A new method is used to solve the rectangular plate bending problem with mixed boundary conditions. The method overcomes the complicated derivation of the classical solution by Fourth-order differential problem into integrating question. Under uniform loading rectangular plate bending problem with one side fixed the opposite side half simply supported half fixed the other two sides free rectangular plate, one side simply supported the opposite side half simply supported half fixed the other two sides free rectangular plate is systematically solved. According to the actual boundary conditions of the rectangular plate, the corresponding characteristic equation can easily be set up. It is presented deflection curve equation and the numerical calculation. By compared the results of the equation to the finite element program, we are able to demonstrate the correctness of the method. So the method not only has certain theoretical value, but also can be directly applied to engineering practice.