We study the age changes of the anthropometric as well as of the mass-inertial characteristics (MIC) of Bulgarian women aged 18-25 versus those aged 30-40. We do that via mathematical modelling of the human body (HB). Nowadays mathematical modelling is one of the modern methods for the determination of the MIC of different segments of the body, as well as of the whole body, and for studying the changes of the inertial characteristics during a specific motion of the considered person. The current work presents a 3D mathematical model (MM) of the HB, that is also generated in a computer environment. Both the model and its computer generation allow for the calculation of the MIC of all segments of the body, as well as for the whole HB in specific body positions. We consider such body postures which are presented in the corresponding classification of astronauts’ standard positions of interest for NASA. The obtained results are compared with those reported in the literature by other authors. The proposed models shall be also helpful in problems appearing in medicine (orthopaedics and traumatology), computer simulations, rehabilitation robotics, and sports, as well as in areas such as ergonomics, simulation of human behaviour in space, forensics (body fall, car crash) and more.