ABSTRACT Thirty-seven portable accelerometers were deployed in the eastern San Francisco Bay communities of Walnut Creek and Concord to study site response in a fault-bounded, urban, sedimentary basin. Local earthquakes were recorded for a period of two years from 2017 to 2019 resulting in 101 well-recorded events. Site response is estimated by two methods: the reference site spectral ratio method and a source-site spectral inversion method. The reference site spectral ratio method allows investigation of the variability of site amplification with source azimuth and frequency. The source-site spectral inversion method yields the best least-squares fit to site response for a database of ground-motion records. Both methods show substantial amplification in the Walnut Creek–Concord basin below 2 Hz indicating strong surface-wave development. Greater amplification is seen for sources aligned along the long axis of the basin. Inversion using close-in sources at short distances yields lower amplification at longer periods than the entire data set due to reduced surface-wave generation for steeper angles of incidence. Inversion of site response spectra for shallow shear-wave velocity using a global search algorithm yields VS30 values consistent with generalized mapping results based on geology and topography but with greater variability due to local site variations. 3D finite-element modeling shows greater amplification in the Walnut Creek–Concord basin with a basin-edge effect likely contributing to higher ground motions. Topography is also seen to lead to increased scattering and shadowing effects.