Benign Multicystic Peritoneal Mesothelioma Research Articles

Benign Multicystic Peritoneal Mesothelioma: A Case Report

Benign multicystic peritoneal mesothelioma (BMPM) is a rare tumor originating from peritoneal mesothelial cells. Here, we present a case of an 18-year-old male with right lower abdominal pain. Physical examination revealed a palpable mass with unclear boundaries. Laboratory tests showed elevated levels of monocytes and high-sensitivity C-reactive protein. CT scan revealed a cystic mass in the ileocecal region with multiple septations. Laparoscopic surgery confirmed a cystic solid mass resembling beads on the colon’s right side. Immunohistochemistry confirmed BMPM diagnosis. BMPM, especially in the ileocecal region, is uncommon and presents diagnostic challenges. Differential diagnosis includes lymphangioma, peritoneal metastasis, and malignant mesothelioma. CT findings, such as thin cyst walls and septations, aid in diagnosis. Recognition of BMPM’s imaging features improves diagnostic accuracy. Surgical resection remains the primary treatment. This case underscores the importance of considering BMPM in young male patients with abdominal pain and emphasizes the value of imaging modalities in accurate diagnosis and management.

Benign Multicystic Peritoneal Mesothelioma: Two Rare Cases and Review of the Literature

Background:: Benign multicystic peritoneal mesothelioma is a multiloculated cystic mass which originates from the peritoneum. This rare tumor is usually seen in women of childbearing age and has a high recurrence rate after surgery. Case Presentation:: We present two benign multicystic peritoneal mesothelioma cases with different imaging modalities, which were also pathologically proven. Conclusion:: The imaging features which may be diagnostic should be well known as there are very few reports regarding this entity

Pelvic cyst that turned out to be a rare benign multicystic peritoneal mesothelioma

Pelvic cyst that turned out to be a rare benign multicystic peritoneal mesothelioma

Benign Multicystic Peritoneal Mesothelioma as a Rare Cause of Death

Abstract Introduction/Objective Benign multicystic peritoneal mesothelioma (BMPM) is a tumor arising from the serosa of the peritoneal cavity, often in the pelvis, and is comprised of multiple cysts lined by bland mesothelial cells. It is a rare entity with less than 200 cases reported. The clinical course is often indolent with nonspecific symptoms. It has a strong predilection for females (90%) and is commonly associated with endometriosis or prior surgeries. A high local recurrence rate (50%) following excision has been reported, but malignant transformation is rare. Methods/Case Report The decedent was a 53-year-old male with a history of multiple hernia repairs who presented following three days of diffuse abdominal pain and obstipation. Imaging showed large volume, complex ascites with multiple rim-enhancing fluid collections, diffuse peritoneal thickening, and a soft tissue density in the lower abdomen/pelvis. Exploratory laparotomy was congruent and revealed 2L of purulent ascites, numerous peritoneal cystic lesions, and a bulky tumor in the pelvis. Blood and ascites cultures later grew Bacteroides species, and Escerichia coli was also isolated from the blood. Postoperatively, the decedent continued to decline, and death occurred the following day. Autopsy demonstrated that the firm pelvic mass entrapped the bladder, rectum, and segments of the small intestine. Sectioning revealed numerous cystic spaces of varying size. Microscopically, they were lined by a single layer of benign cells with mild to focally moderate atypia. These cells stained positive for Calretinin, Pan-cytokeratin, and D2-40 and negative for CD31, which is characteristic of mesothelial cells. These findings are consistent with BMPM. Results (if a Case Study enter NA) NA. Conclusion The decedent’s death is the result of sepsis following acute peritonitis due to BMPM. Death resulting from this entity is exceedingly rare, and to our knowledge this case is only the second reported death due to BMPM.

Multiloculated peritoneal inclusion cyst in male patient: a case report

Multilocular peritoneal inclusion cyst (MPIC), also known as benign multicystic peritoneal mesothelioma, is a rare mesothelial lesion arising from the peritoneal mesothelium. This condition most commonly occurs in females of reproductive age group and are very rare in males. We report a case of young male patient, presented with the chief complaint of lower abdominal pain, without any previous history of surgery. After radiological investigations which were suggestive of pelvic inclusion cysts, pt. was planned for diagnostic laparoscopy (D/L). On D/L, multiple free-floating cysts were found in pelvis between rectum and bladder which were successfully extracted and sent for histopathological examination (HPE). HPE confirmed it to be MPIC.

Benign multicystic peritoneal mesothelioma occurring in bilateral inguinal canals metachronously: a case report

BackgroundBenign multicystic peritoneal mesothelioma (BMPM) is a benign tumor that usually occurs in middle-aged females. Although several published studies have reported the occurrence of this tumor in the abdominal cavity, few have documented its development in the inguinal region.Case presentationWe present a case of a 48-year-old female presenting with a bulge in her left inguinal region. Physical examination revealed a golf ball-sized nodule in the left inguinal region that could not be pushed back into the abdominal cavity. Contrast-enhanced computed tomography showed a multicystic tumor; therefore, the patient was diagnosed with inguinal hernia or hydrocele of the Nuck’s canal. We performed surgical resection and hernia repair using the mesh plug method. The resected specimen was 80 mm in length and contained a multicystic tumor. Pathological examination showed that the cyst wall was lined by a single layer of cuboidal to single layer squamous epithelium. Immunohistochemistry revealed positivity for calretinin in the epithelial cells, for which a diagnosis of BMPM was established. The patient returned to our hospital after 5 years with symptoms similar to the previous episode, but this time in the right inguinal region. Imaging studies showed a tumor in the right inguinal region with the same characteristics as the previous one. The patient underwent tumor resection and hernia repair using the same technique. The resected tumor was 45 mm in length and had characteristics similar to the previously resected tumor. The presence of calretinin and D2-40 on immunohistochemistry led to the diagnosis of BMPM. There was no recurrence of BMPM for 33 months after the secondary surgery.ConclusionsHere we present the first report of metachronous BMPM occurring in bilateral inguinal canals. Although the pathogenesis of BMPM remains unclear, reactive changes have been suggested to cause tumors originating from the groin. The treatment of choice for BMPM is surgical resection. For diagnosis, pathological examination with immunostaining can be useful. The most appropriate postoperative follow-up for inguinal BMPM is controversial, and the accumulation of more inguinal BMPM cases is needed.

Benign multi-cystic peritoneal mesothelioma discovered at the time of acute appendicitis: a rare pathology in association with a common disease.

Benign multi-cystic peritoneal mesothelioma discovered at the time of acute appendicitis: a rare pathology in association with a common disease.

A rare case of benign multicystic peritoneal mesothelioma misdiagnosed as hydatid cyst found in the liver parenchyma and abdomen cavity of a male with asbestos exposure

BackgroundBenign Multicystic Peritoneal Mesothelioma (BMPM) is one of the rarest diseases in medicine with only more than 200 cases worldwide. This paper aims to report a case of Benign Multicystic Peritoneal Mesothelioma that strangely arose from the liver and was long treated as Hydatid cyst. The case also had many risk factors including asbestos exposure that had not yet been linked with Benign Multicystic Peritoneal Mesothelioma.Case presentationWe report a case of a 62 years old male with a history of a perforated peptic ulcer and a cystic mass in the liver that was misdiagnosed as hydatid cyst 7 years ago. He presented with generalized abdominal pain and bloating. Image studies showed many cystic formations filled with clear fluid. An en bloc surgery was performed and a pathologic study showed a multiloculated mass lined by flat or cuboidal epithelium leading to the diagnosis of BMPM. A follow up was scheduled after 3 months revealed total recurrence.ConclusionBMPM resembles many other cystic lesions in the abdomen and should be taken into consideration when dealing with nontypical cystic formations. Its diagnostic and treatment methods are still hazy making this disease difficult to approach.

Benign multicystic peritoneal mesothelioma: a case report

Free-floating peritoneal masses found during laparotomy should arouse a suspicion of benign multicystic peritoneal mesothelioma and they must be removed and subjected to histopathological examination and immunochemical staining to ascertain their benign nature. The objective of the study was to report a rare case of benign multicystic peritoneal mesotheliomas. We report an incidental finding of multiple free-floating peritoneal masses in a pregnant primigravida woman with a normal antenatal course who underwent a cesarean section in a rural hospital setting in India for fetal distress. The masses were removed from the peritoneal cavity during the surgery and subjected to histopathological examination and found to be benign multicystic peritoneal mesotheliomas. Immunohistochemistry of the cysts revealed that the mesothelial cells lining the cysts were positive for calretinin and WT1 and negative for CD31.

A Case of Retroperitoneal Benign Multicystic Peritoneal Mesothelioma with Acute Abdomen

A Case of Retroperitoneal Benign Multicystic Peritoneal Mesothelioma with Acute Abdomen

BENIGN CYSTIC MESOTHELIOMA OF OMENTUM: MIMICKING ABDOMINAL LYMPHANGIOMA

Benign multicystic peritoneal mesothelioma (BMPM) or benign cystic mesothelioma is a very rare disease characterized by proliferative lesions of the peritoneal mesothelial cells mainly in the pelvic or abdominal cavity. It occurs predominantly in young to middle-aged women and the majority of cases were associated with a history of abdominal or pelvic operation, a history of endometriosis, and pelvic inflammatory disease. BMPM involving only the omentum is not mentioned in the literature; here, we present a unique case of BMPM which was diagnosed as cystic lymphangioma with differential diagnosis of pseudomyxoma peritonei in a 40-year-old patient presenting as recurrent abdominal pain.

Benign multi-cystic peritoneal mesothelioma of the porta hepatis

Presenter: Tayler James MD | Keck Hospital of USC Background: Benign multi-cystic peritoneal mesothelioma (BMPM) is a rare neoplasm of mesothelioma cells originating from serosal linings of viscous organs. her in we present a case report of benign multi-cystic peritoneal mesothelioma (BMPM) of the porta hepatis Methods: We performed a chart review of the patient and collected - preoperative findings, imaging, operative findings, and outcomes Results: A 61-year-old Hispanic woman presented with complaints of several years of chronic abdominal pain. Computerized tomography (CT) demonstrated a multi-cystic abdominal mass located near the porta hepatis. Fine needle aspiration (FNA) demonstrated benign ductal epithelial cells in a background of mucin and bile without the presence of malignant cells. During laparotomy, a large cystic mass seen emanating from the small bowel mesentery and attached to the porta hepatis as well as additional innumerable small cystic lesions through the abdomen were removed. Grossly, the abdominal mass specimen, measuring 26 x 18 x 8 cm, showed multi-loculated cysts filled with serous fluid. The final diagnosis was benign multi-cystic peritoneal mesothelioma (BMPM). Conclusion: This case highlights the difficulty of diagnosing BMPMs and differentiating it from malignant diseases that can present similarly and that can be associated with significantly worse prognosis.

Benign multicystic peritoneal mesothelioma: literature review and update

ABSTRACTBenign multicystic peritoneal mesothelioma (BMPM) is a rare peritoneal tumor diagnosed predominantly in pre-menopausal women. Associated risk factors include endometriosis and pelvic inflammatory disease in women, and prior abdominal surgery in both genders. To date, the pathogenesis of this disease remains controversial with possible etiologies, including a neoplastic versus a reactive process. Given the risk factors, some authors believe that this disease is secondary to a reactive process. However, because some studies describe cases where there is no prior surgical history or inflammatory milieu present, and because of this entity’s predilection for recurrence, some authors believe the origin to be neoplastic. Some genetic and familial associations have also been reported. Malignant transformation is extremely rare, with only two cases reported in the literature, despite the recurrence potential. Like the etiology, the name of this entity is also controversial. Some authors prefer the term “peritoneal inclusion cyst (PCM)” instead of “benign cystic mesothelioma” and argue that the term mesothelioma should only be used when there is evidence of atypia. Most cases of BMPM are discovered incidentally. Others reflect sequela of tumor mass effect. It appears intra-operatively as large, multi-focal, cystic lesions in the peritoneal and pelvic cavity. Diagnosis is achieved through surgical sampling with histopathological examination. Immunobiologically, BMPM exhibits multiple small cystic spaces with flattened lining containing calretinin positive cells without atypical features, mitotic figures, or tissue invasion. Treatment includes cytoreductive surgery. Here we present a case of BMPM in a 60-year-old male – a rare disease in an uncommon patient population.

Benign Multi-Cystic Peritoneal Mesothelioma: A Case Report

Benign multicystic peritoneal mesothelioma (BMPM) is a rare disorder that occurs predominantly in reproductive-aged women. A 42-year-old male referred to our emergency department in Mousavi Hospital of Zanjan University, suffering from diffuse abdominal pain. He mentioned a history of operation two years ago, during which cystic tumors had been removed from his abdomen. A cytoreductive surgery was performed. The pathologic study confirmed the diagnosis of BMPM and immunohistochemical analysis verified the negative expression of CD34 marker and positive expression of calretinine in the cyst lining. Preoperative diagnosis of BMPM is difficult and definitive diagnosis requires histological evaluation of the specimen. Due to the rarity of BMPM, the need for familiarity with this benign but aggressive tumor is felt.

Benign Multicystic Peritoneal Mesothelioma in a Male Patient with Previous Wilms’ Tumor: A Case Report and Review of the Literature

Benign multicystic peritoneal mesothelioma (BMPM) is a rare condition, more common in females of reproductive age, which arises from the peritoneal mesothelium. A 33-year-old male presented to our unit with abdominal pain and constipation. His past medical history included a previous unilateral nephrectomy for Wilms' tumor and the previous incidental finding of some intra-abdominal cystic formations at the level of the mesentery. After performing a CT scan, an exploratory laparotomy was done and a voluminous cystic mesenteric mass, composed of 3 confluent formations, was observed. Some other similar but significantly smaller lesions were found. An en bloc resection of the mesenteric mass together with the corresponding intestinal loops, an appendicectomy, and some peritoneal biopsies were performed. The postoperative period was complicated by a peritonitis due to dehiscence of the intestinal anastomosis, which required another operation, and a delayed return of normal bowel function, which was resolved through prokinetic therapy. Through histological examination, a BMPM was diagnosed. At 8 months of follow-up, the patient is free of symptoms. BMPM exact etiopathogenesis still remains uncertain. Given his high recurrence rate, a long-term follow-up is recommended.

A Surgical Case of Benign Multicystic Peritoneal Mesothelioma Arisen from the Inguinal Region

症例は53歳，女性．右鼠径部腫瘤を主訴に来院した．CTで右鼠径部嚢胞性腫瘍および外鼠径ヘルニアと診断し手術を行った．ヘルニア嚢を高位結紮後に腫瘍を切除しヘルニア修復術を施行した．病変は多嚢胞性充実性腫瘍で，病理組織学的に嚢胞内壁を覆う細胞は中皮細胞であった．免疫化学染色でcalretinin，cytokeratin陽性かつEMA陰性で，良性多嚢胞性腹膜中皮腫と診断した．術後2年，再発を認めていない．良性多嚢胞性腹膜中皮腫は稀な疾患であるが，術後再発が多く根治的切除が必要とされる．鼠径部の良性多嚢胞性腹膜中皮腫は鼠径ヘルニアの合併が多いためヘルニアの慢性炎症の関与が示唆される．自験例を含めた5例の鼠径部良性多嚢胞性腹膜中皮腫の内4例に術後再発を認めなかった．鼠径部発症例は腫瘍が体表近くで限局性に増大するため，ヘルニアの存在と共に早期に発見されやすく根治的切除となる可能性がある．

腹部手術後に発生した良性多嚢胞性腹膜中皮腫の2例

腹部手術後に発生した良性多嚢胞性腹膜中皮腫の2例

Recurrent benign multicystic peritoneal mesothelioma: Approach to this rare condition

Abstract Background Benign multicystic mesothelioma is a rare benign tumour derived from the peritoneal mesothelium. The aim of this paper is to present a case of this rare tumour and review the clinical features, diagnosis and treatment of this disease. Clinical case The case is presented of a 22-year-old female diagnosed with multicystic mesothelioma after an urgent resection of intra-abdominal tumour in the context of acute abdominal pain. In the subsequent follow-up, the patient had a recurrence of the lesion, and at 2 years was treated by further resection. Conclusions Benign multicystic mesothelioma is a benign tumour of unknown origin, and with a non-specific clinical manifestation. The most effective treatment is surgical, although there is a high tendency to local recurrence.

Two Cases of Benign Multicystic Peritoneal Mesothelioma Presenting As an Intra-Abdominal Cystic Disease in Men: A Case Series and Literature Review

Two Cases of Benign Multicystic Peritoneal Mesothelioma Presenting As an Intra-Abdominal Cystic Disease in Men: A Case Series and Literature Review

Benign Multicystic Omental Mesothelioma in Pregnancy: A Case Report and Review of the Literature

Benign Multicystic Peritoneal Mesothelioma (BMPM) is a very rare condition of unknown pathogenesis, that occurs mainly in women in their reproductive age (5:1 female/male ratio). The pathogenesis of BMPM is unclear and doubts regarding its neoplastic and reactive nature exist. Furthermore, the differential diagnosis with other diseases remains uncertain. In most cases the diagnosis is accidental, during a laparotomy performed for other reasons, since the diagnostic imaging does not allow a definite diagnosis preoperatively. Radical surgical resection is the “gold standard” for treatment of BMPM, despite a high rate of recurrence (about 50%). We report on a case of a 30-year-old pregnant woman with multilocular omental cystic mass, 36 x 22 cm in size, underwent elective caesarean section at term of pregnancy. The definitive histologic diagnosis was benign multicystic mesothelioma of the omentum. BMPM detected in pregnancy or during cesarean delivery is very rare; in fact only three other cases have been reported. Particularly, we present the only case, described in the literature, of a young female with benign multicystic omental mesothelioma in pregnancy that was treated solely by surgery, without recurrence after Case Study D’Agate et al.; BJMMR, 7(2): 138-144, 2015; Article no.BJMMR.2015.217 139 three years follow-up. In this article we also describe diagnostic evaluation, treatment, prognosis of this rare disease as the possible positive effects of adjuvants medical treatments.