Behavioral Levels Of Analysis Research Articles

A Provisional Taxonomy of Subjectively Experienced Positive Emotions.

Over the past two decades, scholars have conducted studies on the subjective experience of over 30 positive emotional states (see Weidman, Steckler, & Tracy, 2017). Yet, evidence from research on the non-verbal expression and biological correlates of positive emotions suggests that people likely experience far fewer than 30 distinct positive emotions. The present research provided an initial, lexically driven examination of how many, and which, positive emotions cohere as distinct subjective experiences, at both the state and trait levels. Four studies (including two pre-registered replications) using factor and network analyses of 5939 participants' emotional experiences, elicited through the relived emotions task, found consistent evidence for nine distinct positive emotion states and five distinct traits. At both levels, many frequently studied positive emotions were found to overlap considerably or entirely with other ostensibly distinct states in terms of the subjective components used to describe them, suggesting that researchers currently study more positive emotions than individuals experience distinctively. These findings provide the first-ever comprehensive portrait of the taxonomic structure of subjectively experienced positive emotions, with the ultimate aim of inspiring further examination of the positive emotion space at the subjective experiential as well as more biological and behavioral levels of analysis.

In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish.

Zebrafish is a lower vertebrate model organism that facilitates integrative analysis of the in vivo effects of potassium and other ion channel mutations at the molecular, cellular, developmental, circuit, systems, and behavioral levels of analysis. Here, we describe a method for extracellular, loose patch electrophysiological recording of electrical activity in cerebellar Purkinje cells in living, awake zebrafish, with the goal of investigating pathological mechanisms underlying channelopathies or other diseases that disrupt cerebellar function. Purkinje cell excitability and a functional cerebellar circuit develop rapidly in zebrafish and show strong conservation with the mammalian cerebellum.

Mind the Brain: The Mediating and Moderating Role of Neurophysiology

Most studies involving experimental manipulations or interventions tailored to modulate behavior do not account for variability in the critical antecedent of behavior, the brain. Here, we describe elegant approaches to model the role that neurophysiology can play in mediating or moderating relationships in this context. We highlight the capacity for these approaches to improve the inferential power of research, bridge the gap between neural and behavioral levels of analysis, and bolster the prospects for reproducibility.

Using the NIMH Research Domain Criteria (RDoC) in human and nonhuman primate research.

In this article, we provide a commentary on Kozak and Cuthbert ()'s theoretical paper discussing the NIMH Research Domain Criteria (RDoC) initiative and on Latzman et al. (2016)'s empirical investigation of the RDoC negative valence systems domain in chimpanzees, conducted with experimental procedures across genetic, neurobiological, and behavioral levels of analysis. We discuss the pros and cons of the RDoC approach to research on mental illness as well as the strengths and weaknesses of the implementation of this approach in the chimpanzee study.

Emotional memory.

Research on the reconsolidation effect was greatly revitalized by the highly analytic demonstration of memory reconsolidation (Nader et al. Nature 406:722-726, 2000) in a well-defined behavioral protocol (auditory fear conditioning in the rat). Since this study, reconsolidation has been demonstrated in hundreds of studies over a range of species, tasks, and amnesic agents. Evidence for reconsolidation does not come solely from the behavioral level of analysis. Cellular and molecular correlates of reconsolidation have also been found. In this chapter, I will first define the evidence on which reconsolidation is concluded to exist. I will then discuss some of the conceptual issues facing the field in determining when reconsolidation does and does not occur. Lastly I will explain the clinical implications of this effect.

On interpretation and task selection in studies on the effects of noise on cognitive performance.

This paper discusses two things researchers should consider when selecting tasks for cognitive noise studies and interpreting their findings: (a) The “process impurity” problem and (b) the propensity of sound to capture attention. Theoretical and methodological problems arise when the effects of noise on complex tasks (e.g., reading comprehension) are interpreted as reflecting an impairment of a specific cognitive process/system/skill. One reason for this is that complex tasks are, by definition, process impure (i.e., they involve several, distinct cognitive processes/systems/skills). Another reason is that sound can capture attention. When sound captures attention, the impairment to task scores is caused by an interruption, not by malfunctioning cognitive processes/systems/skills. Selecting more “process pure” tasks (e.g., the Stroop task) is not a solution to these problems. On the contrary, it introduces further problems with generalizability and representativeness. It is argued that cognitive noise researchers should employ representative noise, representative tasks (which are necessarily complex/process impure), and interpret the results on a behavioral level of analysis rather than on a cognitive level of analysis.

Multilevel models from biology to psychology: Mission impossible?

Systematic efforts are underway to address major flaws in the current diagnostic taxonomy of mental disorders, fostering hope that a new nosology might be based on brain biology. The National Institute of Mental Health Research Domains Criteria (RDoC) initiative aims to redefine mental illness leveraging information that spans molecular to behavioral levels of analysis. Major effort is still needed to forge multilevel conceptual and measurement models capable of representing knowledge within and across these levels. The development of such models may help refine and share complex hypotheses, and reduce the risk of replacing the current taxonomy with dimensions and/or categories that manifest little incremental biological validity. To create useful models we need to define concepts, relations among concepts, and links to supporting evidence. Some methods already enable representation of concepts and measures at the levels of behavioral and basic biological processes, but a major gap at the level of neural circuitry must be bridged to link basic biological and behavioral levels. We provide a schematic framework, using as an example the representation of selected "working memory" concepts and evidence across multiple levels of analysis as these have been described in the RDoC Workshops. This example illustrates multiple challenges and some possible solutions that may help clarify the aims of individual research projects and enable integration of diverse efforts on RDoC and related initiatives.

A developmental neuroscience of borderline pathology: emotion dysregulation and social baseline theory.

Theoretical and empirical research has linked poor emotion regulation abilities with dysfunctional frontolimbic circuitry. Consistent with this, research on borderline personality disorder (BPD) finds that frontolimbic dysfunction is a predominant neural substrate underlying the disorder. Emotion regulation is profoundly compromised in BPD. However, BPD is also associated with broad impairment across multiple domains, including impulse control, interpersonal relationships, and cognitive functioning. To date, BPD research has focused largely on single areas of dysfunction, failing to account for overlap at either the biological or behavioral levels of analysis. We examine the literature on frontolimbic dysfunction in BPD within the context of Coan's social baseline theory. Social baseline theory proposes that healthy human functioning is dependent upon adequate social support and that, at baseline, biological systems are adapted to operate interdependently rather than independently. The social baseline perspective is particularly useful for understanding borderline personality development because the impulsive and emotionally dysregulated behaviors common among those with BPD occur almost invariably within an interpersonal context. We discuss clinical and research implications of this work.

Perception and action.

The phrase perception and action is used widely but in diverse ways in the context of the relationship between perceptual and motor processes. This review describes and integrates five perspectives on perception and action which rely on both neurophysiological and behavioral levels of analysis. The two visual systems view proposes dissociable but interactive systems for conscious processing of objects/space and the visual control of action. The integrative view proposes tightly calibrated but flexible systems for perception and motor control in spatial representation. The embodied view posits that action underlies perception, involving common coding or motor simulation systems, and examines the relationship between action observation, imitation, and the understanding of intention. The ecological view emphasizes environmental information and affordances in perception. The functional view defines the relationship between perception, action planning, and semantics in goal-directed actions. Although some of these views/approaches differ in significant ways, their shared emphasis on the importance of action in perception serves as a useful unifying framework. WIREs Cogn Sci 2010 1 800-810 For further resources related to this article, please visit the WIREs website.

Pb 2+: An endocrine disruptor in Drosophila?

Environmental exposure to Pb 2+ affects hormone-mediated responses in vertebrates. To help establish the fruit fly, Drosophila melanogaster, as a model system for studying such disruption, we describe effects of Pb 2+ on hormonally regulated traits. These include duration of development, longevity, females' willingness to mate, fecundity and adult locomotor activity. Developmental Pb 2+ exposure has been shown to affect gene expression in a specific region of the Drosophila genome (~ 122 genes) involved in lead-induced changes in adult locomotion and to affect regulation of intracellular calcium levels associated with neuronal activity at identified synapses in the larval neuromuscular junction. We suggest ways in which Drosophila could become a new model system for the study of endocrine disruptors at genetic, neural and behavioral levels of analysis, particularly by use of genomic methods. This will facilitate efforts to distinguish between behavioral effects of Pb 2+ caused by direct action on neural mechanisms versus effects of Pb + 2 on behavior mediated through endocrine disruption.

Mechanisms of exposure therapy: How neuroscience can improve psychological treatments for anxiety disorders

Exposure therapy for anxiety disorders has been one of success stories of clinical psychology and psychiatry. Nevertheless, a significant minority of patients fail to benefit from extant treatments. This clinical impasse is prompting renewed attempts to understand fear and its reduction at neural, cellular, and molecular as well as behavioral levels of analysis. The purpose of this article is to provide a review of theories of exposure therapy, including recent developments in emotional processing theory, and to discuss insights from neuroscience that promise to improve psychological treatments for reducing pathological fears.

Questioning Our Philosophical and Methodological Research Assumptions: Psychological Perspectives

Philosophical and methodological assumptions often made by researchers working at the behavioral level of analysis in adapted physical activity are reviewed. Particular attention is given to movement skill acquisition research guided by a cognitive science or information processing approach and an ecological task analysis approach. In the final section of this paper, emerging views are used to illustrate other assumptions often tacitly made by movement skill researchers. Alternative possibilities offered by recent perspectives are also presented.

Gender Differences in Transformational Leadership: An Examination of Superior, Leader, and Subordinate Perspectives

This study examined gender differences intransformational leadership from multiple perspectives.The sample was employees of a large international bank inAustralia. Ratings were obtained from branch managers' (n = 120 female and n = 184 male), theirsuperiors (n = 32) and subordinates (n = 588). Thefindings showed that superiors evaluated female managersas more transformational than male managers. Consistent with the superior observations, at the globallevel, female managers rated themselves as moretransformational than males, however, at the morespecific, behavioral level of analysis, significantgender differences were noted only for those subscaleswhich are more interpersonally-oriented. Subordinatesevaluated their female and male leadersequally.

GM1 ganglioside treatment reduces visual deficits after graded crush of the rat optic nerve

Despite numerous reports of beneficial effects of GM1 ganglioside treatment following brain lesions in animals, the underlying neurobiological mechanism of ganglioside-induced functional restoration is still unclear. In order to obtain a better insight into this question, we have made use of a newly developed animal model of brain injury that would potentially permit us to determine the causal relationships(s) among behavioral and neuroanatomical/neurochemical parameters of restoration of function. Following graded crush of the adult rat optic nerve, we have treated the rats with intraperitoncally injected gangliosides and studied the functional outcome with electrophysiological and behavioral parameters. The electrophysiological recprding of the compound action potential (CAP) from excised rat optic nerve revealed a significant loss of CAP throughout the first 2 weeks after the injury. However, when rats were treated daily for 7 days with GM1-gangliosides, the CAP measured 10 days after the crush was significantly larger compared to operated controls without treatment. Thus, GM1 appeared to be capable of delaying or partially preventing retinal ganglion cells or their axons from secondary degeneration. Loss of visual function was also evident on the behavioral level of analysis: when rats with unilateral optic nerve crush were evaluated in a visual orienting paradigm, the rats revealed deficits in their ability to orient towards small, moving visual stimuli. However, within about 2 weeks, the animals recovered spontaneously to near normal performance. Daily treatment with GM1-gangliosides was found to significantly improve outcome, largely due to a reduction of the immediate post-lesion deficit. In a second behavioral experiment we also created graded crush in rats bilaterally and evaluated the animals visual capacities in a two-choice brightness discrimination task. In this park, an initial loss of function was followed by recovery within about 2 weeks, but GM1 treatment was without beneficial effects in this paradigm. It is concluded that GM1 improves outcome after graded crush of the adult rat optic nerve, although it appears that improved function needs to be documented with sufficiently sensitive behavioral assays.

Process and Content in Behavioral and Cultural Phenomena

The phenomena to be explained in terms of scientific principles may be termed the “content” of a science. Behavioral content is organized at the level of individual organisms. Human behavioral repertoires are unique and complex organizations of activity/environment relations. The content of human behavior is accounted for in terms of evolutionary processes occurring at the behavioral level of analysis, during the lifetime of individual organisms. Cultural content originates when behavioral repertoires of two or more individuals form an enduring unit that has the possibility of lasting beyond the lifetime of those individuals. Evolutionary processes occurring at the cultural level of analysis account for cultural practices that extend across generations. The units that come into existence as a result of behavioral and cultural evolutionary processes are the content of behavioral and cultural sciences. Science-based solutions to human problems involve making use of knowledge of behavioral and cultural processes to bring about change in behavioral and cultural content.

Neurological models of cognitive processing

A framework is proposed from which to evaluate contemporary neurological models of cognitive processing. Selected models are classified as unidimensional, bidimensional, or tridimensional according to the neuraxes that they address. The empirical research that supports each model is considered in terms of anatomical, physiological, and behavioral levels of analysis. Applied implications of the models for learning and individual differences are identified as they relate to psychoeducational assessment and intervention. Finally, differences and similarities among the selected models are synthesized.

Contingencies and Metacontingencies: Toward a Synthesis of Behavior Analysis and Cultural Materialism

A synthesis of cultural materialism and behavior analysis might increase the scientific and technological value of both fields. Conceptual and substantive relations between the two fields show important similarities, particularly with regard to the causal role of the environment in behavioral and cultural evolution. Key concepts in Marvin Harris's cultural materialist theories are outlined. A distinction is made between contingencies at the behavioral level of analysis (contingencies of reinforcement) and contingencies at the cultural level of analysis (metacontingencies). Relations between the two kinds of contingencies are explored in cultural practices from paleolithic to industrial sociocultural systems. A synthesis of these two fields may offer the opportunity to resolve serious problems currently facing modern cultures.

Kinematic and electromyographic changes that occur as a function of learning a time-constrained aiming task.

The present study attempted to examine the changes associated with learning two time-constrained aiming movements at the neuromuscular and behavioral levels of analysis. Electromyographic data and movement kinematics were used to assess changes due to practice. Eight right-handed females were required to perform a 45 degrees horizontal forearm extension in either 200 ms or 500 ms for 100 trials on each of four consecutive days. Both groups demonstrated an improvement in performance and a decrease in within-subject variability in the endpoint response measures, movement trajectory, and myoelectric pattern. With practice, there was a decrease in the amount of cocontraction between the agonist and antagonist muscles during movement execution, which indicated an elimination of unwanted neural activity. For the 200 ms task, the acceleration profile became symmetrical and triphasic myoelectric pattern became evident. The deceleratory phase of the 500 ms task was longer than the acceleratory phase, and a biphasic pattern became apparent. The results suggest that two different control strategies were developed in the execution of the two movements examined. In addition, the relative invariance of the spatial-temporal dependent measures, as compared to the variability of the EMG, led us tot he conclusion that the movement planning hierarchy was concerned with the spatial-temporal domain, whereas the amplitude and timing of muscular activity were planned at a lower level and thus played a subordinate role in movement production.

Toward the behavioral assessment of biological aging in the laboratory mouse: concepts, terminology, and objectives.

The thesis is presented that much of the controversy and confusion concerning the measurement of biological aging stems from the lack of agreement on clearly defined objectives, constructs, and methods to validate measures. To alleviate some of the confusion, basic terminology borrowed from psychometrics is offered to provide a conceptual framework within which such issues can be discussed. This psychometric nomenclature is subsequently applied to the development and evaluation of a test battery designed to assess biological aging in laboratory mice at a behavioral level of analysis. Reference is made to the assessment of reliability, content validity, construct validity, and predictive validity of tests of biological aging.

Effects of chemical stimulation of the midbrain reticular formation on appetitive behavior.

Implant-produced bilateral lesions in the midbrain reticular formation reliably facilitated the acquisition and performance of simple appetitive habits in maze as well as operant conditioning situations. Cholinergic stimulation of the same site reliably impaired behavior in all appetitive test situations during acquisition as well as at the asymptote of performance. Initial or infrequently repeated cholinergic stimulations produced markedly larger effects than daily administrations. These effects are discussed in relation to previous observations of directly opposite results in aversive test situations. It has been suggested (Lindsley, 1951, 1957), largely on the basis of electrophysiological evidence, that the reticular formation of the thalamus and brainstem may be the anatomical substrate for nonspecific motivational processes. The concept of a general or activating mechanism has been used extensively in psychological theories of motivation, but so far there has been little evidence for a link between the anatomical, electrophysiological, and behavioral levels of analysis. We have provided some behavioral evidence for the hypothesis that some aspects of the thalamic portion of the reticular formation may be related to motivational processes of a general arousal nature (Grossman & Peters, 1966; Grossman, Peters, Freedman, & Wilier, 1965). A recent analysis of the eifects of lesions and chemical stimulation in the midbrain reticular formation (MRF) on avoidance behavior (Grossman, 1966) suggested that similar motivational functions may be represented at lower levels of this complex system of interneurons. However, the results of these experiments permit an alternative interpretation in terms of specific motivational mechanisms con