This work presents the design and experimental validation of a compact frequency reconfigurable coplanar waveguide (CPW)-fed ultra-wideband (UWB) antenna with a capability to on-demand reject WLAN frequencies within the range of 5.15 GHz to 5.85 GHz, specifically tailored for applications in microwave imaging. The design and experimental results are presented and discussed. The bandwidth enhancement is obtained by using T-shaped slots between the feedline and the ground plane of the antenna, and the WLAN band is rejected by using an open loop resonator (OLR) placed on the antenna backside. Switching between UWB with and without WLAN band-notched modes is performed using a PIN diode and a bias circuit. The simulation results corroborate well with the experimental data and clearly showed an interesting frequency reconfigurable behavior for use in microwave imaging applications. An antenna performance simulation and analysis model is presented for breast tumor detection, and the tumor effect has been noticed for both operating modes of the antenna.