Basal Water Research Articles

Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway

Weaning stress causes substantial economic loss in the swine industry. Moreover, weaning-induced intestinal barrier damage and dysfunction of the gut-liver axis are associated with reduced growth performance in piglets. Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, the mechanisms involved and their overall effects on the gut-liver axis have not been explored. Here, sodium metasilicate (SMS) was used to prepare metasilicate-based AMW (basal water + 500 mg/L SMS). A total of 240 newly weaned piglets were allocated to the Control and SMS groups (6 replicate pens per group and 20 piglets per pen) for a 15-day trial period. Histopathological evaluations were conducted using hematoxylin and eosin staining. To analyze the composition of the gut microbiota, 16S rRNA PacBio SMRT Gene Full-Length Sequencing was performed. Western blotting and immunofluorescence were employed to assess protein expression levels. Our results indicated that metasilicate-based AMW effectively alleviated weaning-induced colonic or liver morphological injury and inflammatory response, as well as liver cholesterol metabolism disorders. Further analysis showed that metasilicate-based AMW promoted deoxycholic acid (DCA) biosynthesis by increasing the abundance of Lactobacillus_delbrueckii in the colon (P < 0.001). This consequently improved weaning-induced colon and liver injury and dysfunction through the DCA-secondary bile acid (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. Growth performance parameters, including final body weight (P = 0.034) and average daily gain (P < 0.001), in the SMS group were significantly higher than those in the Control group. Therefore, metasilicate-based AMW maintains gut-liver axis homeostasis by regulating the microbiota-mediated SBA-SBAR pathway in piglets under weaning stress. Our research provides a new strategy for mitigating stress-induced gut-liver axis dysfunction in weaned piglets.

Observing and Modeling Short‐Term Changes in Basal Friction During Rain‐Induced Speed‐Ups on an Alpine Glacier

AbstractBasal shear stress on hard‐bedded glaciers results from normal stress against bed roughness, which depends on basal water pressure and cavity size. These quantities are related in a steady state but are expected to behave differently under rapid changes in water input, which may lead to a transient frictional response not captured by existing friction laws. Here, we investigate transient friction using Global Positioning System vertical displacement and horizontal velocity observations, basal water pressure measurements, and cavitation model predictions during rain‐induced speed‐up events at Glacier d'Argentière, French Alps. We observe up to a threefold increase in horizontal surface velocity, spatially migrating at rates consistent with subglacial flow drainage, and associated with surface uplift and increased water pressure. We show that frictional changes are mainly driven by changes in water pressure at nearly constant cavity size. We propose a generalized friction law capable of capturing observations in both the transient and steady‐state regimes.

Transient subglacial water routing efficiency modulates ice velocities prior to surge termination on Sít’ Kusá, Alaska

Abstract Glacier surges are opportunities to study large amplitude changes in ice velocities and accompanying links to subglacial hydrology. Although the surge phase is generally explained as a disruption in the glacier's ability to drain water from the bed, the extent and duration of this disruption remain difficult to observe. Here we present a combination of in situ and remotely sensed observations of subglacial water discharge and evacuation during the latter half of an active surge and subsequent quiescent period. Our data reveal intermittently efficient subglacial drainage prior to surge termination, showing that glacier surges can persist in the presence of channel-like subglacial drainage and that successive changes in subglacial drainage efficiency can modulate active phase ice dynamics at timescales shorter than the surge cycle. Our observations favor an explanation of fast ice flow sustained through an out-of-equilibrium drainage system and a basal water surplus rather than binary switching between states in drainage efficiency.

Monitoring dynamics of Kyagar Glacier surge and repeated draining of Ice-dammed lake using multi-source remote sensing

Glacier surges, a primary factor contributing to various glacial hazards, has long captivated the attention of the global glaciological community. This study delves into the dynamics of Kyagar Glacier surging and the associated drainage features of its Ice-dammed lake, employing high temporal resolution optical imagery. Our findings indicate that the surge on Kyagar Glacier began in late spring and early summer of 2014 and concluded during the summer of 2016. This surge resulted in the transfer of 0.321 ± 0.012 km3 of glacier mass from the reservoir zone to the receiving zone, leading to the formation of an ice-dammed lake at the glacier's terminus. The lake experienced five outbursts between 2015 and 2019, with the largest discharge occurring in 2017. And the maximum water depth during this period was 112 ± 11 m, resulting in a water storage volume of (158.37 ± 28.32) × 106 m3. On the other hand, our analysis of the relationship between glacier surface velocity and albedo, coupled with an examination of subglacial dynamics, revealed that increased precipitation during the active phase of the Kyagar Glacier results in accumulation of mass in the upper glacier. This accumulation induces changes in basal shear stress, triggering the glacier's transition into an unstable state. Consequently, glacier deformation rates escalate, surface crevasses proliferate, potentially providing conduits for surface meltwater to infiltrate the glacier bed. This, in turn, leaded to elevated basal water pressure, initiating glacier sliding. Furthermore, we postulated that the repetitive drainage of Kyagar Ice-dammed lake was primarily influenced by the opening and closing of subglacial drainage pathways and variations in inflow volumes. Future endeavors necessitate rigorous field observations to enhance glacier surge simulations, deepening our comprehension of glacier surge mechanisms and mitigating the impact of associated glacial hazards.

Antiproliferative Effects in Colorectal Cancer and Stabilisation in Cyclodextrins of the Phytoalexin Isorhapontigenin.

Isorhapontigenin has been proposed as a better alternative for oral administration than the famous resveratrol, as it shares many biological activities, but with a structure that could make its delivery easier. Although this hydrophobic structure could enhance bioavailability, it could also be a disadvantage in the development of products. In this research, we study the antiproliferative activity of this stilbene against colorectal cancer and overcome its limitations through molecular encapsulation in cyclodextrins. The cytotoxic activity against human colorectal cancer cells of isorhapontigenin was similar to that of resveratrol or piceatannol, supporting its use as a bioactive alternative. The study of the encapsulation through fluorescence spectroscopy and molecular docking revealed that the complexation satisfies a 1:1 stoichiometry and that HP-β-CD is the most suitable CD to encapsulate this stilbene. Through a spectrophotometric assay, it was observed that this CD could double the basal water solubility, exceeding the solubility of other hydroxylated stilbenes. The stability of these inclusion complexes was higher at a pH below 9 and refrigeration temperatures. Moreover, the use of CDs retained more than 78% of isorhapontigenin after storage for 12 weeks, compared to 15% in free form. Overall, these findings could help design novel formulations to better deliver isorhapontigenin.

Assessing the potential for ice flow piracy between the Totten and Vanderford glaciers, East Antarctica

Abstract. The largest regional drivers of current surface elevation increases in the Antarctic Ice Sheet are associated with ice flow reconfiguration in previously active ice streams, highlighting the important role of ice dynamics in mass balance calculations. Here, we investigate controls on the evolution of the flow configuration of the Vanderford and Totten glaciers – key outlet glaciers of the Aurora Subglacial Basin (ASB) – the most rapidly thinning region of the East Antarctic Ice Sheet (EAIS). We synthesise factors that influence the ice flow in this region and use an ice sheet model to investigate the sensitivity of the catchment divide location to changes in surface elevation due to thinning at the Vanderford Glacier (VG) associated with ongoing retreat and thickening at the Totten Glacier (TG) associated with an intensification of the east–west snowfall gradient. The present-day catchment divide between the Totten and Vanderford glaciers is not constrained by the geology or topography but is determined by the large-scale ice sheet geometry and its long-term evolution in response to climate forcing. Furthermore, the catchment divide migrates under relatively small changes in surface elevation, leading to ice flow and basal water piracy from the Totten to the Vanderford Glacier. Our findings show that ice flow reconfigurations occur not only in regions of West Antarctica like the Siple Coast but also in the east, motivating further investigations of past, and the potential for future, ice flow reconfigurations around the whole Antarctic coastline. Modelling of ice flow and basal water piracy may require coupled ice sheet thermomechanical and subglacial hydrology models constrained by field observations of subglacial conditions. Our results have implications for ice sheet mass budget studies that integrate over catchments and the validity of the zero flow assumption when selecting sites for ice core records of past climate.

Examining the effect of ice dynamic changes on subglacial hydrology through modelling of a synthetic Antarctic glacier

Abstract Hydrologic pathways beneath ice sheets and glaciers play an important role in regulating ice flow. Antarctica has experienced, and will continue to experience, changes in ice dynamics and geometry, but the associated changes in subglacial hydrology have received less attention. Here, we use the GlaDS subglacial hydrology model to examine drainage evolution beneath an idealised Antarctic glacier in response to steepening ice surface slopes, accelerating ice velocities and subglacial lake drainages. Ice surface slope changes exerted a dominant influence, redirecting basal water to different outlet locations and substantially increasing channelised discharge crossing the grounding line. Faster ice velocities had comparatively negligible effects. Subglacial lake drainage results indicated that lake refilling times play a key role in drainage system evolution, with lake flux more readily accommodated following shorter refilling times. Our findings are significant for vulnerable Antarctic regions currently experiencing dynamic thinning since subglacial water re-routing could destabilise ice shelves through enhanced sub-shelf melting, potentially hastening irreversible retreat. These changes could also affect subglacial lake activity. We, therefore, emphasise that including a nuanced and complex representation of subglacial hydrology in ice-sheet models could provide critical information on the timing and magnitude of sea-level change contributions from Antarctica.

Novel signalling pathways in nephrogenic syndrome of inappropriate antidiuresis: functional implication of site-specific AQP2 phosphorylation.

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare X-linked disease caused by gain-of-function mutations of arginine vasopressin receptor 2 (V2R). Patients with NSIAD are characterized by the inability to excrete a free water load and by inappropriately increased urinary osmolality despite very low levels of plasma vasopressin, resulting in euvolaemic hyponatraemia. To dissect the signalling downstream V2R constitutively active variants, Flp-In T-REx Madin-Darby canine kidney (FTM) cells, stably transfected with V2R mutants (R137L, R137C and F229V) and AQP2-wt or non-phosphorylatable AQP2-S269A/AQP2-S256A, were used as cellular models. All three activating V2R mutations presented constitutive plasma membrane expression of AQP2-wt and significantly higher basal water permeability. In addition, V2R-R137L/C showed significantly higher activity of Rho-associated kinase (ROCK), a serine/threonine kinase previously suggested to be involved in S269-AQP2 phosphorylation downstream of these V2R mutants. Interestingly, FTM cells expressing V2R-R137L/C mutants and AQP2-S269A showed a significant reduction in AQP2membrane abundance and a significant reduction in ROCK activity, indicating the crucial importance of S269-AQP2 phosphorylation in the gain-of-function phenotype. Conversely, V2R-R137L/C mutants retained the gain-of-function phenotype when AQP2-S256A was co-expressed. In contrast, cells expressing the F229V mutant and the non-phosphorylatable AQP2-S256A had a significant reduction in AQP2membrane abundance along with a significant reduction in basal osmotic water permeability, indicating a crucial role of Ser256 for this mutant. These data indicate that the constitutive AQP2 trafficking associated with the gain-of-function V2R-R137L/C mutants causing NSIAD is protein kinaseA independent and requires an intact Ser269 in AQP2 under the control of ROCK phosphorylation. KEY POINTS: Nephrogenic syndrome of inappropriate antidiuresis is caused by two constitutively active variant phenotypes of AVPR2, one sensitive to vaptans (V2R-F229V) and the other vaptan resistant (V2R-R137C/L). In renal cells, all three activating arginine vasopressin receptor 2 (V2R) variants display constitutive AQP2 plasma membrane expression and high basal water permeability. In cells expressing V2R-R137L/C mutants, disruption of the AQP2-S269 phosphorylation site caused the loss of the gain-of-function phenotype, which, in contrast, was retained in V2R-F229V-expressing cells. Cells expressing the V2R-F229V mutant were instead sensitive to disruption of the AQP2-S256 phosphorylation site. The serine/threonine kinase Rho-associated kinase (ROCK) was found to be involved in AQP2-S269 phosphorylation downstream of the V2R-R137L/C mutants. These findings might have clinical relevance for patients with nephrogenic syndrome of inappropriate antidiuresis.

Differential effects of thirst and satiety on conditioned taste aversion acquisition, retrieval, and memory extinction

Thirst is an essential motivational component that could modulate the strength of conditioning; pioneer studies show that the rats' sexual dimorphism observed in the rate of aversive memory extinction of conditioned taste aversion (CTA) is affected by the state of fluid deprivation. On the other hand, previous evidence suggests that fluid intake volume and temporal context before and during conditioning may influence CTA. Furthermore, although CTA has been demonstrated using various types of stimuli, neural processing and homeostatic regulation of water and nutritional balance may differ depending on the stimulus used and the conditioning stages. Therefore, this study explored the effects of state motivated by thirst and satiation, using saccharin, as a non-caloric sweet stimulus, during CTA and the aversive memory extinction process under similar contextual and temporal conditions. First, we implemented an ad libitum water protocol in male and female adult rats to evaluate saccharin aversive memory formation; we compared this with a traditional CTA with liquid deprivation in the same context and temporal consumption conditions. Furthermore, we evaluated whether liquid satiety affects the acquisition or the aversive memory retrieval differentially. Our results show that the ad libitum liquid regimen allows reliable quantifications of basal water consumption, monitored every hour for more than five days. We observed a reliable CTA, where the magnitude of aversive memory and its extinction is significantly higher in both male and female rats; the strong CTA observed is substantially due to the satiety state during taste aversion memory retrieval. Our data show that although liquid deprivation does not affect CTA acquisition, it does induce weakness in the magnitude of aversive retrieval expression and fast aversive memory extinction, similarly in male and females. Overall, the results indicate that the need to satiate the demand for liquids during retrieval prevails over the conditioned aversion learned, suggesting, that thirst is a source of temporary variables dominating the aversive responses during CTA retrieval.

High-fat diet changes the behavioural and hormonal responses to water deprivation in male Wistar rats.

What is the central question of this study? What is the effect of an obesogenic diet on the control of hydromineral balance in rats? What is the main finding and its importance? The results showed that, when dehydrated, rats fed a high-fat diet drink less water than their control-diet-fed counterparts. Changes in aquaporin-7 and peroxisome proliferator-activated receptor α expression in the white adipose tissue might be involved. High-fat diet (HFD) increases fat accumulation, glycaemia and blood triglycerides and is used as a model to study obesity. Besides the metabolic changes, obesity likely affects water intake. We assessed the effects of HFD on behavioural and hormonal responses to water deprivation. Additionally, we measured if the adipose tissue is differentially affected by water deprivation in control and HFD-fed rats. HFD rats showed a decreased basal water intake when compared to control-fed rats. When subjected to 48h of water deprivation, as expected, both control and HFD rats drank more water than the hydrated rats. However, the increase in water intake was lessened in HFD dehydrated rats. Similarly, the increase in haematocrit in dehydrated rats was less pronounced in HFD dehydrated rats. These results suggest that HFD diminishes drinking behaviour. White adipose tissue weight, glycaemia and plasma glycerol concentration were increased in HFD rats; however, after 48h of water deprivation, these parameters were significantly decreased in dehydrated HFD rats, when compared to controls. The increase in adipose tissue caused by HFD may mitigate the effects of dehydration, possibly through the increased production of metabolic water caused by lipolysis in the adipocytes. Oxytocin possibly mediates the lipolytic response, since both its secretion and receptor expression are affected by dehydration in both control and HFD rats, which suggests that oxytocin signalling is maintained in these conditions. Changes in mediators of lipolysis, such as aquaporin-7 and peroxisome proliferator-activated receptor α, might contribute to the different effects observed in control and HFD rats.

An overview of GPR subsurface exploration of planets and moons

Geophysical techniques were first tested beyond Earth during the Apollo program. Of those examined, radio-wave propagation methods appeared to be the most suitable for the moon and other solar system bodies. This was due to the electromagnetic characteristics of planetary subsurfaces and the possibility to remotely perform measurements on board spacecrafts and rovers. After the first successful experiment on the moon, more than 20 years passed before ground-penetrating radar (GPR) was included in the payload of a planetary mission. Technological advancements in GPR design and successful results of radio echo sounding measurements for the detection of basal water below terrestrial ice sheets paved the way for the application of similar techniques to search for liquid water in the Martian subsurface. Since deployment of the first two subsurface radar sounders above Mars, the number of proposed planetary missions relying on GPR for surveying the subsurface of planets, moons, and other objects has grown progressively. Six orbiting radar sounders and five GPRs mounted on rovers/landers have been employed so far to explore the moon, Mars, and comet 67P/GC. Some of these are in full operation and some are just starting to operate. Planned missions to the icy moons of Jupiter will also depend heavily on radar sounders to detect evidence of an internal ocean on Europa and to understand the habitability conditions on Europa, Ganymede, and Callisto. Finally, planetary missions to Earth's twin, the planet Venus, could take advantage of GPR to understand the cause of its drastic change in climatic conditions and the geologic phenomena that contributed to changing a watery and hospitable surface into a hot and asphyxiating inhabitable planet.

Surface topographic impact of subglacial water beneath the south polar ice cap of Mars

Bright radar reflections observed in the Ultimi Scopuli region of Mars’ south polar layered deposits1,2,3 by the Mars Advanced Radar for Subsurface and Ionosphere Sounding instrument have been interpreted as the signature of areas of subglacial water beneath it. However, other studies put forward alternative explanations, which do not imply the presence of liquid water4,5,6. Here we shed light on the issue by looking at the surface topography of the region. On Earth, reduced or absent basal friction, and consequent ice velocity changes, cause a distinct topographic signature over subglacial lakes7. Using Mars Orbiter Laser Altimeter data8, we identify and characterize an anomaly in the surface topography of the south polar layered deposits overlying the area of the putative lakes, similar to those found above terrestrial subglacial lakes of similar size. Ice flow model results suggest that comparable topographic anomalies form within 0.5–1.5 Myr with locally elevated geothermal heating9 or 2–5 Myr without elevated geothermal heating2. These findings offer independent support for the presence of basal water beneath Ultimi Scopuli and suggest that surface topography could supplement radar returns to help identify other potential subglacial water bodies.

Basal hydrofractures near sticky patches

Basal crevasses are macroscopic structural discontinuities at the base of ice sheets and glaciers that arise by fracture. Motivated by observations and by the mechanics of elastic fracture, we hypothesise that spatial variations in basal stress (in the presence of basal water pressure) can promote and localise basal crevassing. We quantify this process in the theoretical context of linear elastic fracture mechanics. We develop a model evaluating the effect of shear-stress variation on the growth of basal crevasses. Our results indicate that sticky patches promote the propagation of basal crevasses, increase their length of propagation into the ice and, under some conditions, give them curved trajectories that incline upstream. A detailed exploration of the parameter space is conducted to gain a better understanding of the conditions under which sticky-patch-induced basal crevassing is expected beneath ice sheets and glaciers.

Advances in understanding subglacial meltwater drainage from past ice sheets

AbstractMeltwater drainage beneath ice sheets is a fundamental consideration for understanding ice–bed conditions and bed-modulated ice flow, with potential impacts on terminus behavior and ice-shelf mass balance. While contemporary observations reveal the presence of basal water movement in the subglacial environment and inferred styles of drainage, the geological record of former ice sheets, including sediments and landforms on land and the seafloor, aids in understanding the spatiotemporal evolution of efficient and inefficient drainage systems and their impact on ice-sheet behavior. We highlight the past decade of advances in geological studies that focus on providing process-based information on subglacial hydrology of ice sheets, how these studies inform theory, numerical models and contemporary observations, and address the needs for future research.

Inferring forms of glacier slip laws from estimates of ice-bed separation during glacier slip

AbstractSea-level projections depend sensitively on the parameterization used for basal slip in glacier flow models. During slip over rock-beds, ice-bed separation increases with slip velocity and basal water pressure. We present a method for using these variables and measured bed topography to estimate the average bed slope in contact with ice, ${\bar m}$. Three-dimensional numerical modeling of slip over small areas of former beds has shown that changes in ${\bar m}$ with increasing slip velocity and water pressure mimic changes in basal drag. Computed values of ${\bar m}$ can thus provide the form of the slip law that relates drag to velocity and water pressure, avoiding computationally expensive numerical modeling. The method is applied to 618 sections from four former glacier beds. Results generally show an increase in ${\bar m}$, and hence inferred basal drag, with slip velocity up to a limiting value, consistent with a regularized Coulomb slip law.

Threshold response to melt drives large-scale bed weakening in Greenland.

Ice speeds in Greenland are largely set by basal motion1, which is modulated by meltwater delivery to the ice base2-4. Evidence suggests that increasing melt rates enhance the subglacial drainage network's capacity to evacuate basal water, increasing bed friction and causing the ice to slow5-10. This limits the potential of melt forcing to increase mass loss as temperatures increase11. Here we show that melt forcing has a pronounced influence on dynamics, but factors besides melt rates primarily control its impact. Using a method to examine friction variability across the entirety of western Greenland, we show that the main impact of melt forcing is an abrupt north-to-south change in bed strength that cannot be explained by changes in melt production. The southern ablation zone is weakened by 20-40 per cent compared with regions with no melt, whereas in northern Greenland the ablation zone is strengthened. We show that the weakening is consistent with persistent basal water storage and that the threshold is linked to differences in sliding and hydropotential gradients, which exert primary control on the pressures within drainage pathways that dewater the bed. These characteristics are mainly set by whether a margin is land or marine terminating, suggesting that dynamic changes that increase mass loss are likely to occur in northern Greenland as temperatures increase. Our results point to physical representations of these findings that will improve simulated ice-sheet evolution at centennial scales.

Microbial Networks Reveal the Structure of Water Microbial Communities in Kalamaili Mountain Ungulate Nature Reserve

Water microorganisms contribute to the key components of ecosystems in dryland waters, which are extremely important for wildlife. However, the distribution patterns of water microbes across different basal water sources are still largely unknown. This study was conducted to compare microorganisms in the water bodies of different types of water sources in the Kalamaili Mountain Ungulate Nature Reserve in China. Bioinformatic analysis revealed that the undirected microbial co-existence network consisted of 15 main modules referring to different water sources, which indicated specific molecular co-existence relationships. It was found that the most dominant phyla (namely Proteobacteria, Patescibacteria, Firmicutes, Bacteroidota, and Actinobacteriota) of the molecular ecological network shared the same structures as the microbial community, which justified the construction of the network via a random network formation. Principal coordinate analysis (PCoA) based on Bray–Curtis distances revealed that there were still considerable variations among different habitats, showing separate sample clusters. Additionally, the different topological roles of subnetworks trimmed to a uniform size indicated different co-existence patterns in the microbiome. The artificially recharged water from concrete pond substrate (ARC) subnetworks had a relatively discrete co-occurrence, while the natural water sources (NRE) and artificially recharged water from earthen pond substrate (ARE) groups were more compact with giant modules. The NRE and ARE groups were also richer in microbial composition and had a higher number of species with low abundance. Consequently, concrete substrates may contribute to dysfunction in water microbiomes. Moreover, the functional diversity of the NRE and ARE groups is due to more intra-module connections and more inter-module connections, indirectly leading to a stable function resilient to external environmental influences. In conclusion, the microecology of the NRE was more stable than that of the concrete substrate, and artificial transportation had less effect on the microbial community.

Evidence of Seasonal Uplift in the Argentière Glacier (Mont Blanc Area, France)

AbstractThe hydromechanical processes by which basal water controls sliding at the glacier bed are poorly known, despite glacier basal motion being responsible for a large part of ice flux in temperate alpine glaciers. Previous studies suggest that sliding strongly relates to the quantity of water being stored at the ice‐bedrock interface. However, this water storage is difficult to quantify accurately on the basis of surface‐motion observations, given that uplift can also be affected by changes in vertical‐strain rates and sliding velocity change. Here, we use a comprehensive data set of in situ measurements performed over 2 years on the Argentière Glacier in the French Alps to investigate the relationships between horizontal and vertical velocities, basal sliding, subglacial runoff and bed separation. We observe strikingly large uplifts varying spatially between 0.20 and 0.90 m over the winter/spring seasons between January and June and with a consistent spatial pattern from 1 year to another. We show, based on observations and three dimensional ice‐flow modeling, that these large uplifts cannot be explained solely by changes in strain rates or in sliding up an inclined bed. Our results reveal that more than 80% of the observed uplift is related to enhanced bed separation through cavitation, allowing us to estimate the volume occupied by water‐filled subglacial cavities. Our interpretation of uplift being mainly caused by increased cavitation is also consistent with an associated increase in the observed surface horizontal velocity. These findings provide important observational constraints for testing subglacial hydrological models.

Multi-decadal basal slip enhancement at Saskatchewan Glacier, Canadian Rocky Mountains

AbstractGlacier motion responds dynamically to changing meltwater inputs, but the multi-decadal response of basal sliding to climate remains poorly constrained due to its sensitivity across multiple timescales. Observational records of glacier motion provide critical benchmarks to decode processes influencing glacier dynamics, but multi-decadal records that precede satellite observation and modern warming are rare. Here we present a record of motion in the ablation zone of Saskatchewan Glacier that spans seven decades. We combine in situ and remote-sensing observations to inform a first-order glacier flow model used to estimate the relative contributions of sliding and internal deformation on dynamics. We find a significant increase in basal sliding rates between melt-seasons in the 1950s and those in the 1990s and 2010s and explore three process-based explanations for this anomalous behavior: (i) the glacier surface steepened over seven decades, maintaining flow-driving stresses despite sustained thinning; (ii) the formation of a proglacial lake after 1955 may support elevated basal water pressures; and (iii) subglacial topography may cause dynamic responses specific to Saskatchewan Glacier. Although further constraints are necessary to ascertain which processes are of greatest importance for Saskatchewan Glacier's dynamic evolution, this record provides a benchmark for studies of multi-decadal glacier dynamics.

The Hydration Status of Adult Patients with Oropharyngeal Dysphagia and the Effect of Thickened Fluid Therapy on Fluid Intake and Hydration: Results of Two Parallel Systematic and Scoping Reviews.

Background: The effect of oropharyngeal dysphagia (OD) and thickened fluid (TF) therapy on hydration status has not been well defined in the literature. We aimed to assess the hydration status in patients with OD and the effect TF therapy has on it. Methods: Two literature reviews following PRISMA methodology (each one including a systematic and a scoping review) were performed: (R1) hydration status in adult patients with OD; (R2) effect of TF therapy on fluid intake and dehydration. Narrative and descriptive methods summarized both reviews. Quality assessment was assessed by Joanna Briggs Institute tools and GRADE. Results: (R1) Five out of twenty-two studies using analytical parameters or bioimpedance showed poorer hydration status among OD and 19–100% prevalence of dehydration; (R2) two high quality studies (total of 724 participants) showed positive effects of TF on hydration status. Among the articles included, nine out of ten studies that evaluated fluid intake reported a reduced TF intake below basal water requirements. Conclusions: Dehydration is a highly prevalent complication in OD. There is scientific evidence on the positive effect of TF therapy on the hydration status of patients with OD. However, strict monitoring of fluid volume intake is essential due to the low consumption of TF in these patients.