Fanconi’s anemia is an autosomal recessive disorder that was first reported in 1927. These patients usually present with specific characteristics, which include pancytopenia, progressive bone marrow failure, and congenital anomalies.1,2 The disease involves many organs including the skin and the genitourinary, musculoskeletal, cardiovascular, and neurologic systems.3 The clinical findings in Fanconi’s anemia patients are hyperpigmentation; a small reproductive organ in males; kidney problems, such as a missing, rotated, or misshapen kidney; thumb and arm abnormalities; skeletal anomalies of the hip, spine, or ribs; low birth weight; short stature; growth retardation; a defect in the tissue separating the chambers of the heart; and mental retardation or a learning disability.2-4 Most of the previously reported cases of Fanconi’s anemia had symptoms of anemia during childhood.2 However, the symptoms may not become apparent until adulthood. Patients often die young from acute leukemia.2 If patients develop the anemic phase late, some of them will develop other diseases. An increasing number of reports have shown that patients with Fanconi’s anemia are at risk for second malignancies, for example, leukemia, squamous cell carcinoma, and hepatocellular carcinoma. The hepatic lesions that occur in Fanconi’s anemia are diffuse hyperplasia, hyperplastic nodules, benign hepatoma, and hepatocellular carcinoma. However, it has been suggested that the hepatocellular carcinoma is related to the treatment of the pancytopenia with an androgen.4 A bone marrow transplant has enabled some of these patients to survive into their 20s, when they are at risk for developing tongue cancer, which may be related to the immunosuppressive drugs used for the marrow transplantation. This report describes a Fanconi’s anemia patient who developed squamous cell carcinoma on the dorsum of the tongue after bone marrow transplantation.