Background HIV is still a major global public health issue, despite the major progress in care and treatment. HIV-internalized stigma/self-stigma remains an important issue because it is unclear how many of the CBT interventions that have been developed have a specific focus on reducing the self-stigma associated with HIV. Methods This study used a scoping review that was conducted using PRISMA guidelines with databases from Cochrane, PMC, and ScienceDirect. Studies were eligible if published between 2013–2023, full-text, and using English. Results This study identified seven quantitative studies, one qualitative study, and two mixed-method studies. All the studies reveal the use of CBT as an intervention that helps to reduce self-stigma, improve mental health, and enhance medical adherence. Conclusion This systematic review explores the implementation of cognitive-based therapy (CBT) for facing self-stigma in people living with HIV, including the influence of m-health in the current situation as one of the innovative strategies to improve HIV patient’s well-being.