Background: Despite the significant role of smoking in causing preventable diseases, many women smokers lack an understanding of the associated risks. Gaining insights into their knowledge levels is crucial for designing effective health interventions that promote smoking cessation and enhance overall public health. Objective: To assess the level of awareness regarding the risks and complications of cigarette smoking among female smokers. Methodology: A cross-sectional study was conducted at the Outpatient Department of Medicine, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan, from July to December 2023. The study involved 126 female smokers. Data were collected using a 15-item questionnaire to evaluate the participants' knowledge about the risks and complications of smoking. The responses were categorized as low, moderate, or high knowledge. Statistical analysis was performed using SPSS version 26.0. Results: The participants' average age was 31.25 years (SD = 13.55 years). Knowledge levels about smoking risks among the participants were distributed as follows: 54.8% had low knowledge, 30.2% had moderate knowledge, and 15.1% demonstrated high knowledge of smoking risks and complications. Conclusion: Over half of the female smokers surveyed exhibited low awareness of the dangers associated with smoking. This underscores the need for targeted educational and health-related activities to effectively reduce smoking levels among women.