Basic Data For Further Research Research Articles

독일 집회법의 발전과 시사점

In Germany, it is difficult to uniformly determine the scope of assembly regulations because they extend not only to assembly laws, incidental laws, and subordinate laws, but also to general administrative laws such as the police law, criminal laws such as the criminal law, and even regulations on violations of order. If possible, it will be necessary to accurately understand the German system, but it is necessary to properly limit the scope of the study due to the limitations of ability and time. This study aims to contribute to the interpretation and operation of our assembly law and the improvement of the assembly culture by reviewing various systems established in the German assembly law, which is the birthplace of our legislation, and deriving implications that can contribute to the improvement of our assembly law and assembly culture. However, as the contents are dealt with in a limited time, it is regrettable that all the issues of German assembly law cannot be studied with the same weight, and some are merely introduced. Nevertheless, if this study can be used as basic data for further research on German assembly law in the future, it will have great significance in itself. First, the history and development of German assembly law will be examined, and the discussion will be conducted in the order of implications and keywords of German assembly law. Through this study, we examined the limitations of the guarantee of freedom of assembly and its restrictions, focusing on Article 8 of the German Framework Act on Assembly Freedom and Assembly Act. I also had the opportunity to point out the problems of our current assembly law through comparative legal considerations. It is also true that it is impossible to simply compare the legal reality of Germany and Korea in that the law can be specified in the country's own culture and society. If it is true that our current assembly law was created in 1962 with the mind of the military government, and if our society remained in the mind of that military government even 60 years later, the comparison between the German assembly law and our current assembly law itself would be meaningless. However, although our society may be different from Germany, we are convinced that the constitution is a living and breathing democracy, and we are eager to see spring in our assembly law.

Combined Toxic Effects of Lead and Glyphosate on Apis cerana cerana.

Glyphosate (GY) is the most widely used herbicide in agriculture worldwide. Lead is a common heavy metal in the natural environment. Honeybees, as pollinators, are exposed to these pollutants. So far, few reports have evaluated the toxic effects of GY mixed with heavy metals on honeybees (Apis cerana cerana). This study found that the acute toxicity of lead (LC50 = 1083 mg/L) is much greater than that of GY (LC50 = 4764 mg/L) at 96 h. The acute toxicities of the mixed substances were as follows: LC50 = 621 mg/L of lead and LC50 = 946 mg/L of GY. The combination of lead and GY was more toxic than either of the individual substances alone. Compared to the individual toxicity, combined treatment significantly affected the bees' learning and cognitive abilities and changed the relative expression of genes related to immune defense and detoxification metabolism in A. c. cerana. The combination of lead and GY seriously affected the behavior and physiology of the studied honeybees. This study provides basic data for further research on the combined effects of GY and heavy metals on bee health. It also serves as a reference for effective colony protection.

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs.

To explore potential biomarkers for early diagnosis of atherosclerosis (AS) and provide basic data for further research on AS, the characteristics of serum metabolomics during the progression of AS in mini-pigs were observed dynamically. An AS model in Bama miniature pigs was established by a high-cholesterol and high-fat diet. Fasting serum samples were collected monthly for metabolomics and serum lipid detection. At the end of the treatment period, pathological analysis of the abdominal aorta and coronary artery was performed to evaluate the lesions of AS, thereby distinguishing the susceptibility of mini-pigs to AS. The metabolomics was detected using a high-resolution untargeted metabolomic approach. Statistical analysis was used to identify metabolites associated with AS susceptibility. Based on pathological analysis, mini-pigs were divided into two groups: a susceptible group (n = 3) and a non-susceptible group (n = 6). A total of 1318 metabolites were identified, with significant shifting of metabolic profiles over time in both groups. Dynamic monitoring analysis highlighted 57 metabolites that exhibited an obvious trend of differential changes between two groups with the advance of time. The KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis indicated significant disorders in cholesterol metabolism, primary bile acid metabolism, histidine metabolism, as well as taurine and hypotaurine metabolism. During the progression of AS in mini-pigs induced by high-cholesterol/high-fat diet, the alterations in serum metabolic profile exhibited a time-dependent pattern, accompanied by notable disturbances in lipid metabolism, cholesterol metabolism, and amino acid metabolism. These metabolites may become potential biomarkers for early diagnosis of AS.

Characteristics of Corneal Ulcer Patients at Bali Mandara Eye Hospital in 2021-2022

Background: A corneal ulcer is a pathological discontinuity of corneal epithelium surface. The incidence in developing countries reached 1.5-2 million per year and one of the causes of blindness. Corneal ulcers can occur at any age and gender which is influenced by geographic conditions. The causes of corneal ulcers vary depend on the region, predisposing factors, and microorganisms in the particular community. Purpose: To know the characteristics of corneal ulcers particularly at the Bali Mandara Eye Hospital and as a basic data for further research. Methods: A total of 77 selected medical records at Bali Mandara Hospital from January 2021–May 2022 were used in this descriptive study using a retrospective method. Patient characteristics, etiology, clinical characteristics, management, and complications were identified in this study. Descriptive analysis was performed on all data and presented in frequency tabulation. Results: In this study, 52 cases (67.5%) were male and 25 cases (32.5%) were female. The largest age group was 24-64 years with 34 cases (44.2%). All cases with corneal ulcers (100%) complained of red eye symptoms. Trauma (61.0%) as the most common predisposing factors that was caused by plants (24.7%). The most common etiologies were bacteria (46.8%) followed by fungi (5.2%), and mixed (28.6%). Most of the cases were managed without treatment (66.2%) with the outcome of improvement (55.8%), without complications (53.2%), perforation (28.6%), and descemetocele (15.6%). Conclusion: Most patients with corneal ulcers at the Bali Mandara Eye Hospital are male than female with range of 24-64 years and trauma being the most common predisposing factor. This is because it is the range for productive age and the majority of the population in Indonesia, especially Bali, works as farmers. Most microorganisms that cause corneal ulcers are bacteria. Most patients receive non-surgical treatment with more than 50% of patients experiencing improvements in vision and no complications. Keywords: Corneal Ulcers, keratitis, ocular trauma, visual impairment

SNP Diagnosis in Elite Athletes by Korean Athletic Performance

PURPOSE: The purpose of this study is to analyze SNPs related to performance (maximal strength vs. cardiovascular endurance) of world-class Korean elite athletes using the Genome-Wide Human SNP Array 6.0 and to determine genotypes related to maximal strength and cardiovascular endurance performance that are unique to “Koreans”.METHODS: Using the Genome-Wide Human SNP Array 6.0, we analyzed SNPs obtained from 54 world-class Korean elite athletes (Olympic participants/World Championship medalists). The group was divided into the 16 maximal strength group (12 males and 4 females weightlifters who had won medals at the Olympic and World Championships), 12 cardiovascular endurance group (12 males marathon runners who had run within 2 hours and 12 minutes in international competitions), and 26 individuals from the general population (25 males and 1 female). All the obtained SNPs were subjected to quality control (QC), and a total of 867,982 SNPs were analyzed between the marathon runners and general population subjects (641,040 SNPs) and between weightlifters and general population subjects (634,418 SNPs).RESULTS: The number of SNPs with more than two SNPs within 100 kb, which satisfied the threshold of sample QC and significance level of <i>p</i><.0001, was 60 in marathoners and 18 in weightlifters compared to the general population subjects. When the genomic features of SNPs of each performance trait were analyzed, the 60 SNPs for cardiovascular endurance with two or more SNPs within 100 kb that met the <i>p</i><.0001 threshold for significance were distributed across 15 regions, and the 18 SNPs for maximal strength were distributed across 7 regions.CONCLUSIONS: In conclusion, SNPs related to cardiovascular endurance and maximal strength suggest the possibility of producing gene chips to derive genotypes unique to “Koreans” in the future. Additionally, this study provides important basic data for further research.

Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area.

This study aims to review the blood routine and biochemical indicators of the plateau population for three consecutive years, and analyze the impact of the plateau on these blood indicators of the Tibetan population and the Han immigrant population. These parameters were extracted from the Laboratory Department of Ali District People's Hospital in Tibet from January 2019 to December 2021, including blood routine, liver and kidney function, blood lipids, myocardial enzyme spectrum, and rheumatic factor indicators. Changes in these parameters were analyzed over 3 consecutive years according to inclusion and exclusion criteria. A total of 114 Tibetans and 93 Hans participated in the study. These parameters were significantly different between Tibetan and Han populations. Red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), mean hemoglobin content (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cells (WBC), lymphocytes (LYMPH) and monocytes (MONO) were significantly higher in Hans than Tibetans (p < 0.05). Biochemically, total bilirubin (TBIL), direct bilirubin (DBIL), albumin (ALB), urea nitrogen (Urea), creatinine (Cr), uric acid (UA), glucose (GLU), triglycerides (TG) and creatine kinase isoenzyme (CKMB) were significantly higher in Hans than Tibetans; aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), antistreptolysin (ASO), and C-reactive protein (CRP) were significantly higher in Tibetans than Hans (p < 0.05). There were no obvious continuous upward or downward trend of the parameters for 3 consecutive years. In high-altitude areas, Han immigrants have long-term stress changes compared with Tibetans. The main differences are reflected in the blood system, liver and kidney functions, etc., which provide basic data for further research on the health status of plateau populations.

Transcriptome Studies Reveal the N6-Methyladenosine Differences in Testis of Yaks at Juvenile and Sexual Maturity Stages.

Studying the mechanism of spermatogenesis is key to exploring the reproductive characteristics of male yaks. Although N6-methyladenosine (m6A) RNA modification has been reported to regulate spermatogenesis and reproductive function in mammals, the molecular mechanism of m6A in yak testis development and spermatogenesis remains largely unknown. Therefore, we collected testicular tissue from juvenile and adult yaks and found that the m6A level significantly increased after sexual maturity in yaks. In MeRIP-seq, 1702 hypermethylated peaks and 724 hypomethylated peaks were identified. The hypermethylated differentially methylated RNAs (DMRs) (CIB2, AK1, FOXJ2, PKDREJ, SLC9A3, and TOPAZ1) mainly regulated spermatogenesis. Functional enrichment analysis showed that DMRs were significantly enriched in the adherens junction, gap junction, and Wnt, PI3K, and mTOR signaling pathways, regulating cell development, spermatogenesis, and testicular endocrine function. The functional analysis of differentially expressed genes showed that they were involved in the biological processes of mitosis, meiosis, and flagellated sperm motility during the sexual maturity of yak testis. We also screened the key regulatory factors of testis development and spermatogenesis by combined analysis, which included BRCA1, CREBBP, STAT3, and SMAD4. This study indexed the m6A characteristics of yak testicles at different developmental stages, providing basic data for further research of m6A modification regulating yak testicular development.

Morphological study on the mouthparts of four adult Aphodiinae beetles (Coleoptera: Aphodiinae)

Aphodiinae belong to Scarabaeidae, which are important environment-cleaning insects. In this study, the ultrastructural characteristics of the mouthparts (including the epipharynx, mandible and maxillae) of adult Aphodiinae, namely, Phaeaphodius rectus, Colobopterus erraticus, Paracrossidius transmontanus and Rhyparus sp., were systematically studied. The results are as follows: I. Rhyparus sp. exhibits saprophagy, while the others exhibit coprophagy. II. The three kinds of coprophagous Aphodiinae are all likely to feed on fresh dung. Among them, C. erraticus not only feeds on dung with the highest moisture content but also ingests solid food particles with the smallest diameter. Saprophagous Rhyparus sp. can ingest solid food particles with the largest diameter but feeds on humus with the lowest moisture content. The mouthpart structures of the Aphodiinae were highly consistent with their feeding habits. III. The findings support the utility of the epipharynx as an important morphological characteristic for classification of Aphodiinae at the genus and higher taxonomic levels. However, whether this inference is valid still needs to be verified by molecular biological data. In conclusion, the results of this study not only complement morphological information on the mouthparts of Aphodiinae but also provide basic data for further research on the evolution of the mouthparts of Aphodiinae.

Dampak Penjualan Pakaian Bekas Terhadap Tingkat Pendapatan Pedaganag Di Pasar Pagi Tugu Pahlawan Kota Surabaya

Purpose: The purpose of this study is to analyze the impact of selling used clothes on the level of income of traders at the Tugu Pahlawan Morning Market, Surabaya City. Method: This type of research uses quantitative methods. The research design used was observational analytic with a cross sectional method approach. Respondents were taken by simple random sampling technique with a total of 30 respondents. The independent variable is the sale of used clothes and the dependent variable is the income level of the trader. Statistical test results using a 2 mean pair difference test. Results: The results showed that the income level of traders before selling used clothes was 1,523,833.33 and after selling used clothes was 4,194,500.00. Suggestion: For traders, it is hoped that the results of this study will help traders maintain the quality of their merchandise and be more selective in selling used clothing. For the Faculty of Economics and Business, University of 17 August 1945 Surabaya. The results of this study are expected to be reading material and insight for students about the impact of selling used clothes on the income level of traders. For the Government, it is hoped that the results of this research can become one of the sources of information and contributions to the direction of the policies pursued by the Government. For future researchers, it is hoped that the results of this study can be used as input and basic data for further research.

Transcriptome Revealed the Macrophages Inflammatory Response Mechanism and NOD-like Receptor Characterization in Siberian Sturgeon (Acipenser baerii).

Nucleotide-binding and oligomerization domain-like receptors (NOD-like receptors, NLRs) can regulate the inflammatory response to eliminate pathogens and maintain the host's homeostasis. In this study, the head kidney macrophages of Siberian sturgeon were treated with lipopolysaccharide (LPS) to induce inflammation by evaluating the expression of cytokines. The high-throughput sequencing for macrophages after 12 h treatment showed that 1224 differentially expressed genes (DEGs), including 779 upregulated and 445 downregulated, were identified. DEGs mainly focus on pattern recognition receptors (PRRs) and the adaptor proteins, cytokines, and cell adhesion molecules. In the NOD-like receptor signaling pathway, multiple NOD-like receptor family CARD domains containing 3-like (NLRC3-like) were significantly downregulated, and pro-inflammatory cytokines were upregulated. Based on the transcriptome database, 19 NLRs with NACHT structural domains were mined and named in Siberian sturgeon, including 5 NLR-A, 12 NLR-C, and 2 other NLRs. The NLR-C subfamily had the characteristics of expansion of the teleost NLRC3 family and lacked the B30.2 domain compared with other fish. This study revealed the inflammatory response mechanism and NLRs family characterization in Siberian sturgeon by transcriptome and provided basic data for further research on inflammation in teleost.

Analysis of Morphological Changes on the Hair Surface by Heat Perm Treatment Method

Frequent chemical treatments, such as dyeing and permanent waving, as well as the widespread use of heat-based hair styling devices, like flat irons and curling irons, can cause significant damage to hair fibers, leading to various adverse effects, such as dryness, breakage, split ends, and frizziness. Recently, there has been a trend towards using direct heat perms because they are time-saving, shorter in duration, and less complicated. However, as the damage to hair caused by direct perms increases, this study compares and analyzes the degree of damage to hair fibers caused by both direct heat perms and softening heat perms. Moreover, by comparing, analyzing, and evaluating the morphological changes to the hair surface and cross-section after each type of perm treatment based on hair condition, this study aims to objectively understand the effects of heat perms on hair and provide basic data for further research in this field.

Circumstances Leading To Finding Out about Being Donor-Conceived and Its Perceived Impact on Family Relationships: A Survey of Adults Conceived via Anonymous Donor Insemination in Germany

Recent empirical research on the psychosocial implications of donor insemination is increasingly based on data directly obtained from donor-conceived persons. This descriptive study on donor-conceived adults in Germany inquires into their experience of finding out about being donor-conceived and answers the following research question: how do German adults conceived via anonymous donor insemination find out about the means of their conception and how do they experience family relationships post finding out? An online self-administered questionnaire targeting German donor-conceived adults to obtain qualitative and quantitative data was administered between September and November 2020. Fifty-nine donor-conceived adults were recruited via the support and advocacy group Verein Spenderkinder. Participants had been born in heterosexual-couple-parented families, were between 21 and 46 years old, and found out about the circumstances of their conception between 5 and 46 years of age. A broad spectrum of contexts and circumstances in which participants learned about being donor-conceived were reported, such as discovery via medical records, through disclosure as a result of parental consideration of the child’s current life situation or through direct-to-consumer DNA testing. Finding out about the means of their conception was experienced by participants as affecting their relationships with their family members to different degrees and in various ways. This first systematic inquiry into German donor-conceived adults’ experiences expands the literature and provides basic data for further research. Direct-to-consumer DNA testing is identified as one emerging trigger for finding out, warranting future research. The heuristic value of further in-depth inquiry into donor-conceived adults’ relationship with family members other than their parents, in particular their siblings, is highlighted.

Research Progress of Programmed Cell Death Induced by Acrylamide

Acrylamide exposure through environment pollution and diet is very common in daily life. With the deepening of the study on the toxicity of acrylamide, it has attracted widespread attention for the effects of acrylamide on multiple organs through affecting a variety of programmed cell death. Multiple studies have shown that acrylamide could exert its toxic effect by inducing programmed cell death, but its specific molecular mechanism is still unclear. In this review, the research on the main forms of programmed cell death (apoptosis, autophagy, and programmed necrosis) induced by acrylamide and their possible mechanisms are reviewed. This review may provide basic data for further research of acrylamide and prevention of its toxicity.

Fatigue Among Nursing Students During COVID-19 Pandemic in Medan

The COVID-19 pandemic requires students to implement an online learning system. However, the online learning method will be effective if it is supported by a systematically stable network. Online learning stimulates several problems related to physical and psychological issues. This study aims to describe nursing students’ fatigue during online learning at the Faculty of Nursing, University of Sumatera Utara. This study is a descriptive study with a sample of 87 respondents, which were taken using the proportionate stratified random sampling technique. The research instrument used in this study consisted of two parts, namely demographic data and Chalder fatigue instruments. Data collection is conducted through online with google forms link via WhatsApp group. The prospective samples were fill the agreement to participate in the survey and research link was send directly. Data analysis was conducted to determine the frequency distribution of the variables studied. The results showed that the majority of the samples were female (89.7%), aged 20-22 years (69.4%). For the fatigue level, the data showed that most students were in the range of moderate levels of fatigue (52.2%). And, there are 2 students (2.3%) who are in severe fatigue range. Based on the results of this study, it is hoped that it can become basic data for further research that can provide a more in-depth analysis of the fatigue contributed factors among students during online learning with pandemic COVID-19 affect.

Effect of dihydrotestosterone on melatonin secretion and the expression of melatonin receptors and apoptosis-related factors in sheep epididymides.

Melatonin (MEL) is involved in homeostasis of the epididymis lumen environment. Dihydrotestosterone (DHT) partakes in the development of gonads and organs in male animals. However, whether MEL secretion, the expression of its receptors, MT1 and MT2, and sheep epididymal epithelial cell apoptosis is regulated by DHT remains unclear. In this study, we used immunohistochemical staining to detect the distribution patterns of DHT synthetases [5α-reductase (5α-red)] and its androgen receptor (AR) in sheep epididymides. 5α-red1, 5α-red2 and AR were positively expressed in sperm, epididymal epithelial cells, and the smooth muscle cells of the caput, corpus and cauda regions of the epididymis. DHT concentration and the expression levels of 5α-red and AR in the caput, corpus and cauda regions were measured by enzyme-linked immunosorbent assay, liquid chromatography-mass spectrometry, real-time quantitative polymerase chain reaction and western blot analysis. DHT concentration in the caput was significantly higher than those in corpus and cauda, probably because of the high expression of 5α-red2 in the caput and secretion and transport of DHT by the testicles. DHT inhibited MEL secretion, the expression of its membrane receptors and MEL synthetases in cultured sheep epididymal epithelial cells in vitro. In addition, the Bax/Bcl-2 ratio, ACT CASP3 and caspase-3 mRNA expression were also decreased. The decreasing effect was partially reversed after flutamide treatment. Therefore, DHT regulates sheep epididymal function by influencing MEL expression and apoptosis-related factors. This study provides basic data for further research on the reproductive physiology of male animals.

In vitro bioactivities of Codonopsis javanica root extract from Kon Tum province, Vietnam

Dangshen Codonopsis javanica exhibits invaluable medicinal properties in herbal remedies; however, there has currently not been much specific analysis of the phytochemicals and bioactivities of this plant. The root ethanol extract of C. javanica contains substances such as saponins, phenolic acids, terpenoids, and alkaloids. It displays an antibacterial effect against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus with the IC50 values of 150, 100, 150, and 90 μg/mL, respectively. The antioxidant capacity of the root extract was also observed with an IC50 value of 46.8 ± 6.8 μg/mL. Furthermore, the extract exhibits activity on human cancer cell lines HepG2 (IC50 = 83.6 ± 2.7 μg/mL) and MCF-7 (IC50 = 95.3 ± 2.3 μg/mL). Hence, this study provides the basic data for further research on the bioactivities of natural compounds of Dangshen C. javanica for the first time.

ANALISIS PERILAKU MASYARAKAT TERHADAP KEJADIAN PENYAKIT DEGENERATIF DI WILAYAH KERJA PUSKESMAS KOTA BANJARMASIN

Degenerative disease is a contributor to death from non-communicable diseases (NCD) in the last 10years which has increased from 41.7%. The latest survey in Indonesia shows PTM dominates the top 10 causes ofdeath in all age groups, with stroke, which is a complication as the number one cause of death. This studyaims to determine the relationship between length of smoking and coffee drinking habits with the incidenceof hypertension in the working area of the Banjarmasin City Health Center which was carried out in 2019.This type of research is an analytical survey with a cross-sectional research design. The subjects in this studyamounted to 57 respondents, consisting of male active smokers and consuming coffee. Data were obtainedthrough questionnaires and direct interviews as well as physical examination in the form of blood pressuremeasurements by puskesmas officers, which were then analyzed by chi-square test (α=0.05). The results ofthe statistical test showed that there was a relationship between length of smoking and the incidence ofhypertension (P=0.000), and the habit of drinking coffee with the incidence of hypertension (P=0.002).Suggestions that can be given in research are for puskesmas to further increase public knowledge abouthealth through counseling, especially about the incidence of hypertension, for health workers to optimizecounseling about the incidence of hypertension, especially for men who smoke and consume coffee.experience and add insight, and for other researchers can be used as basic data for further research.

Effects of Bamboo Forest Type and Density on the Growth of Bletilla striata and Root Endophytic Fungi

Bletilla striata is a terrestrial orchid with high ornamental and medicinal values that is widely interplanted in bamboo forests. However, little is known about the effects of bamboo forest type and density on the growth of B. striata and its symbiotic relationship with root endophytic fungi. In this study, the growth state of B. striata, the community composition and diversity of its root endophytic fungal, and the fungal nutritional function were investigated in Phyllostachys edulis, P. iridescens and P. glauca forests with three densities. We found that the type and density of the bamboo forest had significant effects on the growth of B. striata, with the biomass, leaf width, root quantity and width being the highest in the low-density of the P. edulis forest. The community composition and abundance of root endophytic fungi in B. striata varied among different bamboo forests and densities, with P. edulis and P. iridescens forests dominated by Basidiomycota and Serendipita, while P. glauca prevailed by Ascomycota and Dactylonectria. The trophic modes of root endophytic fungi were also affected by forest types and densities. The abundance of symbiotroph fungi was the highest in P. edulis and P. iridescens forests and greatly varied with density gradient, and saprotrophic fungi comprised the highest proportion in the Ph. glauca forest. These results provide basic data for further research and the configuration between bamboo species and terrestrial orchids.

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, respectively. Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage analysis and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biological effects of molecular hydrogen.

PENGALAMAN PENDERITA LUKA DIABETES DENGAN POLA PERAWATAN HOME VISIT DI KLINIK IIN WOUND CARE CIBITUNG, BEKASI

Background : Diabetes Mellitus that is not controlled and handled can be a serious problem. The increase in the number of patients with diabetes mellitus will exacerbate the increased risk of developing diabetic wounds. One of the efforts of diabetic wound patients to optimize their recovery is by using health care services at home visits. Objective: The research was to explore in depth the experiences of diabetic wound patients who received Home Visit care patterns. Methods: This research design uses a qualitative method with a phenomenological study. Data collection was carried out by in-depth interviews on 6 diabetic wound patients who underwent wound care at home visits. Patients were selected by purposive sampling. Results: the study found five themes, namely the reasons for choosing to do treatment at a home visit, experiences while receiving care at a home visit, obstacles experienced during a home visit, efforts to overcome obstacles, and expectations for future home visit care. Suggestion: For further researchers, it is hoped that it can be used as basic data for further research and can take advantage of the categories generated in this research.&#x0D;