior lobe of the lung, irregular pleural thickening, reduced left lung volume, and increased right lung aeration were seen. These findings were consistent with bronchopneumonia. Cranial CT results were assessed as normal. On abdominal ultrasound, the liver parenchyma had dilated vascular structures and multiple hypoechoic areas consistent with multicentric hemangiomatosis ( Fig. 2).Ultrasonography of the liver before treatment. Multiple hypoechoic areas are seen , varying from 10 to 25 mm in diameterimageThe patient was diagnosed as having benign neonatal hemangiomatosis. Respiratory symptoms and pulmonary signs were assessed in favor of bronchopneumonia. Antibiotic therapy with ampicillin + sulbactam for the respiratory disease and 2 mg/kg/day intravenous (IV) methylprednisolone for only 12 days, which was replaced on discharge from hospital with oral methylprednisolone at the same dose. On follow‐up, the skin lesions had begun to fade ( Fig. 3), and had resolved almost completely after 2 months ( Fig. 4). Because of the liver lesions, she remains on the same dose of oral medication. No medical problems are evident.Cutaneous hemangiomas after 1 month of therapyimageCutaneous hemangiomas after 2 months of therapy. There is complete resolutionimage

Benign Neonatal Hemangiomatosis with Aggressive Growth of Cutaneous Lesions

A patient experienced rapidly proliferating, multiple cutaneous hemangiomas subject to significant hemorrhage, with associated asymptomatic pulmonary involvement. The dramatic features of his cutaneous disease, an overview of the spectrum of neonatal hemangiomatosis, and recent therapeutic options are reviewed.

Benign Neonatal Hemangiomatosis: Review and Description of a Patient with Unusually Persistent Lesions

Benign neonatal hemangiomatosis (BNH) is a disorder in which multiple cutaneous hemangiomas appear at birth or shortly thereafter; visceral complications are absent. While previously reported cases of BNH emphasize the relatively early spontaneous regression of the cutaneous lesions, we describe a patient in whom new lesions arose and old ones persisted during the first year of life. The features of BNH are contrasted with those of diffuse neonatal hemangiomatosis (DNH), a dermatosis with a more grave prognosis.

Benign neonatal eruptive hemangiomatosis in identical twins.

Two cases of neonatal hemangiomatosis occurred in identical twins. Work-up for internal hemangiomas were performed on both infants and were negative. Twin no. 1, with extensive lesions, is currently taking oral prednisone, 2 mg/kg/day, with gradual resolution of the lesions. So far, no new hemangiomas have developed in twin no. 2.