Basic Research Articles Research Articles

A bibliometric and Altmetric analysis of the 100 top most cited articles on dentin adhesives

ObjectiveThis study aimed to identify the 100 top-cited articles on dentin adhesives utilizing comprehensive bibliometric and altmetric analyses.Materials and methodsThe Institute of Scientific Information Web of Knowledge database was used to compile the top-cited articles published from 1945 through February 12, 2023. Citation counts were manually retrieved for each article from Scopus, Google Scholar, Dimensions, and Altmetric. The articles were analyzed in terms of their number of citations, year, journal name, author (name, institution, and country), and type and specific field of study. We used descriptive statistics to summarize the results.ResultsThe analysis revealed that the top 100 cited articles originated from 18 English-language journals and collectively accumulated a remarkable 34526 citations. The article with the highest number of citations garnered 1288 references. Among authors, Van Meerbeek B. stood out with nine articles and 4650 citations, followed by Pashley D.H. with six articles and 2769 citations. Japan was the leading contributor by country, while the Catholic University of Leuven led in terms of institutions with 20 articles.ConclusionAccording to this study, basic research and review articles garnered the most citations, respectively. The citation analysis revealed different trends for researchers, the first being that researchers have focused on basic fields such as the ultramorphology of dentin and adhesive interfaces, followed by bond strength to dentin. Two studies on clinical experiences suggested that studies with high-level evidence, such as systematic reviews, meta-analyses, or randomized controlled clinical trials, are required.Clinical relevanceIt is identified that more studies with high-level evidence-based research are needed in the field of dental adhesives.

Host-Bacterium Interaction Mechanisms in Staphylococcus aureus Endocarditis: A Systematic Review.

Staphylococci sp. are the most commonly associated pathogens in infective endocarditis, especially within high-income nations. This along with the increasing burden of healthcare, aging populations, and the protracted infection courses, contribute to a significant challenge for healthcare systems. A systematic review was conducted using relevant search criteria from PubMed, Ovid's version of MEDLINE, and EMBASE, and data were tabulated from randomized controlled trials (RCT), observational cohort studies, meta-analysis, and basic research articles. The review was registered with the OSF register of systematic reviews and followed the PRISMA reporting guidelines. Thirty-five studies met the inclusion criteria and were included in the final systematic review. The role of Staphylococcus aureus and its interaction with the protective shield and host protection functions was identified and highlighted in several studies. The interaction between infective endocarditis pathogens, vascular endothelium, and blood constituents was also explored, giving rise to the potential use of antiplatelets as preventative and/or curative agents. Several factors allow Staphylococcus aureus infections to proliferate within the host with numerous promoting and perpetuating agents. The complex interaction with the hosts' innate immunity also potentiates its virulence. The goal of this study is to attain a better understanding on the molecular pathways involved in infective endocarditis supported by S. aureus and whether therapeutic avenues for the prevention and treatment of IE can be obtained. The use of antibiotic-treated allogeneic tissues have marked antibacterial action, thereby becoming the ideal substitute in native and prosthetic valvular infections. However, the development of effective vaccines against S. aureus still requires in-depth studies.

Ion channels involved in inflammation and pain in osteoarthritis and related musculoskeletal disorders.

Osteoarthritis (OA) is a currently incurable, chronic, progressive and debilitating musculoskeletal condition. One of its hallmark symptoms is chronic nociceptive and neuropathic pain, which significantly reduces the quality of life of OA patients. While research into the pathomechanisms of OA pain is ongoing and several pain pathways are well understood, the true source of OA pain remains unclear. Ion channels and transporters are key mediators of nociceptive pain. In this narrative review article, we summarize the state-of-the-art in relation to the distribution and function of ion channels in all major synovial joint tissues in the context of pain generation. We provide an update on the ion channels likely involved in mediating peripheral and central nociceptive pathways in the nervous system in OA pain, including voltage-gated sodium and potassium channels, members of the transient receptor potential (TRP) channel family, and purinergic receptor complexes. We focus on ion channels and transporters that have a potential to be candidate drug targets for pain management in OA patients. We propose that ion channels expressed by the cells of constituent tissues of OA-afflicted synovial joints including cartilage, bone, synovium, ligament and muscle, should be more thoroughly investigated and targeted in the context of OA pain. Based on key findings from recent basic research articles as well as clinical trials, we propose novel directions for the development of future analgesic therapies to improve the quality of life of OA patients.

Hot topics and fresh look on old problems: A new vision of the Journal of Endometriosis and Pelvic Pain Disorders

We would like to announce a new vision of the Journal of Endometriosis and Pelvic Pain Disorders. Thanks to the contribution by former Editors-in-Chief, Associate Editors, and Editorial Board members, as well as all Readers we have a stable base and our journal is still growing. Today, it is safe to say that the journal has already matured and that it has a specific goal, specific groups of authors and readers—each of them is unique. The audience of our magazine mostly includes clinicians and scientists dealing with the subject of broadly understood gynecology with an emphasis on minimally-invasive gynecology, as well as the issues of pathophysiology, particularly comprising the topic of endometriosis, pelvic pain, reproduction, uterine fibroids, or some parts of endocrinology or gynecological oncology. Currently, our journal publishes a high quality peer-reviewed basic and clinical original research articles and critical reviews focusing specifically on the diagnosis, medical, and surgical treatment of endometriosis, adenomyosis, and associated disorders in all their multidimensional aspects. In our strategy for the forthcoming years, we will especially keep place for the most important current problems, controversial or unresolved topics in particular, which are not lacking in case of such a poorly understood pathology as endometriosis, pelvic pain, or uterine fibroids. To sum up, we believe that our journal will surely continue developing in all most important areas of clinical and scientific publishing—these mean standards, basic research, translational medicine, and clinical concept.

The State of the Catatonia Literature: Employing Bibliometric Analysis of Articles From 1965-2020 to Identify Current Research Gaps.

Since Kahlbaum's classic 19th-century description of catatonia, our conceptualization of this syndrome, as well treatment options for it, has advanced considerably. However, little is known about the current state of the catatonia literature since a comprehensive bibliometric analysis of it has not yet been undertaken. The purpose of this study was to conduct a bibliometric analysis, along with a content analysis of articles reporting new findings, to better understand the catatonia literature and how catatonia research is changing. Using the search term "Title(catatoni∗)" in Web of Science Core Collection for all available years (1965-2020), all available publications (articles, proceeding papers, reviews) pertaining directly to catatonia were identified, and metadata extracted. Semantic and coauthorship network analyses were conducted. A content analysis was also conducted on all available case reports, case series, and research articles written in English. A total of 1015 articles were identified representing 2861 authors, 346 journals, and 15,639 references. The average number of publications per year over the last 20years (31.3) more than doubled in comparison to that in the 20years prior (12.8). The top 3 most common journals were Psychosomatics/Journal of the Academy of Consultation-Liaison Psychiatry, Journal of ECT, and Schizophrenia Research, which represented 12.6% of all publications. Content analysis revealed that catatonia articles are increasingly published in nonpsychiatric journals. There was a notable paucity of clinical trials throughout the study period. Since 2003, articles on catatonia secondary to a general medical condition, as well as articles including child/adolescent patients and patients with autism spectrum disorder or intellectual disability, have made up increasing shares of the literature, with a smaller proportion of articles reporting periodic or recurrent catatonia. We noted a decrease in the proportion of articles detailing animal/invitro studies, genetic/heredity studies, and clinical trials, along with stagnation in the proportion of neuroimaging studies. The catatonia literature is growing through contributions from authors and institutions across multiple countries. However, recent growth has largely been driven by increased case reports, with significant downturns observed in both clinical and basic science research articles. A dearth of clinical trials evaluating potential treatments remain a critical gap in the catatonia literature.

International Working Group (IWG) Response Criteria and Association with Overall Survival in Patients with Myelodysplastic Syndromes Treated with Hypomethylating Agents - a Systematic Review and Meta-Analysis

* A.M.Z. and M.S. contributed equally Introduction: Response assessments in clinical trials and routine practice for patients (pts) with myelodysplastic syndromes (MDS) treated with hypomethylating agents (HMA) are based on the International Working Group (IWG) criteria proposed in 2000 and revised in 2006. However, it is not clear whether response criteria correlate with overall survival (OS). Methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines with a systematic search using controlled vocabulary and free text terms for MDS and survival of Cochrane Library, Google Scholar, Ovid Embase, Ovid Medline, Pubmed, Scopus, and Web of Science Core Collection databases to find relevant articles published from inception to January 2022. The search was peer-reviewed by a second medical librarian. A targeted search of recent conference proceedings was also performed. Titles, abstracts, and full texts were reviewed for inclusion in the meta-analysis by two reviewers independently and conflicts were resolved by consensus discussion. Clinical trials and cohort studies with >100 pts reporting on the association of IWG 2000 or 2006 response criteria with OS among pts treated with HMA monotherapy or combinations were eligible for inclusion. Studies were excluded if they were (i) review or basic research articles, (ii) studies with <50% higher-risk MDS pts (inclusion of a minority of pts with MDS/MPN, oligoblastic AML, and lower-risk MDS was permitted), (iii) not published in English, and (iv) had insufficient reporting of the primary endpoint. The primary endpoint was the hazard ratio (HR) for OS for patients achieving an IWG-defined response (complete remission [CR], marrow CR, partial remission, hematologic improvement [HI]) compared to patients not achieving a response. Random-effects models were used to pool the HRs for death. Cochran Q and I2 indices were used to assess heterogeneity across included studies. Study heterogeneity was graded based on I2 indices as low (I2 <30%), moderate (I2 =30-60%), or high (I2 >60%). Comprehensive Meta-Analysis (CMA version 2.2, Biostat) was used for all analyses. Results: Our search strategy identified 7023 studies after duplicate removal. Following abstract and title review to identify clinical trials and large cohort studies reporting IWG response and OS among MDS pts treated with HMA, 195 studies were assessed for eligibility as full texts. Among these 185 studies were excluded for the following reasons: insufficient reporting of the primary outcome of OS and IWG response (n=114), duplicate publications from the same pt cohort (n=42), <50% higher-risk MDS pts (n=13), cohort studies with <100 pts (n=6), not on HMA therapy (n=4), ongoing clinical trials without published results (n=3), transplant (n=2), and review article (n=1). The final set of studies included 3896 MDS pts treated with azacitidine, decitabine, guadecitabine, or HMA-combination in 9, 4, 1, and 2 studies, respectively. Among the 5 available studies with data on the impact of CR on OS, the HR for death was 0.365 (95% CI: 0.311-0.430) for pts who achieved a CR compared to pts without a CR. Study heterogeneity was low (Cochran's Q=0.5; I2=0%; Figure A). Six studies reported the impact of HI on OS. Pts who achieved HI had favorable outcomes compared to pts without HI (HR: 0.419; 95% CI: 0.299-0.585) but with high heterogeneity across studies (Cochran's Q=14.34; I2=65.13%; Figure B). The prognostic impact of other response categories (e.g., marrow CR, partial remission) was only reported by 1 study each, precluding a meta-analysis. Conclusion: Achieving CR as defined by the IWG MDS response criteria is associated with improved OS among higher-risk MDS pts treated with HMA-based regimens. HI was also associated with OS, but with high study heterogeneity. The strong and consistent association of CR with OS supports its use as an outcome in clinical trials in MDS. The prognostic implications of other response categories as such CR with partial hematologic recovery (CRh) especially with novel combination therapies require additional studies. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal

S1525 The File Drawer Effect in the Gastroenterology and Hepatology Literature

Introduction: The File Drawer Effect, or the tendency for studies with statistically significant results to be published and those with unequivocal or negative findings to remain unpublished or less known, can have a significant impact on the scientific literature available in a field. We sought to examine the proportion of studies with statistically significant results published in the gastroenterology and hepatology literature. Methods: We reviewed all original articles published in 2012 and 2017 in 4 national gastroenterology and hepatology journals (Gut, Journal of Crohn’s and Colitis, Hepatology, and Clinical Gastroenterology and Hepatology). Our primary study outcome was the proportion of studies with a statistically significant finding. The number of times the study was cited according to Google Scholar was recorded and used as a measure of a study’s impact. The type of study (clinical or basic) was also recorded. Results: In total, 1,414 articles were reviewed and 3 were excluded due to unclear study results. Of the studies included, 97.31% (1,373) had at least one positive study result and 2.69% (28) had all negative study results. The proportion of articles with positive findings in 2012 (96.9%) was lower, though not significantly, from the proportion of articles with positive findings in 2017 (97.8%) (P < .38). The proportion of clinical science articles with positive findings (99.3%) was significantly greater than the proportion of basic research articles with positive findings (95.9%) (P < .01). The difference between the median number of times a study was cited and whether the study had a positive or negative result was not found to be statistically significant (P = .26). Conclusion: An overwhelming majority of studies published in the selected journals were found to be positive, and this proportion increased slightly between 2012 and 2017. While a study’s impact did not significantly differ between those with statistically significant and insignificant results, this could not be adequately examined due to the low sample size of negative studies (only 28) and subsequent lack of statistical power. The low representation of studies without statistically significant results, especially in clinical research, highlights a possible publication bias that is prevalent across the specialty’s literature. This bias can potentially drive poor clinical practice, and steps should be considered to further study this effect.

A Discussion Between Past and Present Editor-in-Chief of the International Neurourology Journal: Three Decades of History.

The International Neurourology Journal (Int Neurourol J, INJ) is a quarterly international journal that publishes high-quality research papers that provide the most significant and promising achievements in the fields of clinical neurourology and fundamental science. Specifically, fundamental science includes the most influential research papers from all fields of science and technology, revolutionizing what physicians and researchers practicing the art of neurourology worldwide know. Thus, we welcome valuable basic research articles to introduce cutting-edge translational research of fundamental sciences to clinical neurourology. In the editorials, urologists will present their perspectives on these articles. The original mission statement of the INJ was published on October 12, 1997. INJ provides authors a fast review of their work and makes a decision in an average of 3 to 4 weeks of receiving submissions. If accepted, articles are posted online in fully citable form. Supplementary issues will be published interim to quarterlies, as necessary, to fully allow berth to accept and publish relevant articles. Science Citation Index Expanded (SCIE, Web of Science), Scopus, PubMed, PubMed Central, KoreaMed, KoMCI, WPRIM, WorldWideScience.org, DOI/Crossref, EBSCO, Google Scholar.

Gastroenterology: A New Editorial Team Coming to You From Around the World

Gastroenterology: A New Editorial Team Coming to You From Around the World

The latest research trends in primary biliary cholangitis: a bibliometric analysis.

The bibliometric analysis uses the citation count of an article to measure its impact in the scientific community, but no study has been undertaken to determine the most influential papers in the field of primary biliary cholangitis (PBC). This study aimed to investigate the global research interest regarding PBC in dentistry using a bibliometric approach. We searched the Web of Science Core Collection database to find the top 100 most cited (T100) articles focusing on PBC. The information about each article including citations, authors, journals, countries, institutions, and keywords was recorded for bibliometric analysis. The T100 articles related to PBC were published from 1983 to 2019 and were originated from 26 countries. A total of 805 different authors were from 342 different institutions, and articles written by them were published in 35 journals. The five most frequently occurring keywords were "biochemical response," "ursodeoxycholic acid," "primary biliary cirrhosis," "antimitochondrial antibody," and "autoimmunity." The T100 articles were classified into different research focuses: pathogenesis (41%), treatment (20%), prognosis (12%), epidemiology (9%), diagnosis (8%), and others (10%). These 100 articles included 32 observational studies, 29 basic research articles, 15 reviews, eight meta-analyses, 12 clinical trials, and four clinical guidelines. The 100 top-cited articles are marked with the leading countries, institutions, journals, hotspots, and development trends in the PBC field that could provide the foundation for further investigations.

An Innovative Forum for Gastroenterology and Hepatology Issues.

Welcome to the inaugural issue of Gastro Hep Advances (GHA), the newest addition to the American Gastroenterological Association (AGA) journal family. GHA is meant to be, by nature, of broad scope, to be online and open-access, and to be a rapidly responsive peer-reviewed journal designed to meet the growing needs of the gastroenterology and hepatology community. GHA will publish original clinical, translational, and basic science research articles, as well as comprehensive reviews on current issues.

Hypomethylating Agents and FLT3 Inhibitors As Maintenance Treatment for Acute Myeloid Leukemia and Myelodysplastic Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation–A Systematic Review and Meta-Analysis

BackgroundDisease relapse remains the major cause of death among patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who receive an allogeneic hematopoietic cell transplant (allo-HCT). Maintenance treatment with FLT3 inhibitors and hypomethylating agents (HMA) has been studied in various clinical trials with mixed results. ObjectiveTo synthesize the current evidence on the efficacy and safety of FLT3 inhibitors and HMA for maintenance therapy after allo-HCT in AML and MDS. MethodsFor this systematic review and meta-analysis Cochrane Library, Google Scholar, Ovid Medline, Ovid Embase, PubMed, Scopus, and Web of Science Core Collection were searched from inception to March 2021 for studies on maintenance therapies after allo-HCT in AML and MDS. Studies were excluded if they were reviews, commentaries, case series with <5 patients, or basic research articles, not published in English, not on post-allo-HCT maintenance with FLT3 inhibitors or HMA in AML or MDS, or if they were clinical trials without published results or duplicate publications from the same patient cohort. Studies with insufficient reporting of the primary endpoint (2-year overall survival [OS]) and studies using FLT3 inhibitors or HMA for pre-emptive treatment of imminent relapse based on positive measurable residual disease testing were excluded. Random-effects models were used to pool response rates for the primary outcome of 2-year OS. Hazard ratios (HR) for death and relapse were calculated for studies that included a control group. Rates of relapse-free survival (RFS), non-relapse mortality, and acute and chronic graft-versus-host-disease (GVHD) were studied as secondary endpoints. Downs and Black checklist and risk of bias assessments were used to gauge the quality of individual studies. The study protocol has been registered on PROSPERO (CRD42020187298). ResultsOur search strategy identified 5559 studies. Twenty-one studies with a total of 809 patients were included in the meta-analysis. The 2-year OS rates were 81.7% (95% confidence interval [CI], 73.8%-87.7%) and 65.7% (95% CI, 55.1%-74.9%) among patients treated with FLT3 inhibitors and HMA, respectively. In sensitivity analyses restricted to studies that included a control group, maintenance therapy with FLT3 inhibitors (HR for death = 0.41; 95% CI, 0.26-0.62) or HMA (HR = 0.45; 95% CI, 0.31-0.66) appeared superior to no maintenance therapy. The 2-year RFS rates were 79.8% (95% CI, 75.0%-83.9%) and 62.4% (95% CI, 50.6%-72.9%) among patients treated with FLT3 inhibitors and HMA, respectively. Rates of any grade acute and chronic GVHD were 33.1% (95% CI, 25.4%-41.8%; grade 3/4: 16.5%) and 42.5% (95% CI, 26.3%-60.4%) among FLT3 inhibitor and 42.7% (95% CI, 33.5%-52.4%; grade 3/4: 8.1%) and 41.5% (95% CI, 32.0%-51.6%) among HMA-treated patients, respectively. ConclusionMaintenance therapy with either FLT3 inhibitors or HMA after allo-HCT can lead to prolonged and improved OS and RFS with a favorable safety profile. Additional studies are needed to define the optimal duration of treatment, the role of measurable residual disease status, and transplant characteristics in patient selection.

Adrenals

For this year’s chapter on ‘Adrenals’, we have searched the PubMed for articles on ‘adrenal’ or ‘steroidogenesis’ published in English between June 1, 2020 and May 31, 2021. Our search yielded more than 5,000 citations. We have examined all citations individually and selected the following collection of basic research and clinical articles. Whenever possible, we have avoided topics that have been discussed in the Yearbook 2020, unless progress in the field has been incremental. Emerging themes for this year’s chapter include: i) The role of neuropeptide substance P in the regulation of aldosterone secretion; ii) Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion; iii) Urinary GC-MS steroid metabotyping in treated children with congenital adrenal hyperplasia; iv) Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency; v) Efficacy and safety of osilodrostat in patients with Cushing’s disease (LINC 3): a multicentre phase III study with a double-blind, randomized withdrawal phase; vi) First-trimester prenatal Dexamethasone treatment is associated with alterations in brain structure at adult age; and vii) Perturbed beta-cell function and lipid profile after early prenatal Dexamethasone exposure in individuals without CAH.

Safety and Efficacy of Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplant in Acute Myeloid Leukemia and Myelodysplastic Syndrome - a Systematic Review and Meta-Analysis

Safety and Efficacy of Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplant in Acute Myeloid Leukemia and Myelodysplastic Syndrome - a Systematic Review and Meta-Analysis

Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis.

Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy; however, the underlying mechanisms remain unclear. In this study, we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years, which were included in the Web of Science Core Collection. We found the following: (1) a co-citation analysis of the references cited by all 552 articles indicated 15 clusters. In cluster #0, representing the stem cell field, some highly cited landmark studies emerged between 2009–2013. For example, endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars, in terms of their relationship and therapeutic prospects. Some researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells, using a variety of animal models of retinal vascular disease. All of these achievements provided references for the subsequent stem cell research. (2) An analysis of popular keywords among the 552 articles revealed that, during the past 20 years, a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was observed. The contents of these articles primarily involved the expression of vascular endothelial growth factor, vascular regeneration, oxidative stress, and inflammatory response. (3) A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012, including several studies addressing the expression of various growth factor genes; from 2014 to 2020, mouse models of diabetic retinopathy were recognized as mature animal models, and the most recent research has focused on macular degeneration, macular edema, neurodegeneration, and inflammatory changes in diabetic animal models. (4) Globally, the current authoritative studies have focused on basic research towards the stem cell treatment of diabetic retinopathy. Existing clinical studies are of low quality and have insufficient evidence levels, and their findings have not yet been widely accepted in clinical practice. Major challenges during stem cell transplantation remain, including stem cell heterogeneity, cell delivery, and the effective homing of stem cells to damaged tissue. However, clinical trials examining potential stem cell-based treatments of diabetic retinopathy, including the use of pluripotent stem cells, retinal pigment epithelial cells, bone marrow mesenchymal stem cells, and endothelial progenitor cells, are currently ongoing, and high-quality clinical evidence is likely to appear in the future, to promote clinical transformation.

Adrenals

Preface: For this year’s chapter on ‘Adrenals’, we have searched the PubMed for articles on ‘adrenal’ or ‘steroidogenesis’ published in English between June 1, 2018 and May 31, 2019. Our search yielded more than 5,000 citations. We have examined all citations individually and selected the following collection of basic research and clinical articles. Whenever possible, we have avoided topics that have been discussed in the Yearbook 2018, unless progress in the field has been incremental. Emerging themes for this year’s chapter include: i) Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells; ii) Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex; iii) Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children; iv) An Endocrine Society Clinical Practice Guideline for the diagnosis and management of Congenital Adrenal Hyperplasia Due to Steroid 21-hydroxylase deficiency; and v) Epigenetic alterations associated with early prenatal dexamethasone treatment.

On the (Ir)Relevance of Psychological Research: Students versus Scientists and Implications for Teaching

Research articles are widely used in the training of undergraduate students. Editors and reviewers of the top scientific psychology journals influence the development in the field by publishing certain articles and rejecting others, probably assuming that the published articles are empirically sound and theoretically highly relevant. The current study investigated if published articles are indeed regarded as relevant by a sample of 393 psychology undergraduate students from a university in the Southeast of the United States. The students&amp;rsquo; age ranged between 18 and 57 (M = 23, SD = 6.05) and 84% were female. Students received brief statements about potential research studies and rated them regarding relevance, not knowing that the summaries were from actual research studies published in peer-reviewed journals. Results showed that (1) overall, research articles were regarded as generally irrelevant, (2) applied articles were regarded as more relevant than basic research articles, (3) ratings did not differ based on gender or age, and (4) the more advanced students were in the Psychology program, the higher their relevance ratings were for applied research as compared to basic research. Results are comforting or disturbing; comforting, because students might not have the professional expertise to make such relevance judgments; disturbing, because results might indicate how specialized and insulated journals have become by not addressing topics relevant to a wider population. Results also have implications for teaching research methods and experimental psychology courses.

The 100 most influential manuscripts on hepatocellular carcinoma: a bibliometric analysis.

ObjectiveCitation analysis represents one of the best available methods to identify the most influential articles. This study aimed to identify and characterize the top 100 highly cited articles (T100) that focus on hepatocellular carcinoma and to reveal the trends in accomplishments within this field.MethodsA search of the Thomson Reuters Web of Science citation indexing database was conducted using terms related to hepatocellular carcinoma. The T100 were selected and analyzed further based on the number of citations, authorship, year of publication, journal, country of origin, institution, and article type.ResultsHepatology published the highest number of papers (n = 15), and the United States produced the highest number of contributions (n = 31). Barcelona University was the institution with the highest number of articles in the T100 (n = 9). The T100 articles included 35 observational studies, 13 randomized control studies, 25 basic research articles, 18 reviews, seven clinical guidelines, and two meta-analyses.ConclusionsThis is the first bibliometric study to identify the most influential papers in hepatocellular carcinoma research. This report presents major advances and changes in research regarding hepatocellular carcinoma and can serve as a guide for writing a citable article.

The top 10 most-cited articles on the management of fractured instruments: a bibliometric analysis.

ObjectivesThe purpose of this research was to identify the top 10 most-cited articles on the management of fractured or broken instruments and to perform a bibliometric analysis thereof.Materials and MethodsPublished articles related to fractured instruments were screened from online databases, such as Web of Science, Scopus, PubMed, and ScienceDirect, and highly cited papers, with at least 50 citations since publication, were identified. The most-cited articles were selected and analysed with regard to publication title, authorship, the journal of publication, year, institution, country of origin, article type, and number of citations.ResultsThe top 10 most-cited articles were from various journals. Most were published in the Journal of Endodontics, followed by the International Endodontic Journal, and Dental Traumatology. The leading countries were Australia, Israel, Switzerland, the USA, and Germany, and the leading institution was the University of Melbourne. The majority of articles among the top 10 articles were clinical research studies (n = 8), followed by a basic research article and a non-systematic review article.ConclusionsThis bibliometric analysis revealed interesting information about scientific progress in endodontics regarding fractured instruments. Overall, clinical research studies and basic research articles published in high-impact endodontic journals had the highest citation rates.

Reporting Sex and Sex Differences in Preclinical Studies.

ATVB aims to publish research work that advances scientific fields in a rigorous and reproducible manner. We have implemented multiple approaches to follow the National Institutes of Health (NIH) guidelines for rigor and reproducibility. In 2013, ATVB developed a “checklist” in the peer review process to facilitate comments on multiple technical requirements, including the sex of animals used in preclinical studies. We have also emphasized the NIH guidelines that encourage researchers to study both sexes in preclinical animal models. These include publishing a review1 entitled “Sex differences in the development of cardiovascular diseases” and an ATVB Council statement2 to encourage authors to consider sex differences in designing and reporting experimental arterial pathology studies that details the mode by which ATVB complies with the NIH guidelines.3 The journal appointed a technical review editor, Dr. Hong Lu, who assumed the role in September 2017 in order to assess the many elements required for adherence to the NIH guidelines. These include issues such as the rigor of statistical analyses and animal background strain, age, and sex. The designation of sex of origin in studies of primary cells derived from cell culture is not as common as it is in whole animal studies. This is probably due to the unproven assumption that the lack of the hormonal environment in cell culture eliminates the need for designation of sex. However, since the differences of X and Y sex chromosomes and possibly sex-related differences in genomic imprinting are preserved in cultured cells, these cells could theoretically retain the ability to respond in a sex-dependent manner.4 Therefore, we also encourage and will monitor the reporting of sex in primary cell isolation and culture. In a recent letter to the ATVB editors, Ramirez and Hibbert5 performed a comprehensive literature search and detailed statistical analysis on articles focusing on atherosclerosis and aneurysms from 2006 through 2016. They concluded that publication of guidelines and statements alone is not sufficient to assure the reporting of sex and sex differences in preclinical studies. To more objectively assess whether and how sex information in preclinical research has been reported, the ATVB editors reviewed 332 basic science research articles published in ATVB between 2016 and 2017.6–337 After excluding those that studied only human samples, human cells, cell lines, or computational models, 159 articles published in 2016 and 136 articles published in 2017 were analyzed (Tables ​(Tables11–5), which reported studies in animal models and/or primary cells isolated from animals.6–300 There were 7 species reported in these articles (Table 1), including zebrafish, mouse, rat, rabbit, dog, pig, and nonhuman primates. Among these 295 articles analyzed, 79% and 92% of those from 2016 and 2017, respectively, provided sex information for in vivo models. However, only 11% of the articles in 2016 and 21% in 2017 reported results from both males and females. One hundred and thirty three of 295 articles reported primary cells isolated from mouse, rat, cow, or pig. Twenty-eight percent of the articles in 2016 and 27% in 2017 provided sex information, whereas only 3 articles studied cells from both male and female animals. Table 1. All Animal Species Reported in Preclinical Studies