Objective: to study the Socratic method of teaching and Seminar teaching method in nursing professional basic medical teaching practice and the effect is discussed. Results: The scores of the experimental group were significantly higher than those of the control group (90.7±5.0 vs. 86.5±3.8; T = 3.1, P = 0.016); The scores of basic theory (78.5±6.4vs.77.5±3.1; t = 2.291, P = 0.048), paper score (92.0±5.0 vs. 80.0±5.0; t = 2.021, P = 0.018) were better than the control group, especially in the topic selection and writing level, the experimental group was significantly higher.