Printed microstrip-fed antennas based on a slotted radiating patch are proposed herein. First, a basic rectangular antenna without any slots was designed, being suitable for wideband applications and showing impedance bandwidth of 2714 MHz for $$S_{11} < -10$$S11<-10 dB. Next, dual-band operation for worldwide interoperability for microwave access (WiMAX, from 3.11 to 3.97 GHz) and wireless local-area network (WLAN, 4.97---5.71 GHz) was obtained by including slots only on the left side of the basic design. Then, using a structure with slots on the right side of the radiating patch, WLAN operation was obtained in the frequency range of 2.865---2.096 GHz. The fourth antenna, with slots on both sides of the patch, was characterized and realized for biomedical applications at 2.45 GHz ($$S_{11} <-10$$S11<-10 dB). The proposed antennas can be realized with small ground plane size and total antenna area of only $$27.5 \times 21\,\hbox {mm}^{2}$$27.5×21mm2. This reduction in total antenna area is achieved by using a truncated patch. All the simulations were carried out using Empire XCcel. The designs were characterized based on their radiation pattern, return loss, voltage standing wave ratio (VSWR), gain, and current distribution. The simulated and measured results show good compatibility.