Base isolation technology is widely accepted as an effective strategy for the seismic design of buildings. Although the elastomeric isolator is still extensively adopted for the base-isolation system in practice, there is a trend to use the frictional pendulum bearing (FPB) due to its high vertical bearing capacity, stable performance and good recentering capability. In this paper, the dynamic response of base-isolated high-rise buildings with FPB having a velocity-dependent friction coefficient subjected to uncoupled alongwind and crosswind loads is studied. The response characteristics calculated from response history analysis (RHA) are analyzed. Meanwhile, two statistical linearization methods are utilized to estimate the standard deviation (STD) of the structural response and to obtain the equivalent parameters of the linearized system. The time-varying mean of the base displacement under alongwind load with a non-zero mean is also discussed by the linearization method. Finally, a parameter analysis of the isolation bearing is performed to investigate the effects of the radius and friction coefficient of the sliding plate on the wind-induced vibration. This study highlights the strong nonlinear response characteristics of base-isolated high-rise buildings with FPB and offers design guidelines under strong winds.