Benefits Of Medicine Research Articles

Medical students and house officers’ perception, attitude and potential barriers towards artificial intelligence in Egypt, cross sectional survey

BackgroundArtificial intelligence (AI) is one of the sectors of medical research that is expanding the fastest right now in healthcare. AI has rapidly advanced in the field of medicine, helping to treat a variety of illnesses and reducing the number of diagnostic and follow-up errors.ObjectiveThis study aims to assess the perception and attitude towards artificial intelligence (AI) among medical students & house officers in Egypt.MethodsAn online cross-sectional study was done using a questionnaire on the Google Form website. The survey collected demographic data and explored participants’ perception, attitude & potential barriers towards AI.ResultsThere are 1,346 responses from Egyptian medical students (25.8%) & house officers (74.2%). Most participants have inadequate perception (76.4%) about the importance and usage of AI in the medical field, while the majority (87.4%) have a negative attitude. Multivariate analysis revealed that age is the only independent predictor of AI perception (AOR = 1.07, 95% CI 1.01–1.13). However, perception level and gender are both independent predictors of attitude towards AI (AOR = 1.93, 95% CI 1.37–2.74 & AOR = 1.80, 95% CI 1.30–2.49, respectively).ConclusionThe study found that medical students and house officers in Egypt have an overall negative attitude towards the integration of AI technologies in healthcare. Despite the potential benefits of AI-driven digital medicine, most respondents expressed concerns about the practical application of these technologies in the clinical setting. The current study highlights the need to address the concerns of medical students and house officers towards AI integration in Egypt. A multi-pronged approach, including education, targeted training, and addressing specific concerns, is necessary to facilitate the wider adoption of AI-enabled healthcare.

Astragalus membranaceus: A Traditional Chinese Medicine with Multifaceted Impacts on Breast Cancer Treatment

Breast cancer, the most prevalent malignant tumor among women globally, remains a critical area of focus for researchers striving to refine therapeutic approaches. As an important component of traditional Chinese medicine, Astragalus membranaceus (AM) has demonstrated potential for multifaceted impacts on breast cancer treatment through various mechanisms. To guide clinical practice and further explore the under-researched field of AM in breast cancer treatment, this paper mainly reviews the regulatory roles of AM-derived compounds and extracts on breast cancer cell proliferation, migration, invasion, and chemoresistance. Furthermore, this study delves into the synergistic effects observed when AM is co-administered with chemotherapeutic agents, including the enhancement of chemosensitivity, mitigation of toxic side effects, and reversal of drug resistance. This review indicates that AM holds promise not only as a therapy in breast cancer treatment but also paves the way for innovative integrated treatment approaches that combine the benefits of traditional medicine with modern pharmaceuticals. Nevertheless, future research endeavors are also urged to elucidate the in vivo pharmacological effects and underlying mechanisms of AM to inform more effective clinical treatment strategies.

HERBAL-INFUSED EGYPTIAN BEE HONEY: A BOON OR A CURSE? ITS IMPACT ON SENSORIAL, PHYSICOCHEMICAL, & ANTIBACTERIAL PROPERTIES

Herbal honey mixture remedies are well known for their therapeutic benefits in traditional medicine. This research aspired to assess melissopalynological, sensorial, physicochemical, & antibacterial activity for three types of honey (clover, citrus, and cucurbits) and their mixtures with black seed, date palm pollen, & wheat germ at 1, 2.5, & 5%. The best mixtures were chosen according to overall acceptability. Consumer’s preference was given to raw honey. However, some mixtures were as acceptable as raw honey. Honey’s naturalness is characterized by a predominance of fructose over glucose, as revealed by melissopalynological analysis. Herbs infused with discrete kinds of honey typically exhibited higher electrical conductivity, free acidity, ash, H2O2, and HMF levels, but lower pH. The type of honey herb may affect the physicochemical characteristics of honey in different ways. Honey, whether used alone or in combination with the three herbs, demonstrated the same significant antibacterial effect for Staphylococcus aureus and MRSA. Inhibition zones of honey and its mixtures were lower than the control for Pseudomonas aeruginosa. Most undiluted samples created larger bacterial inhibition zones than their 50% diluted counterparts.

Literature Supported Model for Implementing Effective Use of Simulation and Debriefing in Paramedic Education

The purpose of this paper is to provide a literature supported pathway to incorporating effective simulated learning experiences (SLE) into paramedic precertification courses. The literature is sparse on simulation incorporation into paramedic programs; however, it demonstrates extensive benefit in medicine and nursing. Paramedic educators have access to simulation equipment, yet seldom use it for more than skills development. Studies show that effective simulation can lead to improved patient care, outcomes, and safety, but requires ongoing faculty development, especially in the area debriefing. Learning the structure and purpose of debriefing and committing to practicing the skill is crucial to unpacking meaning from a SLE. This paper describes the reasons for implementing SLEs into paramedic precertification courses, suggests a comprehensive model for faculty development, describes a debriefing method for immersive SLEs, and provides guidance for ongoing simulation professional development.

"I Have Come Because I See You Care About Me": Recruiting Older Black Americans for Genomic Research.

The lack of diversity in genomic studies is a disparity that influences our understanding of human genomic variation and threatens equity in the benefits of precision medicine. Given our current genomic research with Black older adults, we conducted a qualitative study to elucidate participants' knowledge, attitudes, and beliefs about genomic research and research participation and what factors contribute to their willingness to participate and to gain insights into barriers that researchers may have in recruiting Black Americans. We conducted semistructured interviews (N=16) with previous genomic research participants, and an inductive thematic approach was used to code and interpret the data. The mean age was 70, 82% reported <$15,000 annual income, and 100% participated in genomic research. The results note that genomic research is poorly understood despite participation in prior genomic studies, and cultural beliefs about health and managing health impact an individual's research participation. Although not all participants identified with historical distrust, those who did report health system distrust also contributed distrust in research. Relationship building facilitates research participation, especially when perceived as personally relevant and meaningful. Participant incentives and convenience to engage in the study are less important if the personal benefits or relevance of the research are clear. Our results provide new context into the importance of relationship building and research literacy and highlight new considerations for engaging racially diverse populations in research.

Basal Area, Soil, and Elevation Factors Affecting The Essential Oils Yield, Geranyl Acetate, and D-Limonene of Zanthoxylum acanthopodium

Andaliman (Z. acanthopodium) is an aromatic Non-Timber Forest Product (NTFP) plant species that contains essential oils (EOs), which have various benefits for cuisine, medicine, and cosmetics. This study is essential because it is not yet known what biotic factors (basal area) and abiotic factors (soil and elevation) influence the EOs yield, geranyl acetate, and D-limonene as skin anti-aging. This study investigated whether the basal area, soil, and elevation factors influence the EOs yield, geranyl acetate, and D-limonene content of Andaliman fruit. The biotic and abiotic factors were measured from 9 sample plots representing the Andaliman habitats in North Sumatra, Indonesia. A vegetation analysis was conducted to derive the Andaliman basal area of each sample plot. Soil samples were taken randomly in each plot and analyzed for their physicochemical (pH, C, SOM, N, CNR, P, K, Ca, Mg, CEC, BS, SA, DU, CL, WC, and BD) contents. Elevation gradients were measured on each plot. The EOs of Andaliman fruit include yield, geranyl acetate, and D-limonene as skin anti-aging. The data were analyzed using Partial Least Square Regression for Generalized Linear Models (PlsRglm) to determine which biotic and abiotic factors influenced the EOs yield, geranyl acetate, and D-limonene. This study confirmed that clay soil texture was the main factor influencing EOs of Andaliman fruit yield, geranyl acetate, and D-limonene. Apart from soil factors, basal area, and elevation factors were also essential to consider when cultivating Andaliman fruit as a source of skin anti-aging substances. HIGHLIGHTS To the best of the authors’s knowledge, the first study in Indonesia 2024 that integrated biotic and abiotic factors affecting the essential oils (EOs) yield, geranyl acetate and D-limonene contents derived from of acanthopodium fruit as skin anti-aging substance. Using Partial Least Square Regression for Generalized Linear Models (PlsRglm) method for analyzing basal area, soil factors and elevation that influence the EOs of acanthopodium fruit. Of all the abiotic and biotic factors studied, Clay soil texture is the most critical factor that influences acanthopodium fruit EOs as skin anti-aging substances. Basal area and elevation are also essential factors in the cultivation of aromatic Andaliman plants. GRAPHICAL ABSTRACT

Evaluation of Immediate Release Tri-Layer Tablets for Analgesic and Antiulcer Properties in Experimental Animals.

Using animals as a test subject, we aimed to determine whether tri-layer tablets filled with ibuprofen and ranitidine had any effect on pain or ulcers. The effectiveness against ulcers caused by acetic acid and cold stress was tested. Six rats made up each of the four groups that were randomly assigned. As a control, I was given a solvent and placed in the group. The second group served as the control, while groups III and IV were used to evaluate 100 mg and 200 mg tri-layer tablets, respectively. The oral gavage method was used to administer all medications. It was shown that the number of writhing was 5.12 in the T2 group compared to the control group, indicating a decrease in the medication-treated groups. The heated technique demonstrated the substantial analgesic activity of the medication under examination. After 120 minutes, the drug-treated groups had a latency time that was 9.8 seconds longer than the control group. Treatment with the experimental medicine lowered the ulcer index in an ulcer model generated by acetic acid. T2 had a value that was 0.43 lower than the control group. T2 group showed a significant reduction in ulcer index to 0.33 in ulcers generated by cold restraint stress. This study provides support for the use of multilayered tablets in the treatment of pain and ulcer disorders, since it demonstrated the analgesic and antiulcer benefits of the test medicine in animal models. More studies to determine the exact mechanism are necessary.

Precision Medicine With Data-driven Approaches: A Framework For Clinical Translation

Precision medicine-based approaches differentiate themselves by taking into consideration subpopulation variability (e.g. genetic variations, age, gender, race, addictions). To date, traditional models, such as Trial-and-Error Dosing, Empirical Treatment Guidelines, Statistical and Actuarial Models, Pathophysiological Models, and Clinical Judgment and Experience, have been generalized in healthcare fields. However, more comprehensive and innovative technologies are required besides these conventional modelings, which are subject to various limitations such as low efficiency and incapability of processing complex biological systems. Here we review diverse machine learning (ML) algorithms integrated with big data and omics and its applications in various aspects of precision medicine. ML is the branch of artificial intelligence (AI), which has been rapidly developed and highlighted as a promising method to decrease diagnostic errors and aid clinicians with decision-making in recent decades. We focused on applications of ML models such as support vector machine (SVM), K Nearest Neighbor (KNN) random forest (RF), convolutional neural networks (CNNs) and deep learning in drug toxicity prediction, cardiovascular diseases, neurodegenerative diseases, and cancer therapies within precision medicine and specific benefits and challenges of each. This review provides insights on the wider utilization in clinical environments by recognizing current advantages that are expected to expand the scope of AI-driven methods and issues that need to be addressed for further studies.

Therapeutic Potential and Pharmacological Activities of Moscatilin in Medicine for the Treatment of Cancers and other Human Complication: A Review of the Active Components of Dendrobium Species

Background: Plant-derived byproducts have been used to treat numerous kinds of human complications in medicine since a very early age. Moscatilin is a bibenzyl compound found to be present in Dendrobium. Moscatilin, also called 4,4′-dihydroxyl-3,3′,5-trimethoxybibenzyl has potential benefits in medicine for the treatment of ovarian, lung, breast, esophageal, hepatic, colorectal, pancreatic and neck squamous cancer. Methods: The present work summarized the health-beneficial aspects of moscatilin for its effectiveness against numerous kinds of cancerous disorders in medicine. Pharmacological activities and analytical aspects of moscatilin have been analyzed in the present work through available scientific data on Google, Scopus, Science Direct, and PubMed. Results: Scientific data analysis of moscatilin signified their therapeutic effectiveness against ovarian cancer, lung cancer, breast cancer, esophageal cancer, hepatic cancer, colorectal cancer, pancreatic cancer, neck squamous cell cancer, apoptosis, and angiogenesis. Further, moscatilin has a significant effect on inflammation, Alzheimer's disease, diabetic neuropathy, and retinal ischemia. However, analytical data on moscatilin were also discussed in the present work in order to know the effective separation, isolation and identification of moscatilin. Conclusion: Scientific information on moscatilin presented in this work will be helpful to all scientific people to understand the biological importance and therapeutic potential of moscatilin in medicine.

Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy.

Natural products have proven to be promising anti-cancer agents due to their diverse chemical structures and bioactivity. This review examines their central role in cancer treatment, focusing on their mechanisms of action and therapeutic benefits. Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids and polyphenols, which exhibit various anticancer properties. These compounds induce apoptosis, inhibit cell proliferation and cell cycle progression, interfere with microtubule formation, act on topoisomerase targets, inhibit angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance and activate immune cells. Herbal anti-cancer drugs offer therapeutic advantages, particularly selective toxicity against cancer cells, reducing the adverse side effects associated with conventional chemotherapy. Recent studies and clinical trials highlight the benefits of herbal medicines in alleviating side effects, improving tolerance to chemotherapy and the occurrence of synergistic effects with conventional treatments. For example, the herbal medicine SH003 was found to be safe and potentially effective in the treatment of solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients with advanced cancer. The current research landscape on herbal anticancer agents is extensive. Numerous studies and clinical trials are investigating their efficacy, safety and mechanisms of action in various cancers such as lung, prostate, breast and hepatocellular carcinoma. Promising developments include the polypharmacological approach, combination therapies, immunomodulation and the improvement of quality of life. However, there are still challenges in the development and use of natural products as anti-cancer drugs, such as the need for further research into their mechanisms of action, possible drug interactions and optimal dosage. Standardizing herbal extracts, improving bioavailability and delivery, and overcoming regulatory and acceptance hurdles are critical issues that need to be addressed. Nonetheless, the promising anticancer effects and therapeutic benefits of natural products warrant further investigation and development. Multidisciplinary collaboration is essential to advance herbal cancer therapy and integrate these agents into mainstream cancer treatment.

Present Status Of Trace Elements And Heavy Metals In AyurvedicMedicines

The therapeutic benefits of Ayurvedic medicines are historically well known. Sometimes the concentration of trace and heavy metals can vary depending on their geographical sources, whichcan cause extremely harmful effects. Thus, one of the most important topics nowadays is the assessment of toxicity and safety of these Ayurvedic medicines. The presence of these constituents in the soil of the study area can be linked to the formation of toxicants of these harmful elements. They should be used with caution in the field as their uncontrolled ingestion can have harmful dangerous consequences on their consumers. Analysis by atomic absorption spectrometry allowedthe detection of trace and heavy metals. This paper discusses the current status of trace elements and heavy metals in Ayurvedic medicine. Along with this, the effects of trace elements and heavymetals on human health have also been explained. This research paper also contains about in whatway to determination of Trace element and heavy metal from ayurvedic medicines specially “Ras

CRITICAL REVIEW ON PUNARNAVASHTAK KWATHA: AN AYURVEDIC POLYHERBAL FORMULATION

Ayurveda, an ancient system of medicine, represents a vast reservoir of knowledge that is not only historically rich but also profoundly intricate and deep. Far from being a primitive practice, Ayurveda focuses on the preventive aspects of health, emphasizing the importance of maintaining balance and harmony in the body to avoid diseases. This holistic approach involves detailed discussions on the diagnosis and management of a wide range of physical and mental disorders, offering a comprehensive framework for health and well-being. One notable formulation within this traditional system is Punarnavashtak Kwatha. This herbal decoction has garnered significant attention for its efficacy in treating conditions such as shotha (inflammation) and pandu (anemia). The formulation's name, "Punarnavashtak," refers to its primary ingredient, Punarnava, a herb renowned for its rejuvenating properties. The Kwatha, or decoction, form is a widely used and trusted method of preparing Ayurvedic medicines, allowing for the active ingredients of herbs to be effectively extracted and utilized. Punarnavashtak Kwatha exemplifies the importance of Kwatha Kalpana, a widely used dosage form in Ayurvedic medicine that ensures effective extraction and utilization of herbal active ingredients. Ancient Ayurvedic texts provide extensive references to this formulation, detailing its preparation, dosage, and therapeutic applications. Its historical significance, combined with modern therapeutic success, underscores the enduring benefits of Ayurvedic medicine. This formulation not only reflects the depth and richness of Ayurvedic knowledge but also its practical application in promoting health and treating diseases effectively in today's world.

Potential protective effects of Acacia nilotica (L.) against gentamicin - induced nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in Wistar rats

Gentamicin-induced nephrotoxicity limits its therapeutic use as an effective aminoglycoside. Herbal drugs have a distinct place in the world of pharmaceuticals since they are safe, effective, and cost-efficient. Acacia nilotica (L.) has long been recognized for its antihypertensive, antioxidant, anti-inflammatory, and antiplatelet aggregatory benefits in traditional medicine. Still, the protective effect of Acacia nilotica on gentamicin-induced nephrotoxicity is still unknown. Thus, the goal of this research was to examine the protection of ethanolic extract of Acacia nilotica (ANE) against nephrotoxicity triggered by Gentamicin. Thirty-six rats were randomly divided into six groups containing six rats in each group. The distilled water were given in control group. The rats in groups two and three were administered metformin and gentamicin respectively. In groups five and six, rats were administered ANE at doses of 100 and 200 mg/kg. Ten days of daily treatments were given. The urea, creatinine, uric acid, and LDH levels were analyzed on serum, whereas histological evaluation, MDA, GSH, SOD, CAT, TNF-α, IL-6, and caspase-3, were performed on kidney tissue on day 11. The gentamicin-treated group exhibited a significantly elevated MDA, and lower levels of antioxidant enzymes. Kidney function markers, inflammatory markers and caspase-3 expression were significantly elevated in the gentamicin-treated group. ANE significantly restored kidney function biomarkers, upregulated biochemical levels, inhibited TNF-α, caspase-3, cytokine expression, and reduced histological lesions. In conclusion, ANE has the ability to prevent gentamicin-induced nephrotoxicity and reduce nephrotoxic damage. As such, it may represent an effective therapy for patients receiving gentamicin treatment.

Putting meat on the bone: how to fast-track innovative medicines to those who need them and generate data to justify continued use.

Regulatory agencies worldwide have taken significant steps to expedite approval and market authorization of medicines based on their potential to address areas of significant unmet medical need and severe disease burden. However, initial approval of such medicines is often accompanied by limited evidence of benefit, posing a conundrum for payers and health systems who may desire greater certainty of their value. This paper describes a system of "accelerated access" to manage these tensions and coordinate activities across stakeholders, based on discussions held at a multi-stakeholder convening in June 2023. We focus on 6 core, near-term actions that can be taken to improve the current system: clarifying criteria for expedited regulatory approval, enhancing stakeholder coordination, creating expedited pathways in payer and health technology assessment settings, developing joint regulatory/payer/health technology assessment guidance on study design and data needs, linking pricing policy to data uncertainty, and improving patient and public understanding of the processes involved as well as the risks and benefits of the relevant medicines. Many of these actions will require additional resources and personnel, and some will necessitate unprecedented levels of coordination. Nevertheless, each action is designed to work with minimal adjustments to the current system rather than demanding an entirely new approach.

Prevalence, Reasons, and Perceived Benefits of Complementary and Alternative Medicine Among Patients With Rheumatic Diseases in Morocco: A Monocentric Cross-Sectional Study.

Background In general, rheumatologists often have limited knowledge regarding the use of complementary and alternative medicine (CAM) among patients with rheumatic diseases. Understanding the prevalence, reasons for use, and perceived benefits of CAM can help improve patient care and guide clinical practices. This study aimed to assess the prevalence, reasons for use, and perceived benefits of cupping therapy, apitherapy, and traditional cautery treatments among patients with rheumatic diseases. Additionally, it aimed to explore adverse effects, location and pricing disparities in CAM practices, information sources, and the rate of reporting CAM use to treat rheumatologists and to identify factors associated with the use of these CAM approaches. Methodology This single-center, cross-sectional study was conducted in a Moroccan University Hospital and included patients receiving care for rheumatic diseases during hospitalization or outpatient visits from January 2024 to March 2024. The data were collected using a structured, validated, and pilot-tested questionnaire administered by attending rheumatologists. The questionnaire aimed to gather demographic information and to identify patients using CAM, collecting data related to their utilization. Results A total of 100 patients were enrolled (mean age: 52.3 ± 12.8 years, 75% female). Among them, 43% had chronic inflammatory rheumatism. Additionally, 46% reported using at least one of the three CAM methods studied, with 36% using cupping therapy (specifically the wet method), 9% using apitherapy, and 16% using traditional cautery. The main reason for using CAM was to alleviate their pain (55%). Perceptions of effectiveness were reported by 38% of patients using cupping therapy, 20% using apitherapy, and 5.9% using traditional cautery. The use of CAM was significantly lower in patients with a university education (odds ratio = 0.05, 95% confidence interval = 0.003-0.92). Conclusions Our study revealed a significant prevalence of CAM use among patients with rheumatic diseases in Morocco, with cupping therapy emerging as the most commonly utilized method. These findings underscore the importance of enhancing awareness and understanding of CAM practices among both patients and healthcare providers to promote more structured and informed CAM practices.

Using an interprofessional decision-making model to determine the level of collaborative decision-making in a virtual learning environment

Medicine and pharmacy students benefit from interprofessional education that supports the learning of collaboration skills for medicines management decision-making. However, if and how students undertake collaborative decision-making processes in interprofessional student teams has not been investigated. The aim of this study was to determine the level to which pharmacy and medical students collaborate to make medicines management decisions in a learning activity. Eight pharmacy and 13 medical students completed a 9-item survey to evaluate a interprofessional learning activity. A secondary analysis of survey data using a deductive approach, according to the Model of Interprofessional Decision-Making was undertaken. Different levels of collaboration were identified in the students’ responses ranging from the first and lowest level in the model, Individual Decision Making, to the fourth and highest level, Shared Decision. Most student responses were categorised as level three-Deliberation. Findings from this study indicate that pharmacy and medical students collaborate to different levels with each other to make patient care decisions. Further examination is required to see if this is usual variation or related to the design of the learning activity.

β + surgical radio-guidance using a small Compton-angles collimation probe

The fields of radio-guided surgery and interventional nuclear medicine benefit from a growing array of technologies that aid novel healthcare interventions. Among them, surgery probes able to efficiently detect β + emitters are essential to localize tumors previously detected in PET images. Different methods have been proposed for 18F radio-guidance within the body such as detection of 511 keV annihilation photons using electronically or mechanically collimated probes. The main limitations to the widespread use of these techniques are the lack of precise directional capabilities and inadequate sensitivity. We first used the Monte Carlo simulation platform GATE to determine the optimal signal to noise ratio that can be achieved with an ideal probe. Then, we focused on investigating a small Compton-angles collimation prototype probe followed by the construction of an initial proof of concept demonstrator. The performance of the small Compton-angles collimation probe was compared with a commercial probe based on mechanical collimation in terms of sensitivity and directionality. Monte Carlo simulations showed that in case of an ideal probe, with a tumor of 1 cm diameter positioned 5 mm under the skin and with a SUV of 2, the measured signal to background ratio would be of the order of 25%. The small Compton-angles collimated probe prototype showed significantly improved directionality compared to the commercial probe with mechanical collimation, despite having a sensitivity lower than the commercial probe. Monte Carlo simulations provide insights into the substantial impact of the background on the measured signal. Furthermore, the application of small Compton-angles collimation yields promising outcomes, particularly in terms of improving the directionality, with the objective of enhancing the detection of tumors. In addition, the studied prototype probe sensitivity can possibly be improved by upgrading the detector crystal material and geometry.

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.

Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims to provide an overview of the current practices and perceived effectiveness of polynucleotides in aesthetic medicine. A comprehensive search of the literature was conducted using keywords related to polynucleotides, cosmetic application, and aesthetic application. Studies were selected based on their relevance to aesthetic medicine and the inclusion of human subjects. The review found that polynucleotides have been used to improve skin texture, reduce wrinkle depth, and enhance facial appearance. The studies reported varying degrees of efficacy and safety, with some studies demonstrating significant improvements in skin elasticity and hydration. However, others reported limited or no benefits. The review also highlighted the need for further research to establish the optimal use and efficacy of polynucleotides in aesthetic medicine. While the existing literature suggests that polynucleotides may have potential benefits in aesthetic medicine, more research is needed to fully understand their mechanisms of action and optimal use. Clinicians should be aware of the current limitations and potential risks associated with the use of polynucleotides in aesthetic medicine.

Profitability Analysis of Long Coriander Crop Share by Small-Scale Producers in Battambang, Cambodia

This paper is intended to introduce Long Coriander, the best-known leafy vegetable in Southeast Asia. It is a member of the Coriander family. It has a strong coriander scent and adds flavor to common ingredients in Central and Southeast Asian cuisine, particularly in soups, curries, and noodle dishes. Beyond its culinary uses, Long Coriander also has many benefits in medicine. To meet the criteria of this study, researchers seek to investigate the profitability of the Long Coriander crop for small-scale producers in Cambodia&amp;apos;s Battambang Province. It weighs the revenue from producing Long Coriander against the costs of planting and harvesting its crop. The study also illustrates the estimated total revenue and costs for each planting. Producing Long Coriander may beneficially result in large sums of earnings for farmers, with a profit margin of approximately 57%. Furthermore, according to an economic efficiency (EE) analysis, the cost-to-revenue ratio is higher than 1. This proves that the total amount of revenue made from the sale of Long Coriander outweighs the costs of planting and harvesting, so small-scale producers are convincingly supposed to earn more money from this crop. This research study, through dedication and commitment, aims to address the profitability potential of Long Coriander production by integrating the fundamental economic analysis methods to gather rich data that may enhance and influence further agricultural research.

Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines.

Cytokine storm (CS) is the main driver of SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) in severe coronavirus disease-19 (COVID-19). The pathological mechanisms of CS are quite complex and involve multiple critical molecular targets that turn self-limited and mild COVID-19 into a severe and life-threatening concern. At present, vaccines are strongly recommended as safe and effective treatments for preventing serious illness or death from COVID-19. However, effective treatment options are still lacking for people who are at the most risk or hospitalized with severe disease. Chinese herbal medicines have been shown to improve the clinical outcomes of mild to severe COVID-19 as an adjunct therapy, particular preventing the development of mild to severe ARDS. This review illustrates in detail the pathogenesis of CS-involved ARDS and its associated key molecular targets, cytokines and signalling pathways. The therapeutic targets were identified particularly in relation to the turning points of the development of COVID-19, from mild symptoms to severe ARDS. Preclinical and clinical studies were reviewed for the effects of Chinese herbal medicines together with conventional therapies in reducing ARDS symptoms and addressing critical therapeutic targets associated with CS. Multiple herbal formulations, herbal extracts and single bioactive phytochemicals with or without conventional therapies demonstrated strong anti-CS effects through multiple mechanisms. However, evidence from larger, well-designed clinical trials is lacking and their detailed mechanisms of action are yet to be well elucidated. More research is warranted to further evaluate the therapeutic value of Chinese herbal medicine for CS in COVID-19-induced ARDS.