Basis Of Safety Research Articles

Evolution of carbides and Charpy toughness in a low alloy bainitic steel during step-up aging process

The low alloy bainitic steel used in reactor pressure vessels deteriorates during thermal service while the macroscopic thermodynamic parameters that cause thermal aging remains unknown. In this work, a thermal aging restructuring scheme was proposed by step-up aging the steel from 350 °C to 490 °C, with a total duration of 7500 hours. Samples from varied thickness of the steel were characterized in terms of carbides evolution and Charpy impact toughness at 20 °C. The carbide size and its fraction were statistically analyzed showing partial coarsening and dissolution during aging, while the carbide fraction was found linearly correlated with the impact energy for the first time. The critical transition temperature parameter of the aging process was found to be 470 °C for the steel. The macroscopic thermodynamic parameters, including the thermal aging time and temperature, facilitate a comprehensive understanding of the material degradation mechanism and provide a basis for long-term safety of equipment.

Estimation and research of the temperature field models of large space spherical mesh shell structures under localized fire

This paper firstly investigated fire dynamics characteristics and the temperature field distributions of large space spherical mesh shell (SMS) structures under localized fire in FDS, and divided the temperature fields into plume region, smoke accumulation region and ceiling jet region. Based on the classical axisymmetric plume model, the predictive models for the steady-state and transient temperature fields in different fire regions for large space SMS structures were proposed in this paper. Thereafter, the proposed temperature models were compared with the simulated results and experimental test results by other scholars, and they were in good agreement. In order to further discover the realistic fire development progress and temperature distribution of large space fire, and validate the proposed temperature field models, this paper designed and conducted three full-scale large space fire tests (Test-1 ∼ Test-3) with different fire source powers in a large space building. Results showed that temperature fields of large space fires could be consisted of near-fire region (Flame region) and far-fire region (Plume region and Ceiling jet region). The steady-state fire source powers were tested for 443 kW, 886 kW, 1090 kW for Test-1, Test-2 and Test-3, respectively, while their maximum temperatures of the roof reached 75 °C, 105 °C and 120 °C. Based on McCaffrey plume model, we further proposed the transient temperature model in flame region for large space structures, and its accuracy was verified by the test results. Moreover, the proposed steady-state and transient temperature fields for large space SMS structures were compared with the tested temperature field data, and the tested and predicted temperature curves were generally in good agreement in plume and ceiling jet regions. Finally, the test results aimed to provide a scientific basis and reference for the fire safety and structural fire-resistant design of large space buildings.

Bond behavior between geopolymer recycled brick aggregate concrete and steel bars after exposure to high temperatures

The use of recycled brick aggregate (RBA) as the replacement for natural coarse aggregate in geopolymer concrete is an effective method for waste recycling. When the formed geopolymer recycled brick aggregate concrete (GRBC) is employed in structures, it may encounter the risk of fire. Whether the steel bars and GRBC can work together after a fire is the basis for structural safety and analysis. However, previous research on the bond behavior between GRBC and steel bars after exposure to high temperatures is still lacking. In this paper, pull-out tests on 50 GRBC and 50 ordinary recycled brick aggregate concrete (ORBC) were conducted to investigate the effects of temperature (20 °C, 200 °C, 400 °C, 600 °C, and 800 °C), and RBA replacement ratio (0 %, 25 %, 50 %, 75 %, and 100 %). The test results show that the failure pattern of GRBC specimens changes from splitting-pull-out failure to pull-out failure as the heating temperature increases. The bond strength decreases with the increase of temperature or RBA replacement ratio. When the temperature rises from 200 °C to 800 °C, the bond strength of GRBC pull-out specimens decreases by 11.54 %–72.33 % compared with the specimens at room temperature, and the decrease rate is lower than that of ORBC. The bond strength of GRBC specimens with a 100 % replacement ratio decreases by 46.34 %–53.74 % compared with those without replacement. The peak slip of GRBC specimens generally increases with increasing temperature or decreasing RBA replacement ratio. Based on the post-temperature test results and the room temperature model, suitable models for the bond strength and peak slip of GRBC after high temperatures were established. The predicted results of bond stress−relative slip curves were in good agreement with the test results. The findings of this study can provide a foundation for the application of GRBC, and provide a basis for its structural analysis after high temperatures.

Improvements in Transient Testing Reactor (TREAT) with a Choice of Filter

The safe and reliable operation of nuclear reactors has always been one of the topmost priorities in the nuclear industry. Transient testing allows us to understand the time-dependent behavior of the neutron population in response to either a planned change in the reactor conditions or unplanned circumstances. These unforeseen conditions might occur due to sudden reactivity insertions, feedback, power excursions, instabilities, and accidents. To study such behavior, we need transient testing, which is like car crash testing to estimate the durability and strength of a car design. In nuclear designs, such transient testing can simulate a wide range of accidents due to sudden reactivity insertions and helps study the feasibility and integrity of the fuel used in certain reactor types. This testing involves a high neutron flux environment and real-time imaging technology with advanced instrumentation with appropriate accuracy and resolution to study the fuel slumping behavior. With the aid of transient testing and adequate imaging tools, it is possible to test the safety basis for reactor and fuel designs that serves as a gateway in licensing advanced reactors in the future. To that end, it is crucial to fully understand advanced imaging techniques both analytically and via simulations. This paper presents an innovative method of supporting real-time imaging of fuel pins and other structures during transient testing. The major fuel-motion detection device that is studied in this dissertation is the Hodoscope which requires collimators. This paper provides 1) an MCNP model and simulation of a TREAT core with a central fuel element replaced by a slotted fuel element that provides an open path between test samples and a hodoscope detector, and 2) a choice of good filter to improve image resolution.

Combining Multiple Machine Learning Methods Based on CARS Algorithm to Implement Runoff Simulation

Runoff forecasting is crucial for water resource management and flood safety and remains a central research topic in hydrology. Recent advancements in machine learning provide novel approaches for predicting runoff. This study employs the Competitive Adaptive Reweighted Sampling (CARS) algorithm to integrate various machine learning models into a data-driven rainfall–runoff simulation model. We compare the forecasting performance of different machine learning models to improve rainfall–runoff prediction accuracy. This study uses data from the Maduwang hydrological station in the Bahe river basin, which contain 12 measured flood events from 2000 to 2010. Historical runoff and areal mean rainfall serve as model inputs, while flood data at different lead times are used as model outputs. Among the 12 flood events, 9 are used as the training set, 2 as the validation set, and 1 as the testing set. The results indicate that the CARS-based machine learning model effectively forecasts floods in the Bahe River basin. Under the prediction period of 1 to 6 h, the model achieves high forecasting accuracy, with the average NSE ranging from 0.7509 to 0.9671 and the average R2 ranging from 0.8397 to 0.9413, though the accuracy declines to some extent as the lead time increases. The model accurately predicts peak flow and performs well in forecasting high flow and recession flows, though peak flows are somewhat underestimated for longer lead times. Compared to other machine learning models, the SVR model has the highest average RMSE of 0.942 for a 1–6 h prediction period. It exhibits the smallest deviation among low-, medium-, and high-flow curves, with the lowest NRMSE values across training, validation, and test sets, demonstrating better simulation performance and generalization capability. Therefore, the machine learning model based on CARS feature selection can serve as an effective method for flood forecasting. The related findings provide a new forecasting method and scientific decision-making basis for basin flood safety.

Dietary management and access to treatment for patients with glucose deficiency syndrome type 1: an overview review with focus on the European regulatory framework.

Glut-1 deficiency Syndrome (GLUT-1 DS) is a rare disease caused by a mutation in the SLC2A1 gene that codes for the glucose transporter protein GLUT-1 DS. Currently, there is no indicated drug therapy for this condition and ketogenic diet (KD) is the most effective remedy to treat it. The objective of this study was to review the published literature that evaluated the effectiveness of KD in the dietary management of GLUT-1 DS syndrome, describing the state-of-the-art the treatment pathway for patients with GLUT-1 DS syndrome in light of the current European regulatory framework within the National Health Services. The literature search was carried out on September 10, 2023, and all studies conducted in humans diagnosed with GLUT-1 deficiency syndrome and treated with KD were included. A total of 156 scientific papers have been extracted. Applying the exclusion criteria, 38 articles have been considered eligible. In 29 out of 38 studies, the main outcome for determining the efficacy of KD was the measurement of the number of epileptic seizures, demonstrating that patients treated with KD experienced improvements with a clear reduction in the number of epileptic attacks. Currently, in the European Union, only one country provides full reimbursement by the national health system for KD. Although they are crucial for the treatment of GLUT-1 DS, according with current food regulations, KD are not evaluated on the basis of an unambiguous efficacy result, but only on the basis of safety. As a result, it is desirable to carry out clinical studies in the coming years based on the determination of efficacy in target populations, also in view of the marketing of these products on the European market.

Technical regulations and standards as the basis of safety and quality of domestic food

Technical regulations and standards as the basis of safety and quality of domestic food

Determination of Airborne Release Fractions from Loose Powder Contamination Under Impact Stress

Safety basis calculations support the safety considerations necessary for legacy nuclear facilities as they transition from active use, through limited operations and standby modes, until final disposition is achieved. Many of the calculations are governed heavily by the coefficients presented in DOE-HDBK-3010 in the form of airborne release of radioactive material resulting from penetration of the facility per seismic activity, full facility fires, and/or explosions. The main objective of this study is to validate the original data for airborne release fractions (ARFs) for powder contaminants under impact, as determined in DOE-HDBK-3010. The limited data available for impact experiments was generated at the Rocky Flats Plant in 1987, where the median ARFs for surrogate powder contamination were 4E-4 with a bounding value of 1E-2. However, estimating the level of uncertainty was challenging in the absence of multiple measurements conducted under identical test conditions. Moreover, the uncertainty was significantly increased due to the restricted range of the test conditions. A more modern approach has been developed for the experimental design in this study, utilizing standardized techniques and analytical instruments. An impact apparatus was employed to be able deliver repeatable impact forces up to 369 kg·cm (320 in.·lb.). Cesium chloride was used as the surrogate powder contaminant in these experiments as it is extremely soluble in water and is even more so in the acidic media used to leach/dissolve the air filters for concentration analysis using mass spectrometry The developed approach leveraged multiple international standards and historical documents in an attempt to recreate a valid testing system that can be used for future analysis and to analyze mitigation factors such as contamination fixative technologies. The current ARFs were found to be consistent with the original values in DOE-HDBK-3010, 3.47E-4 and 4E-4, respectively.

Influence of different causes on thermal runaway characteristic of LiFePO4 battery

To solve the current battery safety issues and accident investigation problems. Thermal runaway experiments triggered by nail penetration, hot box, flame heating and heating plate were carried out on a commercial 8 Ah pouch LiFePO4 battery. Recorded real-time phenomena, voltage and temperature. Then we discussed the TR process in the light of the latest mechanism study. The local TR is triggered by nail penetration within 3 s. The hot area above 700 °C and the spreading of internal TR was detected. LiFePO4 battery thermal runaway will generally emit white smoke, no fire. And it requires more attention to explosion risk. If the combustible gas is ignited, jet fire will appear, but the injection pressure is not extreme. Thermal runaway triggered by local heating is inconsistent with a voltage drop. A mapping method of thermal runaway parameters radar map is designed, which can indicate the danger degree of TR with shapes. Through comparison, some characteristics are obtained for the judgment of battery accident causes. This research can provide a basis for LFP battery safety evaluate and accident investigation.

Efficacy, safety, and determination of RP2D of ABBV-383, a BCMA bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM).

7531 Background: MM eventually becomes refractory to current treatments, and new therapeutic options with convenient dosing and improved safety are needed to enhance patient (pt) adherence, access, and outcomes. ABBV-383 is a distinctive next-generation BCMA x CD3 bispecific antibody composed of 2 high-affinity BCMA-binding domains, a low-affinity CD3-binding domain designed to reduce cytokine release syndrome (CRS) risk, and a silenced Fc tail for an extended half-life allowing convenient dosing. ABBV-383 monotherapy has shown promising activity in the ongoing first-in-human phase 1 trial in RRMM (Vij et al. Blood 2023;142[suppl 1]:3378). Here, safety and efficacy results are reported that support the RP2D of 60mg Q4W as the optimal therapeutic ABBV-383 monotherapy dose. Methods: This phase 1 open-label, dose-escalation/expansion trial (NCT03933735) enrolled pts with RRMM who received ≥3 prior lines of therapy with exposure to PI, IMiD, and anti-CD38 mAb. ABBV-383 regimens explored in the expansion phase included 60mg Q4W and 40 or 60mg Q3W. A modified dexamethasone premedication schedule and shortened CRS monitoring period were implemented in the 60mg Q4W cohort for cycle 1. IV ABBV-383 was administered as a flat dose with no step-up schedule. Treatment was continued until disease progression/unacceptable toxicity. Primary objectives were to assess safety, tolerability, PK, PD, and determine the RP2D. Efficacy evaluation was a secondary objective. TEAEs were assessed per CTCAE v5.0 and tumor response per IMWG 2016 criteria. Results: As of May 2023, 220 pts received ABBV-383 (median age: 68 yr [35–92]; median prior therapy lines: 5 [3‒23]). Median FU was 4.1 mo (0.8–5.2) at 60mg Q4W (n=21), 12.2 mo (1.3–34.4) at 40mg Q3W (n=55), and 24.2 mo (0.6–33.4) at 60mg Q3W (n=61). At 60mg Q4W, with the modified premedication regimen, CRS was reported in 43% of pts (38% G1, 5% G2), and ICANS in 5% of pts (G2). In Q3W cohorts, CRS was reported in 71% (40mg; 45% G1, 25% G2) and 70% (60mg; 51% G1, 18% G2, 2% G3) of pts. The incidence of G3/4 neutropenia, anemia, and thrombocytopenia was 14/24/10% at 60mg Q4W, 31/31/16% at 40mg Q3W, and 34/13/13% at 60mg Q3W. G3/4 infections occurred in 10/24/34% of pts at 60mg Q4W, 40mg and 60mg Q3W, respectively. ORR and ≥VGPR were 65/50% at 60mg Q4W, 64/53% at 40mg Q3W, and 60/52% at 60mg Q3W. Corresponding exposure-response (ER) analyses and correlative analyses further supported RP2D determination (separate abstract submissions). Conclusions: The optimal therapeutic dose of 60mg Q4W ABBV-383 monotherapy was selected on the basis of safety, efficacy, and ER analyses. The extended interval of Q4W, with a shortened CRS monitoring period in cycle 1 and no step-up dosing, will improve convenience and reduce the treatment burden for pts. ABBV-383 at 60mg Q4W will be investigated in the registrational phase 3 trial (NCT06158841) in RRMM. Clinical trial information: NCT03933735 .

Prospective,multi-center,and large-scale hospital centralized monitoring of clinical safety of Reduning Injection in 100249 children cases

This study utilized a prospective, large-sample, multi-center, and registered key specialty approach of hospitals to monitor the application of Reduning Injection. A total of 100 249 adolescent patients aged 14 years and below who received Reduning Injection were monitored, resulting in 83 cases of adverse events, with 76 of them being classified as adverse drug reaction(ADR). The calculated incidence rate of ADR for Reduning Injection was 0.076%, indicating a very rare ADR. The main symptoms of ADR were pruritus, diarrhea, abdominal pain, vomiting, high fever, dyspnea, convulsion, and chills. All ADR cases were reported for the first time, including three new ADR cases and 73 known ADR cases. The categories of ADR was general ADR. All ADR was mild in severity. There were more males than females in ADR patients. One patient had a history of ADR, and the drug causing ADR was buprofen. The largest number of ADR cases occurred when the dosage of Reduning injection was 5-10 mL. The dropping speed was 30 drops or less per min, and the solvent type was 5% glucose injection. The most common manifestation of ADR patients was pruritus, followed by diarrhea, abdominal pain, vomiting, high fever, dyspnea, convulsions, and chills. 72 patients(94.74% of ADR patients) discontinued the drug, and three patients(3.95% of ADR patients) were given oxygen inhalation. 47 cases(61.84% of ADR patients) were treated with medication, of which dexamethasone was the most used(24 cases, 46.15% of ADR patients). 76 ADR patients were cured or improved. ADRs are more likely to occur when diagnosed with acute bronchitis by western medicine and cough by traditional Chinese medicine(TCM), TCM syndrome type is wind heat syndrome, and the combination medicine is ambroxol hydrochloride and bromhexine hydrochloride injection, ascorbic acid/vitamin C injection. This result provides an evidence-based safety basis for active pharmacovigilance of Reduning Injection in adolescents aged 14 years and below.

Psychological Safety as an Enduring Resource Amid Constraints.

While psychological safety is recognized as valuable in healthcare, its relationship to resource constraints is not well understood. We investigate whether psychological safety mitigates the negative impact of resource constraints on employees. Leveraging longitudinal survey data collected from healthcare workers before and during the COVID-19 crisis (N = 27,240), we examine how baseline psychological safety relates to employee burnout and intent to stay over time, and then investigate this relationship relative to resource constraints (i.e., the inadequacy of staffing and tools). Using hierarchical linear models, we find that psychological safety has enduring protective benefits for healthcare workers during periods of stress, and that these benefits mitigate the negative consequences of resource constraints for burnout and turnover intent over time. These findings extend the empirical basis for psychological safety and suggest that investments in building psychological safety can foster employee resilience and organizational commitment, even when resources are strained.

Cost-Effectiveness of the Baveno VI Criteria Compared With Endoscopy for High-Risk Varices in Patients With Child-Pugh A Cirrhosis

Although upper gastrointestinal endoscopy (EGD) remains the gold standard for detecting varices in cirrhosis, the Baveno VI criteria proposed a combination of transient elastography and platelet count that could rule out high-risk varices, therefore sparing the need for an endoscopy, with significant potential cost savings. We performed a cost-effectiveness analysis of the Baveno VI criteria compared with EGD in the diagnosis of high-risk varices in cirrhosis. We built an analytical decision model to estimate the cost and benefits of using the Baveno VI criteria compared with EGD in patients with Child-Pugh A cirrhosis. The analysis was performed from the UK National Health Service perspective, over 1, 5, and 20 years. A Markov model was populated with data from published evidence. Outcomes were measured in terms of quality-adjusted life years (QALYs) and avoided deaths. The analyses were repeated for Canada and Spain, using relevant cost inputs. The Baveno VI criteria were cost effective compared with endoscopy in all analyses. For 1000 patients, they produced 0.16 additional QALYs at an incremental cost of £326 ($443.41) over 5 years, resulting in an incremental cost of £2081 ($2830) per additional QALY gained. The incremental net monetary benefit of Baveno VI compared with EGD was £2808 ($3819) over 5 years per patient. Baveno VI criteria also were cost effective in Canada and Spain. Deterministic and probabilistic sensitivity analysis supported these findings. The findings demonstrate that the Baveno VI criteria are cost effective, suggesting that they should be considered for widespread implementation on the basis of safety, appropriateness, and economic grounds.

Deriving acceptable limits for non-mutagenic impurities in medicinal products – Durational adjustments

ICH Q3A/B guidelines are not intended for application during the clinical research phase of development and durationally adjusted qualification thresholds are not included. A central tenet of ICH Q3A is that lifetime exposure to 1 mg/day of an unqualified non-mutagenic impurity (NMI) is not a safety concern. An analysis of in vivo toxicology data from 4878 unique chemicals with established NO(A)ELs was conducted to determine whether durationally adjusted qualification limits can be supported. Although not recommended in ICH Q3A/B, a conservative approach was taken by using allometric scaling in the analysis. Following allometric scaling of the 5th percentile of the distribution of NO(A)ELs from available chronic toxicology studies, it was reconfirmed that there is a safety basis for the 1 mg/day qualification threshold in ICH Q3A. Additionally, allometric scaling of the 5th percentile of the distribution of NO(A)ELs from sub-acute and sub-chronic toxicology studies could support acceptable limits of 20 and 5 mg/day for an unqualified NMI for dosing durations of less than or greater than one month, respectively. This analysis supports durationally adjusted NMI qualification thresholds for pharmaceuticals that protect patient safety and contribute to 3Rs efforts for qualifying impurities using new approach methods.

Utilizing transcriptomics and proteomics to unravel key genes and proteins of Oryza sativa seedlings mediated by selenium in response to cadmium stress

BackgroundCadmium (Cd) pollution has declined crop yields and quality. Selenium (Se) is a beneficial mineral element that protects plants from oxidative damage, thereby improving crop tolerance to heavy metals. The molecular mechanism of Se-induced Cd tolerance in rice (Oryza sativa) is not yet understood. This study aimed to elucidate the beneficial mechanism of Se (1 mg/kg) in alleviating Cd toxicity in rice seedlings.ResultsExogenous selenium addition significantly improved the toxic effect of cadmium stress on rice seedlings, increasing plant height and fresh weight by 20.53% and 34.48%, respectively, and increasing chlorophyll and carotenoid content by 16.68% and 15.26%, respectively. Moreover, the MDA, ·OH, and protein carbonyl levels induced by cadmium stress were reduced by 47.65%, 67.57%, and 56.43%, respectively. Cell wall metabolism, energy cycling, and enzymatic and non-enzymatic antioxidant systems in rice seedlings were significantly enhanced. Transcriptome analysis showed that the expressions of key functional genes psbQ, psbO, psaG, psaD, atpG, and PetH were significantly up-regulated under low-concentration Se treatment, which enhanced the energy metabolism process of photosystem I and photosystem II in rice seedlings. At the same time, the up-regulation of LHCA, LHCB family, and C4H1, PRX, and atp6 functional genes improved the ability of photon capture and heavy metal ion binding in plants. Combined with proteome analysis, the expression of functional proteins OsGSTF1, OsGSTU11, OsG6PDH4, OsDHAB1, CP29, and CabE was significantly up-regulated under Se, which enhanced photosynthesis and anti-oxidative stress mechanism in rice seedlings. At the same time, it regulates the plant hormone signal transduction pathway. It up-regulates the expression response process of IAA, ABA, and JAZ to activate the synergistic effect between each cell rapidly and jointly maintain the homeostasis balance.ConclusionOur results revealed the regulation process of Se-mediated critical metabolic pathways, functional genes, and proteins in rice under cadmium stress. They provided insights into the expression rules and dynamic response process of the Se-mediated plant resistance mechanism. This study provided the theoretical basis and technical support for crop safety in cropland ecosystems and cadmium-contaminated areas.

Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties.

As a critical mitotic regulator, Aurora kinase A (AURKA) is aberrantly activated in a wide range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of solid tumors. In this study, we evaluated the preclinical characteristics of JAB-2485, a small-molecule inhibitor of AURKA currently in Phase I/IIa clinical trial in the US (NCT05490472). Biochemical studies demonstrated that JAB-2485 is potent and highly selective on AURKA, with subnanomolar IC50 and around 1500-fold selectivity over AURKB or AURKC. In addition, JAB-2485 exhibited favorable pharmacokinetic properties featured by low clearance and good bioavailability, strong dose-response relationship, as well as low risk for hematotoxicity and off-target liability. As a single agent, JAB-2485 effectively induced G2/M cell cycle arrest and apoptosis and inhibited the proliferation of small cell lung cancer, triple-negative breast cancer, and neuroblastoma cells. Furthermore, JAB-2485 exhibited robust in vivo antitumor activity both as monotherapy and in combination with chemotherapies or the bromodomain inhibitor JAB-8263 in xenograft models of various cancer types. Together, these encouraging preclinical data provide a strong basis for safety and efficacy evaluations of JAB-2485 in the clinical setting.

TPMGD: A genomic database for the traditional medicines in Pakistan

ObjectiveIn Pakistan, traditional medicines are an important component of the medical system, with numerous varieties and great demands. However, due to the scattered resources and the lack of systematic collection and collation, adulteration of traditional Pakistani medicine (TPM) is common, which severely affects the safety of their medicinal use and the import and export trades. Therefore, it is urgent to systematically organize and unify the management of TPM and establish a set of standards and operable methods for the identification of TPM. MethodsWe collected and organized the information on 128 TPMs with regard to their medicinal parts, efficacy, usage, and genetic material, based on Pakistan Hamdard Pharmacopoeia of Eastern Medicine: Pharmaceutical Codex. The genetic information of TPM is summarized from national center for biotechnology information (NCBI) and global pharmacopoeia genome database (GPGD). Furthermore, we utilized bioinformatics technology to supplement the chloroplast genome (cp-genome) data of 12 TPMs. To build the web server, we used the Linux + Apache + MySQL + PHP (LAMP) system and constructed the webpage on a PHP: Hypertext Preprocessor (PHP) model view controller (MVC) framework. ResultsWe constructed a new genomic database, the traditional Pakistani medicine genomic database (TPMGD). This database comprises five entries, namely homepage, medicinal species, species identification, basic local alignment search tool (BLAST), and download. Currently, TPMGD contains basic profiles of 128 TPMs and genetic information of 102 TPMs, including 140 cytochrome c oxidase subunit I (COI) sequences and 119 mitochondrial genome sequences from Bombyx mori, 1 396 internal transcribed spacer 2 (ITS2) sequences and 1 074 intergenic region (psbA-trnH) sequences specific to 92 and 83 plant species, respectively. Additionally, TPMGD includes 199 cp-genome sequences of 82 TPMs. ConclusionTPMGD is a multifunctional database that integrates species description, functional information inquiry, genetic information storage, molecular identification of TPM, etc. The database not only provides convenience for TPM information queries but also establishes the scientific basis for the medication safety, species identification, and resource protection of TPM.

Cost-Effectiveness of Lovotibeglogene Autotemcel (Lovo-Cel) Gene Therapy for Patients with Sickle Cell Disease and Recurrent Vaso-Occlusive Events in the United States.

Gene therapies for sickle cell disease (SCD) may offer meaningful benefits for patients and society. This study evaluated the cost-effectiveness of lovotibeglogene autotemcel (lovo-cel), a one-time gene therapy administered via autologous hematopoietic stem cell transplantation, compared with common care for patients in the United States (US) with SCD aged ≥12years with ≥4 vaso-occlusive events (VOEs) in the past 24months. We developed a patient-level simulation model accounting for lovo-cel and SCD-related events, complications, and mortality over a lifetime time horizon. The pivotal phase1/2 HGB-206 clinical trial (NCT02140554) served as the basis for lovo-cel efficacy and safety. Cost, quality-of-life, and other clinical data were sourced from HGB-206 data and the literature. Analyses were conducted from US societal and third-party payer perspectives. Uncertainty was assessed through probabilistic sensitivity analysis and extensive scenario analyses. Patients treated with lovo-cel were predicted to survive 23.84years longer on average (standard deviation [SD], 12.80) versus common care (life expectancy, 62.24 versus 38.40years), with associated discounted patient quality-adjusted life-year (QALY) gains of 10.20 (SD, 4.10) and direct costs avoided of $1,329,201 (SD, $1,346,446) per patient. Predicted societal benefits included discounted caregiver QALY losses avoided of 1.19 (SD, 1.38) and indirect costs avoided of $540,416 (SD, $262,353) per patient. Including lovo-cel costs ($3,282,009 [SD, $29,690] per patient) resulted in incremental cost-effectiveness ratios of $191,519 and $124,051 per QALY gained from third-party payer and societal perspectives, respectively. In scenario analyses, the predicted cost-effectiveness of lovo-cel also was sensitive to baseline age and VOE frequency and to the proportion of patients achieving and maintaining complete resolution of VOEs. Our analysis of lovo-cel gene therapy compared with common care for patients in the US with SCD with recurrent VOEs estimated meaningful improvements in survival, quality of life, and other clinical outcomes accompanied by increased overall costs for the health care system and for broader society. The predicted economic value of lovo-cel gene therapy was influenced by uncertainty in long-term clinical effects and by positive spillover effects on patient productivity and caregiver burden.

Gasserian ganglion stimulation for refractory trigeminal neuropathic pain

Background and objectivePainful trigeminal neuropathy is a complex clinical entity due to its severity and refractoriness to pharmacological and interventional management. We describe our experience in treating refractory painful trigeminal neuropathy (RPTN) with gasserian ganglion stimulation (GGS). Materials and methodsSix patients with RPTN were treated with GGS in our Unit between 2019 and 2022. The following data were collected: socio-demographic characteristics, triggering event, duration of the disease and treatment received prior to surgery, pre- and post-intervention visual analogue scale (VAS) score, follow-up time, and pre- and post-intervention functionality and quality of life. ResultsAll patients were women who had received aggressive first-, second-, and third-line pharmacological, non-pharmacological, and interventional management before being referred for GGS. Patients reported a 50%–72% decrease in pain on VAS and improved functionality during follow-up. ConclusionsGGS is a promising therapeutic alternative for patients with RPTN. Although the initial outcomes and experience are encouraging, RPTN is recommended on the basis of safety, reproducibility, and trends observed in clinical practice.

Strategy for Weed Control in Potato Fields of the Ganja-Dashkesan Region of Azerbaijan

The impact of integrated weed control measures is assessed. One of the factors that worsens the productivity of a potato plant, and its quality indicators is weed infestation. Weeds choke plants. The research was carried out in the Samukh district of the Ganja-Dashkesan economic region. It was established that the degree of weeding of alternating and continuous potato crops was significantly influenced by complex measures. the use of herbicides through proper agrotechnical processing of the growing season in a potato field cultivated in alternating and continuous crops. This has a positive effect on the productivity of the potato plant, its quality indicators, and creates the basis for the environmental safety of products. Data are provided on various methods of treating plantings against weeds.