Faulting mechanics is examined by combining geochemical and mechanical analyses from a key exposure of a major fault zone crossing the Argentera crystalline massif (French–Italian Alps). The analyses are carried out on co-genetic and syn-tectonic quartz and chlorite extension veins and shear veins associated with late stage deformation in the fault zone. Paleothermometry based on chlorite compositions gives formation temperatures of 300 °C ± 20 °C, that is near the base of the seismogenic zone. δ18O values of quartz and δD and δ18O values of chlorite indicate that veins crystallized from a metamorphic fluid. In parallel, a mechanical analysis based on the Mohr-Coulomb theory shows that the pore fluid factor λv required to simultaneously reactivate the studied fault and to open the extension veins was close to a lithostatic value (λv ∼ 1).Comparisons with the 2003–2004 Ubaye seismic swarm, having occurred in the continuity of the studied fault zone, suggest that the base of the seismogenic zone may act as a limit separating an upper permeable reservoir saturated with meteoric waters under hydrostatic to supra-hydrostatic pressures from a lower low-permeability reservoir containing metamorphic waters under lithostatic pressure. This study suggests that overpressured fluids can be released upwards in the brittle crust by shear-enhanced permeability and can trigger earthquakes.