This study investigates the impact of vertical greenery systems (VGSs) applied to several typical wall configurations on indoor thermal conditions in a building module situated in the Mediterranean climate of Catania, Italy. By means of dynamic simulations in TRNSYS vers.18, the research compares the thermal behavior of walls made of either hollow clay blocks (Poroton) or lava stone blocks against a lightweight wall setup already in place at the University of Catania. The primary focus is on evaluating the VGSs’ capability of reducing peak inner surface temperatures and moderating heat flux fluctuations entering the building. The findings indicate that adding an outer vertical greenery layer to heavyweight walls can decrease the peak inner surface temperature by up to 1.0 °C compared to the same bare wall. However, the greenery’s positive impact is less pronounced than in the case of the lightweight wall. This research underscores the potential of green facades in enhancing the indoor thermal environment in buildings in regions with climates like the Mediterranean one, providing valuable insights for sustainable building design and urban planning.