Benefits Of Disease Prevention Research Articles

Using Directed Acyclic Graphs (DAGs) to Determine if the Total Causal Effect of an Individual Randomized Physical Activity-Promoting Intervention is Identifiable

ABSTRACT Physical activity promotion is a best buy for public health because it has the potential to help individuals feel better, sleep better, and perform daily tasks more easily, in addition to providing disease prevention benefits. There is strong evidence that individual-level theory-based behavioral interventions are effective for increasing physical activity levels in adult populations but causal inference from these interventions often is unclearly articulated. A directed acyclic graph (DAG) can be, but rarely is, used to determine if the causal effect of an individual-level theory-based physical activity-promoting intervention is identifiable (e.g. stripped of any spurious association). The primary objective of the current study was to demonstrate how a DAG can be used to determine if the total causal effect of an individual randomized physical activity-promoting intervention is identifiable. The demonstration was based on the Well-Being and Physical Activity study (ClinicalTrials.gov, identifier: NCT03194854). Annotated files from DAGitty and Mplus are provided.

Sulforaphane-A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies.

Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN's ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN's potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.

Ethnopharmacology of Assamese Fermented Foods: Traditional Wisdom, Therapeutic Potential, and Evolutionary Insights

The migration patterns of humans from various regions over extended periods form the ancestors of the present-day ethnic communities in Assam, a region located in Northeast India. Throughout the process of assimilation, the people of this area developed the skill of fermenting different types of perishable and inedible raw agricultural products into tasty, preserved, and superior foods and drinks pleasing to the senses. Fermented foods have played a crucial role in the cultural and dietary practices of diverse ethnic communities worldwide since ancient times. Particularly in developing countries, their inclusion holds significant importance as it provides a cost-effective method of preserving food while enhancing its nutritional and sensory attributes. The native population of Northeast India, particularly in Assam, has a long-standing tradition of preparing and consuming various smoked, sun-dried, fermented, and salted fish products. This practice, which originated from the astute observations of our ancestors, has resulted in a wide range of fermented food items and beverages that are unique to this region. Among these, Judima, Rice beer, Apong, Jou, Sujen, Khorisa, Kahudi, Napham, Kharoli, Xaj-pani, Chokot, Shidol, and traditional fermented fish products like karati, bordia, and lashim hold significant prominence. These ethnic fermented foods not only influence the local healthcare system but also possess potential therapeutic benefits for disease prevention and managing physiological disorders. The phytochemical constituents present in these fermented foods, individually or in combination, exhibit noteworthy therapeutic potential. The objective of this review is to provide an in-depth understanding of the diverse range of ethnic fermented foods in Northeast India, specifically Assam, their impact on health, and the evolutionary development of their preparation techniques.

Designing Nutrition for Health-Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations.

This review delves into the concept of nutrition by design, exploring the relationship between poultry production, the utilization of dietary by-products to create functional foods, and their impact on human health. Functional foods are defined as products that extend beyond their basic nutritional value, offering potential benefits in disease prevention and management. Various methods, including extraction, fermentation, enrichment, biotechnology, and nanotechnology, are employed to obtain bioactive compounds for these functional foods. This review also examines the innovative approach of enhancing livestock diets to create functional foods through animal-based methods. Bioactive compounds found in these functional foods, such as essential fatty acids, antioxidants, carotenoids, minerals, vitamins, and bioactive peptides, are highlighted for their potential in promoting well-being and mitigating chronic diseases. Additionally, the review explores the functionality of food components within these products, emphasizing the critical roles of bioaccessibility, bioactivity, and bioavailability in promoting health. The importance of considering key aspects in the design of enhanced poultry diets for functional food production is thoroughly reviewed. The safety of these foods through the establishment of regulations and guidelines was reviewed. It is concluded that the integration of nutrition by design principles empowers individuals to make informed choices that can prioritize their health and well-being. By incorporating functional foods rich in bioactive compounds, consumers can proactively take steps to prevent and manage health issues, ultimately contributing to a healthier society and lifestyle.

Effectiveness of health literacy interventions on the health outcomes of higher education students

Abstract Background Health literacy is relevant to the empowerment process of higher education students. It reduces their vulnerability in health decision making. Higher education institutions are planning, implementing, and evaluating health literacy interventions on a variety of topics and using a variety of methodologies in order to achieve health benefits for their participants. Benefits in disease prevention, health promotion and health care have been associated with health literacy interventions. A review was conducted to identify and synthesise evidence on the effectiveness of health literacy interventions delivered in academic settings on the health outcomes of higher education students. Methods A systematic review of the literature was conducted with research on the EBSCO Host-Research Databases platform. The methodology followed the PRISMA guidelines, and the protocol was registered with PROSPERO. Methodological appraisal of the studies was carried out according to the Joanna Briggs Institute appraisal tool. A thematic and narrative synthesis was carried out for literature synthesis. Results This review included 9 articles out of 154 identified. The health gains of health literacy interventions in academic settings were positive changes in mental health; attitudes, norms, and self-efficacy for condom use; emotional, social, and psychological wellbeing; subjective sleep quality, sleep latency, and habitual sleep efficiency; physical activity; and self-reported servings of fried foods. The educational or motivational health literacy interventions contributed to health promotion, disease prevention or healthcare. Conclusions The variety of health literacy interventions that are delivered in an academic setting contributes to positive changes in the health outcomes of students in higher education. Investing in the design and delivery of health literacy interventions is one way to reduce their health vulnerability and protect them from the threats. Key messages • When planning health literacy interventions, it is important to know what health benefits they bring. • Health literacy interventions in an academic setting are important for health outcomes.

Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate.

Pomegranate juice concentrate (PJC) is a rich source of polyphenols, which exhibit significant antioxidant activity and potential health benefits for disease prevention and therapy. In this study, the polyphenolic profile of PJC was investigated for the first time, and it was found that PJC can inhibit oxidative damage to bovine serum albumin (BSA) and deoxyribonucleic acid (DNA), as well as acetylcholinesterase, α-amylase, and tyrosinase activities. The primary polyphenols identified in PJC were 4-Hydroxy-3-Methoxybenzoate, epicatechin, catechin, rutin, ferulic acid, P-coumaric acid, and cinnamic acid. Additionally, PJC demonstrated potent antibacterial effects against human pathogens such as Streptococcus mutans and Aeromonas hydrophila and dose-dependently reduced the proliferation of colorectal, breast, and hepatic cancer cells via apoptosis. Furthermore, PJC blocked B-cell lymphoma 2 (BCl-2) and the expression of a potent cyclin-dependent kinase inhibitor (P21) and enhanced tumor protein (P53) expression, compared to both untreated cells and cells treated with fluoropyrimidine 5-fluorouracil (5-FU). As a result, PJC may be a beneficial ingredient in the formulation of emerging natural-compound-based chemotherapy and functional foods and could be utilized by the food, nutraceutical, and pharmaceutical industries.

Diagnostic value of high-risk HPV other than type 16/18 in high-grade cervical neoplasia among cytology-negative women: A multicenter retrospective study.

Human papillomavirus (HPV) is a necessary cause of cervical cancer, and a tool more sensitive than cytology for the early screening of cervical precancers. The two most carcinogenic genotypes HPV 16/18 have been reported in the majority of studies. High-risk HPVs other than HPV 16/18 (non-16/18-hrHPVs) cause approximately a quarter of cervical cancers, and we aimed to analyze the genotype-specific prevalence, risk and diagnostic efficiency of non-16/18-hrHPVs in cervical carcinogenesis among Chinese cytology-negative women. A total of 7043 females who had abnormal cervical testing results from January 2018 to October 2021 were enrolled, among them 3091 were cytology-negative. Descriptive statistics was used to estimate the HPV genotype-specific prevalence, and multivariable logistic regression was used to estimate the genotype-specific non-16/18 hrHPVs risk of cervical carcinogenesis. The evaluation of diagnostic value among HPV genotypes included the possibility of predicting cervical intraepithelial neoplasia grade 2/3 or worse (CIN2+/CIN3+) and the diagnostic efficiency measured by increased referral rate and referral numbers of colposcopies per additional CIN2+/CIN3+ detected. Among HPV-positive cytology-negative women, the five dominant genotypes for CIN2+/CIN3+ were HPV 31/33/35/52/58. HPV 52/58/33 had comparatively high sensitivity and specificity in predicting CIN2+/CIN3+, while the referral strategy of multiple HPV58 required 26 colposcopies to detect 1 CIN3+, compared with 14, 12, and 8 required by multiple HPV52, 31, and 33, respectively. HPV31/33/35/52/58 infections are significant risk factors for cervical lesions, and multiple HPV 31/33/52 infections should be included in the previously recommended HPV16/18 genotyping triage for colposcopy in China, as the benefits of disease prevention may outweigh the disadvantages of increasing requirements for colposcopy services.

Residual respiratory disability after successful treatment of pulmonary tuberculosis: a systematic review and meta-analysis.

Pulmonary tuberculosis (PTB) can result in long-term health consequences, even after successful treatment. We conducted a systematic review and meta-analysis to estimate the occurrence of respiratory impairment, other disability states, and respiratory complications following successful PTB treatment. We identified studies from January 1, 1960, to December 6, 2022, describing populations of all ages that successfully completed treatment for active PTB and had been assessed for at least one of the following outcomes: occurrence of respiratory impairment, other disability states, or respiratory complications following PTB treatment. Studies were excluded if they reported on participants with self-reported TB, extra-pulmonary TB, inactive TB, latent TB, or if participants had been selected on the basis of having more advanced disease. Study characteristics and outcome-related data were abstracted. Meta-analysis was performed using a random effects model. We adapted the Newcastle Ottawa Scale to evaluate the methodological quality of the included studies. Heterogeneity was assessed using the I2 statistic and prediction intervals. Publication bias was assessed using Doi plots and LFK indices. This study is registered with PROSPERO (CRD42021276327). 61 studies with 41,014 participants with PTB were included. In 42 studies reporting post-treatment lung function measurements, 59.1% (I2=98.3%) of participants with PTB had abnormal spirometry compared to 5.4% (I2=97.4%) of controls. Specifically, 17.8% (I2=96.6%) had obstruction, 21.3% (I2=95.4%) restriction, and 12.7% (I2=93.2%) a mixed pattern. Among 13 studies with 3179 participants with PTB, 72.6% (I2=92.8%) of participants with PTB had a Medical Research Council dyspnoea score of 1-2 and 24.7% (I2=92.2%) a score of 3-5. Mean 6-min walk distance in 13 studies was 440.5m (I2=99.0%) in all participants (78.9% predicted, I2=98.9%) and 403.0m (I2=95.1%) among MDR-TB participants in 3 studies (70.5% predicted, I2=97.6%). Four studies reported data on incidence of lung cancer, with an incidence rate ratio of 4.0 (95% CI 2.1-7.6) and incidence rate difference of 2.7 per 1000 person-years (95% CI 1.2-4.2) when compared to controls. Quality assessment indicated overall low-quality evidence in this field, heterogeneity was high for pooled estimates of nearly all outcomes of interest, and publication bias was considered likely for almost all outcomes. The occurrence of post-PTB respiratory impairment, other disability states, and respiratory complications is high, adding to the potential benefits of disease prevention, and highlighting the need for optimised management after successful treatment. Canadian Institutes of Health Research Foundation Grant.

Appeals of Chinese medicinal cuisine promotion

Chinese medicinal cuisine is one of the Chinese traditional cooking arts based on the concept of dietary treatment, which emphasizes both health promotion and disease prevention benefits. To promote this culinary art, health appeals frequently practiced by functional and organic foods advertisements seem the logical choice. Based on theories of goal framing, regulatory focus and health consciousness, an experiment with factorial design was conducted to investigate the persuasive effectiveness of different appeals of medicinal cuisine advertisements on ad attitude, product attitude and consumption intention. Multivariate analysis was employed to analyze the collected data. The results showed that positive frame message with promotion focus prime and negative frame message with prevention focus prime are more favorable compared to their opposites, the effect of cuisine attitude from prevention focus is significantly larger than that from promotion focus, and health consciousness is one of the factors positively related to outcome variables.

Natural nutraceuticals, especially functional foods, their major bioactive components, formulation, and health benefits for disease prevention: an overview

Nutraceuticals play wide range of important roles, from health promotion, increasing life expectancy, maintaining body cell integrity, to reducing the risks of many diseases. As consumers continue to be attracted to nutraceuticals, such as superfoods, vegetables, fruits, high-protein foods, eating healthy intertwines with finding the right balance. Nowadays, the nutraceutical industries are among the many that target to meet the growing and dynamic consumers’ expectations. Adding to their increasing interest and general acceptability, consumers continue to be attracted to nutraceuticals. How nutraceuticals, especially functional foods, etc., help in tackling health challenges increase the interest among several researchers in this subject area, and given the ever-growing need across communities around the globe for healthy living, strengthens the need for continued synthesis of published information to supplement existing knowledge. This overview, therefore, discusses natural nutraceuticals, especially functional foods, their major bioactive components, formulation, health benefits for disease prevention.

Does Modulation of an Epigenetic Clock Define a Geroprotector?

There is growing interest in the development of interventions (e.g., drugs, diets, dietary supplements, behavioral therapies, etc.) that can enhance health during the aging process, prevent or delay multiple age-related diseases, and ultimately extend lifespan. However, proving that such ‘geroprotectors’ do what they are hypothesized to do in relevant clinical trials is not trivial. We briefly discuss some of the more salient issues surrounding the design and interpretation of clinical trials of geroprotectors, including, importantly, how one defines a geroprotector. We also discuss whether emerging surrogate endpoints, such as epigenetic clocks, should be treated as primary or secondary endpoints in such trials. Simply put, geroprotectors should provide overt health and disease prevention benefits but the time-dependent relationships between epigenetic clocks and health-related phenomena are complex and in need of further scrutiny. Therefore, studies that enable understanding of the relationships between epigenetic clocks and disease processes while simultaneously testing the efficacy of a candidate geroprotector are crucial to move the field forward.

Observational and clinical evidence that plant-based nutrition reduces dietary acid load.

Contemporary diets in Western countries are largely acid-inducing and deficient in potassium alkali salts, resulting in low-grade metabolic acidosis. The chronic consumption of acidogenic diets abundant in animal-based foods (meats, dairy, cheese and eggs) poses a substantial challenge to the human body's buffering capacities and chronic retention of acid wherein the progressive loss of bicarbonate stores can cause cellular and tissue damage. An elevated dietary acid load (DAL) has been associated with systemic inflammation and other adverse metabolic conditions. In this narrative review, we examine DAL quantification methods and index observational and clinical evidence on the role of plant-based diets, chiefly vegetarian and vegan, in reducing DAL. Quantitation of protein and amino acid composition and of intake of alkalising organic potassium salts and magnesium show that plant-based diets are most effective at reducing DAL. Results from clinical studies and recommendations in the form of expert committee opinions suggest that for a number of common illnesses, wherein metabolic acidosis is a contributing factor, the regular inclusion of plant-based foods offers measurable benefits for disease prevention and management. Based on available evidence, dietary shifts toward plant-based nutrition effectively reduces dietary-induced, low-grade metabolic acidosis.

Is Organic Food Good for Health and the Environment?

Global organic food consumption has increased significantly in the last decade. Organic product agriculture is a one-of-a-kind technique that strikes a balance between environmental sustainability and consumer safety by developing a good client relationship with the end customer or consumer group. According to environmental studies, organic farming is less damaging to the environment than traditional agricultural methods. Recent studies show that customers who eat organic foods have lower pesticide exposure, which results in fewer human diseases. Organic food has more nutrients. However, the evidence to support this is lacking, and no well-designed human study has shown any direct health benefits or disease prevention benefits from consuming organically produced food. Furthermore, some researchers mention that for some types of plants, the nutrients in the case of conventional products were better. This study aims to identify the benefits of organic foods over conventional foods and consumers' beliefs about health and environmental benefits associated with organic foods. Secondary data for this research have been gathered from different international journals and the Internet, utilizing information from a variety of scholarly publications. The author addresses the present state of organic farming, as well as the benefits and disadvantages of consuming organic and conventional food,. The article has also investigated the effects of organic and conventional food production on both health and the environment.

Beyond Purple Tomatoes: Combined Strategies Targeting Anthocyanins to Generate Crimson, Magenta, and Indigo Fruit

The range of colours of many flowers and fruits is largely due to variations in the types of anthocyanins produced. The degree of hydroxylation on the B-ring affects the hue of these pigments, causing a shift from the orange end of the visible spectrum to the blue end. Besides colour, this modification can also affect other properties of anthocyanins, including the ability to protect the plant against different stresses or, when included in the human diet, to provide benefits for disease prevention. The level of hydroxylation of the B-ring is determined by the activity of two key hydroxylases, F3′H and F3′5′H, and by the substrate preference of DFR, an enzyme acting downstream in the biosynthetic pathway. We show that, in tomato, a strategy based on fruit-specific engineering of three regulatory genes (AmDel, AmRos1, AtMYB12) and a single biosynthetic gene (AmDFR), together with the availability of a specific mutation (f3′5′h), results in the generation of three different varieties producing high levels of anthocyanins with different levels of hydroxylation. These tomatoes show distinctive colours and mimic the classes of anthocyanins found in natural berries, thus providing unique near-isogenic material for different studies.

Emerging Applications of Nanotechnology in Healthcare Systems: Grand Challenges and Perspectives.

Healthcare, as a basic human right, has often become the focus of the development of innovative technologies. Technological progress has significantly contributed to the provision of high-quality, on-time, acceptable, and affordable healthcare. Advancements in nanoscience have led to the emergence of a new generation of nanostructures. Each of them has a unique set of properties that account for their astonishing applications. Since its inception, nanotechnology has continuously affected healthcare and has exerted a tremendous influence on its transformation, contributing to better outcomes. In the last two decades, the world has seen nanotechnology taking steps towards its omnipresence and the process has been accelerated by extensive research in various healthcare sectors. The inclusion of nanotechnology and its allied nanocarriers/nanosystems in medicine is known as nanomedicine, a field that has brought about numerous benefits in disease prevention, diagnosis, and treatment. Various nanosystems have been found to be better candidates for theranostic purposes, in contrast to conventional ones. This review paper will shed light on medically significant nanosystems, as well as their applications and limitations in areas such as gene therapy, targeted drug delivery, and in the treatment of cancer and various genetic diseases. Although nanotechnology holds immense potential, it is yet to be exploited. More efforts need to be directed to overcome these limitations and make full use of its potential in order to revolutionize the healthcare sector in near future.

P8 Acceptance of Legumes as a Food Group Among Sri Lankan Young Adults

<h3>Background</h3> Although legumes are a staple food worldwide, its consumption has seen a decline in recent times. <h3>Objective</h3> To evaluate the acceptance of legumes as a food group and to identify the levels of legume consumption among Sri Lankan young adults. <h3>Study Design, Settings, Participants</h3> A cross-sectional online survey focusing on the legume consumption patterns, perceived importance, benefits and barriers for consumption and remedies to promote legumes as a food group was evaluated from a conveniently selected group of undergraduate students (n = 180) of ages 19-24 in July 2020. <h3>Measurable Outcome/Analysis</h3> Legume consumers were subdivided based on their recent legume consumption pattern: those who consume below current dietary recommendation (<45g/d, low), those consume above current dietary recommendations; but below levels demonstrating nutritional and disease prevention benefits (45g and 87.5g/d, marginal), and at levels demonstrating nutritional and disease prevention benefits (>87.5g/d, disease prevention). The legume consumption groups were identified to evaluate their differences in consumption, perceived importance, benefits and barriers. The data from the online survey were analyzed using descriptive statistics rather than using significance testing. <h3>Results</h3> The majority were legume consumers (75%) and the mean intake of legume consumption was 114.64g/d, while consumption of lentils (48%) accounts for nearly half of the legume consumption compared to other legume varieties (52%). Most consumers belonged to the disease prevention consumer group (59%). Lentils were the most often consumed, followed by green legumes, chickpeas and green grams, which were most commonly consumed as a curry or either as a breakfast item. Consumers were well-aware of legumes' benefits as a good protein source and as a meat alternative and had fewer barriers for their consumption. The main barriers perceived by non-consumers and low consumers were the cost of legumes and preparation challenges. <h3>Conclusion</h3> The acceptance of legumes as a food group among the young adults was fair and the differences between consumption were due to poor knowledge about legumes' disease prevention benefits, legume and recipe variety, and legume preparation techniques.

Vaccine hesitancy in the office: what can I do?

What office-based interventions in primary care help reduce vaccine hesitancy? Clinicians should explicitly recommend vaccination and focus discussion on the disease-prevention benefits to the individual more than correcting misinformation or on the benefits to society. Interventions are more

A review: Potential of resveratrol and its analogues to mitigate diseases via gut microbial modulation

The stilbenoids form a group of bioactive phenolic compounds found in various plant species whose original functions are to act as protective compounds against microbial infections and toxins. Among the stilbenoids, resveratrol is the most well-studied and has been shown to exert multiple benefits in disease prevention. The bioavailability of resveratrol is one of the major limitations in its role as a disease-prevention agent; however, it has exhibited biological activity in animals and clinical models. Gut microbiota may play a role in overcoming limited bioavailability via microbial transformations. On the other hand, the modulatory effects of stilbenoids on gut microbial dysbiosis induced by several diseases can be crucial in disease alleviation. In addition to gut microbial metabolites, such as SCFAs (short-chain fatty acids), stilbenoids can be used to inhibit microbial growth, making their use a potential strategy in preventing disease progression. In this review, the interactions of stilbenoids (with a major focus on resveratrol and pterostilbene) and gut microbiota will be discussed to clarify the importance of gut microbiota in the strategy of “disease prevention via phytochemicals.”

Lactobacillus commensals autochthonous to human milk have the hallmarks of potent probiotics.

Maternal milk is an important source of essential nutrients for the optimal growth of infants. Breastfeeding provides a continuous supply of beneficial bacteria to colonize the infant gastrointestinal tract (GIT) and offers health benefits for disease prevention and immunity. The purpose of this study was to isolate novel probiotic strains from the breast milk of native Pakistani mothers and to evaluate their probiotic potential. We isolated 21 strains of bacteria from the colostrum and mature milk of 20 healthy mothers, who had vaginal deliveries and were not taking antibiotics. After phenotypic and genotypic characterization, these isolates were tested for survival in the GIT using in vitro acid and bile tests. Nine strains showing good acid tolerance were assessed for their growth rate, bile resistance and ability to hydrolyze bile salts. Out of the four Lactobacillus isolates adjudged to be most promising as probiotics, three were Lactobacillus fermentum strains and one was a strain of Lactobacillus oris. This study demonstrates that human milk is a viable source of commensal bacteria beneficial to both adults and babies.

In vitro antidiabetic evaluation of nanoparticles encompass dual bioflavonoid

The flavonoids which are widely spread in plants. It can be categorized as flavonols, flavonols, flavanones, flavones, anthocyanidin and isoflavones. Apigenin and Hesperidin account these three flavonoids used a significant proportion of flavonol intake in the diet as a functional food. Among all other flavonoids, Apigenin has many health cares and disease-prevention benefits. Polymer-based formulations, such as nanoemulsions and solid lipid nanoparticles, have been developed to increase the therapeutic efficacy of flavonoids. New drug delivery systems such as Dual Loaded Flavono Nanoparticulate System (DLFNPs) have not yet been studied with Apigenin and Hesperidin. In the present study, dual loaded flavonol nanoparticulate systems have been developed for oral delivery of Apigenin to enhance its antioxidant and antidiabetic activities. The fabrication of Dual Loaded Flavono Nanoparticles by Nano precipitation technique. Prepared Dual Loaded Flavono polymeric nanoparticles were subjected to characterization and various pharmacological activities. In vitro results revealed that the Alfa amylase percentage of inhibition 33.5% for Nanoparticles Encompass Dual Bioflavonoid by the indication pet ether extracts have lesser activity. This work will be useful for diabetic research workers to be found in the new chemical entity for the treatment of DM and its associated diseases.