Behavior Of Flavonoids Research Articles

Theoretical investigation on the antioxidant behavior of chrysoeriol and hispidulin flavonoid compounds – A DFT study

Over the recent past, the behavior of flavonoids as antioxidants has become the subject of intense research. The biological properties of these compounds are based on the electronic parameters, describing the charge distribution on the rings of the flavonoid molecules. Antioxidative properties of naturally occurring flavonoids such as chrysoeriol and hispidulin have been studied based on the quantum chemical calculations. The B3LYP/6-311G(d,p) protocol has been used for structure optimization and all other computations. Ionization potentials and O–H bond dissociation enthalpies are found to be consistent with antioxidant activity. Ionization potential and hydrogen abstraction enthalpies of the 4′-OH, 5-OH and 7-OH hydroxyl groups are compared and analyzed with the help of an electronic description and a spin density distribution for each structure. The calculated BDE values for all OH sites of chrysoeriol and hispidulin clearly reveal the importance of the B-ring. Their dipole moments and polarizability analyses show that both the compounds are polar in nature and have the capacity to polarize other atoms. Among the two flavonoid compounds, hispidulin is found to be showing higher antioxidant activity than that of chrysoeriol.

Study of the Electrophoretic Behaviour of Flavonoids

Study of the Electrophoretic Behaviour of Flavonoids

A study of the cyclodextrin complexes of flavonoids and azodyes by thin layer chromatography. Part II. Hydroxypropyl-cyclodextrins

2-Hydroxypropyl-beta -cyclodextrin (1) was recently advocated for general solubility enhancement in pharmacy. In view of this, data are presented of the behaviour of flavonoids, azodyes and other compounds in adsorption chromatography on cellulose layers eluted with aqueous solvents containing various concentrations of 1. The results show that elution is not very different from that previously observed with beta -cyclodextrin except that complete elution of many compounds can be obtained with high concentrations (10-20%) of 1.

Comparison of reversed-phase thin-layer and high-performance liquid chromatography of flavonoid compounds

The reversed-phase high-performance liquid (HPLC) and thin-layer chromatographic (TLC) behaviour of flavonoids with methanol, tetrahydrofuran and acetonitrile as organic modifiers was compared. Twenty-six different correlation cases, together with their statistical parameters, are presented and discussed. Both TLC and HPTLC plates were considered. The dependence of TLC incremental R m , values from different group substitutions on solvent type, solvent composition and type of plate is considered. A method for establishing HPLC gradient elution conditions by using TLC data is discussed.

On the behavior of flavonoids in oxidation systems

On the behavior of flavonoids in oxidation systems