In this study, we reviewed and summarized the data on permafrost and groundwater areas of Central Yakutia to understand the formation and distribution of subpermafrost mineral waters of sodium bicarbonate and chloride-bicarbonate types, and to evaluate their potential use for medical purposes. Analysis of the data indicated that these low-mineralized groundwaters are basic analogues to the Maykop and Karachi mineral waters, with no particular bioactive components. These mineral water types contain 400 to 1200 mg/dm3 bicarbonates, 100 to 600 mg/dm3 chlorides, 50 to 250 mg/dm3 (Karachi) and <50 mg/dm3 (Maykop) sulfates, 400 to 800 mg/dm3 sodium, and <10 mg/dm3 calcium and magnesium. The formation of sodium bicarbonate and chloride-bicarbonate type water in Central Yakutia is influenced by permafrost which promotes concentration of major chemical components under the cold temperatures and slow groundwater circulation. The study of minor and trace constituents indicates that the subpermafrost waters in the study region contain fluorine and lithium in excess of the drinking water standards but are potentially appropriate for balneotherapy. Further research on the bio-physiological effects of subpermafrost waters with elevated fluorine and lithium concentrations contribute to the development of the spa and health resort industry in Yakutia. Moreover, the study will expand the balneological spectrum of disease prevention and treatment for the benefit of residents of Yakutia and the adjacent regions.