Objective: To explore and analyze the work process-based practical training teaching model for basic nursing skills in vocational colleges and its implementation effects. Methods: A total of 82 nursing students from our school were selected for the study, which was conducted from April 2023 to April 2024. Using a random number table method, the students were divided into an observation group and a control group, each with 41 students. The control group received conventional practical training teaching, while the observation group followed the work process-based practical training model for basic nursing skills. The assessment scores and teaching satisfaction of the two groups were compared. Results: The comparison of assessment scores showed that the observation group performed significantly better than the control group (P < 0.05). The comparison of teaching satisfaction also indicated that the observation group had significantly higher satisfaction than the control group (P < 0.05). Conclusion: The work process-based practical training teaching model for basic nursing skills in vocational colleges can improve students’ assessment scores and enhance teaching satisfaction, demonstrating its value for wider application.